NFL Week 6 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Oct 16, 2020

brady bucs vs rodgers green bay

Does a matchup of all-time great quarterbacks Aaron Rodgers vs. Tom Brady sound enticing? That is one of the marquee games of Week 6 around the NFL.

Here’s a quick look at all the Week 6 matchups with Sports Interaction’s NFL odds. Games Sunday unless noted. Las Vegas, the LA Chargers, New Orleans and Seattle are on the bye.

Houston Texans at Tennessee Titans

Tennessee has to play Tuesday night to conclude Week 5 because of a huge COVID-19 outbreak on the team. A handful of players are on the COVID-19/reserve list. On Sunday, Houston played its first game since firing Coach Bill O’Brien and got its first win of the year, 30-14 over Jacksonville. These AFC South rivals split late last season, each winning on the road in the span of just two weeks. Read our complete Texans at Titans preview here. 

Point spread: Bills -4

Pick ATS: Bills

Cincinnati Bengals at Indianapolis Colts

The Colts had a three-game winning streak snapped Sunday in a loss at Cleveland as quarterback Philip Rivers continued to struggle with turnovers. The Bengals’ Joe Burrow had the worst game of his rookie career in a blowout loss at Baltimore. His offensive line is absolutely awful. Here’s our extended preview.

Point spread: Colts -8

Pick ATS: Indianapolis

Denver Broncos at New England Patriots

This game was originally set for Monday in Week 5 but pushed back because of an additional positive COVID-19 test this past weekend for a Patriots player. It should mean that QB Cam Newton, who tested positive for the virus, will be back in time for this one. Broncos QB Drew Lock hasn’t played since Week 2 due to injury but also could return. Full preview here.

Point spread: Patriots -9

Pick ATS: Denver

Atlanta Falcons at Minnesota Vikings

Atlanta fired coach Dan Quinn and GM Thomas Dimitroff after falling to 0-5 with Sunday’s home loss to Carolina. Former Bucs head coach Raheem Morris takes over on an interim basis. Minnesota played well Sunday night in Seattle but lost 27-26 in the final seconds, and star running back Dalvin Cook is undergoing an MRI on Monday. He figures to miss at least this game. Read our extended preview here.

Point spread: Vikings -3.5

Pick ATS: Minnesota

Washington Football Team at New York Giants

Washington lost its fourth in a row Sunday, 30-10 vs. the Rams. There was one terrific moment in that game, though, when backup QB Alex Smith saw his first game action in almost two years. He nearly lost his leg in a horrific 2018 on-field injury. Starter Kyle Allen left in the first half with an injury but is expected to play and start here. The Giants scored a season-high 34 points Sunday but still lost on a late field goal in Dallas. The Giants won both meetings in 2019 vs. their NFC East rivals. Click here for the full preview of this matchup. 

Point spread: Giants -3

Pick ATS: New York (alternate line of -2.5)

Baltimore Ravens at Philadelphia Eagles

Baltimore was dominant defensively Sunday in a 27-3 win over Cincinnati with seven sacks. Lamar Jackson played through an ankle injury but wasn’t the same from a rushing standpoint with just three yards on two carries. The Eagles were 38-29 losers in Pittsburgh. Carson Wentz had two more interceptions and one of the NFL’s best offensive tackles, Lane Johnson, left with an injury. Our complete preview for Ravens vs. Eagles is here. 

Point spread: Ravens -7

Pick ATS: Baltimore (alternate line of -6.5)

Cleveland Browns at Pittsburgh Steelers

This could be interesting as it’s the first time that the Steelers will face Browns defensive Myles Garrett since he nearly seriously injured Pittsburgh quarterback Mason Rudolph with his own helmet during a brawl at the end of the teams’ Week 11 game last year. Garrett would make things worse by accusing Rudolph of using a racial slur, which the QB (now backing up Ben Roethlisberger) emphatically denied and has never been proven. The AFC North rivals split in 2019, each winning at home — Garrett was suspended for the rematch. Here is our extended preview of this game.

Point spread: Steelers -3.5

Pick ATS: Pittsburgh (alternate line of -2.5)

Chicago Bears at Carolina Panthers

The Bears were interested in free-agent QB Teddy Bridgewater this offseason, but the Panthers offered much more money and he took it (who wouldn’t?). Chicago was an upset winner over Tampa Bay last Thursday night, 20-19, to improve to 4-1, but the offence continued to struggle. Carolina won its third in a row, 23-16 in Atlanta. Star running back Christian McCaffrey missed his third straight game and won’t be back this week. Click here for our full Bears at Panthers preview.

Point spread: Panthers -2.5

Pick ATS: Chicago

Detroit Lions at Jacksonville Jaguars

Rather amazingly, the Jaguars have lost four in a row all to teams who entered the game without a victory. Coach Doug Marrone won’t be around much longer. Speaking of coaches who won’t be around much longer, it was a minor surprise the Lions didn’t fire Matt Patricia during their just-completed bye week. Full Lions vs. Jaguars preview here. 

Point spread: Lions -3.5

Pick ATS: Jacksonville

Ryan Fitzpatrick Dolphins

New York Jets at Miami Dolphins

Ryan Fitzpatrick will keep rookie QB Tua Tagovailoa on the bench for at least one more week as Fitz led a 43-17 upset in San Francisco on Sunday in throwing for 350 yards and three touchdowns. The pathetic Jets fell to 0-5 with Sunday’s 30-10 loss to the Cardinals. All of New York’s losses are by at least nine points. Starting QB Sam Darnold missed the game with a shoulder injury but is likely back here. Our extended preview can be read here.

Point spread: Dolphins -8

Pick ATS: New York

Green Bay Packers at Tampa Bay Bucs

Could be the last time that Aaron Rodgers and Tom Brady face off, although a playoff meeting is very possible. Still hard to believe they never met in a Super Bowl. They have split two regular-season meetings all time. The Bucs kept kicking themselves in the foot last Thursday in a 20-19 loss in Chicago. They had 11 penalties for 109 yards and Brady appeared to forget it was fourth down on the game’s final play, an incompletion thrown by him when the Bucs weren’t far from field-goal range. Green Bay is off the bye. Click here for a full preview of this game.

Point spread: Packers -1.5

Pick ATS: Green Bay

Los Angeles Rams at San Francisco 49ers

Sunday night game. Not clear if Niners QB Jimmy Garoppolo will play. He had missed two games with an ankle injury but did play for about a half Sunday in a loss to Miami before being pulled as he clearly wasn’t 100 percent. The Rams improved to 4-1 with a 30-10 win at Washington – all four wins are against NFC East teams. Our complete preview of Rams at 49ers is here.

Point spread: Rams -3.5

Pick ATS: San Francisco

Kansas City Chiefs at Buffalo Bills, Monday

This game was originally to be Thursday night, but the Bills-Titans game for Week 5 had to be shifted to Tuesday due to COVID-19 issues so now this is Monday and there’s no Thursday game in Week 6. Looks to be a terrific matchup between division leaders as well as MVP candidates in Chiefs quarterback Patrick Mahomes and Buffalo counterpart Josh Allen. Click here for our full preview of Chiefs at Bills.

Point spread: Chiefs -4.5

Pick ATS: Chiefs

Arizona Cardinals at Dallas Cowboys, Monday

No question that the biggest news of Week 5 was Dallas losing quarterback Dak Prescott to a gruesome season-ending injury in a close win over the Giants. He leads the NFL in passing yards by far and was on pace to set an NFL single-season record. Arizona snapped a two-game skid with an easy win at the Jets on Sunday. Here’s our extended preview of this matchup.

Point spread: Cardinals -2.5

Pick ATS: Dallas