Bills vs. Panthers Prediction, Odds & Stats - October 26, 2025

Scoreboard	1	2	3	4	Odds
Buffalo Bills 12-5	3	16	21	0	+48
Carolina Panthers 8-9	0	3	0	6	+7

Date	Result	Competition
01/17/26	Buffalo Bills BUF ( 12-5 ) Denver Broncos DEN ( 14-3 ) 30 - 33	AFC East
01/11/26	Buffalo Bills BUF ( 12-5 ) Jacksonville Jaguars JAC ( 13-4 ) 27 - 24	AFC East
01/10/26	L.A. Rams Rams LAR ( 12-5 ) Carolina Panthers CAR ( 8-9 ) 34 - 31	NFC West
01/04/26	N.Y. Jets Jets NYJ ( 3-14 ) Buffalo Bills BUF ( 12-5 ) 8 - 35	AFC East
01/03/26	Carolina Panthers CAR ( 8-9 ) Tampa Bay Buccaneers TB ( 8-9 ) 14 - 16	NFC South
12/28/25	Philadelphia Eagles PHI ( 11-6 ) Buffalo Bills BUF ( 12-5 ) 13 - 12	NFC East
12/28/25	Seattle Seahawks SEA ( 14-3 ) Carolina Panthers CAR ( 8-9 ) 27 - 10	NFC West
12/21/25	Buffalo Bills BUF ( 12-5 ) Cleveland Browns CLE ( 5-12 ) 23 - 20	AFC East
12/21/25	Tampa Bay Buccaneers TB ( 8-9 ) Carolina Panthers CAR ( 8-9 ) 20 - 23	NFC South
12/14/25	Carolina Panthers CAR ( 8-9 ) New Orleans Saints NO ( 6-11 ) 17 - 20	NFC South
12/14/25	Buffalo Bills BUF ( 12-5 ) New England Patriots NE ( 14-3 ) 35 - 31	AFC East
11/30/25	L.A. Rams Rams LAR ( 12-5 ) Carolina Panthers CAR ( 8-9 ) 28 - 31	NFC West

Buffalo Bills BUF Carolina Panthers CAR

	Stat
4	Games Won	4
2	Games Lost	3
7-3	Last 10	4-6
0-0	W L Streak	0-0
1-4	Against The Spread	5-2
0	Money	0
0-0	Home	0-0
0-0	Away	0-0
3-3	Total	4-3

date	home-away	ats	o/u	CAR:Total Net Yards	CAR:Net Rushing Yards	CAR:Passing Yards	BUF:Total Net Yards	BUF:Net Rushing Yards	BUF:Passing Yards
10/26/2025	CAR 9 - BUF 40	BUF -7.5	Over 48	244	114	130	410	245	165
08/24/2024	BUF 26 - CAR 31	CAR +4.5	Over 30.5	414	74	340	320	164	156
08/26/2022	CAR 21 - BUF 0	CAR -5	Under 38	191	81	110	238	50	188
12/19/2021	BUF 31 - CAR 14	BUF -12	Over 43.5	275	151	124	312	119	193
08/16/2019	CAR 14 - BUF 27	BUF +3	Over 40	373	94	279	258	103	155
08/09/2018	BUF 23 - CAR 28	CAR +1	Over 34	342	53	289	431	94	337
09/17/2017	CAR 9 - BUF 3	BUF +7	Under 43	176	69	107	255	77	178

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/17/2026	DEN 33 - BUF 30	L +1.5	Over 46.5	449	183	266
01/11/2026	JAC 24 - BUF 27	W -1	Under 51.5	340	79	261
01/04/2026	BUF 35 - NYJ 8	W -13	Over 39	122	69	53
12/28/2025	BUF 12 - PHI 13	L -2.5	Under 44.5	190	82	108
12/21/2025	CLE 20 - BUF 23	L -10	Over 41	259	164	95
12/14/2025	NE 31 - BUF 35	W -4.5	Over 49.5	349	168	181
12/07/2025	BUF 39 - CIN 34	L -6	Over 32.5	338	62	276
11/30/2025	PIT 7 - BUF 26	W -3.5	Under 47.5	372	249	123
11/20/2025	HOU 23 - BUF 19	L -5	Under 44.5	326	143	183
11/16/2025	BUF 44 - TB 32	W -6	Over 45.5	367	202	165

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/10/2026	CAR 31 - LAR 34	W +10	Over 46.5	333	83	250
01/03/2026	TB 16 - CAR 14	W +3	Under 42.5	338	140	198
12/28/2025	CAR 10 - SEA 27	L +7.5	Under 42.5	139	99	40
12/21/2025	CAR 23 - TB 20	W +2.5	Under 44.5	275	101	174
12/14/2025	NO 20 - CAR 17	L -2.5	Under 41.5	337	81	256
11/30/2025	CAR 31 - LAR 28	W +9.5	Over 45	358	164	194
11/24/2025	SF 20 - CAR 9	L +7	Under 49	340	147	193
11/16/2025	ATL 27 - CAR 30	W +3.5	Over 42	348	125	223
11/09/2025	CAR 7 - NO 17	L -4.5	Under 38.5	175	73	102
11/02/2025	GB 13 - CAR 16	W +11.5	Under 43.5	369	104	265

Buffalo Bills BUF Carolina Panthers CAR

avg	rank	edge in	rank	avg
2.1	1	Qb Rating	1	2.1

Buffalo Bills BUF

	Season stats	rank
Total Yards	293.1	7
Passing Yards	156.94	1
Rushing Yards	136.18	28
Points Scored	21.47	12
Field Goal %	0.92	28

Carolina Panthers CAR

	Season stats	rank
Total Yards	327.2	16
Passing Yards	203.94	14
Rushing Yards	123.29	20
Points Scored	22.35	15
Field Goal %	0.88	20

Buffalo Bills BUF

	Season stats	rank
Total Yards	376.3	4
Passing Yards	216.65	15
Rushing Yards	159.65	1
Points Scored	28.29	4
Field Goal %	0.9	8

Carolina Panthers CAR

	Season stats	rank
Total Yards	295.6	27
Passing Yards	179.29	25
Rushing Yards	116.29	19
Points Scored	18.29	27
Field Goal %	0.83	22

Buffalo Bills BUF

player (position)	status		ats*current	o/u*	notes
Shaq Thompson (LB)	Ques Sat	Neck - 15 / 01 / 26	0-0	0-0	Details
Matt Milano (LB)	Ques Sat	Ankle - 14 / 01 / 26	0-0	0-0	Details
Josh Allen (QB)	Ques Sat	Foot - 14 / 01 / 26	0-0	0-0	Details
A.J. Epenesa (DE)	Ques Sat	Neck - 14 / 01 / 26	0-0	0-0	Details
Landon Jackson (DE)	Out indefinitely	Knee - 14 / 01 / 26	0-0	0-0	Details
Greg Rousseau (DE)	Ques Sat	Back - 14 / 01 / 26	0-0	0-0	Details
Dalton Kincaid (TE)	Ques Sat	Leg - 13 / 01 / 26	0-0	0-0	Details
Gabe Davis (WR)	Out indefinitely	Knee - 13 / 01 / 26	0-0	0-0	Details
Jordan Poyer (DB)	Out Sat	Hamstring - 13 / 01 / 26	0-0	0-0	Details
Matt Prater (K)	Ques Sat	Quadricep - 13 / 01 / 26	0-0	0-0	Details

Carolina Panthers CAR

player (position)	status		ats*current	o/u*	notes
Krys Barnes (LB)	Ques Sat	Back - 01 / 01 / 26	0-0	0-0	Details
Claudin Cherelus (LB)	Questionable	Calf - 01 / 01 / 26	0-0	0-0	Details
Ja'Tavion Sanders (TE)	Out indefinitely	Ankle - 30 / 12 / 25	0-0	0-0	Details
Robert Rochell (DB)	Out indefinitely	Concussion - 29 / 12 / 25	0-0	0-0	Details
Trevin Wallace (LB)	Out indefinitely	Shoulder - 18 / 12 / 25	0-0	0-0	Details
Tetairoa McMillan (WR)	Ques Dec 28	Foot - 17 / 12 / 25	0-0	0-0	Details
Damien Lewis (G)	Out indefinitely	Illness - 17 / 12 / 25	0-0	0-0	Details
Taylor Moton (OT)	Ques Jan 4	Back - 17 / 12 / 25	0-0	0-0	Details
Ikem Ekwonu (OT)	Out indefinitely	Knee - 17 / 12 / 25	0-0	0-0	Details
Tershawn Wharton (DT)	Questionable	Hamstring - 13 / 12 / 25	0-0	0-0	Details

Buffalo Bills BUF

No posts found.

Carolina Panthers CAR

No posts found.

Buffalo Bills BUF

Under is 4-1 in Bills last 5 games as an underdog of 10.5 or greater.

Bills are 0-4 ATS in their last 4 games as a favorite.

Bills are 8-3-1 ATS in their last 12 road games vs. a team with a winning home record.

Bills are 1-5-1 ATS in their last 7 games in Week 8.

Bills are 6-2-1 ATS in their last 9 games as a favorite of 0.5-3.0.

Carolina Panthers CAR

Over is 16-6 in Panthers last 22 games overall.

Panthers are 16-35-1 ATS in their last 52 games as a favorite.

Panthers are 4-0 ATS in their last 4 home games.

Panthers are 8-0 ATS in their last 8 games as a home underdog.

Panthers are 9-4 ATS in their last 13 games in Week 8.

Team	Win / Loss	ATS	OU
Baltimore Ravens BAL	8-9	6-9	10-6
Denver Broncos DEN	14-3	14-5	12-7
Miami Dolphins MIA	7-10	8-8	8-6-2
Houston Texans HOU	12-5	10-8	6-12
Cleveland Browns CLE	5-12	7-9	8-8
Pittsburgh Steelers PIT	10-7	9-8	6-11
New England Patriots NE	14-3	14-5	11-8
Tennessee Titans TEN	3-14	5-11	10-6
L.A. Chargers Chargers LAC	11-6	9-8	8-9
Indianapolis Colts IND	8-9	8-8	8-8
N.Y. Jets Jets NYJ	3-14	7-9	10-6
Cincinnati Bengals CIN	6-11	7-9	8-8
Buffalo Bills BUF	12-5	8-9	9-9
Las Vegas Raiders LV	3-14	6-10	4-12
Jacksonville Jaguars JAC	13-4	7-9	9-8
Kansas City Chiefs KC	6-11	6-10	4-12

Team	Win / Loss	ATS	OU
N.Y. Giants Giants NYG	4-13	7-9	12-4
Chicago Bears CHI	10-6	12-6	11-7
L.A. Rams Rams LAR	12-5	12-7	11-8
Tampa Bay Buccaneers TB	8-9	9-7	7-9
Philadelphia Eagles PHI	11-6	10-6	10-7
Green Bay Packers GB	9-6	6-10	9-8
San Francisco 49ers SF	12-5	11-6	10-8
Arizona Cardinals ARI	3-14	7-9	9-7
Seattle Seahawks SEA	14-3	14-5	11-8
Dallas Cowboys DAL	7-9	7-9	12-4
Minnesota Vikings MIN	9-8	6-10	9-7
Detroit Lions DET	9-8	7-9	10-6
Atlanta Falcons ATL	8-9	8-8	5-11
Carolina Panthers CAR	8-9	10-7	7-10
New Orleans Saints NO	6-11	8-8	5-11
Washington Commanders WAS	5-12	6-10	9-6-1

Buffalo Bills

Pitchers

POS	Player

Hitters

POS	Player

Carolina Panthers

Pitchers

POS	Player

Hitters

POS	Player

Game Statistics

410

244

Total Yards

165

130

Passing Yards

245

114

Rushing Yards

Touchdowns

100

50.0

Field Goal %

Turnovers

Team	Last 5 Matches
Buffalo Bills BUF ( 12-5 )	L W W L W
Carolina Panthers CAR ( 8-9 )	L L W L W

James Cook III Running Back Carolina	14	Touchdowns	7	Rico Dowdle Running Back Buffalo
James Cook III Running Back Carolina	1621	Rushing	1076	Rico Dowdle Running Back Buffalo
Josh Allen Quarterback Carolina	3668	Passing	3011	Bryce Young Quarterback Buffalo
Khalil Shakir Wide Receiver Carolina	72	Receiving	70	Tetairoa McMillan Wide Receiver Buffalo
Greg Rousseau Defensive End Carolina	7	Sacks	5	Derrick Brown Defensive End Buffalo
Jaycee Horn Cornerback Buffalo	5	Interceptions	3	Cole Bishop Safety Carolina

Chuba Hubbard Running Back Buffalo	2	Touchdowns	2	Dalton Kincaid Tight End Carolina
James Cook III Running Back Carolina	163	Rushing	46	Chuba Hubbard Running Back Buffalo
Josh Allen Quarterback Carolina	556	Passing	264	Bryce Young Quarterback Buffalo
Khalil Shakir Wide Receiver Carolina	19	Receiving	9	Jalen Coker Wide Receiver Buffalo
Trevis Gipson Linebacker Buffalo	1	Sacks	1	Greg Rousseau Defensive End Carolina
Mike Jackson Cornerback Buffalo	1	Interceptions	1	Cole Bishop Safety Carolina

team	w games_won	l games_lost	pf points
Houston Texans HOU	12	5	404
Tennessee Titans TEN	3	14	284
Indianapolis Colts IND	8	9	466
Jacksonville Jaguars JAC	13	4	474
Miami Dolphins MIA	7	10	347
New England Patriots NE	14	3	490
N.Y. Jets Jets NYJ	3	14	300
Buffalo Bills BUF	12	5	481
Baltimore Ravens BAL	8	9	424
Cleveland Browns CLE	5	12	279
Pittsburgh Steelers PIT	10	7	397
Cincinnati Bengals CIN	6	11	414
Denver Broncos DEN	14	3	401
L.A. Chargers Chargers LAC	11	6	368
Las Vegas Raiders LV	3	14	241
Kansas City Chiefs KC	6	11	362

Game Preview

Bills vs. Panthers Point Spread: NFL Week 8 Odds, Prediction

The bye week came at an opportune time for Buffalo, with two consecutive poor performances and 18 players hurt or on IR.

Team	Win / Loss	ATS	OU
Baltimore Ravens BAL	8-9	6-9	10-6
Denver Broncos DEN	14-3	14-5	12-7
Miami Dolphins MIA	7-10	8-8	8-6-2
Houston Texans HOU	12-5	10-8	6-12
Cleveland Browns CLE	5-12	7-9	8-8
Pittsburgh Steelers PIT	10-7	9-8	6-11
New England Patriots NE	14-3	14-5	11-8
Tennessee Titans TEN	3-14	5-11	10-6
L.A. Chargers Chargers LAC	11-6	9-8	8-9
Indianapolis Colts IND	8-9	8-8	8-8
N.Y. Jets Jets NYJ	3-14	7-9	10-6
Cincinnati Bengals CIN	6-11	7-9	8-8
Buffalo Bills BUF	12-5	8-9	9-9
Las Vegas Raiders LV	3-14	6-10	4-12
Jacksonville Jaguars JAC	13-4	7-9	9-8
Kansas City Chiefs KC	6-11	6-10	4-12

Team	Win / Loss	ATS	OU
N.Y. Giants Giants NYG	4-13	7-9	12-4
Chicago Bears CHI	10-6	12-6	11-7
L.A. Rams Rams LAR	12-5	12-7	11-8
Tampa Bay Buccaneers TB	8-9	9-7	7-9
Philadelphia Eagles PHI	11-6	10-6	10-7
Green Bay Packers GB	9-6	6-10	9-8
San Francisco 49ers SF	12-5	11-6	10-8
Arizona Cardinals ARI	3-14	7-9	9-7
Seattle Seahawks SEA	14-3	14-5	11-8
Dallas Cowboys DAL	7-9	7-9	12-4
Minnesota Vikings MIN	9-8	6-10	9-7
Detroit Lions DET	9-8	7-9	10-6
Atlanta Falcons ATL	8-9	8-8	5-11
Carolina Panthers CAR	8-9	10-7	7-10
New Orleans Saints NO	6-11	8-8	5-11
Washington Commanders WAS	5-12	6-10	9-6-1

Bills vs. Panthers Prediction, Odds & Stats October 26, 2025

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