Bills vs. Browns Prediction, Odds & Stats - December 21, 2025

Final Score
Buffalo
Bills
Cleveland
Browns
23
20
Buffalo Bills
Cleveland Browns
Scoreboard 1 2 3 4 Odds
Buffalo Bills 12-5 7 13 3 0 +32.5
Cleveland Browns 5-12 7 3 7 3 +10.5

Latest Encounters

Date Result Competition Stats Recap
01/04/26
N.Y. Jets Jets NYJ ( 3-14 )
Buffalo Bills BUF ( 12-5 )
8   -   35
AFC East
01/04/26
Cleveland Browns CLE ( 5-12 )
Cincinnati Bengals CIN ( 6-11 )
20   -   18
AFC North
12/28/25
Philadelphia Eagles PHI ( 11-6 )
Buffalo Bills BUF ( 12-5 )
13   -   12
NFC East
12/28/25
Pittsburgh Steelers PIT ( 10-7 )
Cleveland Browns CLE ( 5-12 )
6   -   13
AFC North
12/14/25
Buffalo Bills BUF ( 12-5 )
New England Patriots NE ( 14-3 )
35   -   31
AFC East
12/14/25
Cleveland Browns CLE ( 5-12 )
Chicago Bears CHI ( 11-6 )
3   -   31
AFC North
12/07/25
Cincinnati Bengals CIN ( 6-11 )
Buffalo Bills BUF ( 12-5 )
34   -   39
AFC North
12/07/25
Tennessee Titans TEN ( 3-14 )
Cleveland Browns CLE ( 5-12 )
31   -   29
AFC South
11/30/25
Buffalo Bills BUF ( 12-5 )
Pittsburgh Steelers PIT ( 10-7 )
26   -   7
AFC East
11/30/25
San Francisco 49ers SF ( 12-5 )
Cleveland Browns CLE ( 5-12 )
26   -   8
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Buffalo Bills Buffalo Bills
10 4 7-3 1W 6-7 0 0-0 0-0 7-7
Cleveland Browns Cleveland Browns
3 11 3-7 2W 5-9 0 0-0 0-0 7-7

Recent Meetings

date home-away ats o/u CLE:Total Net Yards CLE:Net Rushing Yards CLE:Passing Yards BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards
12/21/2025 CLE 20 - BUF 23 CLE +10 Over 41 294 160 134 259 164 95
11/20/2022 BUF 31 - CLE 23 BUF -8.5 Over 50.5 396 80 316 357 171 186
11/10/2019 CLE 19 - BUF 16 CLE -3 Under 41.5 344 84 260 368 147 221
08/17/2018 CLE 17 - BUF 19 BUF +3 Under 38 285 113 172 247 164 83
12/18/2016 BUF 33 - CLE 13 BUF -10.5 Over 43 269 107 162 451 280 171
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 BUF 35 - NYJ 8 W -13 Over 39 122 69 53
12/28/2025 BUF 12 - PHI 13 L -2.5 Under 44.5 190 82 108
12/21/2025 CLE 20 - BUF 23 L -10 Over 41 259 164 95
12/14/2025 NE 31 - BUF 35 W -4.5 Over 49.5 349 168 181
12/07/2025 BUF 39 - CIN 34 L -6 Over 32.5 338 62 276
11/30/2025 PIT 7 - BUF 26 W -3.5 Under 47.5 372 249 123
11/20/2025 HOU 23 - BUF 19 L -5 Under 44.5 326 143 183
11/16/2025 BUF 44 - TB 32 W -6 Over 45.5 367 202 165
11/09/2025 MIA 30 - BUF 13 L -9.5 Under 48.5 376 87 289
11/02/2025 BUF 28 - KC 21 W -2.5 Under 52.5 305 79 226
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 CIN 18 - CLE 20 W +9.5 Under 47 364 142 222
12/28/2025 CLE 13 - PIT 6 W +5.5 Under 34.5 262 78 184
12/21/2025 CLE 20 - BUF 23 W +10 Over 41 294 160 134
12/14/2025 CHI 31 - CLE 3 L +7.5 Under 38.5 361 142 219
12/07/2025 CLE 29 - TEN 31 L -3.5 Over 33.5 412 61 351
11/30/2025 CLE 8 - SF 26 L +6.5 Under 41.5 253 138 115
11/23/2025 LV 10 - CLE 24 W +3.5 Under 36 268 60 208
11/16/2025 CLE 16 - BAL 23 L +7.5 Under 44.5 187 106 81
11/09/2025 NYJ 27 - CLE 20 L +1.5 Over 38 169 127 42
10/26/2025 NE 32 - CLE 13 L +7 Over 40.5 422 177 245

Matchup Edge - Scoring Stats

avg rank edge in rank avg
28.29 4 Points Per Game 30 16.41
21.47 12 Points Allowed Per Game 14 22.29
5 10 1st Quarter Scoring Per Game 17 4.41
4.82 16 1st Quarter Scoring Allowed Per Game 21 5.59
7.35 11 2nd Quarter Scoring Per Game 21 5.18
8.18 19 2nd Quarter Scoring Allowed Per Game 6 5.24
7.06 3 3rd Quarter Scording Per Game 23 2.71
2.53 1 3rd Quarter Scoring Allowed Per Game 16 5.06
8.88 1 4th Quarter Scoring Per Game 26 4.12
5.94 11 4th Quarter Scoring Allowed Per Game 15 6.41
66.2 3 Red Zone Efficiency 20 52.6
376.29 4 Total Yards Per Game 28 262.12
12.92 2 Total Yards Per Play 30 7.99
4.96 2 Rushing Yards Per Play 25 3.92
29.12 21 Passing Attempts Per Game 13 32.82
10.71 12 Passing Yards Per Completion 27 8.69
1.71 6 Passing Tds Per Game 16 0.94
20.24 15 Completions Per Game 22 19
69.5 2 Completion % 29 57.9
104.62 4 Qb Rating 32 69.97
2.35 11 Defense Sacks Per Game 5 3
0.59 11 Defense Interceptions Per Game 3 1.06
1.06 8 Opponent Fumbles Per Game 11 1.24
0.53 5 Opponent Fumbles Lost Per Game 7 0.41
5.94 7 Penalties Per Game 10 6.35
49.88 16 Penalty Yards Per Game 14 49.41
19 8 Takeaway / Giveaway Differential 13 25
3.96 18 Yards Per Punt Return 28 2.51
27.91 4 Yards Per Kickoff Return 31 23.69

Odds Analysis

Team Rankings

offence
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8
Cleveland Browns CLE
Season stats rank
Total Yards 262.1 29
Passing Yards 165.12 30
Rushing Yards 97 27
Points Scored 16.41 31
Field Goal % 0.89 10
defence
Buffalo Bills BUF
Season stats rank
Total Yards 376.3 4
Passing Yards 216.65 15
Rushing Yards 159.65 1
Points Scored 28.29 4
Field Goal % 0.9 8
Cleveland Browns CLE
Season stats rank
Total Yards 262.1 29
Passing Yards 165.12 30
Rushing Yards 97 27
Points Scored 16.41 31
Field Goal % 0.89 10

Injuries

Buffalo Bills BUF
Cleveland Browns CLE

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player