49ers vs. Bills Prediction, Odds & Stats - December 01, 2024

Scoreboard	1	2	3	4	Odds
San Francisco 49ers 6-11	3	0	7	0	+45.5
Buffalo Bills 13-4	7	14	7	7	-6.5

Date	Result	Competition
01/26/25	Buffalo Bills BUF ( 13-4 ) Kansas City Chiefs KC ( 15-2 ) 29 - 32	AFC East
01/19/25	Baltimore Ravens BAL ( 12-5 ) Buffalo Bills BUF ( 13-4 ) 25 - 27	AFC North
01/12/25	Denver Broncos DEN ( 10-7 ) Buffalo Bills BUF ( 13-4 ) 7 - 31	AFC West

San Francisco 49ers SF Buffalo Bills BUF

	Stat
5	Games Won	9
6	Games Lost	2
3-7	Last 10	8-2
0-0	W L Streak	0-0
4-7	Against The Spread	7-4
0	Money	0
0-0	Home	0-0
0-0	Away	0-0
6-5	Total	7-4

date	home-away	ats	o/u	BUF:Total Net Yards	BUF:Net Rushing Yards	BUF:Passing Yards	SF:Total Net Yards	SF:Net Rushing Yards	SF:Passing Yards
12/01/2024	BUF 35 - SF 10	BUF -6.5	Under 46	372	220	152	239	153	86
12/07/2020	SF 24 - BUF 34	BUF -3	Over 48	449	81	368	402	86	316

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/05/2025	ARI 47 - SF 24	L +4.5	Over 43.5	436	138	298
12/30/2024	SF 34 - DET 40	L +3.5	Over 51.5	439	152	287
12/22/2024	MIA 29 - SF 17	L +2.5	Under 46	374	81	293
12/12/2024	SF 6 - LAR 12	L -1.5	Under 48.5	302	142	160
12/08/2024	SF 38 - CHI 13	W -3.5	Over 43.5	162	68	94
12/01/2024	BUF 35 - SF 10	L +6.5	Under 46	239	153	86
11/24/2024	GB 38 - SF 10	L +6	Over 45	241	44	197
11/17/2024	SF 17 - SEA 20	L -6	Under 48.5	289	94	195
11/10/2024	TB 20 - SF 23	L -6.5	Under 49.5	413	75	338
10/27/2024	SF 30 - DAL 24	W -5.5	Over 47.5	292	56	236

date	score	ats	o/u	Total Net Yards	Net Rushing Yards	Passing Yards
01/26/2025	KC 32 - BUF 29	L +1.5	Over 49	368	135	233
01/19/2025	BUF 27 - BAL 25	W +1	Over 51.5	273	147	126
01/12/2025	BUF 31 - DEN 7	W -7.5	Under 47	471	210	261
01/05/2025	NE 23 - BUF 16	L -3	Under 40	309	77	232
12/29/2024	BUF 40 - NYJ 14	W -10.5	Over 44	348	97	251
12/22/2024	BUF 24 - NE 21	L -14	Under 46.5	324	172	152
12/15/2024	DET 42 - BUF 48	W +2.5	Over 56	521	48	473
12/08/2024	LAR 44 - BUF 42	L -4.5	Over 51	457	137	320
12/01/2024	BUF 35 - SF 10	W -6.5	Under 46	372	220	152
11/17/2024	BUF 30 - KC 21	W -2.5	Over 47	366	104	262

San Francisco 49ers SF

	Season stats	rank
Total Yards	317.4	8
Passing Yards	192.82	5
Rushing Yards	124.59	18
Points Scored	25.65	29
Field Goal %	0.94	30

Buffalo Bills BUF

	Season stats	rank
Total Yards	341.5	17
Passing Yards	226.06	24
Rushing Yards	115.47	12
Points Scored	21.65	11
Field Goal %	0.8	13

San Francisco 49ers SF

	Season stats	rank
Total Yards	376.3	4
Passing Yards	249.06	4
Rushing Yards	127.24	12
Points Scored	22.88	13
Field Goal %	0.77	27

Buffalo Bills BUF

	Season stats	rank
Total Yards	359.1	10
Passing Yards	227.94	9
Rushing Yards	131.18	9
Points Scored	30.88	2
Field Goal %	0.83	21

San Francisco 49ers SF

player (position)	status		ats*current	o/u*	notes
Ji'ayir Brown (S)	Questionable	Ankle - 02 / 01 / 25	0-1	1-0	Details
Deommodore Lenoir (DB)	Out	Shoulder - 02 / 01 / 25	0-1	1-0	Details
Ricky Pearsall (WR)	Questionable	Illness - 02 / 01 / 25	0-1	1-0	Details
Isaac Yiadom (CB)	Questionable	Pelvis - 02 / 01 / 25	0-1	1-0	Details
Deebo Samuel Sr. (WR)	Out	Ribs - 02 / 01 / 25	0-1	1-0	Details
Colton McKivitz (OL)	Questionable	Knee - 02 / 01 / 25	0-1	1-0	Details
Leonard Floyd (DL)	Questionable	Shoulder - 31 / 12 / 24	0-2	2-0	Details
Demetrius Flannigan-Fowles (LB)	Out indefinitely	Calf - 31 / 12 / 24	0-2	2-0	Details
Brock Purdy (QB)	Out	Elbow - 31 / 12 / 24	0-2	2-0	Details
Charvarius Ward (CB)	Questionable	Personal - 29 / 12 / 24	0-2	2-0	Details

Buffalo Bills BUF

player (position)	status		ats*current	o/u*	notes
Matt Milano (LB)	Questionable	Hamstring - 22 / 01 / 25	1-0	1-0	Details
Baylon Spector (LB)	Out indefinitely	Calf - 22 / 01 / 25	1-0	1-0	Details
Taylor Rapp (S)	Out	Hip - 20 / 01 / 25	1-0	1-0	Details
Christian Benford (CB)	Questionable	Concussion - 20 / 01 / 25	1-0	1-0	Details
Alec Anderson (OT)	Questionable	Calf - 15 / 01 / 25	2-0	1-1	Details
Ray Davis (RB)	Questionable	Concussion - 14 / 01 / 25	2-0	1-1	Details
Ray Davis (RB)	Questionable	Head - 12 / 01 / 25	2-1	2-1	Details
Ja'Marcus Ingram (CB)	Questionable	Personal - 08 / 01 / 25	2-1	2-1	Details
Brandon Codrington (CB)	Questionable	Hamstring - 08 / 01 / 25	2-1	2-1	Details
Amari Cooper (WR)	Questionable	Personal - 07 / 01 / 25	2-1	2-1	Details

San Francisco 49ers SF

No posts found.

Buffalo Bills BUF

NFL

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August 27, 2026

San Francisco 49ers SF

49ers are 4-11 ATS in their last 15 games as a favorite of 3.5-10.0.

Over is 5-2 in 49ers last 7 games as an underdog of 10.5 or greater.

Under is 4-0 in 49ers last 4 games following a bye week.

49ers are 2-7 ATS in their last 9 games as a road favorite of 3.5-10.0.

49ers are 4-10 ATS in their last 14 games as a favorite.

Buffalo Bills BUF

Bills are 5-2 ATS in their last 7 games as a favorite of 3.5-10.0.

Under is 4-1 in Bills last 5 games as an underdog of 10.5 or greater.

Under is 4-1 in Bills last 5 games following a bye week.

Over is 5-1 in Bills last 6 games overall.

Bills are 6-1 ATS in their last 7 games as a favorite.

Team	Win / Loss	ATS	OU
Detroit Lions DET	15-2	12-5	9-7-1
Philadelphia Eagles PHI	14-3	13-7	9-11
Tampa Bay Buccaneers TB	10-7	10-7	12-5
L.A. Rams Rams LAR	10-7	10-8	8-10
Minnesota Vikings MIN	14-3	11-5	7-10
Washington Commanders WAS	12-5	12-6	12-7
Green Bay Packers GB	11-6	9-8	9-8
Seattle Seahawks SEA	10-7	6-9	8-8
Atlanta Falcons ATL	8-9	6-9	6-9-1
Arizona Cardinals ARI	8-9	10-6	8-8
Dallas Cowboys DAL	7-10	6-9	11-5
San Francisco 49ers SF	6-11	5-11	9-7
Chicago Bears CHI	5-12	7-7	6-10
Carolina Panthers CAR	5-12	7-9	12-4
New Orleans Saints NO	5-12	6-10	7-9
N.Y. Giants Giants NYG	3-14	4-11	6-10

Team	Win / Loss	ATS	OU
Kansas City Chiefs KC	15-2	9-10	8-11
Buffalo Bills BUF	13-4	12-7	12-7
Baltimore Ravens BAL	12-5	11-6	13-5
Houston Texans HOU	10-7	8-8	6-10-2
L.A. Chargers Chargers LAC	11-6	12-5	8-9
Pittsburgh Steelers PIT	10-7	11-6	8-9
Denver Broncos DEN	10-7	12-5	11-5-1
Cincinnati Bengals CIN	9-8	10-6	11-5
Indianapolis Colts IND	8-9	9-7	9-7
Miami Dolphins MIA	8-9	7-9	7-9
N.Y. Jets Jets NYJ	5-12	5-11	9-6-1
Jacksonville Jaguars JAC	4-13	8-7	8-8
New England Patriots NE	4-13	6-9	10-6
Las Vegas Raiders LV	4-13	7-8	8-8
Cleveland Browns CLE	3-14	4-12	6-10
Tennessee Titans TEN	3-14	2-14	9-6-1

San Francisco 49ers

Pitchers

POS	Player

Hitters

POS	Player

Buffalo Bills

Pitchers

POS	Player

Hitters

POS	Player

Game Statistics

239

372

Total Yards

152

Passing Yards

153

220

Rushing Yards

Touchdowns

33.3

Field Goal %

Turnovers

Team	Last 5 Matches
San Francisco 49ers SF ( 6-11 )	L L L L W
Buffalo Bills BUF ( 13-4 )	W W L W W

Ray Davis Running Back San Francisco	6	Touchdowns	6	Jauan Jennings Wide Receiver Buffalo
Jordan Mason Running Back Buffalo	789	Rushing	442	Ray Davis Running Back San Francisco
Brock Purdy Quarterback Buffalo	3864	Passing	179	Mitchell Trubisky Quarterback San Francisco
Jauan Jennings Wide Receiver Buffalo	77	Receiving	76	Khalil Shakir Wide Receiver San Francisco
Leonard Floyd Defensive Lineman Buffalo	8.5	Sacks	8	Greg Rousseau Defensive End San Francisco
Ja'Marcus Ingram Cornerback San Francisco	2	Interceptions	2	Deommodore Lenoir Defensive Back Buffalo

Curtis Samuel Wide Receiver San Francisco	2	Touchdowns
Ty Johnson Running Back San Francisco	94	Rushing
Alec Anderson OT San Francisco	0	Passing	Did not qualify
Khalil Shakir Wide Receiver San Francisco	18	Receiving
Matt Milano Linebacker San Francisco	2	Sacks
Taylor Rapp Safety San Francisco	1	Interceptions

team	w games_won	l games_lost	t games_tied	pf points
Arizona Cardinals ARI	0	0	0	0
L.A. Rams Rams LAR	0	0	0	0
San Francisco 49ers SF	0	0	0	0
Seattle Seahawks SEA	0	0	0	0
Atlanta Falcons ATL	0	0	0	0
Carolina Panthers CAR	0	0	0	0
New Orleans Saints NO	0	0	0	0
Tampa Bay Buccaneers TB	0	0	0	0
Dallas Cowboys DAL	0	0	0	0
N.Y. Giants Giants NYG	0	0	0	0
Philadelphia Eagles PHI	0	0	0	0
Washington Commanders WAS	0	0	0	0
Chicago Bears CHI	0	0	0	0
Detroit Lions DET	0	0	0	0
Green Bay Packers GB	0	0	0	0
Minnesota Vikings MIN	0	0	0	0

Game Preview

49ers vs. Bills Point Spread: NFL Week 13 Odds, Prediction

It’s a potential Super Bowl preview in the Sunday night Week 13 game as the desperate San Francisco 49ers visit the AFC East-leading Buffalo Bills.

Team	Win / Loss	ATS	OU
Detroit Lions DET	15-2	12-5	9-7-1
Philadelphia Eagles PHI	14-3	13-7	9-11
Tampa Bay Buccaneers TB	10-7	10-7	12-5
L.A. Rams Rams LAR	10-7	10-8	8-10
Minnesota Vikings MIN	14-3	11-5	7-10
Washington Commanders WAS	12-5	12-6	12-7
Green Bay Packers GB	11-6	9-8	9-8
Seattle Seahawks SEA	10-7	6-9	8-8
Atlanta Falcons ATL	8-9	6-9	6-9-1
Arizona Cardinals ARI	8-9	10-6	8-8
Dallas Cowboys DAL	7-10	6-9	11-5
San Francisco 49ers SF	6-11	5-11	9-7
Chicago Bears CHI	5-12	7-7	6-10
Carolina Panthers CAR	5-12	7-9	12-4
New Orleans Saints NO	5-12	6-10	7-9
N.Y. Giants Giants NYG	3-14	4-11	6-10

Team	Win / Loss	ATS	OU
Kansas City Chiefs KC	15-2	9-10	8-11
Buffalo Bills BUF	13-4	12-7	12-7
Baltimore Ravens BAL	12-5	11-6	13-5
Houston Texans HOU	10-7	8-8	6-10-2
L.A. Chargers Chargers LAC	11-6	12-5	8-9
Pittsburgh Steelers PIT	10-7	11-6	8-9
Denver Broncos DEN	10-7	12-5	11-5-1
Cincinnati Bengals CIN	9-8	10-6	11-5
Indianapolis Colts IND	8-9	9-7	9-7
Miami Dolphins MIA	8-9	7-9	7-9
N.Y. Jets Jets NYJ	5-12	5-11	9-6-1
Jacksonville Jaguars JAC	4-13	8-7	8-8
New England Patriots NE	4-13	6-9	10-6
Las Vegas Raiders LV	4-13	7-8	8-8
Cleveland Browns CLE	3-14	4-12	6-10
Tennessee Titans TEN	3-14	2-14	9-6-1

49ers vs. Bills Prediction, Odds & Stats December 01, 2024

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