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Dolphins vs. 49ers NFL Betting Odds, Picks:

Game Scheduled
Miami
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San Francisco
49ers
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Miami Dolphins
San Francisco 49ers
Scoreboard Spread Moneyline O/U
Miami Dolphins 0-1 - - -
San Francisco 49ers 1-0 - - -

Dolphins vs. 49ers Week 2 Betting Odds, Prediction and Picks: Can Miami Cover a Huge Spread?

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Miami is expected to be among the worst teams in the NFL this season, while San Francisco is looking to make a deep postseason run.

The Dolphins lost 27-13 to the Raiders in Week 1. Miami managed to generate just 259 total yards of offence, and De’Von Achane was held to just 36 rushing yards on 11 carries. If the Dolphins want to get things rolling offensively, getting Achane more involved will be a top priority.

The 49ers looked extremely impressive in their season opener, as they defeated the Rams 27-7 in Australia. The 49ers ran for 177 yards as a team and went a strong 7-for-12 on 3rd down. Mike Evans put forth a strong debut with his new team, as he hauled in 6 catches for 49 yards and a touchdown on his 49ers debut.

The Dolphins won the most recent meeting between these teams 29-17 in Miami on December 22, 2024.

Dolphins vs. 49ers Kickoff, Weather, TV, Streaming Info

Canada TV/Streaming: In Canada, Dolphins vs. 49ers kicks off Sunday at 4:25 p.m. ET. The game is available to stream on DAZN through NFL Game Pass. Select Sunday afternoon games are also shown on CTV, depending on regional coverage.

The current weather projection for San Francisco on Sunday afternoon calls for mostly sunny skies and a high of 73 degrees.

NFL Betting Odds, Point Spread, Trends

Not surprisingly, the 49ers find themselves as heavy favourites in this Week 2 contest. Specifically, San Francisco is favoured by 13.5 points with odds of -950 on the moneyline. The Dolphins sit at odds of +625, while the total is listed at 44.5 points.

After playing in Australia last Thursday, the 49ers have had a few extra days to prepare for this matchup. That extra prep time could come in handy, as the 49ers are already dealing with a plethora of lingering injuries. This week, both rookie WR De’Zhaun Stribling and TE Jake Tonges were placed on IR with season-ending injuries. While they won’t be available, other impact players such as Christian McCaffrey, Mike Evans, George Kittle and Trent Williams are all expected to be available.

The Dolphins have undergone plenty of changes over the offseason. Most notably, head coach Jeff Hafley took over from Mike McDaniel and Malik Willis is the starting quarterback with Tua Tagovailoa now in Atlanta. It’s clear that the Dolphins are still trying to establish an identity, and trying to do so on the road against a veteran San Francisco team will undoubtedly present plenty of challenges.

NFL Player Odds and Props

Miami Dolphins

De’Von Achane Over 13.5 rush attempts (-129)

De’Von Achane is Miami’s most dangerous offensive weapon, but he couldn’t get much going in the season opener against Las Vegas. He recorded just 11 carries for 36 yards, which equated to a lowly 3.3 yards per rush. Looking to keep the ball out of Brock Purdy’s hands, Miami are likely to give Achane a higher volume of rushing attempts in this one. If the Dolphins have any chance at a major upset, getting Achane involved early and often seems to be the most logical way to do so.

San Francisco 49ers

George Kittle Over 3.5 receptions (-145)

Brock Purdy did a wonderful job of spreading the ball around to different receivers in Week 1. He completed 25 passes to 8 different receivers, but George Kittle only had a pair of catches on 5 targets. It’s clear that Purdy and Kittle have great chemistry, and it would be a bit surprising to see Kittle have another quiet game in this one.

Miami Dolphins

Both the Raiders and Dolphins began new eras in their matchup last week, and the Raiders controlled the game from start to finish. Miami trailed 7-0 after the 1st quarter and 17-6 at halftime en route to suffering a 27-13 defeat. The offensive line was worrisome all game long, as Malik Willis was sacked 5 times and the running game couldn’t muster up much of anything. The 49ers completely shut down Matthew Stafford and the Rams in Week 1, so Willis and company will have their hands full in this matchup.

San Francisco 49ers

After losing to the eventual Super Bowl champion Seattle Seahawks in the NFC Divisional round last year, the 49ers are locked and loaded for another strong season. Injuries are already impacting their season, but they put forth a dominating Week 1 against the Rams, who are also expected to be among the NFL’s best teams this season. This matchup is much more manageable, and with some extra days to prepare, the 49ers should have little trouble cruising to a victory.

Dolphins vs. 49ers Week 2 Score Prediction

DOLPHINS

Away
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San Francisco 49ers

49ERS

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