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Louisville Cardinals vs. Pittsburgh Panthers Odds, Stats - September 27, 2025

Final Score
Sep 27th, 12:00 PM EDT
Louisville
Cardinals
Pittsburgh
Panthers
34
27
Louisville Cardinals
Pittsburgh Panthers
Scoreboard 1 2 3 4 Odds
Louisville Cardinals 8-4 0 17 3 14 +54.5
Pittsburgh Panthers 8-4 17 10 0 0 +3

Latest Encounters

Date Result Competition Stats Recap
12/27/25
Pittsburgh Panthers PITT ( 8-4 )
East Carolina Pirates ECU ( 8-4 )
17   -   23
12/23/25
Toledo Rockets TOL ( 8-4 )
Louisville Cardinals LOU ( 8-4 )
22   -   27
11/29/25
Kentucky Wildcats UK ( 5-7 )
Louisville Cardinals LOU ( 8-4 )
0   -   41
11/29/25
Miami Hurricanes MIA ( 10-2 )
Pittsburgh Panthers PITT ( 8-4 )
38   -   7
11/22/25
Pittsburgh Panthers PITT ( 8-4 )
Georgia Tech Yellow Jackets GT ( 9-3 )
42   -   28
11/22/25
Louisville Cardinals LOU ( 8-4 )
Southern Methodist Mustangs SMU ( 8-4 )
6   -   38
11/15/25
Notre Dame Fighting Irish ND ( 10-2 )
Pittsburgh Panthers PITT ( 8-4 )
37   -   15
11/14/25
Clemson Tigers CLEM ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
20   -   19
11/08/25
California Golden Bears CAL ( 7-5 )
Louisville Cardinals LOU ( 8-4 )
29   -   26
11/01/25
Pittsburgh Panthers PITT ( 8-4 )
Stanford Cardinal STAN ( 4-8 )
35   -   20
11/01/25
Louisville Cardinals LOU ( 8-4 )
Virginia Tech Hokies VT ( 3-9 )
28   -   16
10/25/25
NC State Wolfpack NCST ( 7-5 )
Pittsburgh Panthers PITT ( 8-4 )
34   -   53

Matchup Odds

Team Spread Moneyline Over / Under
Louisville Cardinals LOU
-3 0 0 U+54.50
Pittsburgh Panthers PITT
+3 0 0 O+54.50

Line History

time fav line total
Opening 21 Sep 7:43pm LOU O +56.5 -110
Closing 27 Sep 7:25pm LOU O +68.5 -105

Line History

Team Leaders

Louisville Cardinals LOU
Pittsburgh Panthers PITT
Ja'Kyrian Turner
Running Back Louisville
7 Touchdowns 6
Chris Bell
Wide Receiver Pittsburgh
Isaac Brown
Running Back Pittsburgh
782 Rushing 654
Ja'Kyrian Turner
Running Back Louisville
Miller Moss
Quarterback Pittsburgh
2526 Passing 2101
Mason Heintschel
Quarterback Louisville
Chris Bell
Wide Receiver Pittsburgh
72 Receiving 48
Kenny Johnson
Wide Receiver Louisville
Clev Lubin
Defensive Lineman Pittsburgh
6.5 Sacks 4.5
Jimmy Scott
Defensive Lineman Louisville
Kavir Bains-Marquez
Defensive Back Louisville
3 Interceptions 3
Antonio Watts
Linebacker Pittsburgh
Louisville Cardinals LOU
Pittsburgh Panthers PITT
Isaac Brown
Running Back Pittsburgh
2 Touchdowns 1
Raphael Williams Jr.
Wide Receiver Louisville
Keyjuan Brown
Running Back Pittsburgh
112 Rushing 93
Ja'Kyrian Turner
Running Back Louisville
Mason Heintschel
Quarterback Louisville
256 Passing 153
Miller Moss
Quarterback Pittsburgh
Justin Cook
Running Back Louisville
6 Receiving 6
Caullin Lacy
Wide Receiver Pittsburgh
Rasheem Biles
Linebacker Louisville
2 Sacks 1.5
Clev Lubin
Defensive Lineman Pittsburgh
Kavir Bains-Marquez
Defensive Back Louisville
0 Interceptions 0
Isaac Brown
Running Back Pittsburgh

Matchup Details

team win loss last 10 w/l streak ats money home away total
Louisville Cardinals Louisville Cardinals
3 0 6-4 1W 0-3 0 0-0 0-0 2-1
Pittsburgh Panthers Pittsburgh Panthers
2 1 6-4 1L 2-1 0 0-0 0-0 2-1

Recent Meetings

date home-away ats o/u PITT:Total Net Yards PITT:Net Rushing Yards PITT:Passing Yards LOU:Total Net Yards LOU:Net Rushing Yards LOU:Passing Yards
09/27/2025 PITT 27 - LOU 34 LOU -3.5 Over 54.5 339 80 259 392 53 339
11/23/2024 LOU 37 - PITT 9 LOU -7 Under 57 265 75 190 505 212 293
10/14/2023 PITT 38 - LOU 21 PITT +7.5 Over 44.5 430 80 350 288 88 200
10/22/2022 LOU 24 - PITT 10 LOU -1 Under 55 326 168 158 312 122 190
09/26/2020 PITT 23 - LOU 20 PITT -3.5 Under 53 223 116 107 376 156 220
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/23/2025 LOU 27 - TOL 22 L -9.5 Over 44.5 336 169 167
11/29/2025 LOU 41 - UK 0 W -3.5 Under 47.5 140 40 100
11/22/2025 SMU 38 - LOU 6 L +3.5 Under 53.5 228 128 100
11/14/2025 LOU 19 - CLEM 20 W +5.5 Under 60.5 323 136 187
11/08/2025 LOU 26 - CAL 29 L -18.5 Over 49.5 427 77 350
11/01/2025 VT 16 - LOU 28 W -10.5 Under 54.5 371 235 136
10/25/2025 LOU 38 - BC 24 L -25.5 Over 54.5 360 116 244
10/17/2025 MIA 21 - LOU 24 W +10.5 Under 49.5 367 119 248
10/04/2025 LOU 27 - UVA 30 L -6.5 Under 61.5 237 88 149
09/27/2025 PITT 27 - LOU 34 W -3.5 Over 54.5 392 53 339
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/27/2025 ECU 23 - PITT 17 L -6 Under 51.5 249 72 177
11/29/2025 PITT 7 - MIA 38 L +6.5 Under 50.5 229 30 199
11/22/2025 GT 28 - PITT 42 W +2.5 Over 62.5 378 121 257
11/15/2025 PITT 15 - ND 37 L +10.5 Under 54.5 219 70 149
11/01/2025 STAN 20 - PITT 35 W -14 Over 51.5 326 -10 336
10/25/2025 PITT 53 - NCST 34 W -8.5 Over 57.5 529 106 423
10/18/2025 SYR 13 - PITT 30 W -10.5 Under 54.5 212 76 136
10/11/2025 FSU 31 - PITT 34 W +10.5 Over 58.5 415 170 245
10/04/2025 PITT 48 - BC 7 W -6 Under 55.5 503 172 331
09/27/2025 PITT 27 - LOU 34 L +3.5 Over 54.5 339 80 259

Matchup Edge - Scoring Stats

Louisville Cardinals LOU
Pittsburgh Panthers PITT
avg rank edge in rank avg
30.17 52 Points Per Game 22 35.08
21.08 37 Points Allowed Per Game 71 24.92
6.92 35 1st Quarter Scoring Per Game 21 8.33
5.83 55 1st Quarter Scoring Allowed Per Game 25 4
8.83 53 2nd Quarter Scoring Per Game 16 11.67
6 30 2nd Quarter Scoring Allowed Per Game 72 8.83
6.25 49 3rd Quarter Scording Per Game 22 8.17
3.25 17 3rd Quarter Scoring Allowed Per Game 22 3.58
7.67 45 4th Quarter Scoring Per Game 56 6.92
5 28 4th Quarter Scoring Allowed Per Game 76 7.92
84.2 48 Red Zone Efficiency 52 83.3
388.83 70 Total Yards Per Game 64 392
11.84 84 Total Yards Per Play 99 11.09
5.07 22 Rushing Yards Per Play 96 3.58
32.83 33 Passing Attempts Per Game 19 35.33
10.77 98 Passing Yards Per Completion 43 12.5
1.33 25 Passing Tds Per Game 8 2.33
21 32 Completions Per Game 25 22
64.0 45 Completion % 58 62.3
130.68 86 Qb Rating 56 142.83
1.75 27 Defense Sacks Per Game 6 3.33
0.75 11 Defense Interceptions Per Game 5 1.17
0.58 9 Opponent Fumbles Lost Per Game 15 0.33
7 76 Penalties Per Game 86 7.67
64.5 154 Penalty Yards Per Game 167 70.08
16 14 Takeaway / Giveaway Differential 16 18
8.92 7 Yards Per Punt Return 19 6.06
22.69 39 Yards Per Kickoff Return 36 22.86

Odds Analysis

Team Rankings

offence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Pittsburgh Panthers PITT
Season stats rank
Total Yards 392 64
Passing Yards 275 20
Rushing Yards 117 115
Points Scored 35.08 102
Field Goal % 0.8 94
defence
Louisville Cardinals LOU
Season stats rank
Total Yards 388.8 70
Passing Yards 226.25 67
Rushing Yards 162.58 64
Points Scored 30.17 222
Field Goal % 0.82 80
Pittsburgh Panthers PITT
Season stats rank
Total Yards 392 64
Passing Yards 275 20
Rushing Yards 117 115
Points Scored 35.08 102
Field Goal % 0.8 94

Injuries

Louisville Cardinals LOU
Pittsburgh Panthers PITT

Betting News + Tweets

Louisville Cardinals LOU

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Pittsburgh Panthers PITT

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Line Up - Last Game

Louisville Cardinals
Pitchers
POS Player
Hitters
POS Player
Pittsburgh Panthers
Pitchers
POS Player
Hitters
POS Player
  • LOU
  • -3 +3
  • PITT
NCAAF Odds