Colts vs. Titans Prediction, Odds & Stats - September 21, 2025

Final Score
AFC South
Sep 21st, 1:00 PM EDT
Indianapolis
Colts
Tennessee
Titans
41
20
Indianapolis Colts
Tennessee Titans
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 8-5 17 3 14 7 +42.5
Tennessee Titans 2-11 3 3 7 7 +6

Latest Encounters

Date Result Competition Stats Recap
12/07/25
Indianapolis Colts IND ( 8-5 )
Jacksonville Jaguars JAC ( 9-4 )
19   -   36
 AFC South
12/07/25
Tennessee Titans TEN ( 2-11 )
Cleveland Browns CLE ( 3-10 )
31   -   29
 AFC South
11/30/25
Houston Texans HOU ( 8-5 )
Indianapolis Colts IND ( 8-5 )
20   -   16
 AFC South
11/30/25
Jacksonville Jaguars JAC ( 9-4 )
Tennessee Titans TEN ( 2-11 )
25   -   3
 AFC South
11/23/25
Indianapolis Colts IND ( 8-5 )
Kansas City Chiefs KC ( 6-7 )
20   -   23
 AFC South
11/23/25
Seattle Seahawks SEA ( 10-3 )
Tennessee Titans TEN ( 2-11 )
30   -   24
 NFC West
11/16/25
Houston Texans HOU ( 8-5 )
Tennessee Titans TEN ( 2-11 )
16   -   13
 AFC South
11/09/25
Atlanta Falcons ATL ( 4-9 )
Indianapolis Colts IND ( 8-5 )
25   -   31
 NFC South
11/02/25
Indianapolis Colts IND ( 8-5 )
Pittsburgh Steelers PIT ( 7-6 )
20   -   27
 AFC South
11/02/25
L.A. Chargers Chargers LAC ( 8-4 )
Tennessee Titans TEN ( 2-11 )
27   -   20
 AFC West
10/26/25
Tennessee Titans TEN ( 2-11 )
Indianapolis Colts IND ( 8-5 )
14   -   38
 AFC South

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Indianapolis Colts Indianapolis Colts
2 0 5-5 3L 2-0 0 0-0 0-0 1-1
Tennessee Titans Tennessee Titans
0 2 2-8 1W 0-2 0 0-0 0-0 1-1

Recent Meetings

date home-away ats o/u TEN:Total Net Yards TEN:Net Rushing Yards TEN:Passing Yards IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards
10/26/2025 IND 38 - TEN 14 IND -3.5 Over 48 341 113 228 420 164 256
09/21/2025 TEN 20 - IND 41 IND +1.5 Over 42.5 282 86 196 365 137 228
12/22/2024 IND 38 - TEN 30 IND -4 Over 43.5 307 65 242 458 335 123
10/13/2024 TEN 17 - IND 20 IND -1 Under 42 269 80 189 241 146 95
12/03/2023 TEN 28 - IND 31 IND -2 Over 42 355 55 300 381 177 204
10/08/2023 IND 23 - TEN 16 IND -1 Under 43 348 89 259 429 193 236
10/23/2022 TEN 19 - IND 10 TEN -2 Under 43 292 65 227 254 138 116
10/02/2022 IND 17 - TEN 24 TEN +4.5 Under 44.5 243 127 116 365 38 327
10/31/2021 IND 31 - TEN 34 TEN -1 Over 47.5 340 93 247 307 83 224
09/26/2021 TEN 25 - IND 16 TEN -4.5 Under 50 265 87 178 368 180 188
11/29/2020 IND 26 - TEN 45 TEN +3 Over 51.5 449 229 220 336 56 280
11/12/2020 TEN 17 - IND 34 IND +2.5 Over 49.5 430 133 297 294 157 137
12/01/2019 IND 17 - TEN 31 TEN +3 Over 43 292 154 138 391 82 309
09/15/2019 TEN 17 - IND 19 IND +3 Under 43.5 288 167 121 243 124 119
12/30/2018 TEN 17 - IND 33 IND -2.5 Over 44 436 158 278 258 93 165
11/18/2018 IND 38 - TEN 10 IND -1 Under 48 267 91 176 397 102 295
11/26/2017 IND 16 - TEN 20 TEN -3 Under 44 276 92 184 254 89 165
10/16/2017 TEN 36 - IND 22 TEN -7 Over 46 297 85 212 473 168 305
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 285 89 196
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 364 108 256
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 255 74 181
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 290 140 150
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 368 55 313
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 341 113 228
10/19/2025 LAC 24 - IND 38 W +1.5 Over 48.5 401 120 281
10/12/2025 IND 31 - ARI 27 L -5.5 Over 46.5 400 88 312
10/05/2025 IND 40 - LV 6 W -6.5 Under 46.5 296 106 190
09/28/2025 LAR 27 - IND 20 L +4.5 Under 49.5 333 85 248
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/07/2025 CLE 29 - TEN 31 W +3.5 Over 33.5 412 61 351
11/30/2025 TEN 3 - JAC 25 L +7 Under 41.5 188 67 121
11/23/2025 TEN 24 - SEA 30 W +13 Over 40 296 64 232
11/16/2025 TEN 13 - HOU 16 W +5.5 Under 43.5 229 58 171
11/02/2025 TEN 20 - LAC 27 W +10.5 Over 44 206 88 118
10/26/2025 IND 38 - TEN 14 L +3.5 Over 48 420 164 256
10/19/2025 TEN 13 - NE 31 L +6.5 Over 42.5 255 39 216
10/12/2025 LV 20 - TEN 10 L +5.5 Under 41.5 226 68 158
10/05/2025 ARI 21 - TEN 22 L +8.5 Over 41.5 360 168 192
09/28/2025 HOU 26 - TEN 0 L +5.5 Under 39.5 353 129 224

Matchup Edge - Scoring Stats

Indianapolis Colts IND
Tennessee Titans TEN
avg rank edge in rank avg
28.92 5 Points Per Game 29 15.46
21.92 13 Points Allowed Per Game 29 27.46
6.62 2 1st Quarter Scoring Per Game 13 4.31
3.85 7 1st Quarter Scoring Allowed Per Game 22 6.15
8.31 6 2nd Quarter Scoring Per Game 27 2.92
7 17 2nd Quarter Scoring Allowed Per Game 21 7.85
6.77 4 3rd Quarter Scording Per Game 22 3.08
3.69 6 3rd Quarter Scoring Allowed Per Game 26 7.15
6.77 13 4th Quarter Scoring Per Game 21 5.15
7.15 16 4th Quarter Scoring Allowed Per Game 11 6.31
64.3 5 Red Zone Efficiency 20 52.2
368.46 6 Total Yards Per Game 32 246.23
11.46 6 Total Yards Per Play 32 7.28
4.98 4 Rushing Yards Per Play 22 4.07
32.15 15 Passing Attempts Per Game 10 33.85
11.03 7 Passing Yards Per Completion 32 8.07
1.46 9 Passing Tds Per Game 16 0.69
21.54 11 Completions Per Game 18 20
67.0 9 Completion % 26 59.1
96.53 9 Qb Rating 30 74.89
1.77 17 Defense Sacks Per Game 2 3.77
0.69 8 Defense Interceptions Per Game 10 0.54
0.62 1 Opponent Fumbles Per Game 2 0.69
0.46 7 Opponent Fumbles Lost Per Game 2 0.77
6.38 10 Penalties Per Game 21 7.77
52.69 15 Penalty Yards Per Game 24 59.23
15 6 Takeaway / Giveaway Differential 8 17
6 7 Yards Per Punt Return 9 5.63
27.94 5 Yards Per Kickoff Return 13 26

Odds Analysis

Team Rankings

offence
Indianapolis Colts IND
Season stats rank
Total Yards 368.5 6
Passing Yards 237.54 8
Rushing Yards 130.92 6
Points Scored 28.92 6
Field Goal % 0.93 4
Tennessee Titans TEN
Season stats rank
Total Yards 246.2 32
Passing Yards 161.31 31
Rushing Yards 84.92 31
Points Scored 15.46 31
Field Goal % 0.82 23
defence
Indianapolis Colts IND
Season stats rank
Total Yards 368.5 6
Passing Yards 237.54 8
Rushing Yards 130.92 6
Points Scored 28.92 6
Field Goal % 0.93 4
Tennessee Titans TEN
Season stats rank
Total Yards 246.2 32
Passing Yards 161.31 31
Rushing Yards 84.92 31
Points Scored 15.46 31
Field Goal % 0.82 23

Injuries

Indianapolis Colts IND
Tennessee Titans TEN

Indianapolis vs. Tennessee Betting News

Indianapolis Colts IND

No posts found.
Tennessee Titans TEN

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Indianapolis Vs Tennessee Betting Trends

Indianapolis Colts IND

Colts are 1-6 ATS in their last 7 games as a favorite of 3.5-10.0.

Over is 6-1 in Colts last 7 games overall.

Colts are 7-3 ATS in their last 10 games following a straight up win.

Colts are 13-3 ATS in their last 16 games in Week 3.

Colts are 7-2 ATS in their last 9 games as a favorite of 0.5-3.0.

Tennessee Titans TEN

Titans are 5-15-1 ATS in their last 21 games following a straight up loss.

Titans are 7-19-3 ATS in their last 29 games following a ATS loss.

Over is 5-2 in Titans last 7 games as an underdog of 10.5 or greater.

Titans are 1-10 ATS in their last 11 games as a favorite.

Titans are 5-15-2 ATS in their last 22 home games.

AFC South Standings

Line Up - Last Game

Indianapolis Colts
Pitchers
POS Player
Hitters
POS Player
Tennessee Titans
Pitchers
POS Player
Hitters
POS Player
  • IND
  • -6 +6
  • TEN
NFL Odds