The NFC South-leading Panthers host a struggling Tampa Bay team that could get Baker Mayfield back, but injuries leave the Bucs facing another difficult matchup.
The unbeaten San Francisco 49ers put their 6-0 record on the line in Atlanta, where the Falcons are trying to stop a two-game slide and finally win at home.
The Bengals visit Baltimore with the AFC North race tightly packed, while Lamar Jackson’s uncertain status adds another layer to a matchup between two divisional contenders.
The Roughriders can lock up third place in the West when they host an Edmonton team expected to rest several starters after already clinching the division.
Chelsea are on course for a return to the Champions League this season, with Xabi Alonso’s side having registered four wins in their opening seven games.
The RedBlacks aim to close out a lost 2026 CFL campaign on a high note when they visit the beleaguered Tiger-Cats on Sunday afternoon at Hamilton Stadium.
The Bolts carry a three-game winning streak into Colorado, where the Avalanche look to rebound from consecutive road losses in a matchup between two of the league’s most dangerous offences.