Saints vs. Bills Prediction, Odds & Stats - September 28, 2025

Final Score
New Orleans
Saints
Buffalo
Bills
19
31
New Orleans Saints
Buffalo Bills
Scoreboard 1 2 3 4 Odds
New Orleans Saints 3-10 7 3 6 3 +48.5
Buffalo Bills 9-4 14 0 7 10 -14.5

Latest Encounters

Date Result Competition Stats Recap
12/07/25
New Orleans Saints NO ( 3-10 )
Tampa Bay Buccaneers TB ( 7-6 )
24   -   20
NFC South
12/07/25
Cincinnati Bengals CIN ( 4-9 )
Buffalo Bills BUF ( 9-4 )
34   -   39
AFC North
11/30/25
Buffalo Bills BUF ( 9-4 )
Pittsburgh Steelers PIT ( 7-6 )
26   -   7
AFC East
11/30/25
New Orleans Saints NO ( 3-10 )
Miami Dolphins MIA ( 6-7 )
17   -   21
NFC South
11/23/25
Atlanta Falcons ATL ( 4-9 )
New Orleans Saints NO ( 3-10 )
24   -   10
NFC South
11/20/25
Buffalo Bills BUF ( 9-4 )
Houston Texans HOU ( 8-5 )
19   -   23
AFC East
11/16/25
Tampa Bay Buccaneers TB ( 7-6 )
Buffalo Bills BUF ( 9-4 )
32   -   44
NFC South
11/09/25
New Orleans Saints NO ( 3-10 )
Carolina Panthers CAR ( 7-6 )
17   -   7
NFC South
11/09/25
Buffalo Bills BUF ( 9-4 )
Miami Dolphins MIA ( 6-7 )
13   -   30
AFC East
11/02/25
Kansas City Chiefs KC ( 6-7 )
Buffalo Bills BUF ( 9-4 )
21   -   28
AFC West
11/02/25
New Orleans Saints NO ( 3-10 )
L.A. Rams Rams LAR ( 10-3 )
10   -   34
NFC South
10/26/25
Tampa Bay Buccaneers TB ( 7-6 )
New Orleans Saints NO ( 3-10 )
23   -   3
NFC South

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
New Orleans Saints New Orleans Saints
0 3 3-7 1W 0-3 0 0-0 0-0 2-1
Buffalo Bills Buffalo Bills
3 0 6-4 2W 1-1 0 0-0 0-0 2-1

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards NO:Total Net Yards NO:Net Rushing Yards NO:Passing Yards
09/28/2025 BUF 31 - NO 19 NO +17.5 Over 48.5 356 165 191 298 189 109
11/25/2021 NO 6 - BUF 31 BUF -7 Under 46.5 361 113 248 190 44 146
11/12/2017 BUF 10 - NO 47 NO -2 Over 48.5 482 298 184 198 69 129
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/07/2025 TB 20 - NO 24 W +8.5 Over 41.5 260 139 121
11/30/2025 MIA 21 - NO 17 W +5.5 Under 42.5 294 81 213
11/23/2025 NO 10 - ATL 24 L +2.5 Under 40 302 121 181
11/09/2025 CAR 7 - NO 17 W +4.5 Under 38.5 388 122 266
11/02/2025 LAR 34 - NO 10 L +14 Under 44.5 224 57 167
10/26/2025 NO 3 - TB 23 L +5.5 Under 46.5 212 88 124
10/19/2025 CHI 26 - NO 14 L +3.5 Under 43.5 253 44 209
10/12/2025 NO 19 - NE 25 L +3.5 Under 45.5 333 73 260
10/05/2025 NO 26 - NYG 14 W +1.5 Under 41.5 335 136 199
09/28/2025 BUF 31 - NO 19 W +17.5 Over 48.5 298 189 109
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/07/2025 BUF 39 - CIN 34 L -6 Over 32.5 416 183 233
11/30/2025 PIT 7 - BUF 26 W -3.5 Under 47.5 166 58 108
11/20/2025 HOU 23 - BUF 19 L -5 Under 44.5 261 108 153
11/16/2025 BUF 44 - TB 32 W -6 Over 45.5 414 97 317
11/09/2025 MIA 30 - BUF 13 L -9.5 Under 48.5 370 197 173
11/02/2025 BUF 28 - KC 21 W -2.5 Under 52.5 404 141 263
10/26/2025 CAR 9 - BUF 40 W -7.5 Over 48 244 114 130
10/13/2025 ATL 24 - BUF 14 L -5.5 Under 49.5 443 210 233
10/05/2025 BUF 20 - NE 23 L -8.5 Under 49.5 363 118 245
09/28/2025 BUF 31 - NO 19 L -17.5 Over 48.5 356 165 191

Matchup Edge - Scoring Stats

avg rank edge in rank avg
15.85 28 Points Per Game 5 28.92
24.23 21 Points Allowed Per Game 14 22.54
2 23 1st Quarter Scoring Per Game 7 5.46
7.62 24 1st Quarter Scoring Allowed Per Game 10 4.15
6.38 18 2nd Quarter Scoring Per Game 11 7
9.08 24 2nd Quarter Scoring Allowed Per Game 25 9.23
3.15 21 3rd Quarter Scording Per Game 3 7.31
3.77 7 3rd Quarter Scoring Allowed Per Game 2 2.77
4.31 24 4th Quarter Scoring Per Game 3 9.15
3.77 2 4th Quarter Scoring Allowed Per Game 12 6.38
41.2 29 Red Zone Efficiency 8 61.7
293.77 26 Total Yards Per Game 2 383.69
8.56 28 Total Yards Per Play 1 12.99
3.65 29 Rushing Yards Per Play 1 5.06
34.31 8 Passing Attempts Per Game 25 29.54
8.79 29 Passing Yards Per Completion 8 10.96
1 14 Passing Tds Per Game 5 1.69
22.69 6 Completions Per Game 14 20.62
66.1 13 Completion % 2 69.8
82.96 28 Qb Rating 6 102.53
2.69 8 Defense Sacks Per Game 10 2.38
0.85 5 Defense Interceptions Per Game 7 0.77
1.23 8 Opponent Fumbles Per Game 7 1.15
0.69 3 Opponent Fumbles Lost Per Game 4 0.62
7.23 17 Penalties Per Game 12 6.69
52.92 16 Penalty Yards Per Game 21 56.15
20 11 Takeaway / Giveaway Differential 9 18
3.38 25 Yards Per Punt Return 23 3.42
25.5 17 Yards Per Kickoff Return 7 27.41

Odds Analysis

Team Rankings

offence
New Orleans Saints NO
Season stats rank
Total Yards 293.8 26
Passing Yards 199.38 21
Rushing Yards 94.38 28
Points Scored 15.85 30
Field Goal % 0.69 32
Buffalo Bills BUF
Season stats rank
Total Yards 383.7 2
Passing Yards 225.92 11
Rushing Yards 157.77 1
Points Scored 28.92 5
Field Goal % 0.9 11
defence
New Orleans Saints NO
Season stats rank
Total Yards 293.8 26
Passing Yards 199.38 21
Rushing Yards 94.38 28
Points Scored 15.85 30
Field Goal % 0.69 32
Buffalo Bills BUF
Season stats rank
Total Yards 383.7 2
Passing Yards 225.92 11
Rushing Yards 157.77 1
Points Scored 28.92 5
Field Goal % 0.9 11

Injuries

New Orleans Saints NO
Buffalo Bills BUF

National Football Conference Standings

American Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player