Louisville Cardinals vs. Southern Methodist Mustangs Odds, Stats - November 22, 2025

Final Score
Louisville
Cardinals
Southern Methodist
Mustangs
6
38
Louisville Cardinals
Southern Methodist Mustangs
Scoreboard 1 2 3 4 Odds
Louisville Cardinals 8-4 3 3 0 0 +49.5
Southern Methodist Mustangs 8-4 7 14 3 14 -3.5

Latest Encounters

Date Result Competition Stats Recap
12/23/25
Toledo Rockets TOL ( 8-4 )
Louisville Cardinals LOU ( 8-4 )
22   -   27
11/29/25
Southern Methodist Mustangs SMU ( 8-4 )
California Golden Bears CAL ( 7-5 )
35   -   38
11/29/25
Kentucky Wildcats UK ( 5-7 )
Louisville Cardinals LOU ( 8-4 )
0   -   41
11/14/25
Clemson Tigers CLEM ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
20   -   19
11/08/25
California Golden Bears CAL ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
29   -   26
11/08/25
Southern Methodist Mustangs SMU ( 8-4 )
Boston College Eagles BC ( 2-10 )
45   -   13
11/01/25
Louisville Cardinals LOU ( 8-4 )
Virginia Tech Hokies VT ( 3-9 )
28   -   16
11/01/25
Miami Hurricanes MIA ( 10-2 )
Southern Methodist Mustangs SMU ( 8-4 )
20   -   26
10/25/25
Southern Methodist Mustangs SMU ( 8-4 )
Wake Forest Demon Deacons WAKE ( 8-4 )
12   -   13
10/18/25
Southern Methodist Mustangs SMU ( 8-4 )
Clemson Tigers CLEM ( 7-5 )
35   -   24

Betting Action

Line History

time fav line total
Opening 16 Nov 8:39pm LOU O +53.5 -110
Closing 22 Nov 8:04pm LOU U +44.5 -190

Line History

Matchup Edge - Scoring Stats

Southern Methodist Mustangs SMU
avg rank edge in rank avg
2.1 1 Qb Rating 1 2.1

Team Leaders

Louisville Cardinals LOU
Southern Methodist Mustangs SMU
TJ Harden
TJ Harden
Running Back Louisville
8 Touchdowns 6
Chris Bell
Wide Receiver Southern Methodist
Chris Bell
Isaac Brown
Isaac Brown
Running Back Southern Methodist
782 Rushing 747
TJ Harden
Running Back Louisville
TJ Harden
Kevin Jennings
Kevin Jennings
Quarterback Louisville
3363 Passing 2526
Miller Moss
Quarterback Southern Methodist
Miller Moss
Chris Bell
Chris Bell
Wide Receiver Southern Methodist
72 Receiving 56
Jordan Hudson
Wide Receiver Louisville
Jordan Hudson
Isaiah Smith
Isaiah Smith
Defensive End Louisville
9 Sacks 6.5
Clev Lubin
Defensive Lineman Southern Methodist
Clev Lubin
Ahmaad Moses
Ahmaad Moses
Safety Louisville
5 Interceptions 3
Antonio Watts
Linebacker Southern Methodist
Antonio Watts
Louisville Cardinals LOU
Southern Methodist Mustangs SMU
Isaac Brown
Isaac Brown
Running Back Southern Methodist
2 Touchdowns
Keyjuan Brown
Keyjuan Brown
Running Back Southern Methodist
112 Rushing
Miller Moss
Miller Moss
Quarterback Southern Methodist
153 Passing Did not qualify
Caullin Lacy
Caullin Lacy
Wide Receiver Southern Methodist
6 Receiving
Clev Lubin
Clev Lubin
Defensive Lineman Southern Methodist
1.5 Sacks
Interceptions 0
Isaac Brown
Running Back Southern Methodist
Isaac Brown

Matchup Details

team win loss last 10 w/l streak ats money home away total
Louisville Cardinals Louisville Cardinals
7 3 6-4 1W 4-6 0 0-0 0-0 5-5
Southern Methodist Mustangs Southern Methodist Mustangs
7 3 7-3 1L 4-6 0 0-0 0-0 3-7

Team Rankings

offence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 419 36
Passing Yards 283.5 12
Rushing Yards 135.5 91
Points Scored 32.92 144
Field Goal % 0.61 165
defence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 419 36
Passing Yards 283.5 12
Rushing Yards 135.5 91
Points Scored 32.92 144
Field Goal % 0.61 165

Weather

No weather to report.

Injuries

Louisville Cardinals LOU
Southern Methodist Mustangs SMU