Colts vs. Titans Prediction, Odds & Stats - September 21, 2025

Final Score
Indianapolis
Colts
Tennessee
Titans
41
20
Indianapolis Colts
Tennessee Titans
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 8-8 17 3 14 7 +42.5
Tennessee Titans 3-13 3 3 7 7 +6

Latest Encounters

Date Result Competition Stats Recap
12/28/25
Jacksonville Jaguars JAC ( 12-4 )
Indianapolis Colts IND ( 8-8 )
23   -   17
AFC South
12/28/25
New Orleans Saints NO ( 6-10 )
Tennessee Titans TEN ( 3-13 )
34   -   26
NFC South
12/22/25
San Francisco 49ers SF ( 12-4 )
Indianapolis Colts IND ( 8-8 )
48   -   27
NFC West
12/21/25
Kansas City Chiefs KC ( 6-10 )
Tennessee Titans TEN ( 3-13 )
9   -   26
AFC West
12/14/25
Indianapolis Colts IND ( 8-8 )
Seattle Seahawks SEA ( 13-3 )
16   -   18
AFC South
12/14/25
Tennessee Titans TEN ( 3-13 )
San Francisco 49ers SF ( 12-4 )
24   -   37
AFC South
12/07/25
Indianapolis Colts IND ( 8-8 )
Jacksonville Jaguars JAC ( 12-4 )
19   -   36
AFC South
12/07/25
Tennessee Titans TEN ( 3-13 )
Cleveland Browns CLE ( 4-12 )
31   -   29
AFC South
11/30/25
Houston Texans HOU ( 11-5 )
Indianapolis Colts IND ( 8-8 )
20   -   16
AFC South
11/30/25
Jacksonville Jaguars JAC ( 12-4 )
Tennessee Titans TEN ( 3-13 )
25   -   3
AFC South
11/23/25
Indianapolis Colts IND ( 8-8 )
Kansas City Chiefs KC ( 6-10 )
20   -   23
AFC South
11/23/25
Seattle Seahawks SEA ( 13-3 )
Tennessee Titans TEN ( 3-13 )
30   -   24
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Indianapolis Colts Indianapolis Colts
2 0 3-7 6L 2-0 0 0-0 0-0 1-1
Tennessee Titans Tennessee Titans
0 2 2-8 1L 0-2 0 0-0 0-0 1-1

Recent Meetings

date home-away ats o/u TEN:Total Net Yards TEN:Net Rushing Yards TEN:Passing Yards IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards
10/26/2025 IND 38 - TEN 14 IND -3.5 Over 48 341 113 228 420 164 256
09/21/2025 TEN 20 - IND 41 IND +1.5 Over 42.5 282 86 196 365 137 228
12/22/2024 IND 38 - TEN 30 IND -4 Over 43.5 307 65 242 458 335 123
10/13/2024 TEN 17 - IND 20 IND -1 Under 42 269 80 189 241 146 95
12/03/2023 TEN 28 - IND 31 IND -2 Over 42 355 55 300 381 177 204
10/08/2023 IND 23 - TEN 16 IND -1 Under 43 348 89 259 429 193 236
10/23/2022 TEN 19 - IND 10 TEN -2 Under 43 292 65 227 254 138 116
10/02/2022 IND 17 - TEN 24 TEN +4.5 Under 44.5 243 127 116 365 38 327
10/31/2021 IND 31 - TEN 34 TEN -1 Over 47.5 340 93 247 307 83 224
09/26/2021 TEN 25 - IND 16 TEN -4.5 Under 50 265 87 178 368 180 188
11/29/2020 IND 26 - TEN 45 TEN +3 Over 51.5 449 229 220 336 56 280
11/12/2020 TEN 17 - IND 34 IND +2.5 Over 49.5 430 133 297 294 157 137
12/01/2019 IND 17 - TEN 31 TEN +3 Over 43 292 154 138 391 82 309
09/15/2019 TEN 17 - IND 19 IND +3 Under 43.5 288 167 121 243 124 119
12/30/2018 TEN 17 - IND 33 IND -2.5 Over 44 436 158 278 258 93 165
11/18/2018 IND 38 - TEN 10 IND -1 Under 48 267 91 176 397 102 295
11/26/2017 IND 16 - TEN 20 TEN -3 Under 44 276 92 184 254 89 165
10/16/2017 TEN 36 - IND 22 TEN -7 Over 46 297 85 212 473 168 305
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 IND 17 - JAC 23 L +7 Under 48.5 370 121 249
12/22/2025 IND 27 - SF 48 L +5.5 Over 46.5 440 145 295
12/14/2025 SEA 18 - IND 16 W +10 Under 41.5 215 97 118
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 285 89 196
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 364 108 256
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 255 74 181
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 290 140 150
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 368 55 313
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 341 113 228
10/19/2025 LAC 24 - IND 38 W +1.5 Over 48.5 401 120 281
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 TEN 26 - NO 34 L +3 Over 39 336 108 228
12/21/2025 TEN 26 - KC 9 W +4.5 Under 37.5 376 164 212
12/14/2025 SF 37 - TEN 24 L +12.5 Over 44.5 430 138 292
12/07/2025 CLE 29 - TEN 31 W +3.5 Over 33.5 412 61 351
11/30/2025 TEN 3 - JAC 25 L +7 Under 41.5 188 67 121
11/23/2025 TEN 24 - SEA 30 W +13 Over 40 296 64 232
11/16/2025 TEN 13 - HOU 16 W +5.5 Under 43.5 229 58 171
11/02/2025 TEN 20 - LAC 27 W +10.5 Over 44 206 88 118
10/26/2025 IND 38 - TEN 14 L +3.5 Over 48 420 164 256
10/19/2025 TEN 13 - NE 31 L +6.5 Over 42.5 255 39 216

Matchup Edge - Scoring Stats

Indianapolis Colts IND
avg rank edge in rank avg
27.25 7 Points Per Game 30 17.31
23.38 18 Points Allowed Per Game 26 27.31
6.19 5 1st Quarter Scoring Per Game 16 4.06
4.19 11 1st Quarter Scoring Allowed Per Game 18 5.44
8.44 4 2nd Quarter Scoring Per Game 25 4.25
6.94 15 2nd Quarter Scoring Allowed Per Game 21 8
6.13 7 3rd Quarter Scording Per Game 23 3.13
4.44 11 3rd Quarter Scoring Allowed Per Game 27 7.5
6.13 16 4th Quarter Scoring Per Game 19 5.88
7.63 18 4th Quarter Scoring Allowed Per Game 12 6.38
66.1 3 Red Zone Efficiency 17 56.3
345.06 11 Total Yards Per Game 31 263.69
10.78 12 Total Yards Per Play 30 7.86
4.65 7 Rushing Yards Per Play 19 4.21
32 17 Passing Attempts Per Game 12 33.56
10.64 13 Passing Yards Per Completion 30 8.46
1.44 9 Passing Tds Per Game 15 0.94
21.13 11 Completions Per Game 16 20
66.0 11 Completion % 25 59.6
92.41 13 Qb Rating 28 79.81
1.75 20 Defense Sacks Per Game 5 3.44
0.81 6 Defense Interceptions Per Game 12 0.44
0.69 1 Opponent Fumbles Per Game 4 0.88
0.44 7 Opponent Fumbles Lost Per Game 3 0.69
6.06 9 Penalties Per Game 24 7.75
49.31 14 Penalty Yards Per Game 26 59
20 10 Takeaway / Giveaway Differential 8 18
4.48 16 Yards Per Punt Return 8 5.37
28.81 2 Yards Per Kickoff Return 16 25.77

Odds Analysis

Team Rankings

offence
Indianapolis Colts IND
Season stats rank
Total Yards 345.1 11
Passing Yards 224.69 12
Rushing Yards 120.38 14
Points Scored 27.25 7
Field Goal % 0.94 2
Tennessee Titans TEN
Season stats rank
Total Yards 263.7 31
Passing Yards 169.19 30
Rushing Yards 94.5 28
Points Scored 17.31 30
Field Goal % 0.83 23
defence
Indianapolis Colts IND
Season stats rank
Total Yards 345.1 11
Passing Yards 224.69 12
Rushing Yards 120.38 14
Points Scored 27.25 7
Field Goal % 0.94 2
Tennessee Titans TEN
Season stats rank
Total Yards 263.7 31
Passing Yards 169.19 30
Rushing Yards 94.5 28
Points Scored 17.31 30
Field Goal % 0.83 23

Injuries

Indianapolis Colts IND
Tennessee Titans TEN

AFC South Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player