NFL Point Spreads Week 16: Best Picks Against the Spread

Payton Matthews | Updated Dec 20, 2017

toddgurley_rams

Are you ready for some holiday football? With Christmas Eve falling on Sunday and Christmas on Monday this year, there’s plenty of NFL action to go with the eggnog, caroling and presents.

Here’s a quick look at all the Week 16 matchups with Sports Interaction NFL odds. Games Sunday unless noted.

Saturday Night Football Point Spreads

joe flacco

Colts vs. Ravens Point Spread: NFL Week 16 Odds, Prediction

AT
December 23, 2017, 4:30 PM ET
M&T Bank Stadium
Baltimore
9-7
Pointspread +13.5 -105
Moneyline +700
Over / Under o +41

41%

Betting Action

59%

Pointspread -13.5 -115
Moneyline -1000
Over / Under u +41

41%

Betting Action

59%

Indianapolis is playing out the string as it eyes a Top-5 pick in the 2018 draft. The Colts have amazingly lost seven games this season when leading at halftime, one shy of tying an NFL single-season record. Baltimore is right in the AFC wild-card hunt and off a 27-10 win in Cleveland. If the Ravens win out, they’re in the postseason.

Pick ATS: Baltimore

rodgers

Vikings vs. Packers Point Spread: NFL Week 16 Odds, Prediction

Minnesota
13-3
AT
December 23, 2017, 8:30 PM ET
Lambeau Field
Green Bay
7-9
Pointspread -9.5 -115
Moneyline -460
Over / Under o +41

63%

Betting Action

37%

Pointspread +9.5 -105
Moneyline +350
Over / Under u +41

63%

Betting Action

37%

The NFL season was altered somewhat in Week 6 when the Vikings not only beat the Packers 23-10 but also broke the right collarbone of Green Bay star quarterback Aaron Rodgers. He returned this past Sunday, but the Packers lost 31-24 in Carolina. Rodgers threw for three scores but was picked off three times. Green Bay would be eliminated from the playoff contention with an Atlanta win in Tampa on Monday. Rodgers might not play if that happens.

Pick ATS: TBA

Sunday NFL Point Spreads

lions

Lions vs. Bengals Point Spread: NFL Week 16 Odds, Prediction

Detroit
9-7
AT
December 24, 2017, 1:00 PM ET
Paul Brown Stadium
Pointspread -3.5 -105
Moneyline -180
Over / Under o +43.5

78%

Betting Action

22%

Pointspread +3.5 -115
Moneyline +150
Over / Under u +43.5

78%

Betting Action

22%

The Lions remain in the wild-card hunt but likely would have to win out to have any shot and even that might not be enough. They stayed alive with a 20-10 home win over Chicago on Saturday. Matthew Stafford threw two touchdown passes. The Bengals have completely quit on the season amid reports that Coach Marvin Lewis will not return next year. Cincinnati was blown out again Sunday, 34-7 in Minnesota.

Pick ATS: Detroit

kareem-hunt

Dolphins vs. Chiefs Point Spread: NFL Week 16 Odds, Prediction

Miami
6-10
AT
December 24, 2017, 1:00 PM ET
Arrowhead Stadium
Pointspread +11 -115
Moneyline +475
Over / Under o +43.5

45%

Betting Action

55%

Pointspread -11 -105
Moneyline -675
Over / Under u +43.5

45%

Betting Action

55%

The Dolphins’ playoff hopes went up in smoke Sunday as they lost 24-16 in Buffalo. Jay Cutler, so brilliant in a Week 14 upset of New England, was intercepted three times. Kansas City took over sole possession of first place in the AFC West with a 30-13 rout of the Chargers on Saturday. The Chiefs will take the division with one more victory.

Pick ATS: Kansas City

Buffalo-Bills-RB-LeSean-McCoy

Bills vs. Patriots Point Spread: NFL Week 16 Odds, Prediction

Buffalo
9-7
AT
December 24, 2017, 1:00 PM ET
Gillette Stadium
Pointspread +11 -110
Moneyline +500
Over / Under o +47.5

62%

Betting Action

38%

Pointspread -11 -110
Moneyline -700
Over / Under u +47.5

62%

Betting Action

38%

Tom Brady has beaten Buffalo 27 times in his career. That’s the most of any quarterback against one opponent. No. 27 was in Week 13, 23-3 in Buffalo. You could see some payback here because in that game Patriots tight end Rob Gronkowski delivered a vicious cheap shot on Bills cornerback Tre’Davious White, which led to a White injury (he’s OK now) and one-game suspension for Gronk. Bills players and coaches were understandably furious.  New England won a huge game in Pittsburgh on Sunday and now is in the driver’s seat for the AFC’s top seed. Buffalo remains in the wild-card chase.

Pick ATS: Buffalo

isaiah-crowell-browns

Browns vs. Bears Point Spread: NFL Week 16 Odds, Prediction

Cleveland
0-16
AT
December 24, 2017, 1:00 PM ET
Soldier Field
Chicago
5-11
Pointspread +6 -115
Moneyline +230
Over / Under o +36.5

53%

Betting Action

47%

Pointspread -6 -105
Moneyline -280
Over / Under u +36.5

53%

Betting Action

47%

Only better draft position is at stake here – well, and Cleveland trying to avoid becoming the second team in NFL history to start a season 0-15. Last year, the Browns did get their lone win in Week 16, for what that’s worth. Coach Hue Jackson clearly likes Christmas Eve as he’s 2-0 in his NFL head coaching career on that day (with Raiders in 2011). Chicago lost 20-10 in Detroit this past Saturday. Rookie Mitchell Trubisky, whom the Browns thought about taking No. 1 overall in the 2017 draft, threw for a career-high 314 yards but was intercepted three times.

Pick ATS: Cleveland

greg-olsen

Buccaneers vs. Panthers Point Spread: NFL Week 16 Odds, Prediction

Tampa Bay
5-11
AT
December 24, 2017, 1:00 PM ET
Bank of America Stadium
Carolina
11-5
Pointspread +10.5 -120
Moneyline +400
Over / Under o +47

29%

Betting Action

71%

Pointspread -10.5 +100
Moneyline -525
Over / Under u +47

29%

Betting Action

71%

Carolina goes for the season sweep as it won at Tampa Bay in Week 8, 17-3. Neither team had more than 279 yards of offence, and the Bucs turned it over three times. The Panthers remain tied with New Orleans atop the NFC South following a 31-24 victory over Green Bay. Cam Newton threw four TD passes. The Bucs are on a short week as they hosted Atlanta on Monday.

Pick ATS: Carolina

ingram-mark

Falcons vs. Saints Point Spread: NFL Week 16 Odds, Prediction

Atlanta
10-6
AT
December 24, 2017, 1:00 PM ET
Mercedes-Benz Superdome
Pointspread +5.5 -110
Moneyline +210
Over / Under o +51.5

57%

Betting Action

43%

Pointspread -5.5 -110
Moneyline -260
Over / Under u +51.5

57%

Betting Action

43%

Arguably the biggest game of the week with huge NFC West and wild-card ramifications. Atlanta is on a short week as it visited Tampa Bay on Monday night. New Orleans stayed tied for first in the NFC South with a 31-19 victory over the Jets. The Falcons beat the Saints just two weeks ago, 20-17, thanks to a late interception of Drew Brees in the Atlanta end zone.

Pick ATS: New Orleans

bryce-petty

Chargers vs. Jets Point Spread: NFL Week 16 Odds, Prediction

AT
December 24, 2017, 1:00 PM ET
MetLife Stadium
N.Y. Jets
5-11
Pointspread -7 -110
Moneyline -365
Over / Under o +42.5

75%

Betting Action

25%

Pointspread +7 -110
Moneyline +285
Over / Under u +42.5

75%

Betting Action

25%

The Chargers’ playoff hopes took a big hit Saturday in a 30-13 loss in Kansas City, snapping L.A.’s four-game winning streak. The Bolts turned it over four times, with Philip Rivers throwing three picks. New York is playing out the string and on a two-game losing streak, both by double digits. QB Bryce Petty struggled in his first start of the year Sunday in New Orleans.

Pick ATS: LA Chargers

marcus-mariota

Rams vs. Titans Point Spread: NFL Week 16 Odds, Prediction

L.A. Rams
11-5
AT
December 24, 2017, 1:00 PM ET
Nissan Stadium
Tennessee
9-7
Pointspread -7 +105
Moneyline -255
Over / Under o +46

76%

Betting Action

24%

Pointspread +7 -125
Moneyline +205
Over / Under u +46

76%

Betting Action

24%

The Rams took control of the NFC West with a shockingly easy 42-7 victory in Seattle. It was over at halftime with L.A., which can clinch the division with a victory here, up 34-0. Todd Gurley rushed for 152 yards and three scores and also caught a TD pass. Tennessee lost in San Francisco, 25-23, on a field goal as time expired. One more Titans loss or Jacksonville victory gives the AFC South title to the Jaguars. Those two play Week 17.

Pick ATS: Tennessee

thomas-demaryius

Broncos vs. Washington Point Spread: NFL Week 16 Odds, Prediction

Denver
5-11
AT
December 24, 2017, 1:00 PM ET
FedExField
Pointspread +3 -110
Moneyline +145
Over / Under o +39

25%

Betting Action

75%

Pointspread -3 -110
Moneyline -170
Over / Under u +39

25%

Betting Action

75%

Both clubs had realistic playoff aspirations this year but have hugely underachieved. The Broncos have followed an eight-game skid with back-to-back wins. It rallied for a 25-13 victory in Indianapolis last Thursday behind backup QB Brock Osweiler. Starter Trevor Siemian suffered a season-ending dislocated shoulder in the first quarter. Washington ended a two-game slide with a 20-15 win over Arizona. Kirk Cousins threw two TD passes – he could be targeted by Denver in free agency if the Skins allow Cousins to get there.

Pick ATS: Washington

blake-bortles-leonard-fournette-jacksonville-jaguars

Jaguars vs. 49ers Point Spread: NFL Week 16 Odds, Prediction

AT
December 24, 2017, 4:05 PM ET
Levi's Stadium
Pointspread -4.5 -120
Moneyline -200
Over / Under o +43

77%

Betting Action

23%

Pointspread +4.5 +100
Moneyline +170
Over / Under u +43

77%

Betting Action

23%

Could be a bit of a trap game for the Jaguars as they play on the road for the first time in nearly a month and have a potentially huge Week 17 matchup at division rival Tennessee. Jacksonville leads the AFC South and clinched its first playoff berth since 2007 with a 45-7 rout of Houston on Sunday (Jags win the division with one more victory or Tennessee loss). Blake Bortles threw for 326 yards and three scores in the game of his career. San Francisco, meanwhile, is 3-0 since trade acquisition Jimmy Garoppolo became the starting QB.

Pick ATS: Jacksonville

dez-bryant

Seahawks vs. Cowboys Point Spread: NFL Week 16 Odds, Prediction

Seattle
9-7
AT
December 24, 2017, 4:25 PM ET
AT&T Stadium
Dallas
9-7
Pointspread +4 -105
Moneyline +180
Over / Under o +47.5

36%

Betting Action

64%

Pointspread -4 -115
Moneyline -220
Over / Under u +47.5

36%

Betting Action

64%

Dallas welcomes back superstar running back Ezekiel Elliott, the 2016 NFL rushing king, from his six-game suspension. Is it too late, though, for Elliott to help get the Cowboys a wild-card spot? Dallas kept hope alive with a tight win in Oakland on Sunday night. The Seahawks were stunningly routed at home Sunday by the Rams, 42-7, which was the franchise’s worst loss under Pete Carroll and effectively ended any shot Seattle had of winning the NFC West. The team could miss the playoffs altogether, which hasn’t happened since Russell Wilson was drafted in 2012.

Pick ATS: Dallas

Arizona Cardinals

Giants vs. Cardinals Point Spread: NFL Week 16 Odds, Prediction

AT
December 24, 2017, 4:25 PM ET
State Farm Stadium
Arizona
8-8
Pointspread +3 +105
Moneyline +155
Over / Under o +39.5

50%

Betting Action

50%

Pointspread -3 -125
Moneyline -185
Over / Under u +39.5

50%

Betting Action

50%

Two teams playing out the string and which might each have new starting quarterbacks in 2018 (both could also have new head coaches – New York will for sure). The Giants lost a fourth in a row Sunday, 34-29 vs. Philadelphia. Eli Manning had a big game in the losing effort in throwing for 434 yards and three touchdowns. Arizona lost at Washington, 20-15. Blaine Gabbert was just 16 of 41 for 189 yards and an interception.

Pick ATS: NY Giants

Monday Night Football Point Spreads

leveon bell

Steelers vs. Texans Point Spread: NFL Week 16 Odds, Prediction

Pittsburgh
13-3
AT
December 25, 2017, 4:30 PM ET
NRG Stadium
Houston
4-12
Pointspread -9 -115
Moneyline -490
Over / Under o +45.5

73%

Betting Action

27%

Pointspread +9 -105
Moneyline +380
Over / Under u +45.5

73%

Betting Action

27%

It’s a Christmas matinee with 4:30 p.m. ET kickoff. Houston lost a fourth consecutive game Sunday, 45-7 in Jacksonville. The Texans are down to third-string quarterback T.J. Yates due to injury and he threw for just 128 yards. Pittsburgh suffered a crushing home loss to the Patriots on Sunday, 27-24, to end an eight-game winning streak. Even worse news: star receiver Antonio Brown left with a partially torn calf muscle. He’s not playing this week, but the team thinks he’ll be ready for the playoffs.

Pick ATS: Houston

ap-nick-foles-eagles-giants

Raiders vs. Eagles Point Spread: NFL Week 16 Odds, Prediction

Oakland
6-10
AT
December 25, 2017, 8:30 PM ET
Lincoln Financial Field
Pointspread +10.5 -115
Moneyline +425
Over / Under o +46.5

38%

Betting Action

62%

Pointspread -10.5 -105
Moneyline -550
Over / Under u +46.5

38%

Betting Action

62%

This one is in the typical Monday prime-time slot. The Eagles began life without starting QB Carson Wentz on Sunday and rallied to beat the Giants 34-29 as backup Nick Foles threw four TD passes. The Eagles clinched a first-round bye in the postseason and could clinch the NFC’s top seed in Week 16. Oakland’s playoff chances are all but over following a 20-17 home loss to Dallas on Sunday night. Derek Carr lost a fumble in the final seconds as he was stretching for the winning touchdown.

Pick ATS: Philadelphia

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