49ers vs. Colts Prediction, Odds & Stats - December 22, 2025

Final Score
San Francisco
49ers
Indianapolis
Colts
48
27
San Francisco 49ers
Indianapolis Colts
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 12-5 14 10 10 14 +46.5
Indianapolis Colts 8-9 7 10 3 7 +4.5

Latest Encounters

Date Result Competition Stats Recap
01/04/26
Indianapolis Colts IND ( 8-9 )
Houston Texans HOU ( 12-5 )
30   -   38
AFC South
01/03/26
Seattle Seahawks SEA ( 14-3 )
San Francisco 49ers SF ( 12-5 )
13   -   3
NFC West
12/28/25
Chicago Bears CHI ( 11-6 )
San Francisco 49ers SF ( 12-5 )
38   -   42
NFC North
12/28/25
Jacksonville Jaguars JAC ( 13-4 )
Indianapolis Colts IND ( 8-9 )
23   -   17
AFC South
12/14/25
Tennessee Titans TEN ( 3-14 )
San Francisco 49ers SF ( 12-5 )
24   -   37
AFC South
12/14/25
Indianapolis Colts IND ( 8-9 )
Seattle Seahawks SEA ( 14-3 )
16   -   18
AFC South
12/07/25
Indianapolis Colts IND ( 8-9 )
Jacksonville Jaguars JAC ( 13-4 )
19   -   36
AFC South
11/30/25
San Francisco 49ers SF ( 12-5 )
Cleveland Browns CLE ( 5-12 )
26   -   8
NFC West
11/30/25
Houston Texans HOU ( 12-5 )
Indianapolis Colts IND ( 8-9 )
20   -   16
AFC South
11/24/25
Carolina Panthers CAR ( 8-9 )
San Francisco 49ers SF ( 12-5 )
9   -   20
NFC South

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
San Francisco 49ers San Francisco 49ers
10 4 7-3 1L 9-5 0 0-0 0-0 8-6
Indianapolis Colts Indianapolis Colts
8 6 2-8 7L 8-6 0 0-0 0-0 7-7

Recent Meetings

date home-away ats o/u IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
12/22/2025 IND 27 - SF 48 SF -5.5 Over 46.5 312 58 254 440 145 295
10/24/2021 SF 18 - IND 30 IND +3.5 Over 44.5 295 148 147 280 111 169
08/25/2018 IND 23 - SF 17 IND 0 Under 43.5 390 126 264 349 80 269
10/08/2017 IND 26 - SF 23 IND -1 Over 43 402 66 336 447 159 288
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 361 180 181
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 440 110 330
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 440 145 295
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 306 136 170
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
11/02/2025 NYG 24 - SF 34 W -3 Over 47.5 380 159 221
10/26/2025 HOU 26 - SF 15 L +3 Under 41.5 223 48 175
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 HOU 38 - IND 30 W +9.5 Over 37.5 339 134 205
12/28/2025 IND 17 - JAC 23 L +7 Under 48.5 204 69 135
12/22/2025 IND 27 - SF 48 L +5.5 Over 46.5 312 58 254
12/14/2025 SEA 18 - IND 16 W +10 Under 41.5 314 50 264
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 350 103 247
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 281 86 195
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 494 148 346
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 519 323 196
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 225 38 187
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 420 164 256

Matchup Edge - Scoring Stats

San Francisco 49ers SF
Indianapolis Colts IND
avg rank edge in rank avg
25.71 9 Points Per Game 7 27.41
21.82 13 Points Allowed Per Game 21 24.24
5.59 8 1st Quarter Scoring Per Game 3 6.41
4.06 9 1st Quarter Scoring Allowed Per Game 11 4.29
7.71 8 2nd Quarter Scoring Per Game 6 8.35
7.12 14 2nd Quarter Scoring Allowed Per Game 17 7.53
5.47 9 3rd Quarter Scording Per Game 5 6.35
4.29 12 3rd Quarter Scoring Allowed Per Game 13 4.35
6.76 12 4th Quarter Scoring Per Game 18 5.94
6.35 14 4th Quarter Scoring Allowed Per Game 22 7.88
65.2 4 Red Zone Efficiency 4 65.2
351.41 7 Total Yards Per Game 9 345.59
10.41 15 Total Yards Per Play 11 10.74
3.78 27 Rushing Yards Per Play 9 4.53
33.76 9 Passing Attempts Per Game 15 32.18
10.44 14 Passing Yards Per Completion 10 10.76
1.94 4 Passing Tds Per Game 9 1.47
23.41 4 Completions Per Game 13 21.18
69.3 3 Completion % 11 65.8
98.76 6 Qb Rating 13 92.62
1.59 19 Defense Sacks Per Game 18 1.71
0.94 5 Defense Interceptions Per Game 7 0.82
1.18 10 Opponent Fumbles Per Game 1 0.65
0.35 8 Opponent Fumbles Lost Per Game 5 0.53
4.88 2 Penalties Per Game 8 6.12
38.29 3 Penalty Yards Per Game 18 51.18
22 10 Takeaway / Giveaway Differential 11 23
6.61 3 Yards Per Punt Return 14 4.57
27.16 7 Yards Per Kickoff Return 2 28.76

Odds Analysis

Team Rankings

offence
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
Indianapolis Colts IND
Season stats rank
Total Yards 345.6 9
Passing Yards 227.82 9
Rushing Yards 117.76 17
Points Scored 27.41 8
Field Goal % 0.94 2
defence
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
Indianapolis Colts IND
Season stats rank
Total Yards 345.6 9
Passing Yards 227.82 9
Rushing Yards 117.76 17
Points Scored 27.41 8
Field Goal % 0.94 2

Injuries

San Francisco 49ers SF
Indianapolis Colts IND

National Football Conference Standings

American Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player