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Louisville Cardinals vs. Southern Methodist Mustangs Odds, Stats November 22, 2025

Final Score
Nov 22nd, 12:00 PM EST
Louisville
Cardinals
Southern Methodist
Mustangs
6
38
Louisville Cardinals
Southern Methodist Mustangs
Scoreboard 1 2 3 4 Odds
Louisville Cardinals 8-4 3 3 0 0 +49.5
Southern Methodist Mustangs 8-4 7 14 3 14 -3.5

Latest Encounters

Date Result Competition Stats Recap
01/02/26
Arizona Wildcats ARIZ ( 9-3 )
Southern Methodist Mustangs SMU ( 8-4 )
19   -   24
12/23/25
Toledo Rockets TOL ( 8-4 )
Louisville Cardinals LOU ( 8-4 )
22   -   27
11/29/25
Southern Methodist Mustangs SMU ( 8-4 )
California Golden Bears CAL ( 7-5 )
35   -   38
11/29/25
Kentucky Wildcats UK ( 5-7 )
Louisville Cardinals LOU ( 8-4 )
0   -   41
11/14/25
Clemson Tigers CLEM ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
20   -   19
11/08/25
California Golden Bears CAL ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
29   -   26
11/08/25
Southern Methodist Mustangs SMU ( 8-4 )
Boston College Eagles BC ( 2-10 )
45   -   13
11/01/25
Louisville Cardinals LOU ( 8-4 )
Virginia Tech Hokies VT ( 3-9 )
28   -   16
11/01/25
Miami Hurricanes MIA ( 10-2 )
Southern Methodist Mustangs SMU ( 8-4 )
20   -   26
10/25/25
Southern Methodist Mustangs SMU ( 8-4 )
Wake Forest Demon Deacons WAKE ( 8-4 )
12   -   13

Matchup Odds

Team Spread Moneyline Over / Under
Louisville Cardinals LOU
+3.5 0 0 U+49.50
Southern Methodist Mustangs SMU
-3.5 0 0 O+49.50

Line History

time fav spread money line total
Opening 16 Nov 8:39pm LOU -3 -110 - O +53.5 -110
Closing 16 Nov 8:39pm LOU -3 -110 - O +53.5 -110

Line History

Team Leaders

Louisville Cardinals LOU
Southern Methodist Mustangs SMU
TJ Harden
Running Back Louisville
8 Touchdowns 6
Chris Bell
Wide Receiver Southern Methodist
Isaac Brown
Running Back Southern Methodist
782 Rushing 747
TJ Harden
Running Back Louisville
Kevin Jennings
Quarterback Louisville
3363 Passing 2526
Miller Moss
Quarterback Southern Methodist
Chris Bell
Wide Receiver Southern Methodist
72 Receiving 56
Jordan Hudson
Wide Receiver Louisville
Isaiah Smith
Defensive End Louisville
9 Sacks 6.5
Clev Lubin
Defensive Lineman Southern Methodist
Ahmaad Moses
Safety Louisville
5 Interceptions 3
Antonio Watts
Linebacker Southern Methodist
Louisville Cardinals LOU
Southern Methodist Mustangs SMU
TJ Harden
Running Back Louisville
2 Touchdowns 2
Isaac Brown
Running Back Southern Methodist
Keyjuan Brown
Running Back Southern Methodist
112 Rushing 40
TJ Harden
Running Back Louisville
Kevin Jennings
Quarterback Louisville
278 Passing 153
Miller Moss
Quarterback Southern Methodist
Yamir Knight
Wide Receiver Louisville
7 Receiving 6
Caullin Lacy
Wide Receiver Southern Methodist
Clev Lubin
Defensive Lineman Southern Methodist
1.5 Sacks 1
Billy Walton III
Defensive End Louisville
Alex Kilgore
Linebacker Louisville
1 Interceptions 0
Isaac Brown
Running Back Southern Methodist

Matchup Details

Louisville Cardinals LOU
Southern Methodist Mustangs SMU
Stat
7 Games Won 7
3 Games Lost 3
6-4 Last 10 7-3
0-0 W L Streak 0-0
4-6 Against The Spread 4-6
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
5-5 Total 3-7

Recent Meetings

date home-away ats o/u SMU:Total Net Yards SMU:Net Rushing Yards SMU:Passing Yards LOU:Total Net Yards LOU:Net Rushing Yards LOU:Passing Yards
11/22/2025 SMU 38 - LOU 6 SMU -3.5 Under 53.5 485 178 307 228 128 100
10/05/2024 LOU 27 - SMU 34 SMU +7 Over 58 481 190 291 461 132 329
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/23/2025 LOU 27 - TOL 22 L -9.5 Over 44.5 336 169 167
11/29/2025 LOU 41 - UK 0 W -3.5 Under 47.5 140 40 100
11/22/2025 SMU 38 - LOU 6 L +3.5 Under 53.5 228 128 100
11/14/2025 LOU 19 - CLEM 20 W +5.5 Under 60.5 323 136 187
11/08/2025 LOU 26 - CAL 29 L -18.5 Over 49.5 427 77 350
11/01/2025 VT 16 - LOU 28 W -10.5 Under 54.5 371 235 136
10/25/2025 LOU 38 - BC 24 L -25.5 Over 54.5 360 116 244
10/17/2025 MIA 21 - LOU 24 W +10.5 Under 49.5 367 119 248
10/04/2025 LOU 27 - UVA 30 L -6.5 Under 61.5 237 88 149
09/27/2025 PITT 27 - LOU 34 W -3.5 Over 54.5 392 53 339
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/02/2026 SMU 24 - ARIZ 19 W -2.5 Under 55.5 392 114 278
11/29/2025 CAL 38 - SMU 35 L -11.5 Over 53.5 453 123 330
11/22/2025 SMU 38 - LOU 6 W -3.5 Under 53.5 485 178 307
11/08/2025 BC 13 - SMU 45 W -12.5 Over 54.5 390 106 284
11/01/2025 SMU 26 - MIA 20 W +8.5 Under 50.5 388 23 365
10/25/2025 WAKE 13 - SMU 12 L -3.5 Under 54.5 301 85 216
10/18/2025 CLEM 24 - SMU 35 W +10 Over 50.5 352 35 317
10/11/2025 SMU 34 - STAN 10 W -19.5 Under 55.5 369 122 247
10/04/2025 SMU 31 - SYR 18 L -17.5 Under 57.5 370 76 294
09/20/2025 TCU 35 - SMU 24 L +6.5 Under 63.5 517 138 379

Odds Analysis

Team Rankings

Louisville Cardinals LOU
Season stats rank
Total Yards 301.6 577
Passing Yards 190.58 588
Rushing Yards 111 582
Points Scored 21.08 170
Field Goal % 0.88 629
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 391.3 646
Passing Yards 284.67 695
Rushing Yards 106.67 579
Points Scored 20.67 149
Field Goal % 0.77 583
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 221
Field Goal % 0.82 80
Southern Methodist Mustangs SMU
Season stats rank
Total Yards 419 36
Passing Yards 283.5 12
Rushing Yards 135.5 91
Points Scored 32.92 144
Field Goal % 0.61 165

Injuries

Louisville Cardinals LOU
Southern Methodist Mustangs SMU

Betting News + Tweets

Louisville Cardinals LOU

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Southern Methodist Mustangs SMU

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Louisville Vs Southern Methodist Betting Trends

Louisville Cardinals LOU

Cardinals are 2-8 ATS in their last 10 games as a road underdog of 3.5-10.0.

Cardinals are 2-5 ATS in their last 7 games following a ATS win.

Cardinals are 4-1 ATS in their last 5 games as a road underdog.

Over is 10-2-1 in Cardinals last 13 games as a favorite of 10.5 or greater.

Cardinals are 5-0 ATS in their last 5 road games.

Southern Methodist Mustangs SMU

Under is 4-0 in Mustangs last 4 games as a home underdog of 3.5-10.0.

Mustangs are 4-1 ATS in their last 5 conference games.

Mustangs are 1-8 ATS in their last 9 games as a home underdog of 0.5-3.0.

Under is 5-1 in Mustangs last 6 games as a home underdog of 10.5 or greater.

Under is 4-1 in Mustangs last 5 games as a favorite.

Line Up - Last Game

Louisville Cardinals
Pitchers
POS Player
Hitters
POS Player
Southern Methodist Mustangs
Pitchers
POS Player
Hitters
POS Player
  • LOU
  • +3.5 -3.5
  • SMU
NCAAF Odds