Patriots vs. Bills Prediction, Odds & Stats - October 05, 2025

Final Score
New England
Patriots
Buffalo
Bills
23
20
New England Patriots
Buffalo Bills
Scoreboard 1 2 3 4 Odds
New England Patriots 13-3 3 3 7 10 +49.5
Buffalo Bills 11-5 0 3 7 10 -8

Latest Encounters

Date Result Competition Stats Recap
12/28/25
Philadelphia Eagles PHI ( 11-5 )
Buffalo Bills BUF ( 11-5 )
13   -   12
NFC East
12/28/25
New England Patriots NE ( 13-3 )
N.Y. Jets Jets NYJ ( 3-13 )
42   -   10
AFC East
12/21/25
New England Patriots NE ( 13-3 )
Baltimore Ravens BAL ( 8-8 )
28   -   24
AFC East
12/21/25
Buffalo Bills BUF ( 11-5 )
Cleveland Browns CLE ( 4-12 )
23   -   20
AFC East
12/14/25
Buffalo Bills BUF ( 11-5 )
New England Patriots NE ( 13-3 )
35   -   31
AFC East
12/07/25
Cincinnati Bengals CIN ( 6-10 )
Buffalo Bills BUF ( 11-5 )
34   -   39
AFC North
12/01/25
N.Y. Giants Giants NYG ( 3-13 )
New England Patriots NE ( 13-3 )
15   -   33
NFC East
11/30/25
Buffalo Bills BUF ( 11-5 )
Pittsburgh Steelers PIT ( 9-7 )
26   -   7
AFC East
11/23/25
New England Patriots NE ( 13-3 )
Cincinnati Bengals CIN ( 6-10 )
26   -   20
AFC East
11/20/25
Buffalo Bills BUF ( 11-5 )
Houston Texans HOU ( 11-5 )
19   -   23
AFC East
11/13/25
N.Y. Jets Jets NYJ ( 3-13 )
New England Patriots NE ( 13-3 )
14   -   27
AFC East

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
New England Patriots New England Patriots
2 2 9-1 2W 2-2 0 0-0 0-0 2-2
Buffalo Bills Buffalo Bills
4 0 7-3 1L 1-2 0 0-0 0-0 3-1

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards NE:Total Net Yards NE:Net Rushing Yards NE:Passing Yards
12/14/2025 NE 31 - BUF 35 BUF -4.5 Over 49.5 349 168 181 385 246 139
10/05/2025 BUF 20 - NE 23 NE +8.5 Under 49.5 363 118 245 338 71 267
01/05/2025 NE 23 - BUF 16 NE +3 Under 40 259 130 129 309 77 232
12/22/2024 BUF 24 - NE 21 NE +14 Under 46.5 379 126 253 324 172 152
12/31/2023 BUF 27 - NE 21 NE +12 Over 40 294 103 191 281 127 154
10/22/2023 NE 29 - BUF 25 NE +8.5 Over 41 339 81 258 364 96 268
01/08/2023 BUF 35 - NE 23 BUF -8 Over 44 341 107 234 327 90 237
12/01/2022 NE 10 - BUF 24 BUF -5.5 Under 44 355 132 223 242 60 182
01/15/2022 BUF 47 - NE 17 BUF -4.5 Over 43.5 305 89 216 482 174 308
12/26/2021 NE 21 - BUF 33 BUF +1 Over 44.5 428 114 314 288 149 139
12/06/2021 BUF 10 - NE 14 NE +3 Under 41 241 222 19 230 99 131
12/28/2020 NE 9 - BUF 38 BUF -6.5 Under 47.5 474 130 344 201 145 56
11/01/2020 BUF 24 - NE 21 NE +4 Over 41 349 188 161 339 190 149
12/21/2019 NE 24 - BUF 17 NE -6.5 Over 38.5 268 92 176 414 143 271
09/29/2019 BUF 10 - NE 16 BUF +7.5 Under 41.5 224 74 150 375 135 240
12/23/2018 NE 24 - BUF 12 BUF +13.5 Under 45 289 72 217 390 273 117
10/29/2018 BUF 6 - NE 25 NE -13 Under 44.5 387 76 311 333 46 287
12/24/2017 NE 37 - BUF 16 NE -11 Over 47 326 84 242 411 193 218
12/03/2017 BUF 3 - NE 23 NE -7.5 Under 48.5 435 191 244 268 183 85
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 NYJ 10 - NE 42 W -12.5 Over 42.5 440 155 285
12/21/2025 BAL 24 - NE 28 W +2.5 Over 48.5 453 79 374
12/14/2025 NE 31 - BUF 35 L +4.5 Over 49.5 349 168 181
12/01/2025 NE 33 - NYG 15 W -7.5 Over 46.5 239 111 128
11/23/2025 CIN 20 - NE 26 L -6.5 Under 50 392 107 285
11/13/2025 NE 27 - NYJ 14 W -5.5 Under 42.5 245 140 105
11/09/2025 TB 23 - NE 28 W +2.5 Over 48 435 166 269
11/02/2025 NE 24 - ATL 23 L -4.5 Over 45.5 288 71 217
10/26/2025 NE 32 - CLE 13 W -7 Over 40.5 213 68 145
10/19/2025 TEN 13 - NE 31 W -6.5 Over 42.5 387 175 212
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 BUF 12 - PHI 13 L -2.5 Under 44.5 331 120 211
12/21/2025 CLE 20 - BUF 23 L -10 Over 41 294 160 134
12/14/2025 NE 31 - BUF 35 W -4.5 Over 49.5 385 246 139
12/07/2025 BUF 39 - CIN 34 L -6 Over 32.5 416 183 233
11/30/2025 PIT 7 - BUF 26 W -3.5 Under 47.5 166 58 108
11/20/2025 HOU 23 - BUF 19 L -5 Under 44.5 261 108 153
11/16/2025 BUF 44 - TB 32 W -6 Over 45.5 414 97 317
11/09/2025 MIA 30 - BUF 13 L -9.5 Under 48.5 370 197 173
11/02/2025 BUF 28 - KC 21 W -2.5 Under 52.5 404 141 263
10/26/2025 CAR 9 - BUF 40 W -7.5 Over 48 244 114 130

Matchup Edge - Scoring Stats

avg rank edge in rank avg
28.25 5 Points Per Game 6 27.88
19.38 5 Points Allowed Per Game 12 22.31
6.75 2 1st Quarter Scoring Per Game 10 4.88
4.63 15 1st Quarter Scoring Allowed Per Game 17 5.13
10.69 2 2nd Quarter Scoring Per Game 15 6.94
4.81 4 2nd Quarter Scoring Allowed Per Game 26 8.69
5.63 10 3rd Quarter Scording Per Game 2 7
3.56 7 3rd Quarter Scoring Allowed Per Game 1 2.69
5.19 24 4th Quarter Scoring Per Game 2 9.06
6.38 12 4th Quarter Scoring Allowed Per Game 9 5.81
55.2 18 Red Zone Efficiency 7 64.4
374.5 4 Total Yards Per Game 5 370.44
12.48 3 Total Yards Per Play 2 12.72
4.23 19 Rushing Yards Per Play 2 4.97
30 21 Passing Attempts Per Game 24 29.13
11.76 3 Passing Yards Per Completion 14 10.63
1.88 5 Passing Tds Per Game 8 1.56
21.5 10 Completions Per Game 15 20.13
71.7 1 Completion % 3 69.1
112.54 1 Qb Rating 5 101.89
3 7 Defense Sacks Per Game 11 2.5
0.5 11 Defense Interceptions Per Game 9 0.63
0.75 2 Opponent Fumbles Per Game 9 1.13
0.5 7 Opponent Fumbles Lost Per Game 6 0.56
5.94 7 Penalties Per Game 10 6.13
50.13 17 Penalty Yards Per Game 18 51.25
16 6 Takeaway / Giveaway Differential 9 19
7.56 2 Yards Per Punt Return 19 3.92
25.45 18 Yards Per Kickoff Return 3 28

Odds Analysis

Team Rankings

offence
New England Patriots NE
Season stats rank
Total Yards 374.5 4
Passing Yards 252.75 3
Rushing Yards 121.75 13
Points Scored 28.25 5
Field Goal % 0.87 15
Buffalo Bills BUF
Season stats rank
Total Yards 370.4 5
Passing Yards 214 19
Rushing Yards 156.44 2
Points Scored 27.88 6
Field Goal % 0.9 9
defence
New England Patriots NE
Season stats rank
Total Yards 374.5 4
Passing Yards 252.75 3
Rushing Yards 121.75 13
Points Scored 28.25 5
Field Goal % 0.87 15
Buffalo Bills BUF
Season stats rank
Total Yards 370.4 5
Passing Yards 214 19
Rushing Yards 156.44 2
Points Scored 27.88 6
Field Goal % 0.9 9

Injuries

New England Patriots NE
Buffalo Bills BUF

AFC East Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player