NFL Point Spreads Week 2: Best Picks Against the Spread

Payton Matthews | Updated Sep 14, 2018

It’s quite rare for a 0-2 team to make the playoffs in the NFL, but that proposition will be staring a handful of clubs in the face this time next week.

Here’s a quick look at all the Week 2 matchups with Sports Interaction’s week 2 NFL betting odds. Games are Sunday unless noted.

Baltimore Ravens at Cincinnati Bengals, Thursday

The first quick turnaround Thursday game of the 2018 season, and that usually benefits the team hosting this game. The Bengals had won five straight at home in this AFC North series until losing 20-0 last year in Week 1. Cincinnati did win in Baltimore to close the season. Both clubs opened Sunday with victories. Check out our full betting preview of the Ravens vs. the Bengals!

Point spread: Ravens -1.5

Pick ATS: Cincinnati

Carolina Panthers at Atlanta Falcons

The Falcons lost Thursday night in Philadelphia much the same way they lost there in last year’s playoffs: Failure to score on first-and-goal in the final minute. Carolina was defensively dominant Sunday in a 16-8 home win over Dallas. However, star tight end Greg Olsen left with a foot injury and right tackle Daryl Williams was carted off with a knee injury.

Point spread: Falcons -4.5

Pick ATS: Atlanta

Los Angeles Chargers at Buffalo Bills

One of those 10 a.m. Pacific time starts that West Coast teams dread. Buffalo looked absolutely horrendous in a 47-3 loss in Baltimore on Sunday. Starting QB Nate Peterman was benched in the third quarter after completing five of 18 passes for 24 yards and two interceptions. Rookie Josh Allen wasn’t much better but surely will start this one. The Bolts lost 38-28 at home to Kansas City. L.A. was without stellar defensive end Joey Bosa due to a bone bruise in his foot that could cost him a month or longer. Click here for our complete betting preview of this matchup.

Point spread: Chargers -7.5

Pick ATS: Buffalo

Minnesota Vikings at Green Bay Packers

QB Kirk Cousins’ Minnesota debut was a success as the Vikings beat the visiting 49ers 24-16. He threw for 244 yards and two scores. The Vikings’ defence forced four turnovers. Green Bay had one of the most unlikely comebacks in franchise history, rallying from down 20-3 in the fourth quarter at home to beat Chicago 24-23. QB Aaron Rodgers was carted off in the first half with a knee injury but played in the second and had three fourth-quarter TD passes. Full preview and prediction for this game right here.

Point spread: Packers -1

Pick ATS: Minnesota

Houston Texans at Tennessee Titans

Certainly no shame in losing at New England as Houston did Sunday 27-20. Deshaun Watson struggled in his return from last year’s season-ending ACL tear, completing 17 of 34 for 176 yards with a TD and interception. The Titans lost 27-20 in Miami, a game delayed twice by weather. Tennessee QB Marcus Mariota left with an elbow injury and Delanie Walker, one of the league’s top tight ends, left with a gruesome-looking ankle/leg injury. He’s expected done for the year. There won’t be an opening line on this one until Mariota’s status is clear. Our full Texans vs. Titans betting preview can be read here. 

Point spread: TBA


Cleveland Browns at New Orleans Saints

The Browns’ 17-game losing streak is over! No, they didn’t upset visiting Pittsburgh on Sunday but did rally for a 21-21 tie. Hey, Browns fans will gladly take that, although their team could have won but Zane Gonzalez‘s 43-yard field-goal attempt with 9 seconds left in OT was blocked. It was the NFL’s first tie in Week 1 since 1971. The Saints’ defence was shockingly shredded in a 48-40 home loss to Tampa Bay. New Orleans was the biggest Week 1 favourite. Here’s our full betting preview for Browns at Saints. 

Point spread: Saints -8

Pick ATS: Cleveland

Miami Dolphins at New York Jets

No spread for this one until Tuesday because the Jets played in Detroit on Monday night as rookie QB Sam Darnold made his NFL regular-season debut. Miami dealt with two weather delays but beat visiting Tennessee 27-20 on Sunday. Ryan Tannehill, who missed all of last season, threw for 230 yards and two scores – both to Kenny Stills. Here’s our in-depth betting preview for this matchup.

Point spread: Jets -3

Pick ATS: Miami

Kansas City Chiefs at Pittsburgh Steelers

Pittsburgh blew a 21-7 fourth-quarter lead in Cleveland and settled for a 21-21 tie. Usually automatic kicker Chris Boswell was wide left on a 42-yard field-goal attempt with 1:44 remaining in the OT. With Pro Bowl running back Le’Veon Bell holding out, backup James Conner filled in very capably by rushing for 135 yards and two touchdowns. That might force Bell to reconsider his stance and quickly. The Chiefs won 38-28 at the Chargers as young QB Patrick Mahomes threw four TD passes. Tyreek Hill caught two of them and returned a punt for a score. Find our full betting preview for Chiefs vs. Steelers here. 

Point spread: Steelers -5

Pick ATS: Pittsburgh

Philadelphia Eagles at Tampa Bay Buccaneers

The defending Super Bowl champs didn’t look great offensively but beat the Falcons 18-12 on Thursday without QB Carson Wentz. Unlikely he plays here, either. Tampa Bay was the biggest Week 1 underdog at New Orleans without starting QB Jameis Winston (suspended first three games) but won 48-40 as backup QB Ryan Fitzpatrick threw for 417 yards and five scores. Winston won’t get his job back if that continues. Check out our full betting preview for this matchup here. 

Point spread: Eagles -3

Pick ATS: Philadelphia

Indianapolis Colts at Washington Redskins

Colts QB Andrew Luck played his first regular-season game since the end of the 2016 campaign and threw for 243 yards and two scores, but Indy blew a 23-10 home third-quarter lead vs. Cincinnati and lost 34-23. Alex Smith’s first start as Washington QB was a success as he threw for 255 yards and two scores in a 24-6 win at Arizona. It was also Adrian Peterson’s first game with the team and he rushed for 96 yards and a score. Get our full game preview here. 

Point spread: Redskins -5

Pick ATS: Washington

Arizona Cardinals at Los Angeles Rams

L.A.’s home opener after playing in northern California (Oakland) on Monday night. Arizona was held to 213 yards in 24-6 home loss to Washington. Another stinker like that, and the Cardinals figure to bench starting QB Sam Bradford (153 yards, INT) for rookie first-round pick Josh Rosen.

Point spread: TBA (Rams likely around -10)

Pick ATS: Los Angeles

Detroit Lions at San Francisco 49ers

Off the board because the Lions hosted the Jets on Monday night. So not only a short week for Detroit but having to travel to the West Coast. Not ideal.  The 49ers lost 24-16 at Minnesota. Jimmy Garoppolo was picked off three times in his first loss in eight games as an NFL starter.

Point spread: TBA (49ers likely -3)

Pick ATS: San Francisco

Oakland Raiders at Denver Broncos

A TBA on this spread because Oakland hosted the LA Rams on Monday night. Broncos linebacker Von Miller was a one-man wrecking crew in a 27-24 home win over Seattle as he had three sacks, two forced fumbles and one fumble recovery. Case Keenum threw for 329 yards and three scores in his Broncos regular-season debut but was picked off three times.

Point spread: TBA (Broncos likely around -4.5)

Pick ATS: Denver

New England Patriots at Jacksonville Jaguars

Rematch of last year’s AFC title game the Patriots escaped from at home. They opened with a 27-20 home victory over Houston. Tom Brady threw for 277 yards and three scores. It was Bill Belichick’s 251st regular-season win, passing Hall of Famer Tom Landry third-most all-time. The Jaguars prevailed 20-15 at the New York Giants. However, top running back Leonard Fournette left with a hamstring injury so that must be monitored. Check out our preview for Patriots vs. Jaguars.

Point spread: Jaguars +1.5

Pick ATS: Jacksonville

New York Giants at Dallas Cowboys

The Sunday night game. Get used to the Cowboys being in prime time. New York lost 20-15 at home to Jacksonville on Sunday, but rookie RB Saquon Barkley had a fine debut with 106 yards and a touchdown. Dallas was stymied offensively in a 16-8 loss at Carolina. For a full preview of this game, click here.

Point spread: Cowboys -3.5

Pick ATS: Dallas

Seattle Seahawks at Chicago Bears, Monday

Seattle’s offensive line was a major issue last year and was again Sunday in a 27-24 loss in Denver. Russell Wilson was sacked six times and fumbled twice. His top receiver, Doug Baldwin, left with a right MCL strain so he seems likely to miss this one. Chicago blew a 20-3 fourth-quarter lead at rival Green Bay on Sunday night and lost 24-23. But new addition Khalil Mack was a terror on defence.

Point spread: Bears -3

Pick ATS: Chicago