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Rams vs. 49ers Point Spread: NFL Week 10 Odds, Prediction

Final Score
L.A. Rams
Rams
San Francisco
49ers
42
26
Los Angeles Rams
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Los Angeles Rams 12-5 14 7 7 14 +49.5
San Francisco 49ers 12-5 0 7 7 12 +6

Rams vs. 49ers Point Spread: NFL Week 10 Odds, Prediction

Winners of three straight, capped by last week’s 34-10 win over New Orleans, the Rams enter the weekend tied with Seattle for first place in the division standings with identical 6-2 records. The 49ers have struggled to find consistency since opening the campaign with three straight victories. The Niners have alternated between wins and losses in six games since, capped by last week’s 34-24 road victory over the New York Giants, and find themselves trailing the Rams and Seahawks by a half-game going into Sunday’s action.

The Rams travel to the Bay Area perched as 4.5-point road favourites on the Week 10 betting odds. The 49ers trail as +180 underdogs on the NFL moneyline, and the total is listed at 49.5.

NFL Point Spread and Betting Analysis

While the Rams currently sport the longest current win streak in the NFC, they came up short when they hosted the 49ers in Week 5, dropping a 26-23 decision. That defeat snapped the Rams’ three-game win streak versus the Niners, which featured a pair of wins at Levi’s Stadium, and put the brakes on a four-game head-to-head win streak against the spread. LA leveraged a stout defence in their two recent road wins over the 49ers, allowing just 13 points per game. That marks a big turnaround after allowing 28.3 points per game while losing four straight in San Francisco. But even with those low-scoring affairs, NFL totals bettors taking the OVER when these teams meet have enjoyed a 5-1 run.

Overall, the Rams have been a reliable bet so far this season, going 6-2 ATS, are 8-1 SU and ATS in their past nine away contests overall, and 11-0 SU and 9-2 ATS in their past 11 when favoured on the road by three or more points. Things have not gone as well for the 49ers. The squad has averaged just 21.6 points per game during their current 4-3 run while covering just three times. The Niners have also covered just once during a 2-3 run at home and have gone just 1-4 SU in their past five as home dogs by three or more points.

Los Angeles Rams

The Rams faced little resistance in last week’s 34-10 rout of the Saints, limiting New Orleans to just 224 total yards on the day in yet another dominating defensive performance. Overall, the Rams have surrendered just 20 total points during their current 3-0 run and have put things away early by scoring at least 20 points before halftime twice over that stretch. Matthew Stafford has flashed vintage form while connecting for nine scoring passes over the past two games. Stafford has tossed for just five total TDs in three road appearances and could have his hands full fending off a Niners pass rush that has allowed just three TDs in three home games. But with the Niners defence beset by injuries, Stafford is worth a value wager as a +150 bet on the NFL player props to toss for OVER 2.5 TDs on Sunday.

San Francisco 49ers

Already missing starting quarterback Brock Purdy, who has been sidelined since Week 4 with a tow injury, the Niners must now concern themselves with the health of Mac Jones, who landed on the 49ers injury report with a knee injury. Jones has risen to the occasion in relief of Purdy. The New England Patriots castoff has thrown four total TD passes over the past two weeks and 10 total in seven outings to date and completed a season-high 79.2% of pass attempts in last week’s win over the Giants. Jones also led the way in last month’s win over the Rams, tossing for 342 yards and two scores and will have the benefit of a healthy Christian McCaffrey in the lineup on Sunday. McCaffrey racked up 173 total yards and two total TDs last week. In addition, he recorded 139 total yards and one TD run in LA last month, and sports attractive -118 odds of topping 117.5 rushing and receiving yards on Sunday.

NFL Prediction: Who Will Win Rams vs. 49ers?

RAMS

Away
28
Los Angeles Rams Logo
San Francisco 49ers

49ERS

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