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Patriots vs. Bills Prediction, Odds & Stats October 04, 2026

Final Score
AFC East
Oct 4th, 1:00 PM EDT
New England
Patriots
Buffalo
Bills
29
26
New England Patriots
Buffalo Bills
Scoreboard 1 2 3 4 Odds
New England Patriots 5-4 7 7 7 8 +0
Buffalo Bills 7-1 0 17 0 9
Loading odds...

Latest Encounters

Date Result Competition Stats Recap
11/09/26
Buffalo Bills BUF ( 7-1 )
Minnesota Vikings MIN ( 6-2 )
23   -   6
 AFC East
11/08/26
Green Bay Packers GB ( 6-3 )
New England Patriots NE ( 5-4 )
45   -   27
 NFC North
11/01/26
New England Patriots NE ( 5-4 )
Miami Dolphins MIA ( 1-7 )
24   -   19
 AFC East

Line History

Matchup Details

New England Patriots NE
Buffalo Bills BUF
Stat
1 Games Won 3
2 Games Lost 0
5-4 Last 10 7-1
0-0 W L Streak 0-0
2-1 Against The Spread 3-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-3 Total 2-1

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards NE:Total Net Yards NE:Net Rushing Yards NE:Passing Yards
10/04/2026 BUF 26 - NE 29 NE +7 Over 49.5 340 91 249 405 143 262
12/14/2025 NE 31 - BUF 35 BUF -4.5 Over 49.5 349 168 181 385 246 139
10/05/2025 BUF 20 - NE 23 NE +8.5 Under 49.5 338 71 267 363 118 245
01/05/2025 NE 23 - BUF 16 NE +3 Under 40 259 130 129 309 77 232
12/22/2024 BUF 24 - NE 21 NE +14 Under 46.5 379 126 253 324 172 152
12/31/2023 BUF 27 - NE 21 NE +12 Over 40 294 103 191 281 127 154
10/22/2023 NE 29 - BUF 25 NE +8.5 Over 41 339 81 258 364 96 268
01/08/2023 BUF 35 - NE 23 BUF -8 Over 44 341 107 234 327 90 237
12/01/2022 NE 10 - BUF 24 BUF -5.5 Under 44 355 132 223 242 60 182
01/15/2022 BUF 47 - NE 17 BUF -4.5 Over 43.5 305 89 216 482 174 308
12/26/2021 NE 21 - BUF 33 BUF +1 Over 44.5 428 114 314 288 149 139
12/06/2021 BUF 10 - NE 14 NE +3 Under 41 241 222 19 230 99 131
12/28/2020 NE 9 - BUF 38 BUF -6.5 Under 47.5 474 130 344 201 145 56
11/01/2020 BUF 24 - NE 21 NE +4 Over 41 349 188 161 339 190 149
12/21/2019 NE 24 - BUF 17 NE -6.5 Over 38.5 268 92 176 414 143 271
09/29/2019 BUF 10 - NE 16 BUF +7.5 Under 41.5 224 74 150 375 135 240
12/23/2018 NE 24 - BUF 12 BUF +13.5 Under 45 289 72 217 390 273 117
10/29/2018 BUF 6 - NE 25 NE -13 Under 44.5 387 76 311 333 46 287
12/24/2017 NE 37 - BUF 16 NE -11 Over 47 326 84 242 411 193 218
12/03/2017 BUF 3 - NE 23 NE -7.5 Under 48.5 435 191 244 268 183 85
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/08/2026 NE 27 - GB 45 L -2.5 Over 45 478 129 349
11/01/2026 MIA 19 - NE 24 L -7 Under 44.5 313 131 182
10/22/2026 CHI 30 - NE 24 L +3 Over 50 380 70 310
10/18/2026 NE 26 - NYJ 19 W -7 Over 42.5 324 97 227
10/11/2026 NE 45 - LV 17 W -3.5 Over 45.5 306 38 268
10/04/2026 BUF 26 - NE 29 W +7 Over 49.5 405 143 262
09/27/2026 JAC 35 - NE 6 L +2.5 Under 45 317 83 234
09/20/2026 NE 20 - PIT 3 W -5 Under 43 235 91 144
09/09/2026 SEA 13 - NE 10 L +3.5 Under 44.5 277 109 168
08/27/2026 CLE 37 - NE 13 L -1 Over 35 276 114 162
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/09/2026 MIN 6 - BUF 23 W -3 Under 46.5 178 51 127
11/01/2026 BUF 36 - BAL 10 W -3 Under 55 426 146 280
10/18/2026 LV 30 - BUF 33 L -5 Over 54 378 65 313
10/12/2026 LAR 34 - BUF 37 W +2.5 Over 54.5 454 77 377
10/04/2026 BUF 26 - NE 29 L -7 Over 49.5 340 91 249
09/27/2026 BUF 24 - LAC 16 W -7 Under 50.5 350 176 174
09/17/2026 BUF 41 - DET 31 W -3 Over 52.5 446 203 243
09/13/2026 HOU 31 - BUF 36 W -1.5 Over 44.5 381 124 257
08/27/2026 BUF 28 - PIT 27 L -1 Over 35 266 89 177
08/22/2026 CLE 7 - BUF 31 W +1 Under 39.5 194 84 110

Odds Analysis

Team Rankings

New England Patriots NE
Season stats rank
Total Yards 328.6 14
Passing Yards 231.89 24
Rushing Yards 96.67 9
Points Scored 23 15
Field Goal % 0.78 6
Buffalo Bills BUF
Season stats rank
Total Yards 330.4 16
Passing Yards 238.75 29
Rushing Yards 91.63 7
Points Scored 23.38 16
Field Goal % 0.73 2
New England Patriots NE
Season stats rank
Total Yards 369.4 8
Passing Yards 249.56 9
Rushing Yards 119.89 10
Points Scored 23.44 14
Field Goal % 0.77 24
Buffalo Bills BUF
Season stats rank
Total Yards 386.4 1
Passing Yards 239.75 13
Rushing Yards 146.63 2
Points Scored 32 1
Field Goal % 1 1

Injuries

New England Patriots NE
Buffalo Bills BUF

New England vs. Buffalo Betting News

New England Vs Buffalo Betting Trends

New England Patriots NE

Patriots are 5-2 ATS in their last 7 games as a road underdog of 3.5-10.0.

Over is 5-0 in Patriots last 5 games after allowing more than 30 points in their previous game.

Patriots are 6-1 ATS in their last 7 games as a road underdog.

Over is 6-0 in Patriots last 6 games as a favorite of 10.5 or greater.

Patriots are 9-3 ATS in their last 12 road games.

Buffalo Bills BUF

Under is 4-1 in Bills last 5 games as a home underdog of 3.5-10.0.

Bills are 5-2 ATS in their last 7 home games.

Bills are 4-1 ATS in their last 5 games as a home underdog of 0.5-3.0.

Over is 5-2 in Bills last 7 vs. a team with a losing record.

Over is 6-2 in Bills last 8 games as a favorite.

AFC East Standings

Line Up - Last Game

New England Patriots
Pitchers
POS Player
Hitters
POS Player
Buffalo Bills
Pitchers
POS Player
Hitters
POS Player