NFL Point Spreads Week 3: Best Picks Against the Spread

Payton Matthews | Updated Sep 21, 2018

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This week is the last in the NFL before the byes begin and, at first look, it’s rather lacking in marquee matchups. Sometimes, those weeks are the best ones to cash in.

Here’s a quick look at all the Week 3 matchups with Sports Interaction’s NFL betting odds. Games Sunday unless noted.

New York Jets at Cleveland Browns, Thursday

If you simply were to look at the Jets’ and Browns’ records from last year, this matchup looks like maybe the worst in the history of Thursday night football. However, both franchises appear to be turning things around a bit. The Jets have taken the past five in the series. Cleveland is a home favourite for first time since December 2015. Check out our full preview of this TNF matchup here.

Point spread: Browns -3

Pick ATS: Cleveland (-2.5 alternate line)

New Orleans Saints at Atlanta Falcons

New Orleans was a huge upset victim Week 1 at home vs. Tampa Bay and nearly was again Week 2 vs. visiting Cleveland but rallied in the fourth quarter for the 21-18 escape. The Falcons are also 1-1 after beating Carolina on Sunday. These division rivals split last year, each winning at home. Here’s our full preview of this matchup.

Point spread: Falcons -3

Pick ATS: Atlanta (-2.5 alternate line)

San Francisco 49ers at Kansas City Chiefs

Maybe the biggest story line of the early season is Chiefs second-year quarterback Patrick Mahomes as he’s probably the MVP favourite with 10 touchdown passes and no interceptions. The 49ers bounced back from a Week 1 loss with a win Sunday over the visiting Lions. Our extensive betting preview of this matchup can be found here.

Point spread: Chiefs -6

Pick ATS: Kansas City

Oakland Raiders at Miami Dolphins

Jon Gruden is still looking for his first victory in his return to coaching. Oakland led nearly all game Sunday in Denver but lost on a last-second field goal. Miami is a surprising 2-0 but hasn’t played the toughest competition (Titans and Jets). Oakland won in Miami last year 27-24. Check out our complete betting preview of the Raiders vs. Dolphins here. 

Point spread: Dolphins -3.5

Pick ATS: Oakland

Buffalo Bills at Minnesota Vikings

This has the biggest spread of the early season, but it certainly won’t be the last time they atrocious Bills are double-digit dogs. Rookie Josh Allen struggled in his first start Sunday in a loss to the Chargers. The Vikings should have lost in regulation in Green Bay … and then should have won in overtime but their kicker (likely ex-kicker by now) missed two OT field goals. It ended in a tie. For a complete betting preview of this matchup, click here. 

Point spread: Vikings -16.5

Pick ATS: Buffalo

Indianapolis Colts at Philadelphia Eagles

Will the defending Super Bowl champions have star QB Carson Wentz for the first time this season? Signs seem to be pointing to Wentz making his season debut off that torn ACL. The Colts were underdog winners Sunday at Washington despite having only 281 yards of offence. Check out our full preview of the Colts vs. Eagles game here.

Point spread: Eagles -6

Pick ATS: Philadelphia

Green Bay Packers at Washington Redskins

Green Bay was the victim of a terrible roughing the passer penalty Sunday or they would have beaten the Vikings. The Packers had a chance to win at the end of regulation, but Mason Crosby missed a 52-yard field goal. It would finish as a tie. Washington was held to nine points Sunday in a 12-point home loss to Indianapolis. Click here for our complete betting preview of the Packers vs. Redskins game. 

Point spread: Packers -3

Pick ATS: Green Bay (-2.5 alternate line)

Cincinnati Bengals at Carolina Panthers

The Bengals are on extra rest after beating Baltimore last Thursday – both Bengals wins this year are by the same 34-23 score. It’s the first time in franchise history that Cincinnati has scored at least 30 in its first two games of a season. The beaten-up Panthers lost in Atlanta on Sunday to drop to 1-1. Want more betting info on this matchup? Click here.

Point spread: Panthers -3

Pick ATS: Carolina (-2.5 alternate line)

Tennessee Titans at Jacksonville Jaguars

Jacksonville is a better team than Tennessee, but the Jags are on letdown alert here following an impressive home thumping of the Patriots on Sunday. Blake Bortles had the game of his career. Tennessee didn’t have starting QB Marcus Mariota (elbow) but beat Houston anyway. Click here for an extended preview of this NFL matchup.

Point spread: Jaguars -6.5

Pick ATS: Jacksonville

Denver Broncos at Baltimore Ravens

The Ravens looked like a Super Bowl contender in their Week 1 destruction of Buffalo, but then came back to earth in last Thursday’s loss in Cincinnati. Joe Flacco turned it over three times vs. the Bengals. The Broncos improved to 2-0 with a last-second come-from-behind win over Oakland on Sunday. Click here for our extensive betting preview of this game.

Point spread: Ravens -5

Pick ATS: Baltimore

New York Giants at Houston Texans

The Houston offence hasn’t gotten going yet as the Texans are 0-2 but both those were on the road. New York’s offence has been even worse as Eli Manning looks like he should be put out to pasture. Dig a little deeper into this match with our full Giants vs. Texans betting preview.

Point spread: Texans -3.5

Pick ATS: Houston

Los Angeles Chargers at Los Angeles Rams

Not just the battle of L.A. but possibly a Super Bowl preview. The Rams have been absolutely super in their 2-0 start and might not be an underdog all year. The Bolts have some defensive questions without the injured Joey Bosa. Click here for Sports Interaction’s full preview of the Chargers vs Rams game.

Point spread: Rams -6.5

Pick ATS: Rams

Chicago Bears at Arizona Cardinals

Short week for Chicago as it hosted Seattle on Monday. The Cardinals are the worst team in the NFC as they have totaled just six points in back-to-back blowout losses. Our full preview of the Bears vs. Cardinals matchup is here. 

Point spread: Bears -4.5

Pick ATS: Arizona

Dallas Cowboys at Seattle Seahawks

Short week for the Seahawks as they were in Chicago on Monday. These teams played a wild-card elimination game in Week 16 last year in Dallas, with Seattle winning 21-12 despite Russell Wilson throwing for only 93 yards (but two TDs). Seattle would end up not making the playoffs, either, because of Week 17 results. Here’s our full betting preview of this game. 

Point spread: TBA (likely Seahawks -3)

Pick ATS: Seattle (-2.5 alternate line)

New England Patriots at Detroit Lions

Sunday night game. Perhaps first-year Detroit Matt Patricia should have stayed as New England’s defensive coordinator? His Lions have not been very good in losses to the Jets and 49ers. It’s sort of a homecoming game for Patriots QB Tom Brady as he of course played collegiately down the road from Detroit at the University of Michigan. Click here for our full preview of the Patriots vs. the Lions. 

Point spread: Patriots -6.5

Pick ATS: Detroit

Pittsburgh Steelers at Tampa Bay Buccaneers, Monday

This is the finale of Bucs starting quarterback Jameis Winston’s three-game suspension, but he might have lost his job as backup Ryan Fitzpatrick has excelled in a 2-0 start. We don’t know when the holdout of star Steelers running back Le’Veon Bell will end. Most prognosticators don’t think he’ll play Week 3, either. Bell loses around $850,000 (U.S.) for every game he sits. Get a closer look at this matchup with our complete MNF betting preview.

Point spread: Steelers -2.5

Pick ATS: Pittsburgh