NFL Point Spreads Week 10: Best Picks Against the Spread

Payton Matthews | Updated Nov 06, 2018


The NFL trade deadline was last Tuesday, and it gave bettors an idea of which teams already are throwing in the towel and which are going all-in for a Super Bowl run.

Here’s a quick look at all the Week 10 matchups with Sports Interaction’s NFL odds. On the bye are Denver, Baltimore, Houston and Minnesota. Games Sunday unless noted.

Carolina Panthers at Pittsburgh Steelers, Thursday

Finally, a good Thursday night matchup! Both the Panthers and Steelers are contenders in their respective divisions (Pittsburgh leads AFC North) and legitimate threats to reach the Super Bowl. It’s just the second time that Carolina QB Cam Newton and Pittsburgh counterpart Ben Roethlisberger face off. Click here for the full preview of this TNF matchup.

Point spread: Steelers -5

Pick ATS: Carolina

Detroit Lions at Chicago Bears

Chicago blasted the sorry Bills in Buffalo on Sunday 41-9 despite just 190 yards of offence. The Bears had two defensive touchdowns. Top WR Allen Robinson and pass-rushing star Khalil Mack both missed their second straight game due to injury. The Lions traded top WR Golden Tate last Tuesday and looked flat without him in a 24-9 loss in Minnesota. Matthew Stafford was sacked a career-high 10 times.

Point spread: Bears -6.5

Pick ATS: Chicago

New Orleans Saints at Cincinnati Bengals

Cincinnati comes off its bye. The Saints won the biggest game in the NFC this season to date, 45-35 over the previously unbeaten Rams on Sunday. That could be huge come playoff time in terms of a tiebreaker. Michael Thomas was a monster in catching 12 passes for 211 yards and a score in New Orleans’ seventh straight win. Drew Brees was his usual amazing self with four TD passes. This could be a bit of a letdown game.

Point spread: Saints -4

Pick ATS: Cincinnati

Atlanta Falcons at Cleveland Browns

Cleveland became the first team this season to fire its head coach last week but it didn’t change much as the Browns went out and lost a fourth in a row Sunday, 37-21 to Kansas City. The Browns allowed 499 yards. Baker Mayfield had a solid game, throwing two TD passes to Duke Johnson and finishing 29 of 42 for 297 yards with one interception. Atlanta came out of its bye and played its best game of the year, routing the Redskins in Washington to win a third straight game.

Point spread: Falcons -4

Pick ATS: Atlanta

New England Patriots at Tennessee Titans

Potential letdown game for New England off Sunday’s huge matchup and win vs. Green Bay, but it’s a short week for Tennessee off a trip to Dallas on Monday. The Titans are coached by former Patriots linebacker Mike Vrabel. These teams met in the divisional round of last year’s playoffs in Foxboro and New England rolled 35-14. That was the last game for then-Titans coach Mike Mularkey.

Point spread: Patriots -7

Pick ATS: New England

Jacksonville Jaguars at Indianapolis Colts

Both AFC South teams off their bye and trending different directions. The Jags have dropped four straight, didn’t score more than 18 points in any of them and have major quarterback issues. The Colts have scored a combined 79 points in back-to-back wins and have no issues under centre with Andrew Luck. Jacksonville swept Indy last year, but Luck was out injured.

Point spread: Colts -3.5

Pick ATS: Jacksonville

Arizona Cardinals at Kansas City Chiefs

Trap game alert for Kansas City! Arizona is terrible but off its bye, while the Chiefs could be peering ahead to an incredible Week 11 Monday night matchup in Mexico City against the Los Angeles Rams. Kansas City continued its offensive domination Sunday in a 37-21 win in Cleveland. Ho-hum, another 375 yards passing and three scores from MVP favourite Patrick Mahomes. Read our full preview of this matchup here, complete with our score prediction. 

Point spread: Chiefs -16.5

Pick ATS: Arizona

Buffalo Bills at New York Jets

Two bad offences here but both clubs think they landed their franchise quarterback in the first round of the 2018 draft in Josh Allen (Bills) and Sam Darnold (Jets). Allen hasn’t played since mid-October due to an elbow injury and it’s not thought he will make it back by this Sunday but monitor that. The guy who replaced him as a starter, Derek Anderson, missed Sunday’s blowout loss to Chicago with a concussion. Check out our complete preview of the Bills vs. the Jets here.

Point spread: Jets -8

Pick ATS: Buffalo

Washington Redskins at Tampa Bay Buccaneers

The Redskins may lead the NFC East, but they also may have been exposed as frauds in Sunday’s 38-14 home loss to Atlanta. Washington isn’t a team built to come from behind. The Bucs have the NFL’s worst defence and that showed in a 42-28 loss in Carolina – the Panthers had 35 first-half points, a franchise record.

Point spread: Bucs -2.5

Pick ATS: Tampa Bay

Los Angeles Chargers at Oakland Raiders

Oakland embarrassed itself last Thursday night in a blowout loss to an equally bad San Francisco 49ers team, the Raiders’ fourth straight defeat (all by at least 14 points). The Chargers won a thriller in Seattle, 25-17, stopping the Seahawks on an un-timed down on the L.A. 6. The Raiders lost at the Chargers in Week 5, 26-10, to start this losing streak. Philip Rivers threw for 339 yards and two scores for L.A.

Point spread: Chargers -9.5

Pick ATS: Oakland

Miami Dolphins at Green Bay Packers

Miami stopped a two-game losing streak Sunday with a 13-6 win over the visiting Jets. The game’s only touchdown was a Dolphins 25-yard interception return. The Fins picked off four passes total. Green Bay finally gets a schedule break after facing the loaded Patriots and Rams the past two weeks and losing both.

Point spread: Packers -10

Pick ATS: Green Bay

Seattle Seahawks at Los Angeles Rams

Members of the 1972 Miami Dolphins can rest easy as there will be no unbeaten team this season. The Rams were the last to lose, dropping a shootout in New Orleans. The Rams rallied from 21 down to tie but then ran out of gas. Seattle lost at home in excruciating fashion to the Chargers as a Russell Wilson pass on an untimed down from the L.A. 6 was incomplete. Seattle nearly upset the Rams in Week 5 but L.A. rallied for a 33-31 victory.

Point spread: Rams -10

Pick ATS: Los Angeles

Dallas Cowboys at Philadelphia Eagles

The Sunday night game. Dallas is on a short week after hosting Tennessee on Monday, and the Cowboys are winless on the road this year. The Eagles are off their bye and will play their first game since acquiring receiver Golden Tate from Detroit. These teams split last year, each winning on the road but there were extenuating circumstances in both. Check out our complete preview and prediction for the Cowboys vs Eagles SNF game here. 

Point spread: Eagles -6

Pick ATS: Philadelphia

New York Giants at San Francisco 49ers, Monday

Last Thursday’s Raiders-49ers game was one of the worst prime-time matchups ever. This isn’t much better. The one-win Giants are off their bye and on a five-game losing streak. They are awful on offence. The 49ers got their second win of 2018 in last Thursday’s game by crushing Oakland 34-3 as unknown QB Nick Mullens made his NFL debut and was historically good for a first-time starter.

Point spread: 49ers -3

Pick ATS: San Francisco

NFL Week 10 Odds and Picks ATS

8:20PMCarolina Panthers at Pittsburgh SteelersSteelers -4Panthers
9:30AMDetroit Lions at Chicago BearsBears -6.5Bears
1:00PMArizona Cardinals at Kansas City ChiefsChiefs -16.5Cardinals
1:00PMNew England Patriots at Tennessee TitansTBDTBD
1:00PMAtlants Falcons at Cleveland BrownsFalcons -4.5Falcons
1:00PMBuffalo Bills at New York JetsJets -8Bills
1:00PMJacksonville Jaguars at Indianapolis ColtsColts -3Jaguars
1:00PMNew Orleans Saints at Cincinnati BengalsSaints -5Bengals
1:00PMWashington Redskins at Tampa Bay BuccaneersBucs -1.5Buccaneers
4:05PMChargers at Oakland RaidersChargers -10Raiders
4:25PMMiami Dolphins at Green Bay PackersPackers -9Packers
4:25PMSeattle Seahawks at Los Angeles RamsRams -10Rams
8:20PMDallas Cowboys at Philadelphia EaglesEagles -6Eagles
8:15PMNew York Giants at San Francisco 49ers49ers -349ers