Colts vs. Rams Prediction, Odds & Stats - September 28, 2025

Final Score
Indianapolis
Colts
L.A. Rams
Rams
20
27
Indianapolis Colts
Los Angeles Rams
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 8-8 3 7 0 10 +49.5
Los Angeles Rams 11-4 3 10 0 14 -3.5

Latest Encounters

Date Result Competition Stats Recap
12/28/25
Jacksonville Jaguars JAC ( 12-4 )
Indianapolis Colts IND ( 8-8 )
23   -   17
AFC South
12/22/25
San Francisco 49ers SF ( 12-4 )
Indianapolis Colts IND ( 8-8 )
48   -   27
NFC West
12/18/25
L.A. Rams Rams LAR ( 11-4 )
Seattle Seahawks SEA ( 13-3 )
37   -   38
NFC West
12/14/25
Indianapolis Colts IND ( 8-8 )
Seattle Seahawks SEA ( 13-3 )
16   -   18
AFC South
12/14/25
Detroit Lions DET ( 8-8 )
L.A. Rams Rams LAR ( 11-4 )
34   -   41
NFC North
12/07/25
L.A. Rams Rams LAR ( 11-4 )
Arizona Cardinals ARI ( 3-13 )
45   -   17
NFC West
12/07/25
Indianapolis Colts IND ( 8-8 )
Jacksonville Jaguars JAC ( 12-4 )
19   -   36
AFC South
11/30/25
Houston Texans HOU ( 11-5 )
Indianapolis Colts IND ( 8-8 )
20   -   16
AFC South
11/30/25
L.A. Rams Rams LAR ( 11-4 )
Carolina Panthers CAR ( 8-8 )
28   -   31
NFC West
11/23/25
Tampa Bay Buccaneers TB ( 7-9 )
L.A. Rams Rams LAR ( 11-4 )
7   -   34
NFC South
11/23/25
Indianapolis Colts IND ( 8-8 )
Kansas City Chiefs KC ( 6-10 )
20   -   23
AFC South
11/16/25
Seattle Seahawks SEA ( 13-3 )
L.A. Rams Rams LAR ( 11-4 )
19   -   21
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Indianapolis Colts Indianapolis Colts
3 0 3-7 6L 3-0 0 0-0 0-0 2-1
L.A. Rams Rams L.A. Rams Rams
2 1 8-2 1L 2-1 0 0-0 0-0 2-1

Recent Meetings

date home-away ats o/u LAR:Total Net Yards LAR:Net Rushing Yards LAR:Passing Yards IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards
09/28/2025 LAR 27 - IND 20 LAR -4.5 Under 49.5 462 102 360 333 85 248
10/01/2023 IND 23 - LAR 29 LAR -1 Over 44.5 467 164 303 329 133 196
09/19/2021 IND 24 - LAR 27 IND +4 Over 47.5 371 101 270 354 109 245
09/10/2017 LAR 46 - IND 9 LAR -3.5 Over 47 225 75 150 373 63 310
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 IND 17 - JAC 23 L +7 Under 48.5 370 121 249
12/22/2025 IND 27 - SF 48 L +5.5 Over 46.5 440 145 295
12/14/2025 SEA 18 - IND 16 W +10 Under 41.5 215 97 118
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 285 89 196
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 364 108 256
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 255 74 181
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 290 140 150
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 368 55 313
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 341 113 228
10/19/2025 LAC 24 - IND 38 W +1.5 Over 48.5 401 120 281
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/18/2025 SEA 38 - LAR 37 L -1.5 Over 42.5 415 171 244
12/14/2025 LAR 41 - DET 34 W -4.5 Over 54.5 519 159 360
12/07/2025 ARI 17 - LAR 45 W -1.5 Over 49 314 51 263
11/30/2025 CAR 31 - LAR 28 L -9.5 Over 45 358 164 194
11/23/2025 LAR 34 - TB 7 W -7 Under 49.5 333 70 263
11/16/2025 LAR 21 - SEA 19 L -3.5 Under 48.5 249 119 130
11/09/2025 SF 26 - LAR 42 W -6 Over 46.5 393 74 319
11/02/2025 LAR 34 - NO 10 W -14 Under 44.5 438 171 267
10/19/2025 JAC 7 - LAR 35 W -3 Under 45.5 358 94 264
10/12/2025 BAL 3 - LAR 17 W -7.5 Under 44 296 179 117

Matchup Edge - Scoring Stats

Indianapolis Colts IND
L.A. Rams Rams LAR
avg rank edge in rank avg
27.25 7 Points Per Game 1 30.47
23.38 18 Points Allowed Per Game 7 19.93
6.19 5 1st Quarter Scoring Per Game 1 7.33
4.19 12 1st Quarter Scoring Allowed Per Game 11 4.07
8.44 5 2nd Quarter Scoring Per Game 4 8.73
6.94 15 2nd Quarter Scoring Allowed Per Game 10 5.93
6.13 7 3rd Quarter Scording Per Game 4 6.67
4.44 12 3rd Quarter Scoring Allowed Per Game 2 2.93
6.13 17 4th Quarter Scoring Per Game 9 7.27
7.63 18 4th Quarter Scoring Allowed Per Game 11 6.27
66.1 3 Red Zone Efficiency 5 65.2
345.06 11 Total Yards Per Game 2 396.73
10.78 12 Total Yards Per Play 7 11.44
4.65 7 Rushing Yards Per Play 10 4.57
32 17 Passing Attempts Per Game 6 34.67
10.64 13 Passing Yards Per Completion 2 11.9
1.44 9 Passing Tds Per Game 1 2.67
21.13 11 Completions Per Game 7 22.73
66.0 11 Completion % 12 65.6
92.41 13 Qb Rating 2 111.85
1.75 20 Defense Sacks Per Game 25 1.27
0.81 6 Defense Interceptions Per Game 15 0.33
0.69 1 Opponent Fumbles Per Game 5 0.93
0.44 9 Opponent Fumbles Lost Per Game 8 0.47
6.06 9 Penalties Per Game 1 4.47
49.31 14 Penalty Yards Per Game 1 34.53
20 10 Takeaway / Giveaway Differential 2 12
4.48 16 Yards Per Punt Return 10 4.93
28.81 2 Yards Per Kickoff Return 26 24.8

Odds Analysis

Team Rankings

offence
Indianapolis Colts IND
Season stats rank
Total Yards 345.1 11
Passing Yards 224.69 12
Rushing Yards 120.38 14
Points Scored 27.25 7
Field Goal % 0.94 2
L.A. Rams Rams LAR
Season stats rank
Total Yards 396.7 2
Passing Yards 270.47 2
Rushing Yards 126.27 7
Points Scored 30.47 1
Field Goal % 0.75 29
defence
Indianapolis Colts IND
Season stats rank
Total Yards 345.1 11
Passing Yards 224.69 12
Rushing Yards 120.38 14
Points Scored 27.25 7
Field Goal % 0.94 2
L.A. Rams Rams LAR
Season stats rank
Total Yards 396.7 2
Passing Yards 270.47 2
Rushing Yards 126.27 7
Points Scored 30.47 1
Field Goal % 0.75 29

Injuries

Indianapolis Colts IND
L.A. Rams Rams LAR

American Football Conference Standings

National Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
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Hitters
POS Player