Bills vs. Jets Week 10 Betting Odds, Prediction and Picks: Buffalo Chases Fifth Straight Win
The Buffalo Bills look to cement their lead atop the AFC conference standings with a fifth straight win when they visit the division rival New York Jets on Sunday afternoon in NFL Week 10 betting action at MetLife Stadium. The Bills dominated in a 23-6 win in Minnesota on the Week 9 edition of Monday Night Football, and have outscored opponents by a wide 59-16 combined margin over their past two contests. The Jets return home following a 35-12 loss in Kansas City that extends their current losing streak to four games including a pair of narrow defeats on home turf.
The Bills travel to the Big Apple perched as 7.5-point favourites on the NFL Week 10 odds while the Jets trail as +350 home underdogs on the NFL moneyline. The total is pegged at just 51.
Bills vs. Jets Kickoff, Weather, TV, Streaming Info
Kickoff is scheduled for 1;00 pm EST at MetLife Stadium. Gametime weather forecast calls for partly cloudy skies with the temperature expected to reach 10 degrees Celsius. CBS is carrying all the action in the US, with CTV offering select regional coverage in Canada.
NFL Betting Odds, Point Spread, Trends
The Bills swept last year’s season series with the Jets while outscoring New York by a 65-18 margin, and has now topped the Jets in five straight meetings while limiting their AFC East rivals to just 11.6 points per game. Buffalo has also covered in five straight head-to-head dates, and is 5-2 ATS in its past seven versus New York when pegged as betting chalk by 8+ points.
Buffalo has averaged 32.3 points during the team’s current 4-0 SU run, and now leads the NFL with 32.0 points scored per game. The Bills defence has surrendered just 16 points and just one total TD over the past two weeks after giving up 31 points per game in their three previous outings. Overall, the Bills are 6-2 ATS this season and have covered three times while going a perfect 4-0 on the road.
While New York managed to keep things close in an entertaining 38-33 loss to Las Vegas in Week 8, last week’s feeble offensive performance was more in character, and marked the fifth time this season the squad has failed to reach 20 points. Overall, the Jets have just one home win, a 17-10 comeback victory over Cleveland, and have not helped their cause while averaging just five points first-quarter points at home this season.
NFL Player Odds and Props
James Cook has rushed for 814 yards and eight touchdowns in eight games, exceeding 93.5 yards five times and 100+ yards four times, and tallied 132 yards against the Jets in their last meeting in September 2025. New York has surrendered more than 140 rushing yards per game over its last four contests, adding value to Cook’s -115 odds on the NFL player props to compile OVER 93.5 rushing yards.
Breece Hall has picked up 128 receiving yards through four appearances, averaging 32 yards per game. Hall returned from a quadriceps injury last week and caught three of four targets for 26 yards. And with the Jets enduring offensive-line struggles Geno Smith could use Hall as a short-yardage outlet, making him worth backing as a -133 wager to pick up OVER 15.5 receiving yards.
Buffalo Bills
Josh Allen completed 21 of 31 passes for 234 yards, one touchdown and one interception last week versus the Vikings. Allen has thrown for 2,027 yards and 12 touchdowns against six interceptions, but has been sacked 17 times. Receiver D.J. Moore has been less productive, making just 19 catches for 285 yards and two touchdowns in six appearances. Injuries on the offensive line are a concern. Spencer Brown missed Thursday’s practice with an ankle injury, while Dion Dawkins, Connor McGovern, and Alec Anderson were limited.
New York Jets
The Jets were outscored 21-0 in the second half versus the Chiefs and finished with just 229 total yards. Geno Smith completed 18 of 32 passes for 165 yards without a touchdown or interception and was sacked five times, bring his season total to 28. Overall, Smith has tossed for 2,078 yards, 12 touchdowns and three interceptions. Rookie Omar Cooper Jr. made eight catches for 58 yards on 11 targets against Kansas City, while Braelon Allen leads the rushing attack with 598 yards.
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