Sports Interaction

49ers vs. Colts Prediction, Odds & Stats - December 22, 2025

Final Score
San Francisco
49ers
Indianapolis
Colts
48
27
San Francisco 49ers
Indianapolis Colts
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 12-5 14 10 10 14 +46.5
Indianapolis Colts 8-9 7 10 3 7 +4.5

Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
NFC West
01/04/26
Indianapolis Colts IND ( 8-9 )
Houston Texans HOU ( 12-5 )
30   -   38
AFC South
01/03/26
Seattle Seahawks SEA ( 14-3 )
San Francisco 49ers SF ( 12-5 )
13   -   3
NFC West
12/28/25
Chicago Bears CHI ( 11-6 )
San Francisco 49ers SF ( 12-5 )
38   -   42
NFC North
12/28/25
Jacksonville Jaguars JAC ( 13-4 )
Indianapolis Colts IND ( 8-9 )
23   -   17
AFC South
12/14/25
Tennessee Titans TEN ( 3-14 )
San Francisco 49ers SF ( 12-5 )
24   -   37
AFC South
12/14/25
Indianapolis Colts IND ( 8-9 )
Seattle Seahawks SEA ( 14-3 )
16   -   18
AFC South
12/07/25
Indianapolis Colts IND ( 8-9 )
Jacksonville Jaguars JAC ( 13-4 )
19   -   36
AFC South
11/30/25
Houston Texans HOU ( 12-5 )
Indianapolis Colts IND ( 8-9 )
20   -   16
AFC South

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
San Francisco 49ers San Francisco 49ers
10 4 7-3 1L 9-5 0 0-0 0-0 8-6
Indianapolis Colts Indianapolis Colts
8 6 2-8 7L 8-6 0 0-0 0-0 7-7

Recent Meetings

date home-away ats o/u IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
12/22/2025 IND 27 - SF 48 SF -5.5 Over 46.5 312 58 254 440 145 295
10/24/2021 SF 18 - IND 30 IND +3.5 Over 44.5 295 148 147 280 111 169
08/25/2018 IND 23 - SF 17 IND 0 Under 43.5 390 126 264 349 80 269
10/08/2017 IND 26 - SF 23 IND -1 Over 43 402 66 336 447 159 288
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 236 108 128
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 361 75 286
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 361 180 181
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 440 110 330
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 440 145 295
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 306 136 170
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 HOU 38 - IND 30 W +9.5 Over 37.5 339 134 205
12/28/2025 IND 17 - JAC 23 L +7 Under 48.5 204 69 135
12/22/2025 IND 27 - SF 48 L +5.5 Over 46.5 312 58 254
12/14/2025 SEA 18 - IND 16 W +10 Under 41.5 314 50 264
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 350 103 247
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 281 86 195
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 494 148 346
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 519 323 196
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 225 38 187
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 420 164 256

Matchup Edge - Scoring Stats

San Francisco 49ers SF
Indianapolis Colts IND
avg rank edge in rank avg
25.71 9 Points Per Game 7 27.41
21.82 13 Points Allowed Per Game 21 24.24
5.59 8 1st Quarter Scoring Per Game 3 6.41
4.06 9 1st Quarter Scoring Allowed Per Game 11 4.29
7.71 8 2nd Quarter Scoring Per Game 6 8.35
7.12 14 2nd Quarter Scoring Allowed Per Game 17 7.53
5.47 9 3rd Quarter Scording Per Game 5 6.35
4.29 12 3rd Quarter Scoring Allowed Per Game 13 4.35
6.76 12 4th Quarter Scoring Per Game 18 5.94
6.35 14 4th Quarter Scoring Allowed Per Game 22 7.88
65.2 4 Red Zone Efficiency 4 65.2
351.41 7 Total Yards Per Game 9 345.88
10.41 15 Total Yards Per Play 11 10.75
3.78 27 Rushing Yards Per Play 9 4.54
33.76 9 Passing Attempts Per Game 15 32.18
10.44 14 Passing Yards Per Completion 10 10.76
1.94 4 Passing Tds Per Game 9 1.47
23.41 4 Completions Per Game 13 21.18
69.3 3 Completion % 11 65.8
98.76 6 Qb Rating 13 92.62
1.59 19 Defense Sacks Per Game 18 1.71
0.94 5 Defense Interceptions Per Game 7 0.82
1.18 10 Opponent Fumbles Per Game 1 0.65
0.35 8 Opponent Fumbles Lost Per Game 5 0.53
4.88 2 Penalties Per Game 8 6.12
38.29 3 Penalty Yards Per Game 18 51.18
22 10 Takeaway / Giveaway Differential 11 23
6.61 3 Yards Per Punt Return 14 4.57
27.16 7 Yards Per Kickoff Return 2 28.76

Odds Analysis

Team Rankings

offence
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
Indianapolis Colts IND
Season stats rank
Total Yards 345.9 9
Passing Yards 227.82 9
Rushing Yards 118.06 17
Points Scored 27.41 8
Field Goal % 0.94 2
defence
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
Indianapolis Colts IND
Season stats rank
Total Yards 345.9 9
Passing Yards 227.82 9
Rushing Yards 118.06 17
Points Scored 27.41 8
Field Goal % 0.94 2

Injuries

San Francisco 49ers SF
Indianapolis Colts IND

San Francisco vs. Indianapolis Betting News

San Francisco 49ers SF

No posts found.

Indianapolis Colts IND

No posts found.

National Football Conference Standings

American Football Conference Standings

Line Up - Last Game

Pitchers
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