Seahawks vs. Cardinals Week 2 Betting Odds, Prediction and Picks: Darnold Injury Shifts the Spread
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Sports Interaction Staff
Two NFC West rivals who both opened their 2026 NFL campaigns with victories will meet on Sunday when the Seahawks travel to face the Cardinals at State Farm Stadium in Glendale.
The Seahawks began their Super Bowl title defence with a 13-10 victory over the New England Patriots, but the result came at a cost, as starting quarterback Sam Darnold suffered a glute injury on Seattle’s opening possession.
Drew Lock stepped in and helped guide the Seahawks to victory, throwing for 187 yards and a touchdown.
The Cardinals also started the season with a victory, beating the Los Angeles Chargers 26-14 on the road.
Jacoby Brissett threw for 277 yards and one touchdown, while Arizona’s defence forced Justin Herbert into a difficult afternoon.
Seattle swept the Cardinals in their two meetings last season and have won nine consecutive games against their NFC West rivals.
Seahawks vs. Cardinals Kickoff, Weather, TV, Streaming Info
Kick-off is set for 4:25 PM ET at State Farm Stadium in Glendale, Arizona.
The game will be shown nationally on FOX, while the weather forecast suggests hot conditions at around 98°F in Glendale at the time of kick-off.
Thankfully for the players and spectators at State Farm Stadium, this venue is fully air-conditioned.
NFL Betting Odds, Point Spread, Trends
Seattle enters this contest as favourites despite the absence of their starting quarterback.
The Seahawks opened as 5.5-point favourites against Arizona, although the line has come in to 1.5 points following the news that Darnold will miss Sunday’s encounter.
Arizona, meanwhile, will look to build on an impressive Week 1 performance against the Chargers.
The Cardinals scored 26 points against LA and controlled the game after taking a 14-7 lead into halftime.
Seattle are the -225 favourites on the money line, while the Cardinals are the +160 underdogs to take down the reigning Super Bowl champions.
NFL Player Odds and Props
Seattle Seahawks
Cooper Kupp anytime touchdown (+475)
Having had a quiet game against New England last week, expect to see more from wide receiver Cooper Kupp in Sunday’s game in Glendale. Kupp has scored seven touchdowns previously against the Cardinals and can be a thorn in Arizona’s side again this weekend.
Arizona Cardinals
Marvin Harrison Jr. anytime touchdown (+300)
Going for 33 yards from just one reception against the Chargers, Marvin Harrison Jr. showed how dangerous he can be when found by Brissett. Harrison Jr. should see more of the ball this weekend and looks capable of adding to the 12 touchdowns he has scored in his first two seasons in the NFL.
Seattle Seahawks
The Seahawks overcame an early setback in Week 1 after losing Darnold, with Lock stepping in and leading the team to a narrow victory. Seattle’s defence remains their strength, while the offence has several weapons capable of taking pressure off Lock. Kupp remains an important target through the air, while Seattle will also look to its running game to keep the Cardinals’ defence honest. The Seahawks will be hoping wide receiver Tory Horton can return after practicing fully on Wednesday, while safety Nick Emmanwori and Ty Okada face a race against time for the weekend.
Arizona Cardinals
Arizona could hardly have asked for a better start to the season after taking down the Chargers 26-14 in LA. Brissett looked comfortable in his first start of the campaign, while the Cardinals defence did enough to keep the Chargers’ offence under control. Harrison Jr. will be one of the key players to watch, with Arizona hoping their star receiver can take another step forward this term. The Cardinals have placed safety Kitan Crawford on IR with an ankle injury, while left guard Isaac Seumalo missed practice due to a shoulder issue.
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