Sports Interaction

Saints vs. Bills Prediction, Odds & Stats - September 28, 2025

Final Score
New Orleans
Saints
Buffalo
Bills
19
31
New Orleans Saints
Buffalo Bills
Scoreboard 1 2 3 4 Odds
New Orleans Saints 6-11 7 3 6 3 +48.5
Buffalo Bills 12-5 14 0 7 10 -14.5

Latest Encounters

Date Result Competition Stats Recap
01/17/26
Buffalo Bills BUF ( 12-5 )
Denver Broncos DEN ( 14-3 )
30   -   33
AFC East
01/11/26
Buffalo Bills BUF ( 12-5 )
Jacksonville Jaguars JAC ( 13-4 )
27   -   24
AFC East
01/04/26
N.Y. Jets Jets NYJ ( 3-14 )
Buffalo Bills BUF ( 12-5 )
8   -   35
AFC East
01/04/26
New Orleans Saints NO ( 6-11 )
Atlanta Falcons ATL ( 8-9 )
17   -   19
NFC South
12/28/25
Philadelphia Eagles PHI ( 11-6 )
Buffalo Bills BUF ( 12-5 )
13   -   12
NFC East
12/28/25
New Orleans Saints NO ( 6-11 )
Tennessee Titans TEN ( 3-14 )
34   -   26
NFC South
12/21/25
N.Y. Jets Jets NYJ ( 3-14 )
New Orleans Saints NO ( 6-11 )
6   -   29
AFC East
12/21/25
Buffalo Bills BUF ( 12-5 )
Cleveland Browns CLE ( 5-12 )
23   -   20
AFC East
12/14/25
Carolina Panthers CAR ( 8-9 )
New Orleans Saints NO ( 6-11 )
17   -   20
NFC South
12/14/25
Buffalo Bills BUF ( 12-5 )
New England Patriots NE ( 14-3 )
35   -   31
AFC East
12/07/25
New Orleans Saints NO ( 6-11 )
Tampa Bay Buccaneers TB ( 8-9 )
24   -   20
NFC South
11/30/25
New Orleans Saints NO ( 6-11 )
Miami Dolphins MIA ( 7-10 )
17   -   21
NFC South

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
New Orleans Saints New Orleans Saints
0 3 5-5 1L 0-3 0 0-0 0-0 2-1
Buffalo Bills Buffalo Bills
3 0 7-3 1W 1-1 0 0-0 0-0 2-1

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards NO:Total Net Yards NO:Net Rushing Yards NO:Passing Yards
09/28/2025 BUF 31 - NO 19 NO +14.5 Over 48.5 356 165 191 298 189 109
11/25/2021 NO 6 - BUF 31 BUF -7 Under 46.5 361 113 248 190 44 146
11/12/2017 BUF 10 - NO 47 NO -2 Over 48.5 482 298 184 198 69 129
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 ATL 19 - NO 17 W +4 Under 43.5 340 108 232
12/28/2025 TEN 26 - NO 34 W -3 Over 39 423 103 320
12/21/2025 NO 29 - NYJ 6 W -4.5 Under 40 195 64 131
12/14/2025 NO 20 - CAR 17 W +2.5 Under 41.5 281 127 154
12/07/2025 TB 20 - NO 24 W +8.5 Over 41.5 260 139 121
11/30/2025 MIA 21 - NO 17 W +5.5 Under 42.5 294 81 213
11/23/2025 NO 10 - ATL 24 L +2.5 Under 40 302 121 181
11/09/2025 CAR 7 - NO 17 W +4.5 Under 38.5 388 122 266
11/02/2025 LAR 34 - NO 10 L +14 Under 44.5 224 57 167
10/26/2025 NO 3 - TB 23 L +5.5 Under 45.5 212 88 124
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 DEN 33 - BUF 30 L +1.5 Over 46.5 349 70 279
01/11/2026 JAC 24 - BUF 27 W -1 Under 51.5 359 154 205
01/04/2026 BUF 35 - NYJ 8 W -13 Over 39 470 211 259
12/28/2025 BUF 12 - PHI 13 L -2.5 Under 44.5 331 120 211
12/21/2025 CLE 20 - BUF 23 L -10 Over 41 294 160 134
12/14/2025 NE 31 - BUF 35 W -4.5 Over 49.5 385 246 139
12/07/2025 BUF 39 - CIN 34 L -6 Over 32.5 416 183 233
11/30/2025 PIT 7 - BUF 26 W -3.5 Under 47.5 166 58 108
11/20/2025 HOU 23 - BUF 19 L -5 Under 44.5 261 108 153
11/16/2025 BUF 44 - TB 32 W -6 Over 45.5 414 97 317

Matchup Edge - Scoring Stats

avg rank edge in rank avg
18 27 Points Per Game 4 28.29
22.53 16 Points Allowed Per Game 12 21.47
1.71 29 1st Quarter Scoring Per Game 10 5
7.18 24 1st Quarter Scoring Allowed Per Game 16 4.82
6.65 16 2nd Quarter Scoring Per Game 11 7.35
8.29 20 2nd Quarter Scoring Allowed Per Game 19 8.18
3.76 19 3rd Quarter Scording Per Game 3 7.06
3.65 9 3rd Quarter Scoring Allowed Per Game 1 2.53
5.88 19 4th Quarter Scoring Per Game 1 8.88
3.41 1 4th Quarter Scoring Allowed Per Game 11 5.94
44.4 26 Red Zone Efficiency 3 66.2
313.59 22 Total Yards Per Game 4 376.29
9.02 26 Total Yards Per Play 2 12.92
3.69 28 Rushing Yards Per Play 2 4.96
34.76 6 Passing Attempts Per Game 21 29.12
9.39 24 Passing Yards Per Completion 12 10.71
1.12 14 Passing Tds Per Game 6 1.71
23.35 5 Completions Per Game 15 20.24
67.2 6 Completion % 2 69.5
88.71 20 Qb Rating 4 104.62
2.88 6 Defense Sacks Per Game 11 2.35
0.71 9 Defense Interceptions Per Game 11 0.59
1.18 10 Opponent Fumbles Per Game 8 1.06
0.71 2 Opponent Fumbles Lost Per Game 5 0.53
6.94 15 Penalties Per Game 7 5.94
54.12 23 Penalty Yards Per Game 16 49.88
24 12 Takeaway / Giveaway Differential 8 19
3.78 20 Yards Per Punt Return 18 3.96
25.23 22 Yards Per Kickoff Return 4 27.91

Odds Analysis

Team Rankings

offence
New Orleans Saints NO
Season stats rank
Total Yards 313.6 23
Passing Yards 219.29 13
Rushing Yards 94.29 28
Points Scored 18 28
Field Goal % 0.71 32
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8
defence
New Orleans Saints NO
Season stats rank
Total Yards 313.6 23
Passing Yards 219.29 13
Rushing Yards 94.29 28
Points Scored 18 28
Field Goal % 0.71 32
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8

Injuries

New Orleans Saints NO
Buffalo Bills BUF

National Football Conference Standings

American Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player