Betting Action
Recent Meetings
| date | home-away | ats | o/u | IND:Total Net Yards | IND:Net Rushing Yards | IND:Passing Yards | SF:Total Net Yards | SF:Net Rushing Yards | SF:Passing Yards |
|---|---|---|---|---|---|---|---|---|---|
| 12/22/2025 | IND 27 - SF 48 | SF -5.5 | Over 46.5 | 312 | 58 | 254 | 440 | 145 | 295 |
| 10/24/2021 | SF 18 - IND 30 | IND +3.5 | Over 44.5 | 295 | 148 | 147 | 280 | 111 | 169 |
| 08/25/2018 | IND 23 - SF 17 | IND 0 | Under 43.5 | 390 | 126 | 264 | 349 | 80 | 269 |
| 10/08/2017 | IND 26 - SF 23 | IND -1 | Over 43 | 402 | 66 | 336 | 447 | 159 | 288 |
| date | score | ats | o/u | Total Net Yards | Net Rushing Yards | Passing Yards |
|---|---|---|---|---|---|---|
| 01/03/2026 | SF 3 - SEA 13 | L +2.5 | Under 48.5 | 361 | 180 | 181 |
| 12/28/2025 | SF 42 - CHI 38 | W -3 | Over 51.5 | 440 | 110 | 330 |
| 12/22/2025 | IND 27 - SF 48 | W -5.5 | Over 46.5 | 440 | 145 | 295 |
| 12/14/2025 | SF 37 - TEN 24 | W -12.5 | Over 44.5 | 306 | 136 | 170 |
| 11/30/2025 | CLE 8 - SF 26 | W -6.5 | Under 41.5 | 252 | 91 | 161 |
| 11/24/2025 | SF 20 - CAR 9 | W -7 | Under 49 | 230 | 69 | 161 |
| 11/16/2025 | ARI 22 - SF 41 | W -3.5 | Over 47.5 | 281 | 95 | 186 |
| 11/09/2025 | SF 26 - LAR 42 | L +6 | Over 46.5 | 401 | 126 | 275 |
| 11/02/2025 | NYG 24 - SF 34 | W -3 | Over 47.5 | 380 | 159 | 221 |
| 10/26/2025 | HOU 26 - SF 15 | L +3 | Under 41.5 | 223 | 48 | 175 |
| date | score | ats | o/u | Total Net Yards | Net Rushing Yards | Passing Yards |
|---|---|---|---|---|---|---|
| 01/04/2026 | HOU 38 - IND 30 | W +9.5 | Over 37.5 | 339 | 134 | 205 |
| 12/28/2025 | IND 17 - JAC 23 | L +7 | Under 48.5 | 204 | 69 | 135 |
| 12/22/2025 | IND 27 - SF 48 | L +5.5 | Over 46.5 | 312 | 58 | 254 |
| 12/14/2025 | SEA 18 - IND 16 | W +10 | Under 41.5 | 314 | 50 | 264 |
| 12/07/2025 | JAC 36 - IND 19 | L -1.5 | Over 45.5 | 350 | 103 | 247 |
| 11/30/2025 | IND 16 - HOU 20 | L -3.5 | Under 44.5 | 281 | 86 | 195 |
| 11/23/2025 | KC 23 - IND 20 | L +3.5 | Under 49.5 | 494 | 148 | 346 |
| 11/09/2025 | IND 31 - ATL 25 | W -7 | Over 48.5 | 519 | 323 | 196 |
| 11/02/2025 | PIT 27 - IND 20 | L -2.5 | Under 51.5 | 225 | 38 | 187 |
| 10/26/2025 | IND 38 - TEN 14 | W -3.5 | Over 48 | 420 | 164 | 256 |
Matchup Edge - Scoring Stats
| avg | rank | edge in | rank | avg |
|---|---|---|---|---|
| 25.71 | 9 | Points Per Game | 7 | 27.41 |
| 21.82 | 13 | Points Allowed Per Game | 21 | 24.24 |
| 5.59 | 8 | 1st Quarter Scoring Per Game | 3 | 6.41 |
| 4.06 | 9 | 1st Quarter Scoring Allowed Per Game | 11 | 4.29 |
| 7.71 | 8 | 2nd Quarter Scoring Per Game | 6 | 8.35 |
| 7.12 | 14 | 2nd Quarter Scoring Allowed Per Game | 17 | 7.53 |
| 5.47 | 9 | 3rd Quarter Scording Per Game | 5 | 6.35 |
| 4.29 | 12 | 3rd Quarter Scoring Allowed Per Game | 13 | 4.35 |
| 6.76 | 12 | 4th Quarter Scoring Per Game | 18 | 5.94 |
| 6.35 | 14 | 4th Quarter Scoring Allowed Per Game | 22 | 7.88 |
| 65.2 | 4 | Red Zone Efficiency | 4 | 65.2 |
| 351.41 | 7 | Total Yards Per Game | 9 | 345.59 |
| 10.41 | 15 | Total Yards Per Play | 11 | 10.74 |
| 3.78 | 27 | Rushing Yards Per Play | 9 | 4.53 |
| 33.76 | 9 | Passing Attempts Per Game | 15 | 32.18 |
| 10.44 | 14 | Passing Yards Per Completion | 10 | 10.76 |
| 1.94 | 4 | Passing Tds Per Game | 9 | 1.47 |
| 23.41 | 4 | Completions Per Game | 13 | 21.18 |
| 69.3 | 3 | Completion % | 11 | 65.8 |
| 98.76 | 6 | Qb Rating | 13 | 92.62 |
| 1.59 | 19 | Defense Sacks Per Game | 18 | 1.71 |
| 0.94 | 5 | Defense Interceptions Per Game | 7 | 0.82 |
| 1.18 | 10 | Opponent Fumbles Per Game | 1 | 0.65 |
| 0.35 | 8 | Opponent Fumbles Lost Per Game | 5 | 0.53 |
| 4.88 | 2 | Penalties Per Game | 8 | 6.12 |
| 38.29 | 3 | Penalty Yards Per Game | 18 | 51.18 |
| 22 | 10 | Takeaway / Giveaway Differential | 11 | 23 |
| 6.61 | 3 | Yards Per Punt Return | 14 | 4.57 |
| 27.16 | 7 | Yards Per Kickoff Return | 2 | 28.76 |
Odds Analysis
Team Rankings
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Injuries
| player (position) | status | ats*current | o/u* | notes | |
|---|---|---|---|---|---|
| Luke Gifford (LB) | Ques Jan 11 | Quadricep - 06 / 01 / 26 | 0-0 | 0-0 | Details |
| Tatum Bethune (LB) | out for season | Groin - 06 / 01 / 26 | 0-0 | 0-0 | Details |
| Ricky Pearsall (WR) | Ques Jan 11 | Knee - 05 / 01 / 26 | 0-0 | 0-0 | Details |
| George Kittle (TE) | Ques Jan 3 | Ankle - 30 / 12 / 25 | 0-0 | 0-0 | Details |
| Upton Stout (CB) | Ques Sat | Concussion - 29 / 12 / 25 | 0-0 | 0-0 | Details |
| Trent Williams (OT) | Ques Jan. 11 | Hamstring - 29 / 12 / 25 | 0-0 | 0-0 | Details |
| Renardo Green (CB) | Ques Jan. 3 | Neck - 27 / 12 / 25 | 0-0 | 0-0 | Details |
| Spencer Burford (OL) | Ques Jan. 11 | Knee - 20 / 12 / 25 | 0-0 | 0-0 | Details |
| Ricky Pearsall (WR) | Ques Dec 28 | Knee - 20 / 12 / 25 | 0-0 | 0-0 | Details |
| Christian McCaffrey (RB) | Ques Sun | Illness - 12 / 12 / 25 | 0-0 | 0-0 | Details |
| player (position) | status | ats*current | o/u* | notes | |
|---|---|---|---|---|---|
| Sauce Gardner (CB) | Out Sun | Calf - 02 / 01 / 26 | 0-0 | 0-0 | Details |
| Zaire Franklin (LB) | Ques Sun | Illness - 02 / 01 / 26 | 0-0 | 0-0 | Details |
| Will Mallory (TE) | Out Sun | Chest - 02 / 01 / 26 | 0-0 | 0-0 | Details |
| Dalton Tucker (G) | Ques Sun | Shoulder - 29 / 12 / 25 | 0-0 | 0-0 | Details |
| Tanor Bortolini (C) | Ques Sun | Concussion - 27 / 12 / 25 | 0-0 | 0-0 | Details |
| Drew Ogletree (TE) | Ques Sun | Neck - 27 / 12 / 25 | 0-0 | 0-0 | Details |
| Bernhard Raimann (OT) | Ques Sun | Elbow - 27 / 12 / 25 | 0-0 | 0-0 | Details |
| Buddy Johnson (LB) | Ques Sun | Illness - 26 / 12 / 25 | 0-0 | 0-0 | Details |
| Tyler Goodson (RB) | Ques Sun | Ankle - 24 / 12 / 25 | 0-0 | 0-0 | Details |
| DeForest Buckner (DT) | Ques Sun | Neck - 24 / 12 / 25 | 0-0 | 0-0 | Details |
San Francisco vs. Indianapolis Betting News
San Francisco Vs Indianapolis Betting Trends
49ers are 1-4 ATS in their last 5 games as a road underdog of 3.5-10.0.
49ers are 5-12 ATS in their last 17 games following a ATS win.
Over is 10-3 in 49ers last 13 games in Week 16.
49ers are 1-6 ATS in their last 7 games as a road underdog.
49ers are 6-2 ATS in their last 8 road games.
Colts are 4-0 ATS in their last 4 games as a home underdog of 0.5-3.0.
Over is 5-2 in Colts last 7 Monday games.
Over is 9-3 in Colts last 12 games as a favorite.
Colts are 1-4 ATS in their last 5 games following a ATS win.
Under is 10-4 in Colts last 14 games in Week 16.
National Football Conference Standings
Line Up - Last Game
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