Patriots vs. Bills Prediction, Odds & Stats - October 05, 2025

Scoreboard	1	2	3	4	Odds
New England Patriots 14-3	3	3	7	10	+49.5
Buffalo Bills 12-5	0	3	7	10	-8

Date	Result	Competition
02/08/26	Seattle Seahawks SEA ( 14-3 ) New England Patriots NE ( 14-3 ) 29 - 13	NFC West
01/25/26	New England Patriots NE ( 14-3 ) Denver Broncos DEN ( 14-3 ) 10 - 7	AFC East
01/18/26	Houston Texans HOU ( 12-5 ) New England Patriots NE ( 14-3 ) 16 - 28	AFC South
01/17/26	Buffalo Bills BUF ( 12-5 ) Denver Broncos DEN ( 14-3 ) 30 - 33	AFC East
01/11/26	L.A. Chargers Chargers LAC ( 11-6 ) New England Patriots NE ( 14-3 ) 3 - 16	AFC West
01/11/26	Buffalo Bills BUF ( 12-5 ) Jacksonville Jaguars JAC ( 13-4 ) 27 - 24	AFC East
01/04/26	Miami Dolphins MIA ( 7-10 ) New England Patriots NE ( 14-3 ) 10 - 38	AFC East
01/04/26	N.Y. Jets Jets NYJ ( 3-14 ) Buffalo Bills BUF ( 12-5 ) 8 - 35	AFC East
12/28/25	Philadelphia Eagles PHI ( 11-6 ) Buffalo Bills BUF ( 12-5 ) 13 - 12	NFC East
12/28/25	New England Patriots NE ( 14-3 ) N.Y. Jets Jets NYJ ( 3-14 ) 42 - 10	AFC East
12/21/25	Buffalo Bills BUF ( 12-5 ) Cleveland Browns CLE ( 5-12 ) 23 - 20	AFC East
12/14/25	Buffalo Bills BUF ( 12-5 ) New England Patriots NE ( 14-3 ) 35 - 31	AFC East

New England Patriots NE Buffalo Bills BUF

	Stat
2	Games Won	4
2	Games Lost	0
9-1	Last 10	7-3
0-0	W L Streak	0-0
2-2	Against The Spread	1-2
0	Money	0
0-0	Home	0-0
0-0	Away	0-0
2-2	Total	3-1

date	home-away	ats	o/u	BUF:Total Net Yards	BUF:Net Rushing Yards	BUF:Passing Yards	NE:Total Net Yards	NE:Net Rushing Yards	NE:Passing Yards
12/14/2025	NE 31 - BUF 35	BUF -4.5	Over 49.5	349	168	181	385	246	139
10/05/2025	BUF 20 - NE 23	NE +8.5	Under 49.5	363	118	245	338	71	267
01/05/2025	NE 23 - BUF 16	NE +3	Under 40	259	130	129	309	77	232
12/22/2024	BUF 24 - NE 21	NE +14	Under 46.5	379	126	253	324	172	152
12/31/2023	BUF 27 - NE 21	NE +12	Over 40	294	103	191	281	127	154
10/22/2023	NE 29 - BUF 25	NE +8.5	Over 41	339	81	258	364	96	268
01/08/2023	BUF 35 - NE 23	BUF -8	Over 44	341	107	234	327	90	237
12/01/2022	NE 10 - BUF 24	BUF -5.5	Under 44	355	132	223	242	60	182
01/15/2022	BUF 47 - NE 17	BUF -4.5	Over 43.5	305	89	216	482	174	308
12/26/2021	NE 21 - BUF 33	BUF +1	Over 44.5	428	114	314	288	149	139
12/06/2021	BUF 10 - NE 14	NE +3	Under 41	241	222	19	230	99	131
12/28/2020	NE 9 - BUF 38	BUF -6.5	Under 47.5	474	130	344	201	145	56
11/01/2020	BUF 24 - NE 21	NE +4	Over 41	349	188	161	339	190	149
12/21/2019	NE 24 - BUF 17	NE -6.5	Over 38.5	268	92	176	414	143	271
09/29/2019	BUF 10 - NE 16	BUF +7.5	Under 41.5	224	74	150	375	135	240
12/23/2018	NE 24 - BUF 12	BUF +13.5	Under 45	289	72	217	390	273	117
10/29/2018	BUF 6 - NE 25	NE -13	Under 44.5	387	76	311	333	46	287
12/24/2017	NE 37 - BUF 16	NE -11	Over 47	326	84	242	411	193	218
12/03/2017	BUF 3 - NE 23	NE -7.5	Under 48.5	435	191	244	268	183	85

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
02/08/2026	NE 13 - SEA 29	L +4.5	Under 46.5	335	141	194
01/25/2026	DEN 7 - NE 10	L -5.5	Under 40.5	206	141	65
01/18/2026	NE 28 - HOU 16	W -3.5	Over 41.5	241	48	193
01/11/2026	NE 16 - LAC 3	W -3.5	Under 45.5	207	87	120
01/04/2026	NE 38 - MIA 10	W -14	Over 44.5	180	63	117
12/28/2025	NYJ 10 - NE 42	W -12.5	Over 42.5	440	155	285
12/21/2025	BAL 24 - NE 28	W +2.5	Over 48.5	453	79	374
12/14/2025	NE 31 - BUF 35	L +4.5	Over 49.5	349	168	181
12/01/2025	NE 33 - NYG 15	W -7.5	Over 46.5	239	111	128
11/23/2025	CIN 20 - NE 26	L -6.5	Under 50	392	107	285

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/17/2026	DEN 33 - BUF 30	L +1.5	Over 46.5	349	70	279
01/11/2026	JAC 24 - BUF 27	W -1	Under 51.5	359	154	205
01/04/2026	BUF 35 - NYJ 8	W -13	Over 39	470	211	259
12/28/2025	BUF 12 - PHI 13	L -2.5	Under 44.5	331	120	211
12/21/2025	CLE 20 - BUF 23	L -10	Over 41	294	160	134
12/14/2025	NE 31 - BUF 35	W -4.5	Over 49.5	385	246	139
12/07/2025	BUF 39 - CIN 34	L -6	Over 32.5	416	183	233
11/30/2025	PIT 7 - BUF 26	W -3.5	Under 47.5	166	58	108
11/20/2025	HOU 23 - BUF 19	L -5	Under 44.5	261	108	153
11/16/2025	BUF 44 - TB 32	W -6	Over 45.5	414	97	317

New England Patriots NE Buffalo Bills BUF

avg	rank	edge in	rank	avg
2.1	1	Qb Rating	1	2.1

New England Patriots NE

	Season stats	rank
Total Yards	295.2	8
Passing Yards	193.53	10
Rushing Yards	101.71	6
Points Scored	18.82	4
Field Goal %	0.83	13

Buffalo Bills BUF

	Season stats	rank
Total Yards	293.1	7
Passing Yards	156.94	1
Rushing Yards	136.18	28
Points Scored	21.47	12
Field Goal %	0.92	28

New England Patriots NE

	Season stats	rank
Total Yards	379.4	3
Passing Yards	250.47	4
Rushing Yards	128.88	6
Points Scored	28.82	2
Field Goal %	0.84	19

Buffalo Bills BUF

	Season stats	rank
Total Yards	376.3	4
Passing Yards	216.65	15
Rushing Yards	159.65	1
Points Scored	28.29	4
Field Goal %	0.9	8

New England Patriots NE

player (position)	status		ats*current	o/u*	notes
Drake Maye (QB)	Ques Feb 8	Shoulder - 28 / 01 / 26	0-0	0-0	Details
Robert Spillane (LB)	Ques Sun	Ankle - 25 / 01 / 26	0-0	0-0	Details
Marte Mapu (LB)	Ques Sun	Hip - 24 / 01 / 26	0-0	0-0	Details
Harold Landry III (LB)	Ques Feb 8	Knee - 24 / 01 / 26	0-0	0-0	Details
Eric Gregory (DT)	Out indefinitely	Undisclosed - 24 / 01 / 26	0-0	0-0	Details
Christian Gonzalez (CB)	Ques Sun	Head - 12 / 01 / 26	0-0	0-0	Details
TreVeyon Henderson (RB)	Ques Jan 11	Personal - 09 / 01 / 26	0-0	0-0	Details
Kayshon Boutte (WR)	Ques Jan 11	Hamstring - 09 / 01 / 26	0-0	0-0	Details
Vederian Lowe (OT)	Ques Feb 8	Illness - 08 / 01 / 26	0-0	0-0	Details
Charles Woods (CB)	Ques Sun	Foot - 02 / 01 / 26	0-0	0-0	Details

Buffalo Bills BUF

player (position)	status		ats*current	o/u*	notes
Shaq Thompson (LB)	Ques Sat	Neck - 15 / 01 / 26	0-0	0-0	Details
Matt Milano (LB)	Ques Sat	Ankle - 14 / 01 / 26	0-0	0-0	Details
Josh Allen (QB)	Ques Sat	Foot - 14 / 01 / 26	0-0	0-0	Details
A.J. Epenesa (DE)	Ques Sat	Neck - 14 / 01 / 26	0-0	0-0	Details
Landon Jackson (DE)	Out indefinitely	Knee - 14 / 01 / 26	0-0	0-0	Details
Greg Rousseau (DE)	Ques Sat	Back - 14 / 01 / 26	0-0	0-0	Details
Dalton Kincaid (TE)	Ques Sat	Leg - 13 / 01 / 26	0-0	0-0	Details
Gabe Davis (WR)	Out indefinitely	Knee - 13 / 01 / 26	0-0	0-0	Details
Jordan Poyer (DB)	Out Sat	Hamstring - 13 / 01 / 26	0-0	0-0	Details
Matt Prater (K)	Ques Sat	Quadricep - 13 / 01 / 26	0-0	0-0	Details

New England Patriots NE

No posts found.

Buffalo Bills BUF

No posts found.

New England Patriots NE

Patriots are 7-3 ATS in their last 10 games as a favorite of 3.5-10.0.

Over is 8-3 in Patriots last 11 games overall.

Patriots are 1-5 ATS in their last 6 games as a favorite.

Patriots are 5-2 ATS in their last 7 road games vs. a team with a winning home record.

Patriots are 3-7-1 ATS in their last 11 games following a straight up win.

Buffalo Bills BUF

Bills are 4-1 ATS in their last 5 games as a favorite of 3.5-10.0.

Bills are 5-1 ATS in their last 6 games following a ATS loss.

Under is 4-1 in Bills last 5 games as an underdog of 10.5 or greater.

Over is 5-1 in Bills last 6 games overall.

Bills are 1-3-1 ATS in their last 5 games following a straight up win.

Team	Win / Loss	ATS	OU
Miami Dolphins MIA	7-10	8-8	8-6-2
New England Patriots NE	14-3	14-5	11-8
N.Y. Jets Jets NYJ	3-14	7-9	10-6
Buffalo Bills BUF	12-5	8-9	7-10

New England Patriots

Pitchers

POS	Player

Hitters

POS	Player

Buffalo Bills

Pitchers

POS	Player

Hitters

POS	Player

Game Statistics

338

363

Total Yards

267

245

Passing Yards

118

Rushing Yards

Touchdowns

100

Field Goal %

Turnovers

Team	Last 5 Matches
New England Patriots NE ( 14-3 )	L W W W W
Buffalo Bills BUF ( 12-5 )	W W L W W

James Cook III Running Back New England	14	Touchdowns	10	TreVeyon Henderson Running Back Buffalo
James Cook III Running Back New England	1621	Rushing	911	TreVeyon Henderson Running Back Buffalo
Drake Maye Quarterback Buffalo	4394	Passing	3668	Josh Allen Quarterback New England
Stefon Diggs Wide Receiver Buffalo	85	Receiving	72	Khalil Shakir Wide Receiver New England
Harold Landry III Linebacker Buffalo	8.5	Sacks	7	Greg Rousseau Defensive End New England
Jaylinn Hawkins Safety Buffalo	4	Interceptions	3	Cole Bishop Safety New England

Dalton Kincaid Tight End New England	2	Touchdowns	1	Kayshon Boutte Wide Receiver Buffalo
Rhamondre Stevenson Running Back Buffalo	217	Rushing	163	James Cook III Running Back New England
Drake Maye Quarterback Buffalo	828	Passing	556	Josh Allen Quarterback New England
Khalil Shakir Wide Receiver New England	19	Receiving	14	Stefon Diggs Wide Receiver Buffalo
Milton Williams Defensive Tackle Buffalo	3	Sacks	1	Greg Rousseau Defensive End New England
Carlton Davis III Cornerback Buffalo	2	Interceptions	1	Cole Bishop Safety New England

team	w games_won	l games_lost	pf points
Houston Texans HOU	12	5	404
Tennessee Titans TEN	3	14	284
Indianapolis Colts IND	8	9	466
Jacksonville Jaguars JAC	13	4	474
Miami Dolphins MIA	7	10	347
New England Patriots NE	14	3	490
N.Y. Jets Jets NYJ	3	14	300
Buffalo Bills BUF	12	5	481
Baltimore Ravens BAL	8	9	424
Cleveland Browns CLE	5	12	279
Pittsburgh Steelers PIT	10	7	397
Cincinnati Bengals CIN	6	11	414
Denver Broncos DEN	14	3	401
L.A. Chargers Chargers LAC	11	6	368
Las Vegas Raiders LV	3	14	241
Kansas City Chiefs KC	6	11	362