Bills vs. Panthers Prediction, Odds & Stats - October 26, 2025

Final Score
Buffalo
Bills
Carolina
Panthers
40
9
Buffalo Bills
Carolina Panthers
Scoreboard 1 2 3 4 Odds
Buffalo Bills 12-5 3 16 21 0 +48
Carolina Panthers 8-9 0 3 0 6 +7

Latest Encounters

Date Result Competition Stats Recap
01/04/26
N.Y. Jets Jets NYJ ( 3-14 )
Buffalo Bills BUF ( 12-5 )
8   -   35
AFC East
01/03/26
Carolina Panthers CAR ( 8-9 )
Tampa Bay Buccaneers TB ( 8-9 )
14   -   16
NFC South
12/28/25
Philadelphia Eagles PHI ( 11-6 )
Buffalo Bills BUF ( 12-5 )
13   -   12
NFC East
12/28/25
Seattle Seahawks SEA ( 14-3 )
Carolina Panthers CAR ( 8-9 )
27   -   10
NFC West
12/21/25
Buffalo Bills BUF ( 12-5 )
Cleveland Browns CLE ( 5-12 )
23   -   20
AFC East
12/21/25
Tampa Bay Buccaneers TB ( 8-9 )
Carolina Panthers CAR ( 8-9 )
20   -   23
NFC South
12/14/25
Carolina Panthers CAR ( 8-9 )
New Orleans Saints NO ( 6-11 )
17   -   20
NFC South
12/14/25
Buffalo Bills BUF ( 12-5 )
New England Patriots NE ( 14-3 )
35   -   31
AFC East
12/07/25
Cincinnati Bengals CIN ( 6-11 )
Buffalo Bills BUF ( 12-5 )
34   -   39
AFC North
11/30/25
Buffalo Bills BUF ( 12-5 )
Pittsburgh Steelers PIT ( 10-7 )
26   -   7
AFC East
11/30/25
L.A. Rams Rams LAR ( 12-5 )
Carolina Panthers CAR ( 8-9 )
28   -   31
NFC West
11/24/25
Carolina Panthers CAR ( 8-9 )
San Francisco 49ers SF ( 12-5 )
9   -   20
NFC South

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Buffalo Bills Buffalo Bills
4 2 7-3 1W 1-4 0 0-0 0-0 3-3
Carolina Panthers Carolina Panthers
4 3 4-6 2L 5-2 0 0-0 0-0 4-3

Recent Meetings

date home-away ats o/u CAR:Total Net Yards CAR:Net Rushing Yards CAR:Passing Yards BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards
10/26/2025 CAR 9 - BUF 40 BUF -7.5 Over 48 244 114 130 410 245 165
08/24/2024 BUF 26 - CAR 31 CAR +4.5 Over 30.5 414 74 340 320 164 156
08/26/2022 CAR 21 - BUF 0 CAR -5 Under 38 191 81 110 238 50 188
12/19/2021 BUF 31 - CAR 14 BUF -12 Over 43.5 275 151 124 312 119 193
08/16/2019 CAR 14 - BUF 27 BUF +3 Over 40 373 94 279 258 103 155
08/09/2018 BUF 23 - CAR 28 CAR +1 Over 34 342 53 289 431 94 337
09/17/2017 CAR 9 - BUF 3 BUF +7 Under 43 176 69 107 255 77 178
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 BUF 35 - NYJ 8 W -13 Over 39 122 69 53
12/28/2025 BUF 12 - PHI 13 L -2.5 Under 44.5 190 82 108
12/21/2025 CLE 20 - BUF 23 L -10 Over 41 259 164 95
12/14/2025 NE 31 - BUF 35 W -4.5 Over 49.5 349 168 181
12/07/2025 BUF 39 - CIN 34 L -6 Over 32.5 338 62 276
11/30/2025 PIT 7 - BUF 26 W -3.5 Under 47.5 372 249 123
11/20/2025 HOU 23 - BUF 19 L -5 Under 44.5 326 143 183
11/16/2025 BUF 44 - TB 32 W -6 Over 45.5 367 202 165
11/09/2025 MIA 30 - BUF 13 L -9.5 Under 48.5 376 87 289
11/02/2025 BUF 28 - KC 21 W -2.5 Under 52.5 305 79 226
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/03/2026 TB 16 - CAR 14 W +3 Under 42.5 338 140 198
12/28/2025 CAR 10 - SEA 27 L +7.5 Under 42.5 139 99 40
12/21/2025 CAR 23 - TB 20 W +2.5 Under 44.5 275 101 174
12/14/2025 NO 20 - CAR 17 L -2.5 Under 41.5 337 81 256
11/30/2025 CAR 31 - LAR 28 W +9.5 Over 45 358 164 194
11/24/2025 SF 20 - CAR 9 L +7 Under 49 340 147 193
11/16/2025 ATL 27 - CAR 30 W +3.5 Over 42 348 125 223
11/09/2025 CAR 7 - NO 17 L -4.5 Under 38.5 175 73 102
11/02/2025 GB 13 - CAR 16 W +11.5 Under 43.5 369 104 265
10/26/2025 CAR 9 - BUF 40 L +7.5 Over 48 244 114 130

Matchup Edge - Scoring Stats

avg rank edge in rank avg
28.29 4 Points Per Game 26 18.29
21.47 12 Points Allowed Per Game 15 22.35
5 10 1st Quarter Scoring Per Game 23 3.71
4.82 16 1st Quarter Scoring Allowed Per Game 11 4.29
7.35 11 2nd Quarter Scoring Per Game 23 4.24
8.18 19 2nd Quarter Scoring Allowed Per Game 24 8.94
7.06 3 3rd Quarter Scording Per Game 16 4.18
2.53 1 3rd Quarter Scoring Allowed Per Game 12 4.29
8.88 1 4th Quarter Scoring Per Game 17 6
5.94 11 4th Quarter Scoring Allowed Per Game 4 4.82
66.2 3 Red Zone Efficiency 19 53.3
376.29 4 Total Yards Per Game 26 295.59
12.92 2 Total Yards Per Play 19 9.76
4.96 2 Rushing Yards Per Play 17 4.29
29.12 21 Passing Attempts Per Game 18 30.29
10.71 12 Passing Yards Per Completion 25 9.26
1.71 6 Passing Tds Per Game 10 1.41
20.24 15 Completions Per Game 19 19.35
69.5 2 Completion % 16 63.9
104.62 4 Qb Rating 22 87.88
2.35 11 Defense Sacks Per Game 16 2.06
0.59 11 Defense Interceptions Per Game 9 0.71
1.06 8 Opponent Fumbles Per Game 6 0.94
0.53 5 Opponent Fumbles Lost Per Game 3 0.65
5.94 7 Penalties Per Game 4 5.59
49.88 16 Penalty Yards Per Game 7 44.82
19 8 Takeaway / Giveaway Differential 11 23
3.96 18 Yards Per Punt Return 25 3.14
27.91 4 Yards Per Kickoff Return 29 24.15

Odds Analysis

Team Rankings

offence
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8
Carolina Panthers CAR
Season stats rank
Total Yards 295.6 27
Passing Yards 179.29 26
Rushing Yards 116.29 19
Points Scored 18.29 27
Field Goal % 0.83 22
defence
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8
Carolina Panthers CAR
Season stats rank
Total Yards 295.6 27
Passing Yards 179.29 26
Rushing Yards 116.29 19
Points Scored 18.29 27
Field Goal % 0.83 22

Injuries

Buffalo Bills BUF
Carolina Panthers CAR

American Football Conference Standings

National Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player