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Cardinals vs. 49ers Prediction, Odds & Stats September 27, 2026

Final Score
NFC West
Sep 27th, 4:05 PM EDT
Arizona
Cardinals
San Francisco
49ers
30
36
Arizona Cardinals
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Arizona Cardinals 1-4 0 6 7 17 +48
San Francisco 49ers 5-0 7 10 6 13 -8.5
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Latest Encounters

Date Result Competition Stats Recap
10/11/26
Detroit Lions DET ( 3-2 )
Arizona Cardinals ARI ( 1-4 )
45   -   21
 NFC North
10/11/26
San Francisco 49ers SF ( 5-0 )
Seattle Seahawks SEA ( 3-2 )
32   -   29
 NFC West
10/04/26
Denver Broncos DEN ( 3-2 )
San Francisco 49ers SF ( 5-0 )
14   -   24
 AFC West

Line History

Matchup Details

Arizona Cardinals ARI
San Francisco 49ers SF
Stat
1 Games Won 2
1 Games Lost 0
1-4 Last 10 5-0
0-0 W L Streak 0-0
1-1 Against The Spread 2-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-2 Total 1-1

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards
09/27/2026 SF 36 - ARI 30 ARI +8.5 Over 48 437 140 297 365 93 272
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 281 95 186 488 36 452
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 260 106 154 355 73 282
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
10/11/2026 ARI 21 - DET 45 L +4.5 Over 54 412 163 249
10/04/2026 NYG 36 - ARI 24 L +6.5 Over 44 270 123 147
09/27/2026 SF 36 - ARI 30 W +8.5 Over 48 365 93 272
09/20/2026 ARI 7 - SEA 31 L +10 Under 44.5 381 162 219
09/13/2026 LAC 14 - ARI 26 W +10.5 Under 46.5 393 116 277
08/28/2026 GB 42 - ARI 38 L -1 Over 36 492 166 326
08/22/2026 ARI 13 - DAL 34 L -1 Over 37 413 175 238
08/13/2026 LV 14 - ARI 27 W +1.5 Over 39.5 368 156 212
08/06/2026 ARI 30 - CAR 33 L +1.5 Over 35.5 378 141 237
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
10/11/2026 SEA 29 - SF 32 W +3 Over 47 251 89 162
10/04/2026 SF 24 - DEN 14 W -2.5 Under 46 358 140 218
09/27/2026 SF 36 - ARI 30 L -8.5 Over 48 437 140 297
09/20/2026 SF 35 - MIA 13 W -10.5 Over 46 382 95 287
09/10/2026 LAR 7 - SF 27 W +2.5 Under 48.5 290 122 168
08/27/2026 LV 12 - SF 18 W +1 Under 38.5 251 113 138
08/20/2026 LAC 17 - SF 41 W +1 Over 39.5 229 68 161
08/13/2026 SF 13 - TEN 19 L +2 Under 38.5 322 84 238

Odds Analysis

Team Rankings

Arizona Cardinals ARI
Season stats rank
Total Yards 363.4 25
Passing Yards 236.8 25
Rushing Yards 126.6 24
Points Scored 32.4 32
Field Goal % 1 29
San Francisco 49ers SF
Season stats rank
Total Yards 297.2 6
Passing Yards 199.6 8
Rushing Yards 97.6 10
Points Scored 18.6 3
Field Goal % 0.86 16
Arizona Cardinals ARI
Season stats rank
Total Yards 301.2 23
Passing Yards 209.6 19
Rushing Yards 91.6 23
Points Scored 21.6 22
Field Goal % 0.8 18
San Francisco 49ers SF
Season stats rank
Total Yards 365 9
Passing Yards 236.4 13
Rushing Yards 128.6 8
Points Scored 30.8 3
Field Goal % 0.63 32

Injuries

Arizona Cardinals ARI
San Francisco 49ers SF

Arizona vs. San Francisco Betting News

Arizona Vs San Francisco Betting Trends

Arizona Cardinals ARI

Over is 8-3 in Cardinals last 11 games after allowing more than 350 total yards in their previous game.

Cardinals are 22-7-3 ATS in their last 32 games as a road underdog of 3.5-10.0.

Over is 5-1 in Cardinals last 6 games as a favorite.

Over is 5-2 in Cardinals last 7 games after allowing more than 30 points in their previous game.

Under is 5-1 in Cardinals last 6 games in Week 3.

San Francisco 49ers SF

Over is 4-1 in 49ers last 5 games as a home underdog of 3.5-10.0.

49ers are 3-1-1 ATS in their last 5 home games.

49ers are 10-4-1 ATS in their last 15 games as a home underdog of 0.5-3.0.

Over is 4-0 in 49ers last 4 games as a favorite.

49ers are 6-1-1 ATS in their last 8 games following a ATS win.

NFC West Standings

Line Up - Last Game

Arizona Cardinals
Pitchers
POS Player
Hitters
POS Player
San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
  • ARI
  • +8.5 -8.5
  • SF
NFL Odds