NFL Point Spreads Week 11: Best Picks Against the Spread

Payton Matthews | Updated Nov 15, 2018


While Week 10 in the NFL was rather … weak … this week is definitely chock-full of interesting matchups, highlighted by a Monday Night Football epic.

Here’s a quick look at all the Week 11 matchups with Sports Interaction’s NFL odds. On the bye are Buffalo, Cleveland, Miami, New England, NY Jets and San Francisco

Green Bay Packers at Seattle Seahawks

These teams seem to play every year, largely because each usually won its division and thus had a first-place schedule. The Pack have won three straight in the series, but it’s their first trip to Seattle since the NFC Championship Game following the 2014 season, which Green Bay choked away late and lost in overtime. Click here for our full preview and prediction for this MNF matchup between the Packers and the Seahawks.

Point spread: Seahawks -2.5

Pick ATS: Seattle

Dallas Cowboys at Atlanta Falcons

Just when it appeared Atlanta had turned its season around with a three-game winning streak, it was dominated in a 28-16 loss in Cleveland on Sunday. Matt Ryan threw for 330 yards and two scores, but the defence was not good. Dallas won its first road game of 2018 in a Sunday night upset, 27-20 in Philadelphia. Ezekiel Elliott had 151 yards rushing and the go-ahead TD. Here’s our complete preview of the Cowboys vs. Falcons game. 

Point spread: Falcons -3

Pick ATS: Atlanta

Carolina Panthers at Detroit Lions

Carolina’s three-game losing streak ended in a giant thud: 52-21 at Pittsburgh last Thursday. That tied the most points allowed in franchise history. The Panthers are just a vastly different team (i.e. worse) on the road. The Lions have largely mailed it in during a three-game skid, losing each by at least 12 points. Here’s our full preview of this game.

Point spread: Panthers -3.5

Pick ATS: Detroit

Tennessee Titans at Indianapolis Colts

The big upset Sunday was Tennessee beating New England 34-10. Derrick Henry rushed for two scores and Marcus Mariota threw for two. The Titans’ defence is legit and allowed only 284 yards. Indianapolis has followed a four-game losing streak with three straight wins. It was 29-26 Sunday over Jacksonville as Andrew Luck had three TD passes. He’s clearly back in pre-shoulder surgery form. Click here for our complete preview and score prediction for this game. 

Point spread: Colts -3

Pick ATS: Indianapolis

Tampa Bay Buccaneers at New York Giants

Two teams with former No. 1 overall picks at quarterback but both of whom likely will be elsewhere (or retired) in 2019 because of their terrible play. The Bucs already have benched Jameis Winston, while the Giants may be close to doing the same with Eli Manning. He could take a seat here depending on what happened in New York’s game at San Francisco on Monday night. Tampa somehow scored only three points in a home loss to Washington on Sunday despite 501 yards of offence. That’s seemingly impossible (and a record). For more on this game, check out our full prediction and preview. 

Point spread: TBA (likely to open around a pick’em)

Pick ATS: Tampa Bay

Houston Texans at Washington Redskins

The Texans are off their bye on a six-game winning streak – after starting 0-3 – and atop the AFC South. The NFC East-leading Redskins were statistically dominated Sunday in Tampa but won 16-3 thanks to four takeaways. The Bucs reached the red zone five times yet had just that field goal. Click here for an extended preview of this game.

Point spread: Texans -2.5

Pick ATS: Houston

Pittsburgh Steelers at Jacksonville Jaguars

Rematch of last season’s divisional round game, which the Jaguars surprisingly won 45-42 in Pittsburgh. Jags also won easily in the Steel City during the 2017 regular season. The Steelers are on extra rest after shockingly crushing the Panthers 52-21 last Thursday for a fifth straight win. Ben Roethlisberger had one of the games of his career with just three incompletions, five TDs and a perfect rating. Jacksonville lost its fifth in a row Sunday, 29-26 at Indianapolis. See our full preview of the Steelers vs. Jags matchup here.

Point spread: Steelers -5

Pick ATS: Jacksonville

Cincinnati Bengals at Baltimore Ravens

Last meeting of the season between AFC North rivals. Cincinnati beat visiting Baltimore 34-23 on Thursday night in Week 2. Andy Dalton threw four TD passes in the first half, three to A.J. Green. However, Green is likely out here with a foot injury after missing Sunday’s embarrassing home 51-14 loss to New Orleans. Baltimore comes off its bye on a three-game losing streak. There’s talk Coach John Harbaugh’s fate for 2019 already has been decided – he won’t be back. There was no opening line here because it’s not 100 per cent that injured Ravens QB Joe Flacco will play. For more on this game, check out our complete preview and prediction for the Ravens vs. the Bengals.

Point spread: TBA

Pick ATS: Wait on Flacco

Oakland Raiders at Arizona Cardinals

This is really the only game on the schedule where both teams have zero chance at the playoffs as they are a combined 3-15. Could be hard to watch with two of the league’s worst offences. The loser increases its chances of landing the No. 1 pick in the 2019 NFL Draft. Sports Interaction’s full preview of this matchup here.

Point spread: Cardinals -4

Pick ATS: Arizona

Denver Broncos at Los Angeles Chargers

Denver comes off its bye week, while the Chargers won their sixth in a row Sunday, 20-6 in Oakland. It’s the team’s longest winning streak since 2009. These teams play again Week 17 in Denver, which should have meaning for the Chargers, but the Broncos will be long eliminated from playoff contention by then. The AFC West rivals split in 2017. Click here for an extended preview of this game.

Point spread: Chargers -7

Pick ATS: Los Angeles

Philadelphia Eagles at New Orleans Saints

This nearly was last season’s NFC title game matchup, although it would have been in Philadelphia. Had the Saints not lost in the divisional round at Minnesota in the most incredible ending in league playoff history, it would have been. The Saints were this writer’s NFC champion prediction back in the summer and they look the part on an eight-game winning streak. They destroyed the Bengals on their field Sunday. The Eagles looked poor Sunday night in a 27-20 home loss to Dallas. Here’s our full preview and prediction for the Eagles vs. Saints game.

Point spread: Saints -7

Pick ATS: New Orleans

Minnesota Vikings at Chicago Bears

This game was flexed to Sunday night. The Vikings are off their bye and neck-and-neck with the Bears for the NFC North lead (Vikes one game back in win column). Chicago dominated the Lions on Sunday, 34-22. Mitchell Trubisky threw three TD passes and for a career-high 355 yards. Minnesota has won three straight and six of the past seven in the series. Here’s our full preview and prediction for this NFC North matchup.

Point spread: Bears -3

Pick ATS: Chicago

Kansas City Chiefs vs. Los Angeles Rams, Monday

From Mexico City and quite simply the most anticipated game of the year between 9-1 teams, not something we would have expected back in August. Two incredible offences in what could easily be a Super Bowl preview. The Saints (handed Rams their only loss) in the NFC and Patriots (handed Chiefs their only loss) in the AFC may have something to say about that, however. This total (63.5) at Sports Interaction is the highest ever for an NFL game.

Point spread: Rams -2.5

Pick ATS: LA Rams