NFL Point Spreads Week 4: Best Picks Against the Spread

Payton Matthews | Updated Sep 26, 2018


The 3-0 Miami Dolphins will have a real test in Week 4 as they travel to Foxboro to face the Patriots.

No teams want their bye week this early in the year, but that’s the case for the Washington Redskins and Carolina Panthers in Week 4. Here’s a quick look at all the Week 4 matchups with Sports Interaction’s NFL odds. Games Sunday unless noted.

Minnesota Vikings at Los Angeles Rams, Thursday

You aren’t going to find any better Thursday night matchups in 2018 as this could easily be an NFC Championship Game preview between arguably the NFL’s best defence (Vikings) and its top offence (Rams). Saddle up! For a closer look at this TNF matchup, click here.

Point spread: Rams -6.5

Pick ATS: Los Angeles

Cincinnati Bengals at Atlanta Falcons

Will the Bengals have receiver AJ Green? The former Georgia star left Sunday’s defeat at Carolina with a groin injury. That would be a significant loss if he can’t play, especially as Cincinnati is without top running back Joe Mixon. Atlanta is very banged up on defence and it showed in Sunday’s loss to the Saints.

Point spread: Falcons -5

Pick ATS: Atlanta

Tampa Bay Buccaneers at Chicago Bears

Short week for surprising Tampa as it hosted Pittsburgh on Monday. The suspension of QB Jameis Winston is now over, but presumably Ryan Fitzpatrick keeps the starting job for now. Chicago is the surprise leader of the NFC North at 2-1 following a comeback win in Arizona on Sunday. Click here for an in-depth preview of this game. 

Point spread: TBA (Likely Bears around -2.5)

Pick ATS: Chicago

Detroit Lions at Dallas Cowboys

The Lions avoided a 0-3 start under first-year coach Matt Patricia with their upset Sunday night of Patricia’s former Patriots team. The Cowboys are a very bad offensive club right now, averaging just 13.7 points per game.

Point spread: Cowboys -3.5

Pick ATS: Dallas

Buffalo Bills at Green Bay Packers

Buffalo pulled off the NFL’s biggest point spread upset since 1995 as they were 17-point dogs in Minnesota and routed the Vikings 27-6. Survivor Pools around the world are in tatters. Green Bay suffered its first loss Sunday as it fell in Washington. Aaron Rodgers can barely move on his injured knee. The NFL schedule-makers blew this as these winter weather franchises need to be playing on the frozen tundra in December and not in late September. Check out our full preview of the Bills vs. Packers game right here.

Point spread: Packers -10

Pick ATS: Green Bay

Philadelphia Eagles at Tennessee Titans

Injured Titans starting quarterback Marcus Mariota came off the bench Sunday and led his team to an offensively ugly upset win in Jacksonville. Probably will be back starting for this one. The Eagles welcomed Carson Wentz back from his ACL injury with a home win over the Colts.

Point spread: Eagles -3

Pick ATS: Philadelphia

Houston Texans at Indianapolis Colts

Is there a more disappointing team than the winless Texans? So much talent there but it’s not working yet. Coach Bill O’Brien’s seat is getting very warm. This will be our first look at Deshaun Watson vs. Andrew Luck. For our complete betting analysis of this game, click here.

Point spread: Colts -2.5

Pick ATS: Houston

Miami Dolphins at New England Patriots

That one of these teams is leading the AFC East is no surprise. That it’s the 3-0 Dolphins and not the 1-2 Patriots is. New Patriots receiver Josh Gordon didn’t make his debut Sunday night in a loss at Detroit but likely will here. It’s also the last game of WR Julian Edelman’s four-game suspension. New England is looking to avoid its first three-game losing streak since 2002.  Read our extensive preview of this game right here. 

Point spread: Patriots -7

Pick ATS: New England

New York Jets at Jacksonville Jaguars

Sam Darnold is going to be a fine quarterback for the Jets, but he looked like a rookie Thursday night in completing fewer than 50 per cent of his passes with two picks in a loss at the Browns. Jacksonville’s defence, No. 1 against the pass last year, could really do a number on him. The Jags were caught in a major letdown game Sunday and lost to the Titans. For a closer look at this NFL matchup, check out our full betting preview.

Point spread: Jaguars -7.5

Pick ATS: NY Jets

Cleveland Browns at Oakland Raiders

The Browns ended their 19-game winless streak Thursday night with a come-from-behind 21-17 win over the Jets (we projected a Cleveland win). Cleveland also started the Baker Mayfield era as he was the hero after taking over for Tyrod Taylor. Jon Gruden’s return to Oakland hasn’t gone well so far with the Silver & Black at 0-3. Check out our complete betting preview for the Browns vs. the Raiders. 

Point spread: Raiders -3

Pick ATS: Cleveland

Seattle Seahawks at Arizona Cardinals

Two bad offensive teams here. Have the Cardinals already decided to hand the team over to rookie quarterback Josh Rosen? He replaced veteran Sam Bradford in Sunday’s loss to the Bears. Coach Steve Wilks hasn’t made his decision on this week yet, but at 0-3 it likely will be Rosen.

Point spread: Seahawks -3

Pick ATS: Seahawks

New Orleans Saints at New York Giants

Drew Brees is 39 yet as good as ever as he was magnificent in Sunday’s shootout win over the Falcons. He also set the NFL’s all-time completion record. He’s a closing on the yardage record. The Giants were upset winners in Houston on Sunday. Their 27 points nearly matched their total the first two games combined. Here’s a closer look at the Saints vs. Giants matchup. 

Point spread: Saints -3.5

Pick ATS: NY Giants

San Francisco 49ers at Los Angeles Chargers

Awful news for the 49ers on Sunday as not only did they lose in Kansas City but also believe quarterback Jimmy Garoppolo suffered a season-ending knee injury. That should be confirmed on Monday. There go the Niners’ playoff hopes. The Chargers are struggling defensively in their 1-2 start without injured star pass-rusher Joey Bosa.

Point spread: Chargers -9.5

Pick ATS: LA Chargers

Baltimore Ravens at Pittsburgh Steelers

Sunday night. This has been the most physical rivalry in the NFL for years, and while these franchises don’t like one another they at least do respect each other. Pittsburgh, on a short week after visiting Tampa on Monday, has followed a four-game winning streak in the series by taking the past three. Check our full betting preview of this matchup here. 

Point spread: TBA (likely Steelers -3)

Pick ATS: Pittsburgh

Kansas City Chiefs at Denver Broncos, Monday

Without question, young Chiefs quarterback Patrick Mahomes is the NFL MVP through three games. His 13 TD passes are a league record through the first three games of a season. That offence has been unstoppable. Denver went on the road for the first time Sunday and lost in Baltimore. The Broncos were swept by the Chiefs in 2017.

Point spread: Chiefs -4

Pick ATS: Denver