NFL Point Spreads Week 12: Best Picks Against the Spread

Payton Matthews | Updated Nov 20, 2017

lions v vikings

To many in the USA, this is the best week of the NFL season because of the annual tripleheader on the American Thanksgiving holiday this Thursday.

Football and turkey are a match made in heaven! Also, there will be no more bye weeks this season. Here’s a quick look at all the Week 12 matchups including their Sports Interaction NFL odds. Games Sunday unless noted.

Thursday Night Football Point Spreads

latavius murray

Minnesota Vikings vs. Detroit Lions Spread: NFL Week 12 Odds, Prediction

Minnesota
13-3
AT
November 23, 2017, 12:30 PM ET
Ford Field
Detroit
9-7
Pointspread -3 -110
Moneyline -140
Over / Under o +46.5

61%

Betting Action

39%

Pointspread +3 -110
Moneyline +120
Over / Under u +46.5

61%

Betting Action

39%

It’s the second year in a row these NFC North rivals face off on Thanksgiving. The Lions won on a field goal as time expired last year. Both come off wins Sunday, with Detroit escaping in Chicago 27-24 on a late Matt Prater field goal, and Minnesota winning its sixth in a row, 24-7 over the Rams.

Pick ATS: Detroit

dez bryant

Chargers vs. Cowboys Point Spread: NFL Week 12 Odds, Prediction

AT
November 23, 2017, 4:30 PM ET
AT&T Stadium
Dallas
9-7
Pointspread -1 -105
Moneyline -110
Over / Under o +47.5

58%

Betting Action

42%

Pointspread +1 -115
Moneyline -110
Over / Under u +47.5

58%

Betting Action

42%

The Chargers last played on Thanksgiving in 1969, which is the longest drought in the league and a year before the AFL and NFL even merged. L.A. comes off its most dominant effort of the season, a 54-24 rout of Buffalo. The Chargers picked off five Bills passes in the first half on the way to a 37-7 lead at intermission. Dallas has been without suspended star running back Ezekiel Elliott the past two games and has been blown out in each. It was 37-9 at home on Sunday night to the Eagles.

Pick ATS: Dallas

roger-lewis

Giants vs. Washington Point Spread: NFL Week 12 Odds, Prediction

AT
November 23, 2017, 8:30 PM ET
FedExField
Pointspread +7 +100
Moneyline +285
Over / Under o +45

29%

Betting Action

71%

Pointspread -7 -120
Moneyline -365
Over / Under u +45

29%

Betting Action

71%

The NFL added a night game to Thanksgiving back in 2006. This will be the first time ever that Washington hosts a game on the holiday. It lost in Dallas last Thanksgiving. Washington totally gagged away what looked to be a sure win in New Orleans on Sunday, falling 34-31 in overtime. New York got just its second victory of the season, 12-9 in overtime over the heavily-favoured Chiefs.

Pick ATS: Washington

Sunday NFL Point Spreads

Bills vs. Chiefs Point Spread: NFL Week 12 Odds, Prediction

Buffalo
9-7
AT
November 26, 2017, 1:00 PM ET
Arrowhead Stadium
Pointspread +9 -115
Moneyline +310
Over / Under o +47

60%

Betting Action

40%

Pointspread -9 -105
Moneyline -400
Over / Under u +47

60%

Betting Action

40%

The Chiefs were double-digit favourites at the New York Giants but were upset coming out of their bye week, 12-9 in overtime. It was only the third loss in 19 career games off a bye for Coach Andy Reid. Bills coach Sean McDermott opted to give rookie Nathan Peterman his first NFL start Sunday at the Chargers, and it backfired spectacularly in a 54-24 loss as Peterman threw five first-half interceptions and was benched. Kansas City has won the past three in this series, most recently in 2015.

Pick ATS: Buffalo

jacoby-brissett-colts

Titans vs. Colts Point Spread: NFL Week 12 Odds, Prediction

Tennessee
9-7
AT
November 26, 2017, 1:00 PM ET
Lucas Oil Stadium
Pointspread -3.5 -110
Moneyline -180
Over / Under o +47

73%

Betting Action

27%

Pointspread +3.5 -110
Moneyline +150
Over / Under u +47

73%

Betting Action

27%

The Colts come off their bye. The Titans saw their four-game winning streak come to a crashing halt in Pittsburgh on Thursday night, 40-17, their second loss this season by at least 23 points. Tennessee goes for the season sweep as it beat the Colts 36-22 in Nashville in Week 6 on a Monday night. Marcus Mariota hit Taywan Taylor on a 53-yard TD pass with 5:29 left for the winning points – then the Titans added on a Derrick Henry 72-yard garbage TD with less than a minute to go to kill Colts bettors who took the 7.5 points. Indy had won 11 straight in this series.

Pick ATS: Tennessee

browns bengals

Browns vs. Bengals Point Spread: NFL Week 12 Odds, Prediction

Cleveland
0-16
AT
November 26, 2017, 1:00 PM ET
Paul Brown Stadium
Pointspread +8 -105
Moneyline +300
Over / Under o +39

41%

Betting Action

59%

Pointspread -8 -115
Moneyline -380
Over / Under u +39

41%

Betting Action

59%

Cleveland keeps finding new and inventive ways to keep losing as it fell 19-7 vs. the Jaguars on Sunday. The Browns had just 184 yards and five turnovers. Cincinnati ended a two-game slide with a 20-17 victory in Denver. Andy Dalton threw three TD passes. The Bengals have owned their northern Ohio neighbors for the past few years and that continued in Week 4 with a 31-7 Cincinnati victory. Dalton was 17 of 18 for 215 yards and three scores in the first half as the Bengals took a 21-0 lead into intermission.

Pick ATS: Cincinnati

falcons

Buccaneers vs. Falcons Point Spread: NFL Week 12 Odds, Prediction

Tampa Bay
5-11
AT
November 26, 2017, 1:00 PM ET
Mercedes-Benz Stadium
Atlanta
10-6
Pointspread +10 -110
Moneyline +475
Over / Under o +47.5

39%

Betting Action

61%

Pointspread -10 -110
Moneyline -675
Over / Under u +47.5

39%

Betting Action

61%

The Falcons are on a short week after visiting Seattle on Monday. The Bucs won their second in a row following a five-game skid, 30-20 at Miami. Both victories have come behind backup QB Ryan Fitzpatrick, and he may start again with Jameis Winston still dealing with an injured shoulder. These NFC South rivals split last year, each winning on the road. This will be Tampa’s first look at the new Mercedes-Benz Stadium.

Pick ATS: TBA

Dolphins vs. Patriots Point Spread: NFL Week 12 Odds, Prediction

Miami
6-10
AT
November 26, 2017, 1:00 PM ET
Gillette Stadium
Pointspread +17 -115
Moneyline +950
Over / Under o +49

45%

Betting Action

55%

Pointspread -17 -105
Moneyline -1600
Over / Under u +49

45%

Betting Action

55%

The Dolphins committed a whopping 17 penalties and turned it over five times in a 30-20 home loss to Tampa Bay. QB Jay Cutler was picked off three times before leaving in the NFL’s concussion protocol. So it’s wait and see if Cutler plays this week, although he might have lost his job regardless to Matt Moore, who played much better than Cutler in relief. The Patriots won their sixth straight Sunday, 33-8 over the Raiders in Mexico City. Tom Brady was brilliant in completing 30 of 37 for 339 yards and three scores. New England has won the past eight at home against AFC East rival Miami. Brady missed last year’s game.

Pick ATS: Miami

greg-olsen

Panthers vs. Jets Point Spread: NFL Week 12 Odds, Prediction

Carolina
11-5
AT
November 26, 2017, 1:00 PM ET
MetLife Stadium
N.Y. Jets
5-11
Pointspread -6 -120
Moneyline -290
Over / Under o +39.5

81%

Betting Action

19%

Pointspread +6 +100
Moneyline +230
Over / Under u +39.5

81%

Betting Action

19%

Both teams come out of their bye week. Carolina is playing its best football of the season on a three-game winning streak and off a 45-21 wipeout of Miami on Monday night in Week 10. Cam Newton was terrific in throwing for 254 yards and four scores while rushing for 95 yards. Carolina had a team-record 548 yards. Newton is likely to get back Pro Bowl tight end Greg Olsen from injury this week. The Jets have dropped four of their past five.

Pick ATS: Carolina

eagles

Bears vs. Eagles Point Spread: NFL Week 12 Odds, Prediction

Chicago
5-11
AT
November 26, 2017, 1:00 PM ET
Lincoln Financial Field
Pointspread +13.5 -115
Moneyline +750
Over / Under o +44

29%

Betting Action

71%

Pointspread -13.5 -105
Moneyline -1150
Over / Under u +44

29%

Betting Action

71%

It’s a quarterback matchup of the past two No. 2 overall picks in the NFL Draft in Philly’s Carson Wentz (2016) and Chicago’s Mitchell Trubisky. Wentz is 1-0 vs. the Bears, leading a 29-14 victory in Chicago early last season. The Bears lost their third in a row Sunday, 27-24 to Detroit. Connor Barth missed a potentially tying 46-yard field goal in the final seconds. He has struggled all season, so it wouldn’t be surprising if the Bears held kicker tryouts this week. The Eagles trounced the Cowboys in Dallas on Sunday night, 37-9 for their eighth consecutive win. They continue to have the NFL’s best record at 9-1 and already essentially have won the NFC East.

Pick ATS: Chicago

carlos-hyde

Seahawks vs. 49ers Point Spread: NFL Week 12 Odds, Prediction

Seattle
9-7
AT
November 26, 2017, 4:05 PM ET
Levi's Stadium
Pointspread -7 -110
Moneyline -325
Over / Under o +44.5

79%

Betting Action

21%

Pointspread +7 -110
Moneyline +265
Over / Under u +44.5

79%

Betting Action

21%

The 49ers are out of their bye and got their first win of the season in Week 10, 31-21 over the New York Giants. It’s thought that San Francisco will give quarterback Jimmy Garoppolo, acquired from the Patriots at the end of last month, his first start here with the off week to prepare and learn the offense. Garoppolo hasn’t had meaningful NFL action since Week 2 of last season with New England. Seattle is on a short week as it hosted Atlanta on Monday. The Seahawks beat the Niners ugly in Week 2, 12-9.

Pick ATS: TBA

ingram-mark

Saints vs. Rams Point Spread: NFL Week 12 Odds, Prediction

AT
November 26, 2017, 4:25 PM ET
Los Angeles Memorial Coliseum
L.A. Rams
11-5
Pointspread +2.5 +100
Moneyline +120
Over / Under o +54.5

61%

Betting Action

39%

Pointspread -2.5 -120
Moneyline -140
Over / Under u +54.5

61%

Betting Action

39%

With both teams playing much better than expected, this game was flexed from a 1 p.m. ET start to 4:25 p.m. ET. They played last year in New Orleans, and the Saints won 49-21 behind 310 yards passing and four scores from Drew Brees. These Rams are light years better than that team. L.A. did have its four-game winning streak snapped Sunday in a 24-7 loss at Minnesota. The Saints had a miracle comeback win vs. the Redskins in overtime and have won eight in a row.

Pick ATS: Los Angeles

jaguars defence

Jaguars vs. Cardinals Point Spread: NFL Week 12 Odds, Prediction

AT
November 26, 2017, 4:25 PM ET
State Farm Stadium
Arizona
8-8
Pointspread -6 -125
Moneyline -275
Over / Under o +37

76%

Betting Action

24%

Pointspread +6 +105
Moneyline +225
Over / Under u +37

76%

Betting Action

24%

The Jags are in sole possession of first place in the AFC South following a 19-7 victory in Cleveland. That excellent Jacksonville defense forced five turnovers. Rookie Leonard Fournette rushed for 111 yards. He was questionable for the game with an ankle injury and appeared to tweak it during the game, so monitor his status. The Cardinals lost 31-21 in Houston. Third-string QB Blaine Gabbert got the start due to injuries and threw three TD passes but was picked off twice. Arizona might have No. 2 QB Drew Stanton back for this one.

Pick ATS: Arizona

Brock Osweiler

Broncos vs. Raiders Point Spread: NFL Week 12 Odds, Prediction

Denver
5-11
AT
November 26, 2017, 4:25 PM ET
RingCentral Coliseum
Oakland
6-10
Pointspread +4 +100
Moneyline +185
Over / Under o +41

22%

Betting Action

78%

Pointspread -4 -120
Moneyline -225
Over / Under u +41

22%

Betting Action

78%

The Broncos are a mess as they are on a six-game skid following Sunday’s 20-17 home loss to Cincinnati. It’s the franchise’s longest losing streak in 27 years. Look for Coach Vance Joseph to perhaps make a quarterback change this week. The Brock Osweiler experiment isn’t working. The Raiders came out of their bye week and laid an egg in Mexico City, losing 33-8 to New England. That Oakland defense has yet to pick off a pass this season. Denver goes for the season sweep as it beat the Raiders 16-10 in Week 4. Oakland QB Derek Carr was knocked out of the game with a back injury in the third quarter. Neither team reached 300 yards of offense.

Pick ATS: Oakland

Sunday Night Football Point Spreads

brown-antonio

Packers vs. Steelers Point Spread: NFL Week 12 Odds, Prediction

Green Bay
7-9
AT
November 26, 2017, 8:30 PM ET
Heinz Field
Pittsburgh
13-3
Pointspread +14.5 +105
Moneyline +850
Over / Under o +43.5

31%

Betting Action

69%

Pointspread -14.5 -125
Moneyline -1450
Over / Under u +43.5

31%

Betting Action

69%

Matchup: Green Bay at Pittsburgh Sunday, November 26th 2017 Sunday night matchup between franchises that have combined for 13 Super Bowl appearances and 10 victories. The last time either team reached the game was against each other following the 2010 season. Pittsburgh has won five straight and routed a good Titans team 40-17 last Thursday night behind a season-high four TD passes from Ben Roethlisberger – three to Antonio Brown. Green Bay was beaten 23-0 at home by Baltimore, with the Packers turning it over five times. They just aren’t close to the same team without the injured Aaron Rodgers.

Pick ATS: Green Bay

Monday Night Football Point Spreads

savage houston

Texans vs. Ravens Point Spread: NFL Week 12 Odds, Prediction

Houston
4-12
AT
November 27, 2017, 8:30 PM ET
M&T Bank Stadium
Baltimore
9-7
Pointspread +8 +100
Moneyline +300
Over / Under o +40.5

39%

Betting Action

61%

Pointspread -8 -120
Moneyline -380
Over / Under u +40.5

39%

Betting Action

61%

Not quite the matchup that ESPN was hoping for when the MNF schedule was released. It’s only the 10th all-time meeting between the teams. Houston got its first win since QB Deshaun Watson went down with a season-ending injury, 31-21 over Arizona on Sunday. Rookie D’Onta Foreman rushed for two scores but left with an apparent serious injury in the fourth quarter. Baltimore took advantage of five Packers turnovers and won 23-0 in Green Bay.

Pick ATS: Baltimore

SportsInteraction