Chargers vs. Bills Week 3 Betting Odds, Prediction and Picks: Can Justin Herbert Save L.A.’s Season?

L.A. Chargers

0-2

September 27, 2026, 1:00 PM ET

Highmark Stadium

Buffalo

2-0

Pointspread	+7 0
Moneyline	0
Over / Under	o +50.5

Matchup Odds

Pointspread	-7 0
Moneyline	0
Over / Under	u +50.5

Matchup Odds

Sun Sep 27 1:00PM ET

LAC +7

50.5

BUF -7

Sun Sep 27 1:00PM ET

CAR -3

CLE +3

Sun Sep 27 1:00PM ET

NYJ +6.5

DET -6.5

Sun Sep 27 1:00PM ET

HOU -2.5

IND +2.5

Sun Sep 27 1:00PM ET

KC -10.5

MIA +10.5

Sun Sep 27 1:00PM ET

TEN +6

NYG -6

Sun Sep 27 1:00PM ET

CIN -3.5

42.5

PIT +3.5

Sun Sep 27 1:00PM ET

SEA -6.5

40.5

WAS +6.5

Sun Sep 27 1:00PM ET

NE +2.5

JAC -2.5

Sun Sep 27 4:05PM ET

ARI +8.5

SF -8.5

Sun Sep 27 4:05PM ET

MIN -2.5

TB +2.5

Sun Sep 27 4:25PM ET

LV +3

43.5

NO -3

Sun Sep 27 4:25PM ET

BAL -3

52.5

DAL +3

Sun Sep 27 8:20PM ET

LAR -2.5

45.5

DEN +2.5

Mon Sep 28 8:15PM ET

PHI -4

CHI +4

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Offensive Leaders		Full Passing Yards Stats

1	Jordan Love Jordan Love	Green Bay Packers GB	844
2	Tyler Shough Tyler Shough	New Orleans Saints NO	662
3	Bryce Young Bryce Young	Carolina Panthers CAR	648
4	C.J. Stroud C.J. Stroud	Houston Texans HOU	627
5	Josh Allen Josh Allen	Buffalo Bills BUF	582

Offensive Leaders		Full Rushing Yards Stats

1	Bijan Robinson Bijan Robinson	Atlanta Falcons ATL	349
2	Kenneth Walker III Kenneth Walker III	Kansas City Chiefs KC	290
3	Derrick Henry Derrick Henry	Baltimore Ravens BAL	212
4	Jahmyr Gibbs Jahmyr Gibbs	Detroit Lions DET	208
5	James Cook III James Cook III	Buffalo Bills BUF	192

Offensive Leaders		Full Receiving Yards Stats

1	Christian Watson Christian Watson	Green Bay Packers GB	284
2	Jaxon Smith-Njigba Jaxon Smith-Njigba	Seattle Seahawks SEA	277
3	Drake London Drake London	Atlanta Falcons ATL	274
4	Chris Olave Chris Olave	New Orleans Saints NO	268
5	Matthew Golden Matthew Golden	Green Bay Packers GB	253

Defensive Leaders		Full Tackles Stats

1	Anthony Hill Jr. Anthony Hill Jr.	Tennessee Titans TEN	26
2	Evan Williams Evan Williams	Green Bay Packers GB	25
3	Alex Singleton Alex Singleton	Denver Broncos DEN	24
4	Jacob Rodriguez Jacob Rodriguez	Miami Dolphins MIA	22
5	Akeem Davis-Gaither Akeem Davis-Gaither	Indianapolis Colts IND	22

Defensive Leaders		Full Sacks Stats

1	Greg Rousseau Greg Rousseau	Buffalo Bills BUF	4
2	T.J. Watt T.J. Watt	Pittsburgh Steelers PIT	3.5
3	Dallas Turner Dallas Turner	Minnesota Vikings MIN	3
4	Alex Highsmith Alex Highsmith	Pittsburgh Steelers PIT	3
5	Aidan Hutchinson Aidan Hutchinson	Detroit Lions DET	3

Defensive Leaders		Full Interceptions Stats

1	Julian Love Julian Love	Seattle Seahawks SEA	2
2	Jevon Holland Jevon Holland	N.Y. Giants Giants NYG	2
3	Hezekiah Masses Hezekiah Masses	Las Vegas Raiders LV	2
4	Devin Lloyd Devin Lloyd	Carolina Panthers CAR	2
5	Renardo Green Renardo Green	San Francisco 49ers SF	1

American Football Conference - AFCW

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Kansas City Chiefs KC	2	0	64	40	0-1	0-1	0-0	0-0	1-1	1-1
Las Vegas Raiders LV	2	0	53	27	0-2	1-0	0-0	0-0	2-0	0-2
Denver Broncos DEN	1	1	30	44	1-1	1-0	0-0	0-0	1-1	0-2
L.A. Chargers Chargers LAC	0	2	28	52	0-2	1-0	0-0	0-0	0-2	0-2

American Football Conference - AFCS

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Jacksonville Jaguars JAC	1	1	47	30	1-1	1-0	0-0	0-0	1-1	1-1
Houston Texans HOU	0	2	37	56	0-2	0-1	0-0	0-0	0-2	1-1
Indianapolis Colts IND	0	2	53	74	0-2	0-0	0-0	0-0	1-1	2-0
Tennessee Titans TEN	0	2	30	47	1-1	1-0	0-0	0-0	1-1	1-1

American Football Conference - AFCE

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Buffalo Bills BUF	2	0	77	62	2-0	1-0	0-0	0-0	2-0	2-0
New England Patriots NE	1	1	30	16	1-0	0-1	0-0	0-0	2-0	0-2
N.Y. Jets Jets NYJ	1	1	40	30	0-2	1-0	0-0	0-0	1-0	0-2
Miami Dolphins MIA	0	2	26	62	0-2	0-1	0-0	0-0	0-2	1-1

American Football Conference - AFCN

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Cincinnati Bengals CIN	2	0	53	33	2-0	1-0	0-0	0-0	2-0	1-1
Baltimore Ravens BAL	1	1	58	47	2-0	1-0	0-0	0-0	1-1	1-1
Pittsburgh Steelers PIT	1	1	23	33	1-1	0-1	0-0	0-0	1-1	0-2
Cleveland Browns CLE	1	1	33	53	1-1	1-1	0-0	0-0	1-1	2-0

American Football Conference - AFCW

Denver Broncos DEN	0-0	0-0	0-0	0-0
L.A. Chargers Chargers LAC	0-0	0-0	0-0	0-0
Las Vegas Raiders LV	0-0	0-0	0-0	0-0

American Football Conference - AFCS

Jacksonville Jaguars JAC	0	0	0	0	0	0-0	0-0	0-0	0-0
Tennessee Titans TEN	0	0	0	0	0	0-0	0-0	0-0	0-0

American Football Conference - AFCE

Buffalo Bills BUF	0-0	0-0	0-0	0-0
New England Patriots NE	0-0	0-0	0-0	0-0
N.Y. Jets Jets NYJ	0-0	0-0	0-0	0-0

American Football Conference - AFCN

Baltimore Ravens BAL	0-0	0-0	0-0	0-0
Cincinnati Bengals CIN	0-0	0-0	0-0	0-0
Cleveland Browns CLE	0-0	0-0	0-0	0-0
Pittsburgh Steelers PIT	0-0	0-0	0-0	0-0

American Football Conference

National Football Conference - NFCW

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Seattle Seahawks SEA	2	0	44	17	0-1	0-1	0-0	0-0	1-1	0-2
San Francisco 49ers SF	2	0	62	20	0-1	2-0	0-0	0-0	2-0	1-1
L.A. Rams Rams LAR	1	1	35	33	1-1	2-0	0-0	0-0	1-1	0-2
Arizona Cardinals ARI	1	1	33	45	0-2	1-1	0-0	0-0	1-1	0-2

National Football Conference - NFCS

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Carolina Panthers CAR	1	1	71	62	1-0	2-1	0-0	0-0	1-1	1-1
New Orleans Saints NO	1	1	54	48	0-1	1-1	0-0	0-0	2-0	1-1
Atlanta Falcons ATL	1	2	51	68	0-1	1-1	0-0	0-0	0-2	0-2
Tampa Bay Buccaneers TB	0	2	46	56	1-0	1-1	0-0	0-0	0-2	2-0

National Football Conference - NFCE

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Philadelphia Eagles PHI	2	0	48	42	0-1	0-2	0-0	0-0	0-2	1-1
N.Y. Giants Giants NYG	1	1	34	48	0-1	2-0	0-0	0-0	1-1	0-2
Dallas Cowboys DAL	1	1	57	48	0-1	2-0	0-0	0-0	1-1	1-1
Washington Commanders WAS	0	2	42	61	1-0	0-2	0-0	0-0	1-1	1-1

National Football Conference - NFCN

team	w	l	pf	pa	home	away	div	conf	ats	o/u
Minnesota Vikings MIN	2	0	48	25	0-1	1-1	0-0	0-0	2-0	1-1
Detroit Lions DET	1	1	62	71	1-0	1-1	0-0	0-0	0-2	2-0
Chicago Bears CHI	1	1	62	46	1-0	1-1	0-0	0-0	1-1	1-1
Green Bay Packers GB	1	2	56	91	1-0	1-1	0-0	0-0	0-1	1-1

National Football Conference - NFCW

L.A. Rams Rams LAR	0-0	0-0	0-0	0-0
San Francisco 49ers SF	0-0	0-0	0-0	0-0
Arizona Cardinals ARI	0-0	0-0	0-0	0-0

National Football Conference - NFCS

Carolina Panthers CAR	0-0	0-0	0-0	0-0
Tampa Bay Buccaneers TB	0-0	0-0	0-0	0-0
Atlanta Falcons ATL	0-0	0-0	0-0	0-0
New Orleans Saints NO	0-0	0-0	0-0	0-0

National Football Conference - NFCE

N.Y. Giants Giants NYG	0-0	0-0	0-0	0-0
Dallas Cowboys DAL	0-0	0-0	0-0	0-0
Washington Commanders WAS	0-0	0-0	0-0	0-0

National Football Conference - NFCN

Green Bay Packers GB	0-0	0-0	0-0	0-0
Chicago Bears CHI	0-0	0-0	0-0	0-0
Detroit Lions DET	0-0	0-0	0-0	0-0
Minnesota Vikings MIN	0-0	0-0	0-0	0-0

National Football Conference

Nfl Betting News and Matchup Odds

Chargers vs. Bills Week 3 Betting Odds, Prediction and Picks: Can Justin Herbert Save L.A.&#8217;s Season?

LAC +7

BUF -7

CAR -3

CLE +3

NYJ +6.5

DET -6.5

HOU -2.5

IND +2.5

KC -10.5

MIA +10.5

TEN +6

NYG -6

CIN -3.5

PIT +3.5

SEA -6.5

WAS +6.5

NE +2.5

JAC -2.5

ARI +8.5

SF -8.5

MIN -2.5

TB +2.5

LV +3

NO -3

BAL -3

DAL +3

LAR -2.5

DEN +2.5

PHI -4

CHI +4

NFL Betting News

League Leaders

Chargers vs. Bills Week 3 Betting Odds, Prediction and Picks: Can Justin Herbert Save L.A.’s Season?