Louisville Cardinals vs. Southern Methodist Mustangs Odds, Stats - November 22, 2025

Final Score
Louisville
Cardinals
Southern Methodist
Mustangs
6
38
Louisville Cardinals
Southern Methodist Mustangs
Scoreboard 1 2 3 4 Odds
Louisville Cardinals 8-4 3 3 0 0 +49.5
Southern Methodist Mustangs 8-4 7 14 3 14 -3.5

Latest Encounters

Date Result Competition Stats Recap
01/02/26
Arizona Wildcats ARIZ ( 9-3 )
Southern Methodist Mustangs SMU ( 8-4 )
19   -   24
12/23/25
Toledo Rockets TOL ( 8-4 )
Louisville Cardinals LOU ( 8-4 )
22   -   27
11/29/25
Southern Methodist Mustangs SMU ( 8-4 )
California Golden Bears CAL ( 7-5 )
35   -   38
11/29/25
Kentucky Wildcats UK ( 5-7 )
Louisville Cardinals LOU ( 8-4 )
0   -   41
11/14/25
Clemson Tigers CLEM ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
20   -   19
11/08/25
California Golden Bears CAL ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
29   -   26
11/08/25
Southern Methodist Mustangs SMU ( 8-4 )
Boston College Eagles BC ( 2-10 )
45   -   13
11/01/25
Louisville Cardinals LOU ( 8-4 )
Virginia Tech Hokies VT ( 3-9 )
28   -   16
11/01/25
Miami Hurricanes MIA ( 10-2 )
Southern Methodist Mustangs SMU ( 8-4 )
20   -   26
10/25/25
Southern Methodist Mustangs SMU ( 8-4 )
Wake Forest Demon Deacons WAKE ( 8-4 )
12   -   13

Line History

time fav line total
Opening 16 Nov 8:39pm LOU O +53.5 -110
Closing 22 Nov 8:04pm LOU U +44.5 -190

Line History

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Matchup Edge - Scoring Stats

Southern Methodist Mustangs SMU
avg rank edge in rank avg
30.17 52 Points Per Game 32 32.92
21.08 37 Points Allowed Per Game 35 20.67
6.92 35 1st Quarter Scoring Per Game 54 5.67
5.83 55 1st Quarter Scoring Allowed Per Game 11 2.75
8.83 53 2nd Quarter Scoring Per Game 42 9.67
6 30 2nd Quarter Scoring Allowed Per Game 44 6.75
6.25 49 3rd Quarter Scording Per Game 49 6.25
3.25 17 3rd Quarter Scoring Allowed Per Game 15 3.08
7.67 45 4th Quarter Scoring Per Game 8 10.25
5 28 4th Quarter Scoring Allowed Per Game 65 7.25
84.2 48 Red Zone Efficiency 21 90.0
388.83 70 Total Yards Per Game 36 419
11.84 85 Total Yards Per Play 89 11.75
5.07 23 Rushing Yards Per Play 54 4.41
32.83 35 Passing Attempts Per Game 17 35.67
10.77 102 Passing Yards Per Completion 60 11.98
1.33 25 Passing Tds Per Game 11 2.17
21 32 Completions Per Game 11 23.67
64.0 44 Completion % 30 66.4
130.68 87 Qb Rating 39 148.5
1.75 27 Defense Sacks Per Game 31 1.58
0.75 11 Defense Interceptions Per Game 9 0.83
0.58 9 Opponent Fumbles Lost Per Game 11 0.5
7 76 Penalties Per Game 77 7.08
64.5 155 Penalty Yards Per Game 170 73
16 14 Takeaway / Giveaway Differential 14 16
8.92 7 Yards Per Punt Return 60 3.23
22.69 39 Yards Per Kickoff Return 124 17.47

Team Leaders

Louisville Cardinals LOU
Southern Methodist Mustangs SMU
TJ Harden
Running Back Louisville
8 Touchdowns 6
Chris Bell
Wide Receiver Southern Methodist
Isaac Brown
Running Back Southern Methodist
782 Rushing 747
TJ Harden
Running Back Louisville
Kevin Jennings
Quarterback Louisville
3363 Passing 2526
Miller Moss
Quarterback Southern Methodist
Chris Bell
Wide Receiver Southern Methodist
72 Receiving 56
Jordan Hudson
Wide Receiver Louisville
Isaiah Smith
Defensive End Louisville
9 Sacks 6.5
Clev Lubin
Defensive Lineman Southern Methodist
Ahmaad Moses
Safety Louisville
5 Interceptions 3
Antonio Watts
Linebacker Southern Methodist
Louisville Cardinals LOU
Southern Methodist Mustangs SMU
TJ Harden
Running Back Louisville
2 Touchdowns 2
Isaac Brown
Running Back Southern Methodist
Keyjuan Brown
Running Back Southern Methodist
112 Rushing 40
TJ Harden
Running Back Louisville
Kevin Jennings
Quarterback Louisville
278 Passing 153
Miller Moss
Quarterback Southern Methodist
Yamir Knight
Wide Receiver Louisville
7 Receiving 6
Caullin Lacy
Wide Receiver Southern Methodist
Clev Lubin
Defensive Lineman Southern Methodist
1.5 Sacks 1
Billy Walton III
Defensive End Louisville
Alex Kilgore
Linebacker Louisville
1 Interceptions 0
Isaac Brown
Running Back Southern Methodist

Matchup Details

team win loss last 10 w/l streak ats money home away total
Louisville Cardinals Louisville Cardinals
7 3 6-4 1W 4-6 0 0-0 0-0 5-5
Southern Methodist Mustangs Southern Methodist Mustangs
7 3 7-3 1L 4-6 0 0-0 0-0 3-7

Team Rankings

offence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 419 36
Passing Yards 283.5 12
Rushing Yards 135.5 91
Points Scored 32.92 144
Field Goal % 0.61 165
defence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 419 36
Passing Yards 283.5 12
Rushing Yards 135.5 91
Points Scored 32.92 144
Field Goal % 0.61 165

Weather

No weather to report.

Injuries

Louisville Cardinals LOU
Southern Methodist Mustangs SMU