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Chargers vs. Bills Prediction, Odds & Stats September 27, 2026

Final Score
AFC West
Sep 27th, 1:00 PM EDT
L.A. Chargers
Chargers
Buffalo
Bills
16
24
Los Angeles Chargers
Buffalo Bills
Scoreboard 1 2 3 4 Odds
Los Angeles Chargers 0-5 10 0 3 3 +50.5
Buffalo Bills 3-1 0 10 0 14 -7
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Latest Encounters

Date Result Competition Stats Recap
10/11/26
Denver Broncos DEN ( 3-2 )
L.A. Chargers Chargers LAC ( 0-5 )
23   -   17
 AFC West
10/04/26
L.A. Chargers Chargers LAC ( 0-5 )
Seattle Seahawks SEA ( 3-2 )
23   -   30
 AFC West
10/04/26
New England Patriots NE ( 3-2 )
Buffalo Bills BUF ( 3-1 )
29   -   26
 AFC East

Line History

Matchup Details

L.A. Chargers Chargers LAC
Buffalo Bills BUF
Stat
0 Games Won 2
2 Games Lost 0
0-5 Last 10 3-1
0-0 W L Streak 0-0
0-2 Against The Spread 2-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-2 Total 2-0

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards LAC:Total Net Yards LAC:Net Rushing Yards LAC:Passing Yards
09/27/2026 BUF 24 - LAC 16 BUF -7 Under 50.5 350 176 174 348 131 217
12/23/2023 LAC 22 - BUF 24 LAC +13 Over 43 335 105 230 273 98 175
11/29/2020 BUF 27 - LAC 17 BUF -4.5 Under 51.5 367 76 291 332 172 160
09/16/2018 BUF 20 - LAC 31 LAC -7.5 Over 41.5 349 109 240 293 84 209
11/19/2017 LAC 54 - BUF 24 LAC -7 Over 43.5 393 173 220 429 146 283
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
10/11/2026 LAC 17 - DEN 23 L +3.5 Under 42 224 106 118
10/04/2026 SEA 30 - LAC 23 L +3 Over 45.5 301 147 154
09/27/2026 BUF 24 - LAC 16 L +7 Under 50.5 348 131 217
09/20/2026 LAC 14 - LV 26 L -9 Under 43 305 57 248
09/13/2026 LAC 14 - ARI 26 L -10.5 Under 46.5 393 116 277
08/27/2026 LAC 18 - LAR 20 L -2.5 Under 39.5 298 148 150
08/20/2026 LAC 17 - SF 41 L -1 Over 39.5 321 146 175
08/13/2026 HOU 7 - LAC 27 W +1.5 Under 38 379 104 275
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
10/04/2026 BUF 26 - NE 29 L -7 Over 49.5 340 91 249
09/27/2026 BUF 24 - LAC 16 W -7 Under 50.5 350 176 174
09/17/2026 BUF 41 - DET 31 W -3 Over 52.5 446 203 243
09/13/2026 HOU 31 - BUF 36 W -1.5 Over 44.5 381 124 257
08/27/2026 BUF 28 - PIT 27 L -1 Over 35 266 89 177
08/22/2026 CLE 7 - BUF 31 W +1 Under 39.5 194 84 110
08/15/2026 BUF 29 - CAR 14 W +1 Over 38 420 151 269

Odds Analysis

Team Rankings

L.A. Chargers Chargers LAC
Season stats rank
Total Yards 311.6 10
Passing Yards 193 6
Rushing Yards 118.6 22
Points Scored 25.8 23
Field Goal % 0.83 13
Buffalo Bills BUF
Season stats rank
Total Yards 372.3 27
Passing Yards 256.25 30
Rushing Yards 116 18
Points Scored 26.75 25
Field Goal % 0.83 14
L.A. Chargers Chargers LAC
Season stats rank
Total Yards 292.8 25
Passing Yards 164.6 30
Rushing Yards 128.2 9
Points Scored 16.8 30
Field Goal % 0.78 22
Buffalo Bills BUF
Season stats rank
Total Yards 386.3 7
Passing Yards 247.25 10
Rushing Yards 139 6
Points Scored 31.75 2
Field Goal % 1 4

Injuries

L.A. Chargers Chargers LAC
Buffalo Bills BUF

L.A. Chargers vs. Buffalo Betting News

L.A. Chargers Vs Buffalo Betting Trends

L.A. Chargers Chargers LAC

Chargers are 37-16-2 ATS in their last 55 games as a road underdog of 3.5-10.0.

Under is 5-1 in Chargers last 6 games as a favorite.

Under is 14-3 in Chargers last 17 games in Week 3.

Chargers are 2-6 ATS in their last 8 road games.

Under is 5-0 in Chargers last 5 games as a road underdog of 3.5-10.0.

Buffalo Bills BUF

Under is 4-1 in Bills last 5 games as a home underdog of 3.5-10.0.

Bills are 4-1 ATS in their last 5 games as a home underdog of 0.5-3.0.

Over is 5-1 in Bills last 6 vs. a team with a losing record.

Over is 6-1 in Bills last 7 games as a favorite.

Bills are 4-10-1 ATS in their last 15 games following a ATS win.

Line Up - Last Game

Los Angeles Chargers
Pitchers
POS Player
Hitters
POS Player
Buffalo Bills
Pitchers
POS Player
Hitters
POS Player
  • LAC
  • +7 -7
  • BUF
NFL Odds