The Eagles and Jaguars meet in London in a potential Super Bowl preview, with Jacksonville entering as a 5.5-point favourite after winning 11 of its last 12 regular-season games.
The Sens continue their Original Six road swing in Boston, where former Bruins goaltender Linus Ullmark is expected to face Jeremy Swayman in a matchup between two Atlantic Division rivals.
The Toronto Argonauts will be missing star quarterback Chad Kelly when they play host to the surging BC Lions on Saturday afternoon in CFL Week 18 betting action at BMO Field.
The Montreal Alouettes can clinch first place in the CFL East when they host the Winnipeg Blue Bombers in Week 18, with Montreal entering as a 6.5-point home favourite.
The Toronto Maple Leafs look to build on their first win of the campaign, when they host the archrival Ottawa Senators on Saturday night in NHL betting action at Scotiabank Arena.
The Baltimore Ravens look to keep pace in the hotly contested race for the top of the AFC North when they host the winless Tennessee Titans on Sunday afternoon in NFL Week 4 betting action at M&T Bank Stadium.