NFL Point Spreads, Week 1 Predictions: Best Picks Against the Spread

Payton Matthews | Updated Sep 03, 2019

packers vs bears week 1

Welcome to the 2019 NFL regular season! Each week, we’ll have this quick glance of every game on the schedule, and Sports Interaction will also have each matchup covered individually.

One unusual facet of Week 1 is two Monday night games. Here’s a quick look at all the Week 1 matchups – always the toughest to handicap — with Sports Interaction NFL odds. Games Sunday unless noted.

NFL Week 1 Odds

Green Bay Packers at Chicago Bears, Thursday

The NFL opted to put the NFL’s oldest rivalry in the Kickoff Game this year instead of having the defending Super Bowl champions (Patriots) host it as had been the case in past seasons. That’s because the league wanted something special to kick off its 100th anniversary season. It’s also the debut of Green Bay head coach Matt LaFleur. These teams split last year, each winning at home. Read our full preview of this game here.

Point spread: Bears -3

Pick ATS: Chicago

Tennessee Titans at Cleveland Browns

The Browns haven’t made the playoffs since 2002 but are a chic pick to reach the Super Bowl for the first time in franchise history with a ton of young talent led by QB Baker Mayfield and the off-season trade addition of Odell Beckham Jr. The Titans, meanwhile, appear to have a quarterback problem. They haven’t covered the past four in this series.

Point spread: Browns -5.5

Pick ATS: Cleveland

Baltimore Ravens at Miami Dolphins

Most believe the Miami Dolphins will be the worst team in the NFL this year, and this is the debut of new head coach Brian Flores, formerly the Patriots’ defensive coordinator. The cupboard is pretty bare in Miami. Baltimore figures to be one of the most run-heavy teams in the league again behind mobile QB Lamar Jackson and new addition Mark Ingram. The Ravens have covered eight straight in the series. Check out the full preview for this matchup here. 

Point spread: Ravens -5

Pick ATS: Baltimore

Atlanta Falcons vs. Minnesota Vikings

Two teams that disappointed in 2018 but could easily return to the playoffs this year. The Vikings need QB Kirk Cousins to be better for that to happen, though. Star Falcons receiver Julio Jones didn’t play at all this pre-season due to injury but is expected to start.  Atlanta has failed to cover its past four in this series. Our full preview for this game is here.

Point spread: Vikings -4

Pick ATS: Minnesota

Buffalo Bills at New York Jets

Matchup of AFC East foes who believe they are on the rise between second-year quarterbacks Josh Allen (Buffalo) and Sam Darnold (NY Jets). This also will be the Jets debut of Le’Veon Bell, the former All-Pro running back of the Pittsburgh Steelers. The underdog is 7-1 ATS in the past eight meetings. The full preview for the Bills at Jets game is here. 

Point spread: Jets -3

Pick ATS: NY Jets

Washington Redskins at Philadelphia Eagles

The coach most likely to be fired first this season? Oddsmakers believe it’s Washington’s Jay Gruden. New addition Case Keenum starts at quarterback, but it’s only a matter of time before rookie Dwayne Haskins takes over. The Eagles are good enough to win a second Super Bowl in three years if injury-prone QB Carson Wentz can stay healthy. The favourite has covered the past five in the series. Click here for the complete Redskins vs. Eagles preview.

Point spread: Eagles -8.5

Pick ATS: Washington

Los Angeles Rams at Carolina Panthers

The Rams take the field for the first time since their high-powered offence was completely shut down in the 13-3 Super Bowl loss to the Patriots in February. None of L.A.’s top players saw action this pre-season. Carolina coach Ron Rivera says he has “no doubt” star quarterback Cam Newton will play even though Newton left Week 3 of the pre-season with an ankle injury. The Rams are 0-5 ATS in their past five in Charlotte.

Point spread: Rams -3

Pick ATS: Carolina

Kansas City Chiefs at Jacksonville Jaguars

Kansas City had the best offence in the NFL by far last year and in franchise history thanks to the new face of the league, quarterback and MVP Patrick Mahomes. The Madden NFL 20 cover boy became the second player ever with at least 5,000 yards and 50 touchdowns passing in the same season. This will be the Jaguars debut of quarterback Nick Foles, the former Super Bowl MVP winner from the Eagles. The Chiefs are 4-1 ATS in the past five meetings, but we like the home side. Click here for a complete preview of Chiefs at Jaguars. 

Point spread: Chiefs -4

Pick ATS: Jacksonville

Indianapolis Colts at Los Angeles Chargers

This looked to be one of the marquee matchups of Week 1 between 2018 playoff teams, but the Colts are still reeling from the shocking retirement of star quarterback Andrew Luck. It’s Jacoby Brissett’s team now. Pro Bowl Chargers running back Melvin Gordon held out of all training camp and the pre-season looking for a new contract, but there is optimism he will return for this game. The Colts are 2-7 ATS in the past nine meetings.

Point spread: Chargers -7

Pick ATS: Los Angeles

Cincinnati Bengals at Seattle Seahawks

One of just two interconference Week 1 matchups. Cincinnati is without Pro Bowl receiver AJ Green following ankle surgery, and he’s likely to miss at least a few more games as well. Seattle quarterback Russell Wilson takes the field as the NFL’s highest-paid player (for now and by average annual value of a contract) for the first time. These teams haven’t met since 2015, with the Bengals 3-0-1 ATS in the past four.

Point spread: Seahawks -9.5

Pick ATS: Cincinnati

New York Giants at Dallas Cowboys

Will Pro Bowl running back Ezekiel Elliott, the rushing champion two of the past three years, be there Week 1 for Dallas? He has held out all of training camp and the pre-season looking to become the highest-paid tailback in league history. Be a bit of a surprise if Zeke doesn’t miss at least a few regular-season games. The Giants are rebuilding after trading Odell Beckham Jr. and losing a few other key players via trade or free agency. Dallas has covered the past four in the series.

Point spread: Cowboys -7

Pick ATS: NY Giants if no Elliott

Detroit Lions at Arizona Cardinals

It’s the regular-season debut of the No. 1 overall pick in this year’s draft, Arizona quarterback Kyler Murray. The 2018 Heisman winner from Oklahoma had his ups and downs this pre-season. Also the NFL debut of his head coach, Kliff Kingsbury. Arizona is without top cornerback Patrick Peterson, suspended the first six games. Like the Cardinals, the Lions finished last in their division in 2018. Detroit was 6-2 ATS on the road, however.

Point spread: Lions -2.5

Pick ATS: Detroit

San Francisco 49ers at Tampa Bay Buccaneers

The 49ers haven’t won a game in the Eastern Time Zone in years but catch a bit of a break here with the 4:25 p.m. ET start instead of 1 p.m. ET. First game for San Francisco QB Jimmy Garoppolo since blowing out his knee in Week 3 last year. It’s the Bucs head coaching debut of Bruce Arians, hired to try and fix quarterback and former Heisman winner Jameis Winston. The Niners are 1-4 ATS in their past five in Tampa.

Point spread: Bucs -1

Pick ATS: Tampa Bay

Pittsburgh Steelers at New England Patriots

Probably the AFC’s best rivalry right now. The Patriots would normally have hosted the annual Thursday night Kickoff Game as defending Super Bowl champions but instead get the honours for the first Sunday night matchup. Tom Brady begins life without retired tight end Rob Gronkowski, a future Hall of Famer. Pittsburgh, meanwhile, starts life without two Pro Bowlers in running back Le’Veon Bell (didn’t play at all last year) and receiver Antonio Brown. The Steelers are 2-5 ATS in their past seven in New England.

Point spread: Patriots -6

Pick ATS: New England

Houston Texans at New Orleans Saints, Monday

Houston lost top running back Lamar Miller to a torn ACL in Week 3 of the pre-season, which should turn trade acquisition Duke Johnson, formerly of Cleveland, into the featured back. Texans defensive end Jadeveon Clowney, the former No. 1 overall pick, has been holding out and might continue to do so into the regular season – or could have been traded by the time you read this. Could this be the final season for 40-year-old Saints quarterback Drew Brees? If New Orleans wins the Super Bowl, don’t be surprised if it is. New Orleans has failed to cover its past five games. Click here to read a complete preview for Texans at Saints.

Point spread: Saints -7

Pick ATS: Houston

Denver Broncos at Oakland Raiders, Monday

It’s the Oakland debut of former Steelers Pro Bowl receiver Antonio Brown, who was largely the focus of HBO’s “Hard Knocks” show this summer. Brown never played a down in the pre-season and barely practiced because of frostbite on his feet and helmet issues. Diva! It’s the head-coaching debut of Denver’s Vic Fangio and also the Broncos debut of ex-Ravens QB Joe Flacco. The home team is 5-1 ATS in the past six meetings. Here’s the full preview for this game.

Point spread: Pick’em

Pick ATS: Denver

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