49ers vs. Cowboys NFL Betting Odds, Picks: Dallas out for upset
The San Francisco 49ers take on the Dallas Cowboys on Sunday afternoon in Week 10 of the NFL season.
The 49ers have arguably been the best team in the NFL this season. San Francisco enters with an overall record of 7-1, and defeated the Raiders 38-17 in their most recent outing.
On the other side, the Cowboys are 4-5 and in second place in the NFC East. After a crushing 33-30 overtime loss to the Cardinals in Week Eight, the Cowboys were able to bounce back with a 27-23 win over the Colts last week.
The 49ers won the most recent meeting 30-24 two seasons ago in San Francisco. The 49ers have won each of the last four meetings between these teams.
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49ers vs. Cowboys Kickoff, Weather, TV, Streaming Info
Kickoff is slated for 4:25 PM ET at AT&T Stadium in Arlington, TX.
The weather forecast for Sunday afternoon in Arlington shows temperatures around 12C with a 70% chance of rain. Even if the weather is inclement, AT&T Stadium is domed, so the play on the field won’t be impacted.
Check out our full list of Week 10 NFL score predictions.
NFL Betting Odds, Point Spread, Trends
Playing on the road, oddsmakers are giving the edge in this matchup to San Francisco. The 49ers are 3.5-point favourites on the NFL odds board, with a moneyline of -205. The Cowboys have odds of +170 on the moneyline while the total is listed at 55.5.
NFL Player Odds and Props
San Francisco 49ers
Brock Purdy has been extremely efficient this season, and he has a favourable matchup on his hands this week. The Cowboys have allowed 1,327 passing yards this season, which ranks 31st in the NFL.
Purdy looks calm, cool, and collected running the San Francisco offence this season, and with a great group of pass-catchers at his disposal, he should be able to have a solid night through the air. Purdy’s passing yard prop total for this one is set at 254.5.
Dallas Cowboys
Dak Prescott’s 2,381 passing yards on the season are good for third in the NFL. Prescott continues to air it out early and often on a weekly basis, as his 336 pass attempts also rank third among all NFL quarterbacks this season.
If the Cowboys are going to pull the upset and take down the 49ers, Prescott will need to be on his game. His passing attempts prop total is set at 36.5, which he has exceeded four times this season.
San Francisco 49ers
The 49ers reeled off six straight wins to begin the season. After suffering a 29-20 loss to the Falcons in Week 7, the 49ers were able to regroup during their bye week and get back into the win column in Week Nine with a convincing 38-17 victory over the Raiders.
Earlier this week, San Francisco made the move to acquire veteran WR Keenan Allen from the Colts. Allen has brought in 40 catches for 351 yards and a touchdown through eight games with the Colts this season. His presence brings even more experience to an already experience-heavy San Francisco group of pass-catchers that also includes Deebo Samuel, George Kittle, and Mike Evans.
Brock Purdy is looking like a legitimate MVP candidate through eight games. He is completing 69.1% of his passes for 1,980 yards and 17 touchdowns with just five interceptions.
Dallas Cowboys
After going 7-9-1 last season, Brian Schottenheimer has led the Cowboys to a pedestrian 4-5 record this season. Dallas is coming off a win, but they have yet to win back-to-back games in 2026.
The Cowboys are averaging 360.4 total yards of offence per game, and rank sixth in the NFL by putting up 26.1 points per game. However, the defence continues to be a major cause for concern. Dallas is surrendering 372.7 total yards per game, which ranks 30th in the league. They are also allowing 26.2 points per contest, which ranks 26th.
Dak Prescott is completing 64.9% of his passes for 2,381 yards and 16 touchdowns with five picks. CeeDee Lamb is closing in on the 1,000-yard mark, as he has 904 yards on 70 catches so far this season.
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