49ers vs. Colts Prediction, Odds & Stats - December 22, 2025

Scoreboard	Spread	Moneyline	O/U
San Francisco 49ers 10-4	San Francisco 49ers -5.5 (-118) on Sports Interaction	San Francisco 49ers -275 on Sports Interaction	46.5 (-115) on Sports Interaction
Indianapolis Colts 8-6	Indianapolis Colts +5.5 (-102) on Sports Interaction	Indianapolis Colts +225 on Sports Interaction	46.5 (-105) on Sports Interaction

Date	Result	Competition
12/14/25	Tennessee Titans TEN ( 2-12 ) San Francisco 49ers SF ( 10-4 ) 24 - 37	AFC South
12/14/25	Indianapolis Colts IND ( 8-6 ) Seattle Seahawks SEA ( 11-3 ) 16 - 18	AFC South
12/07/25	Indianapolis Colts IND ( 8-6 ) Jacksonville Jaguars JAC ( 10-4 ) 19 - 36	AFC South
11/30/25	San Francisco 49ers SF ( 10-4 ) Cleveland Browns CLE ( 3-11 ) 26 - 8	NFC West
11/30/25	Houston Texans HOU ( 9-5 ) Indianapolis Colts IND ( 8-6 ) 20 - 16	AFC South
11/24/25	Carolina Panthers CAR ( 7-7 ) San Francisco 49ers SF ( 10-4 ) 9 - 20	NFC South
11/23/25	Indianapolis Colts IND ( 8-6 ) Kansas City Chiefs KC ( 6-8 ) 20 - 23	AFC South
11/16/25	San Francisco 49ers SF ( 10-4 ) Arizona Cardinals ARI ( 3-11 ) 41 - 22	NFC West
11/09/25	L.A. Rams Rams LAR ( 11-3 ) San Francisco 49ers SF ( 10-4 ) 42 - 26	NFC West
11/09/25	Atlanta Falcons ATL ( 5-9 ) Indianapolis Colts IND ( 8-6 ) 25 - 31	NFC South
11/02/25	San Francisco 49ers SF ( 10-4 ) N.Y. Giants Giants NYG ( 2-12 ) 34 - 24	NFC West
11/02/25	Indianapolis Colts IND ( 8-6 ) Pittsburgh Steelers PIT ( 8-6 ) 20 - 27	AFC South

Spread Bets • 5.5
San Francisco 49ers SF	50%
Indianapolis Colts IND	50%

Totals (O/U) • 46.5
Over	0%
Under	0%

Money Bets •
San Francisco 49ers SF	0%
Indianapolis Colts IND	0%

team	win	loss	last 10	w/l streak	ats	money	home	away	total
San Francisco 49ers San Francisco 49ers	10	4	7-3	4W	9-5	0	0-0	0-0	8-6
Indianapolis Colts Indianapolis Colts	8	6	5-5	4L	8-6	0	0-0	0-0	7-7

date	home-away	ats	o/u	IND:Total Net Yards	IND:Net Rushing Yards	IND:Passing Yards	SF:Total Net Yards	SF:Net Rushing Yards	SF:Passing Yards
10/24/2021	SF 18 - IND 30	IND +3.5	Over 44.5	295	148	147	280	111	169
08/25/2018	IND 23 - SF 17	IND 0	Under 43.5	390	126	264	349	80	269
10/08/2017	IND 26 - SF 23	IND -1	Over 43	402	66	336	447	159	288

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
12/14/2025	SF 37 - TEN 24	W -12.5	Over 44.5	306	136	170
11/30/2025	CLE 8 - SF 26	W -6.5	Under 41.5	252	91	161
11/24/2025	SF 20 - CAR 9	W -7	Under 49	230	69	161
11/16/2025	ARI 22 - SF 41	W -3.5	Over 47.5	281	95	186
11/09/2025	SF 26 - LAR 42	L +6	Over 46.5	401	126	275
11/02/2025	NYG 24 - SF 34	W -3	Over 47.5	380	159	221
10/26/2025	HOU 26 - SF 15	L +3	Under 41.5	223	48	175
10/19/2025	SF 20 - ATL 10	W -3	Under 46.5	292	62	230
10/12/2025	TB 30 - SF 19	L +2.5	Over 47	363	67	296
10/02/2025	LAR 23 - SF 26	W +8.5	Over 47.5	407	74	333

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
12/14/2025	SEA 18 - IND 16	W +10	Under 41.5	314	50	264
12/07/2025	JAC 36 - IND 19	L -1.5	Over 45.5	350	103	247
11/30/2025	IND 16 - HOU 20	L -3.5	Under 44.5	281	86	195
11/23/2025	KC 23 - IND 20	L +3.5	Under 49.5	494	148	346
11/09/2025	IND 31 - ATL 25	W -7	Over 48.5	519	323	196
11/02/2025	PIT 27 - IND 20	L -2.5	Under 51.5	225	38	187
10/26/2025	IND 38 - TEN 14	W -3.5	Over 48	420	164	256
10/19/2025	LAC 24 - IND 38	W +1.5	Over 48.5	445	54	391
10/12/2025	IND 31 - ARI 27	L -5.5	Over 46.5	355	150	205
10/05/2025	IND 40 - LV 6	W -6.5	Under 46.5	317	96	221

San Francisco 49ers SF Indianapolis Colts IND

avg	rank	edge in	rank	avg
24.57	11	Points Per Game	6	28
20.93	10	Points Allowed Per Game	11	21.64
4.79	10	1st Quarter Scoring Per Game	3	6.36
2.93	2	1st Quarter Scoring Allowed Per Game	7	3.79
7.43	10	2nd Quarter Scoring Per Game	5	8.43
7.21	15	2nd Quarter Scoring Allowed Per Game	13	6.71
5.43	11	3rd Quarter Scording Per Game	6	6.29
4.5	12	3rd Quarter Scoring Allowed Per Game	7	3.64
6.71	13	4th Quarter Scoring Per Game	15	6.5
6.29	11	4th Quarter Scoring Allowed Per Game	16	7.29
63.0	7	Red Zone Efficiency	4	64.9
347.5	10	Total Yards Per Game	8	357.5
10.14	18	Total Yards Per Play	8	11.25
3.51	30	Rushing Yards Per Play	5	4.84
34.29	8	Passing Attempts Per Game	18	31.79
10.44	15	Passing Yards Per Completion	11	10.76
1.79	4	Passing Tds Per Game	8	1.43
23.57	3	Completions Per Game	11	21.29
68.8	4	Completion %	9	67.0
96.64	10	Qb Rating	11	95.11
1.57	18	Defense Sacks Per Game	16	1.71
0.93	5	Defense Interceptions Per Game	8	0.71
1.21	8	Opponent Fumbles Per Game	1	0.64
0.43	6	Opponent Fumbles Lost Per Game	6	0.43
5.21	2	Penalties Per Game	9	6.14
37.79	2	Penalty Yards Per Game	12	49.93
19	11	Takeaway / Giveaway Differential	8	16
7.16	4	Yards Per Punt Return	11	5.22
27.95	4	Yards Per Kickoff Return	3	28.15

offence

San Francisco 49ers SF

	Season stats	rank
Total Yards	347.5	10
Passing Yards	246.14	4
Rushing Yards	101.36	25
Points Scored	24.57	11
Field Goal %	0.94	2

Indianapolis Colts IND

	Season stats	rank
Total Yards	357.5	8
Passing Yards	229	9
Rushing Yards	128.5	6
Points Scored	28	6
Field Goal %	0.93	4

defence

San Francisco 49ers SF

	Season stats	rank
Total Yards	347.5	10
Passing Yards	246.14	4
Rushing Yards	101.36	25
Points Scored	24.57	11
Field Goal %	0.94	2

Indianapolis Colts IND

	Season stats	rank
Total Yards	357.5	8
Passing Yards	229	9
Rushing Yards	128.5	6
Points Scored	28	6
Field Goal %	0.93	4

San Francisco 49ers SF

player (position)	status		ats*current	o/u*	notes
Christian McCaffrey (RB)	Ques Sun	Illness - 12 / 12 / 25	0-0	0-0	Details
Kyle Juszczyk (FB)	Ques Sun	Ribs - 11 / 12 / 25	0-0	0-0	Details
Ben Bartch (OL)	Out indefinitely	Foot - 30 / 11 / 25	0-0	0-0	Details
Kyle Juszczyk (FB)	Ques Sun	Ribs - 30 / 11 / 25	0-0	0-0	Details
Nick Martin (LB)	Ques Dec. 22	Concussion - 30 / 11 / 25	0-0	0-0	Details
Luke Gifford (LB)	Ques Nov 30	Hip - 26 / 11 / 25	0-0	0-0	Details
Sam Okuayinonu (DL)	Ques Dec. 22	Ankle - 25 / 11 / 25	0-0	0-0	Details
Eddy Pineiro (K)	Ques Dec 14	Hamstring - 23 / 11 / 25	0-0	0-0	Details
Robert Beal Jr. (DL)	Ques Sun	Concussion - 23 / 11 / 25	0-0	0-0	Details
Tatum Bethune (LB)	Ques Dec. 22	Ankle - 23 / 11 / 25	0-0	0-0	Details

Indianapolis Colts IND

player (position)	status		ats*current	o/u*	notes
Braden Smith (OT)	Out indefinitely	Concussion - 12 / 12 / 25	0-0	0-0	Details
Riley Leonard (QB)	Ques Dec. 22	Knee - 09 / 12 / 25	0-0	0-0	Details
J.T. Tuimoloau (DE)	Ques Dec. 22	Head - 09 / 12 / 25	0-0	0-0	Details
Charvarius Ward (CB)	Out indefinitely	Concussion - 09 / 12 / 25	0-0	0-0	Details
Daniel Jones (QB)	out for season	Achilles - 09 / 12 / 25	0-0	0-0	Details
Anthony Gould (WR)	Ques Dec. 22	Foot - 09 / 12 / 25	0-0	0-0	Details
Josh Downs (WR)	Ques Dec 14	Hip - 04 / 12 / 25	0-0	0-0	Details
Kenny Moore II (CB)	Ques Dec 14	Illness - 04 / 12 / 25	0-0	0-0	Details
Tyquan Lewis (DE)	Ques Dec 14	Ankle - 04 / 12 / 25	0-0	0-0	Details
Tyler Warren (TE)	Ques Nov 30	Illness - 29 / 11 / 25	0-0	0-0	Details

San Francisco 49ers SF

49ers are 1-4 ATS in their last 5 games as a road underdog of 3.5-10.0.

49ers are 5-12 ATS in their last 17 games following a ATS win.

Over is 10-3 in 49ers last 13 games in Week 16.

49ers are 1-6 ATS in their last 7 games as a road underdog.

49ers are 6-2 ATS in their last 8 road games.

Indianapolis Colts IND

Colts are 4-0 ATS in their last 4 games as a home underdog of 0.5-3.0.

Over is 5-2 in Colts last 7 Monday games.

Over is 9-3 in Colts last 12 games as a favorite.

Colts are 1-4 ATS in their last 5 games following a ATS win.

Under is 10-4 in Colts last 14 games in Week 16.

Team	Win / Loss	ATS	OU
L.A. Rams Rams LAR	11-3	10-4	7-7
Chicago Bears CHI	10-4	6-8	8-6
Philadelphia Eagles PHI	9-5	8-6	6-8
Tampa Bay Buccaneers TB	7-7	5-9	8-6
Seattle Seahawks SEA	11-3	10-4	7-7
San Francisco 49ers SF	10-4	9-5	8-6
Green Bay Packers GB	9-4	6-8	8-6
Detroit Lions DET	8-6	7-6	8-5
Carolina Panthers CAR	7-7	5-9	8-6
Dallas Cowboys DAL	6-7	7-6	9-4
Minnesota Vikings MIN	6-8	7-6	8-5
Atlanta Falcons ATL	5-9	7-7	7-6-1
New Orleans Saints NO	4-10	7-7	9-5
Washington Commanders WAS	4-10	7-6	9-4
Arizona Cardinals ARI	3-11	7-7	7-6-1
N.Y. Giants Giants NYG	2-12	6-8	8-6

Team	Win / Loss	ATS	OU
Denver Broncos DEN	12-2	6-7	5-8
New England Patriots NE	11-3	9-5	8-6
Jacksonville Jaguars JAC	10-4	9-5	8-6
Pittsburgh Steelers PIT	8-6	6-7	7-6
L.A. Chargers Chargers LAC	10-4	8-6	7-7
Buffalo Bills BUF	10-4	6-7	7-7
Houston Texans HOU	9-5	5-9	6-8
Indianapolis Colts IND	8-6	8-6	7-7
Baltimore Ravens BAL	7-7	9-5	8-6
Kansas City Chiefs KC	6-8	6-7	5-8
Miami Dolphins MIA	6-8	6-8	8-6
Cincinnati Bengals CIN	4-10	6-8	8-6
N.Y. Jets Jets NYJ	3-11	7-7	9-5
Cleveland Browns CLE	3-11	6-7	7-7
Las Vegas Raiders LV	2-12	5-9	6-8
Tennessee Titans TEN	2-12	5-9	4-10

San Francisco 49ers

Pitchers

POS	Player

Hitters

POS	Player

Indianapolis Colts

Pitchers

POS	Player

Hitters

POS	Player

Team	Last 5 Matches
San Francisco 49ers SF ( 10-4 )	W W W W L
Indianapolis Colts IND ( 8-6 )	L L L W L

12/28/25

8:20 pm ET

Chicago Bears CHI ( 10-4 )

San Francisco 49ers SF ( 10-4 )

vs
Matchup

12/28/25

1:00 pm ET

Jacksonville Jaguars JAC ( 10-4 )

Indianapolis Colts IND ( 8-6 )

vs
Matchup

Jonathan Taylor Running Back San Francisco	18	Touchdowns	14	Christian McCaffrey Running Back Indianapolis
Jonathan Taylor Running Back San Francisco	1443	Rushing	922	Christian McCaffrey Running Back Indianapolis
Daniel Jones Quarterback San Francisco	3101	Passing	2151	Mac Jones Quarterback Indianapolis
Christian McCaffrey Running Back Indianapolis	86	Receiving	72	Michael Pittman Jr. Wide Receiver San Francisco
Laiatu Latu Defensive End San Francisco	7	Sacks	4	Bryce Huff Defensive Lineman Indianapolis
Cam Bynum Safety San Francisco	3	Interceptions	2	Ji'ayir Brown Safety Indianapolis

nfl Standings Complete SF Standings

Philadelphia Eagles PHI
Dallas Cowboys DAL
Washington Commanders WAS
N.Y. Giants Giants NYG
L.A. Rams Rams LAR
Seattle Seahawks SEA
San Francisco 49ers SF
Arizona Cardinals ARI
Chicago Bears CHI
Green Bay Packers GB
Detroit Lions DET
Minnesota Vikings MIN
Tampa Bay Buccaneers TB
Carolina Panthers CAR
Atlanta Falcons ATL
New Orleans Saints NO

Game Preview

49ers vs. Colts Point Spread: NFL Week 16 MNF Odds, Prediction

The Philip Rivers comeback story continues in Week 16 as the fading Indianapolis Colts play host to the San Francisco 49ers.

Team	Win / Loss	ATS	OU
L.A. Rams Rams LAR	11-3	10-4	7-7
Chicago Bears CHI	10-4	6-8	8-6
Philadelphia Eagles PHI	9-5	8-6	6-8
Tampa Bay Buccaneers TB	7-7	5-9	8-6
Seattle Seahawks SEA	11-3	10-4	7-7
San Francisco 49ers SF	10-4	9-5	8-6
Green Bay Packers GB	9-4	6-8	8-6
Detroit Lions DET	8-6	7-6	8-5
Carolina Panthers CAR	7-7	5-9	8-6
Dallas Cowboys DAL	6-7	7-6	9-4
Minnesota Vikings MIN	6-8	7-6	8-5
Atlanta Falcons ATL	5-9	7-7	7-6-1
New Orleans Saints NO	4-10	7-7	9-5
Washington Commanders WAS	4-10	7-6	9-4
Arizona Cardinals ARI	3-11	7-7	7-6-1
N.Y. Giants Giants NYG	2-12	6-8	8-6

Team	Win / Loss	ATS	OU
Denver Broncos DEN	12-2	6-7	5-8
New England Patriots NE	11-3	9-5	8-6
Jacksonville Jaguars JAC	10-4	9-5	8-6
Pittsburgh Steelers PIT	8-6	6-7	7-6
L.A. Chargers Chargers LAC	10-4	8-6	7-7
Buffalo Bills BUF	10-4	6-7	7-7
Houston Texans HOU	9-5	5-9	6-8
Indianapolis Colts IND	8-6	8-6	7-7
Baltimore Ravens BAL	7-7	9-5	8-6
Kansas City Chiefs KC	6-8	6-7	5-8
Miami Dolphins MIA	6-8	6-8	8-6
Cincinnati Bengals CIN	4-10	6-8	8-6
N.Y. Jets Jets NYJ	3-11	7-7	9-5
Cleveland Browns CLE	3-11	6-7	7-7
Las Vegas Raiders LV	2-12	5-9	6-8
Tennessee Titans TEN	2-12	5-9	4-10

49ers vs. Colts Prediction, Odds & Stats - December 22, 2025

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