Saints vs. Bills Prediction, Odds & Stats - September 28, 2025

Scoreboard	1	2	3	4	Odds
New Orleans Saints 6-11	7	3	6	3	+48.5
Buffalo Bills 12-5	14	0	7	10	-14.5

Date	Result	Competition
01/17/26	Buffalo Bills BUF ( 12-5 ) Denver Broncos DEN ( 14-3 ) 30 - 33	AFC East
01/11/26	Buffalo Bills BUF ( 12-5 ) Jacksonville Jaguars JAC ( 13-4 ) 27 - 24	AFC East
01/04/26	N.Y. Jets Jets NYJ ( 3-14 ) Buffalo Bills BUF ( 12-5 ) 8 - 35	AFC East

New Orleans Saints NO Buffalo Bills BUF

	Stat
0	Games Won	3
3	Games Lost	0
5-5	Last 10	7-3
0-0	W L Streak	0-0
0-3	Against The Spread	1-1
0	Money	0
0-0	Home	0-0
0-0	Away	0-0
2-1	Total	2-1

date	home-away	ats	o/u	BUF:Total Net Yards	BUF:Net Rushing Yards	BUF:Passing Yards	NO:Total Net Yards	NO:Net Rushing Yards	NO:Passing Yards
09/28/2025	BUF 31 - NO 19	NO +14.5	Over 48.5	356	165	191	298	189	109
11/25/2021	NO 6 - BUF 31	BUF -7	Under 46.5	361	113	248	190	44	146
11/12/2017	BUF 10 - NO 47	NO -2	Over 48.5	482	298	184	198	69	129

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/04/2026	ATL 19 - NO 17	W +4	Under 43.5	340	108	232
12/28/2025	TEN 26 - NO 34	W -3	Over 39	423	103	320
12/21/2025	NO 29 - NYJ 6	W -4.5	Under 40	195	64	131
12/14/2025	NO 20 - CAR 17	W +2.5	Under 41.5	281	127	154
12/07/2025	TB 20 - NO 24	W +8.5	Over 41.5	260	139	121
11/30/2025	MIA 21 - NO 17	W +5.5	Under 42.5	294	81	213
11/23/2025	NO 10 - ATL 24	L +2.5	Under 40	302	121	181
11/09/2025	CAR 7 - NO 17	W +4.5	Under 38.5	388	122	266
11/02/2025	LAR 34 - NO 10	L +14	Under 44.5	224	57	167
10/26/2025	NO 3 - TB 23	L +5.5	Under 45.5	212	88	124

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/17/2026	DEN 33 - BUF 30	L +1.5	Over 46.5	349	70	279
01/11/2026	JAC 24 - BUF 27	W -1	Under 51.5	359	154	205
01/04/2026	BUF 35 - NYJ 8	W -13	Over 39	470	211	259
12/28/2025	BUF 12 - PHI 13	L -2.5	Under 44.5	331	120	211
12/21/2025	CLE 20 - BUF 23	L -10	Over 41	294	160	134
12/14/2025	NE 31 - BUF 35	W -4.5	Over 49.5	385	246	139
12/07/2025	BUF 39 - CIN 34	L -6	Over 32.5	416	183	233
11/30/2025	PIT 7 - BUF 26	W -3.5	Under 47.5	166	58	108
11/20/2025	HOU 23 - BUF 19	L -5	Under 44.5	261	108	153
11/16/2025	BUF 44 - TB 32	W -6	Over 45.5	414	97	317

New Orleans Saints NO

	Season stats	rank
Total Yards	299.8	10
Passing Yards	179.18	4
Rushing Yards	120.59	19
Points Scored	22.53	16
Field Goal %	0.92	27

Buffalo Bills BUF

	Season stats	rank
Total Yards	293.1	7
Passing Yards	156.94	1
Rushing Yards	136.18	28
Points Scored	21.47	12
Field Goal %	0.92	28

New Orleans Saints NO

	Season stats	rank
Total Yards	313.6	22
Passing Yards	219.29	13
Rushing Yards	94.29	28
Points Scored	18	28
Field Goal %	0.71	32

Buffalo Bills BUF

	Season stats	rank
Total Yards	376.3	4
Passing Yards	216.65	15
Rushing Yards	159.65	1
Points Scored	28.29	4
Field Goal %	0.9	8

New Orleans Saints NO

player (position)	status		ats*current	o/u*	notes
Dillon Radunz (OL)	Ques Sun	Knee - 02 / 01 / 26	1-0	1-0	Details
Jack Stoll (TE)	Out Sun	Knee - 02 / 01 / 26	1-0	1-0	Details
Demario Davis (LB)	Ques Sun	Calf - 02 / 01 / 26	1-0	1-0	Details
Spencer Rattler (QB)	Ques Sun	Finger - 02 / 01 / 26	1-0	1-0	Details
Nathan Shepherd (DT)	Ques Sun	Ankle - 02 / 01 / 26	1-0	1-0	Details
Chris Olave (WR)	Ques Sun	Illness - 01 / 01 / 26	1-0	1-0	Details
Chris Olave (WR)	Ques Sun	Back - 27 / 12 / 25	2-0	1-1	Details
Cesar Ruiz (C)	Ques Sun	Ankle - 27 / 12 / 25	2-0	1-1	Details
Charlie Smyth (K)	Ques Sun	Illness - 26 / 12 / 25	2-0	1-1	Details
Mason Tipton (WR)	Ques Sun	Groin - 25 / 12 / 25	2-0	1-1	Details

Buffalo Bills BUF

player (position)	status		ats*current	o/u*	notes
Shaq Thompson (LB)	Ques Sat	Neck - 15 / 01 / 26	1-0	0-1	Details
Josh Allen (QB)	Ques Sat	Foot - 14 / 01 / 26	1-0	0-1	Details
Greg Rousseau (DE)	Ques Sat	Back - 14 / 01 / 26	1-0	0-1	Details
A.J. Epenesa (DE)	Ques Sat	Neck - 14 / 01 / 26	1-0	0-1	Details
Matt Milano (LB)	Ques Sat	Ankle - 14 / 01 / 26	1-0	0-1	Details
Landon Jackson (DE)	Out indefinitely	Knee - 14 / 01 / 26	1-0	0-1	Details
Dalton Kincaid (TE)	Ques Sat	Leg - 13 / 01 / 26	1-0	0-1	Details
Tyrell Shavers (WR)	Out Sat	Knee - 13 / 01 / 26	1-0	0-1	Details
Jordan Poyer (DB)	Out Sat	Hamstring - 13 / 01 / 26	1-0	0-1	Details
Gabe Davis (WR)	Out indefinitely	Knee - 13 / 01 / 26	1-0	0-1	Details

New Orleans Saints NO

Saints are 1-6 ATS in their last 7 games following a straight up loss.

Saints are 1-4 ATS in their last 5 games following a ATS loss.

Saints are 3-7 ATS in their last 10 games as a road favorite of 3.5-10.0.

Saints are 5-12-1 ATS in their last 18 games as a favorite.

Saints are 1-4 ATS in their last 5 games as a road underdog of 3.5-10.0.

Buffalo Bills BUF

Bills are 4-1 ATS in their last 5 games as a favorite of 3.5-10.0.

Bills are 5-0 ATS in their last 5 games following a ATS loss.

Under is 4-1 in Bills last 5 games as an underdog of 10.5 or greater.

Over is 4-1 in Bills last 5 games overall.

Bills are 3-1-1 ATS in their last 5 home games.

Team	Win / Loss	ATS	OU
N.Y. Giants Giants NYG	4-13	8-8	10-6
Chicago Bears CHI	10-6	11-6	9-8-1
L.A. Rams Rams LAR	12-5	12-7	11-8
Tampa Bay Buccaneers TB	8-9	5-11	8-8
Philadelphia Eagles PHI	11-6	10-7	8-9
Green Bay Packers GB	9-6	6-10	9-8
San Francisco 49ers SF	12-5	11-6	10-8
Arizona Cardinals ARI	3-14	7-9	9-7
Seattle Seahawks SEA	14-3	14-5	11-8
Dallas Cowboys DAL	7-9	7-9	12-4
Minnesota Vikings MIN	9-8	8-8	8-8
Detroit Lions DET	9-8	7-9	10-6
Atlanta Falcons ATL	8-9	9-7	8-7-1
Carolina Panthers CAR	8-9	10-7	7-10
New Orleans Saints NO	6-11	8-8	5-11
Washington Commanders WAS	5-12	6-10	9-6-1

Team	Win / Loss	ATS	OU
Baltimore Ravens BAL	8-9	6-9	10-6
Denver Broncos DEN	14-3	9-9	8-10
Miami Dolphins MIA	7-10	8-8	8-6-2
Houston Texans HOU	12-5	10-8	6-12
Cleveland Browns CLE	5-12	7-9	8-8
Pittsburgh Steelers PIT	10-7	9-8	9-7-1
New England Patriots NE	14-3	14-6	12-8
Tennessee Titans TEN	3-14	5-11	10-6
L.A. Chargers Chargers LAC	11-6	9-8	8-9
Indianapolis Colts IND	8-9	8-8	8-8
N.Y. Jets Jets NYJ	3-14	7-9	10-6
Cincinnati Bengals CIN	6-11	8-8	9-7
Buffalo Bills BUF	12-5	8-9	9-9
Las Vegas Raiders LV	3-14	6-10	8-8
Jacksonville Jaguars JAC	13-4	12-5	10-7
Kansas City Chiefs KC	6-11	6-10	4-12

New Orleans Saints

Pitchers

POS	Player

Hitters

POS	Player

Buffalo Bills

Pitchers

POS	Player

Hitters

POS	Player

Game Statistics

298

356

Total Yards

109

191

Passing Yards

189

165

Rushing Yards

Touchdowns

100

Field Goal %

Turnovers

Team	Last 5 Matches
New Orleans Saints NO ( 6-11 )	L W W W W
Buffalo Bills BUF ( 12-5 )	W W L W W

James Cook III Running Back New Orleans	14	Touchdowns	9	Chris Olave Wide Receiver Buffalo
James Cook III Running Back New Orleans	1621	Rushing	471	Alvin Kamara Running Back Buffalo
Josh Allen Quarterback New Orleans	3668	Passing	2384	Tyler Shough Quarterback Buffalo
Chris Olave Wide Receiver Buffalo	100	Receiving	72	Khalil Shakir Wide Receiver New Orleans
Cameron Jordan Defensive End Buffalo	10.5	Sacks	7	Greg Rousseau Defensive End New Orleans
Cole Bishop Safety New Orleans	3	Interceptions	3	Kool-Aid McKinstry Cornerback Buffalo

Dalton Kincaid Tight End New Orleans	2	Touchdowns
James Cook III Running Back New Orleans	163	Rushing
Josh Allen Quarterback New Orleans	556	Passing	Did not qualify
Khalil Shakir Wide Receiver New Orleans	19	Receiving
Greg Rousseau Defensive End New Orleans	1	Sacks
Cole Bishop Safety New Orleans	1	Interceptions

team	w games_won	l games_lost	t games_tied	pf points
San Francisco 49ers SF	6	1	0	197
Seattle Seahawks SEA	4	4	0	185
L.A. Rams Rams LAR	4	4	0	194
Arizona Cardinals ARI	3	5	0	175
Carolina Panthers CAR	3	4	0	178
Tampa Bay Buccaneers TB	3	5	0	178
Atlanta Falcons ATL	3	5	0	171
New Orleans Saints NO	2	5	0	162
N.Y. Giants Giants NYG	4	2	1	163
Dallas Cowboys DAL	3	5	0	219
Washington Commanders WAS	2	4	1	159
Philadelphia Eagles PHI	2	6	0	137
Minnesota Vikings MIN	6	1	0	140
Chicago Bears CHI	6	2	0	214
Detroit Lions DET	5	2	0	203
Green Bay Packers GB	5	3	0	171

Game Preview

Saints vs. Bills Point Spread: NFL Week 4 Odds, Prediction

A matchup that takes place only once every four years kicks off Sunday afternoon in Buffalo as the 3-0 Bills host the 0-3 New Orleans Saints at 1 p.m. ET.

Team	Win / Loss	ATS	OU
N.Y. Giants Giants NYG	4-13	8-8	10-6
Chicago Bears CHI	10-6	11-6	9-8-1
L.A. Rams Rams LAR	12-5	12-7	11-8
Tampa Bay Buccaneers TB	8-9	5-11	8-8
Philadelphia Eagles PHI	11-6	10-7	8-9
Green Bay Packers GB	9-6	6-10	9-8
San Francisco 49ers SF	12-5	11-6	10-8
Arizona Cardinals ARI	3-14	7-9	9-7
Seattle Seahawks SEA	14-3	14-5	11-8
Dallas Cowboys DAL	7-9	7-9	12-4
Minnesota Vikings MIN	9-8	8-8	8-8
Detroit Lions DET	9-8	7-9	10-6
Atlanta Falcons ATL	8-9	9-7	8-7-1
Carolina Panthers CAR	8-9	10-7	7-10
New Orleans Saints NO	6-11	8-8	5-11
Washington Commanders WAS	5-12	6-10	9-6-1

Team	Win / Loss	ATS	OU
Baltimore Ravens BAL	8-9	6-9	10-6
Denver Broncos DEN	14-3	9-9	8-10
Miami Dolphins MIA	7-10	8-8	8-6-2
Houston Texans HOU	12-5	10-8	6-12
Cleveland Browns CLE	5-12	7-9	8-8
Pittsburgh Steelers PIT	10-7	9-8	9-7-1
New England Patriots NE	14-3	14-6	12-8
Tennessee Titans TEN	3-14	5-11	10-6
L.A. Chargers Chargers LAC	11-6	9-8	8-9
Indianapolis Colts IND	8-9	8-8	8-8
N.Y. Jets Jets NYJ	3-14	7-9	10-6
Cincinnati Bengals CIN	6-11	8-8	9-7
Buffalo Bills BUF	12-5	8-9	9-9
Las Vegas Raiders LV	3-14	6-10	8-8
Jacksonville Jaguars JAC	13-4	12-5	10-7
Kansas City Chiefs KC	6-11	6-10	4-12

Saints vs. Bills Prediction, Odds & Stats September 28, 2025

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