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Clemson Tigers vs. Louisville Cardinals Odds, Stats - November 14, 2025

Final Score
Nov 14th, 7:30 PM EST
Clemson
Tigers
Louisville
Cardinals
20
19
Clemson Tigers
Louisville Cardinals
Scoreboard 1 2 3 4 Odds
Clemson Tigers 7-5 3 7 3 7 +60.5
Louisville Cardinals 8-4 3 6 10 0 +6.5

Latest Encounters

Date Result Competition Stats Recap
12/27/25
Penn State Nittany Lions PSU ( 6-6 )
Clemson Tigers CLEM ( 7-5 )
22   -   10
12/23/25
Toledo Rockets TOL ( 8-4 )
Louisville Cardinals LOU ( 8-4 )
22   -   27
11/29/25
Clemson Tigers CLEM ( 7-5 )
South Carolina Gamecocks SOCAR ( 4-8 )
28   -   14
11/29/25
Kentucky Wildcats UK ( 5-7 )
Louisville Cardinals LOU ( 8-4 )
0   -   41
11/22/25
Furman Paladins FUR ( 6-6 )
Clemson Tigers CLEM ( 7-5 )
10   -   45
11/22/25
Louisville Cardinals LOU ( 8-4 )
Southern Methodist Mustangs SMU ( 8-4 )
6   -   38
11/08/25
Florida State Seminoles FSU ( 5-7 )
Clemson Tigers CLEM ( 7-5 )
10   -   24
11/08/25
California Golden Bears CAL ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
29   -   26
11/01/25
Louisville Cardinals LOU ( 8-4 )
Virginia Tech Hokies VT ( 3-9 )
28   -   16
11/01/25
Duke Blue Devils DUKE ( 8-5 )
Clemson Tigers CLEM ( 7-5 )
46   -   45

Matchup Odds

Team Spread Moneyline Over / Under
Clemson Tigers CLEM
-6.5 0 -175 U+60.50
Louisville Cardinals LOU
+6.5 0 +140 O+60.50

Line History

time fav line total
Opening 10 Jul 2:35am CLEM O +60.5 -110
Closing 15 Nov 3:29am CLEM U +39.5 -140

Line History

Team Leaders

Clemson Tigers CLEM
Louisville Cardinals LOU
Adam Randall
Running Back Louisville
12 Touchdowns 6
Chris Bell
Wide Receiver Clemson
Isaac Brown
Running Back Clemson
782 Rushing 779
Adam Randall
Running Back Louisville
Cade Klubnik
Quarterback Louisville
2750 Passing 2526
Miller Moss
Quarterback Clemson
Chris Bell
Wide Receiver Clemson
72 Receiving 55
Antonio Williams
Wide Receiver Louisville
Clev Lubin
Defensive Lineman Clemson
6.5 Sacks 6
Will Heldt
Defensive End Louisville
Ricardo Jones
Safety Louisville
6 Interceptions 3
Antonio Watts
Linebacker Clemson
Clemson Tigers CLEM
Louisville Cardinals LOU
Isaac Brown
Running Back Clemson
2 Touchdowns 1
Adam Randall
Running Back Louisville
Keyjuan Brown
Running Back Clemson
112 Rushing 35
Adam Randall
Running Back Louisville
Cade Klubnik
Quarterback Louisville
193 Passing 153
Miller Moss
Quarterback Clemson
Caullin Lacy
Wide Receiver Clemson
6 Receiving 6
T.J. Moore
Wide Receiver Louisville
Clev Lubin
Defensive Lineman Clemson
1.5 Sacks 1
Ashton Hampton
Cornerback Louisville
Isaac Brown
Running Back Clemson
0 Interceptions 0
Jeremiah Alexander
Linebacker Louisville

Matchup Details

team win loss last 10 w/l streak ats money home away total
Clemson Tigers Clemson Tigers
4 5 6-4 4W 3-6 0 0-0 0-0 4-5
Louisville Cardinals Louisville Cardinals
7 2 6-4 1W 3-6 0 0-0 0-0 5-4

Recent Meetings

date home-away ats o/u LOU:Total Net Yards LOU:Net Rushing Yards LOU:Passing Yards CLEM:Total Net Yards CLEM:Net Rushing Yards CLEM:Passing Yards
11/14/2025 LOU 19 - CLEM 20 LOU +5.5 Under 60.5 385 171 214 323 136 187
11/02/2024 CLEM 21 - LOU 33 LOU +10.5 Under 62.5 366 210 156 450 222 228
11/12/2022 CLEM 31 - LOU 16 CLEM -6.5 Under 51.5 400 150 250 439 248 191
11/06/2021 LOU 24 - CLEM 30 CLEM -3.5 Over 46 345 125 220 397 223 174
10/19/2019 LOU 10 - CLEM 45 CLEM -24 Under 62.5 551 298 253 263 156 107
11/03/2018 CLEM 77 - LOU 16 CLEM -38 Over 61 312 81 231 661 492 169
09/16/2017 LOU 21 - CLEM 47 CLEM -3 Over 61 613 297 316 433 116 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/27/2025 CLEM 10 - PSU 22 L +1.5 Under 48.5 400 138 262
11/29/2025 SOCAR 14 - CLEM 28 W +2.5 Under 46.5 415 147 268
11/22/2025 CLEM 45 - FUR 10 L -41.5 Under 55.5 271 66 205
11/14/2025 LOU 19 - CLEM 20 L -5.5 Under 60.5 323 136 187
11/08/2025 CLEM 24 - FSU 10 W -2.5 Under 56.5 360 110 250
11/01/2025 CLEM 45 - DUKE 46 L -3.5 Over 54.5 439 78 361
10/18/2025 CLEM 24 - SMU 35 L -10 Over 50.5 429 139 290
10/11/2025 BC 10 - CLEM 41 W -14 Under 54.5 504 226 278
10/04/2025 UNC 10 - CLEM 38 W -14.5 Over 45.5 488 89 399
09/20/2025 CLEM 21 - SYR 34 L -17.5 Over 54.5 433 155 278
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/23/2025 LOU 27 - TOL 22 L -9.5 Over 44.5 333 180 153
11/29/2025 LOU 41 - UK 0 W -3.5 Under 47.5 440 258 182
11/22/2025 SMU 38 - LOU 6 L +3.5 Under 53.5 485 178 307
11/14/2025 LOU 19 - CLEM 20 W +5.5 Under 60.5 385 171 214
11/08/2025 LOU 26 - CAL 29 L -18.5 Over 49.5 351 148 203
11/01/2025 VT 16 - LOU 28 W -10.5 Under 54.5 240 164 76
10/25/2025 LOU 38 - BC 24 L -25.5 Over 54.5 506 319 187
10/17/2025 MIA 21 - LOU 24 W +10.5 Under 49.5 334 63 271
10/04/2025 LOU 27 - UVA 30 L -6.5 Under 61.5 383 54 329
09/27/2025 PITT 27 - LOU 34 W -3.5 Over 54.5 339 80 259

Matchup Edge - Scoring Stats

Clemson Tigers CLEM
Louisville Cardinals LOU
avg rank edge in rank avg
28.67 65 Points Per Game 52 30.17
20.42 32 Points Allowed Per Game 37 21.08
6.92 35 1st Quarter Scoring Per Game 35 6.92
4.75 39 1st Quarter Scoring Allowed Per Game 55 5.83
10.92 24 2nd Quarter Scoring Per Game 53 8.83
7.42 52 2nd Quarter Scoring Allowed Per Game 30 6
4.42 74 3rd Quarter Scording Per Game 49 6.25
4 26 3rd Quarter Scoring Allowed Per Game 17 3.25
6.42 61 4th Quarter Scoring Per Game 45 7.67
4.25 21 4th Quarter Scoring Allowed Per Game 28 5
80.0 67 Red Zone Efficiency 48 84.2
406.5 47 Total Yards Per Game 70 388.83
11.21 95 Total Yards Per Play 84 11.84
4.15 66 Rushing Yards Per Play 22 5.07
36.25 15 Passing Attempts Per Game 33 32.83
11.46 75 Passing Yards Per Completion 98 10.77
1.83 16 Passing Tds Per Game 25 1.33
23.92 10 Completions Per Game 32 21
66.0 33 Completion % 45 64.0
142.94 55 Qb Rating 86 130.68
1.42 33 Defense Sacks Per Game 27 1.75
0.58 15 Defense Interceptions Per Game 11 0.75
0.67 7 Opponent Fumbles Lost Per Game 9 0.58
4.67 40 Penalties Per Game 76 7
45.17 82 Penalty Yards Per Game 154 64.5
15 13 Takeaway / Giveaway Differential 14 16
2.67 73 Yards Per Punt Return 7 8.92
18.08 115 Yards Per Kickoff Return 39 22.69

Odds Analysis

Team Rankings

offence
Clemson Tigers CLEM
Season stats rank
Total Yards 406.5 47
Passing Yards 274 21
Rushing Yards 132.5 95
Points Scored 28.67 284
Field Goal % 0.84 75
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
defence
Clemson Tigers CLEM
Season stats rank
Total Yards 406.5 47
Passing Yards 274 21
Rushing Yards 132.5 95
Points Scored 28.67 284
Field Goal % 0.84 75
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80

Injuries

Clemson Tigers CLEM
Louisville Cardinals LOU

Betting News + Tweets

Clemson Tigers CLEM

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Louisville Cardinals LOU

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Clemson Vs Louisville Betting Trends

Clemson Tigers CLEM

Tigers are 15-6 ATS in their last 21 games as a road underdog of 3.5-10.0.

Tigers are 1-5 ATS in their last 6 games following a ATS win.

Tigers are 3-11 ATS in their last 14 games after allowing less than 20 points in their previous game.

Tigers are 1-4 ATS in their last 5 games as a road underdog.

Tigers are 18-7 ATS in their last 25 games as a road favorite of 10.5 or greater.

Louisville Cardinals LOU

Over is 5-1 in Cardinals last 6 games as a home underdog of 3.5-10.0.

Cardinals are 0-6 ATS in their last 6 home games.

Cardinals are 2-8 ATS in their last 10 games as a home underdog of 0.5-3.0.

Over is 9-1 in Cardinals last 10 vs. a team with a losing record.

Cardinals are 9-3 ATS in their last 12 games as a home favorite of 3.5-10.0.

Line Up - Last Game

Clemson Tigers
Pitchers
POS Player
Hitters
POS Player
Louisville Cardinals
Pitchers
POS Player
Hitters
POS Player
  • CLEM
  • -6.5 +6.5
  • LOU
NCAAF Odds