Liverpool vs. Manchester United EPL Preview and Prediction
It’s Reds vs Red Devils this week in a highly anticipated English Premier League rivalry between mid-table Manchester United and former league-leaders Liverpool.
A win for United this weekend would be the biggest shake-up of the season so far, but it won’t be easy with Liverpool seeking vengeance at Anfield since dropping to second place.
Tune in to kick off this Sunday at 11:30 a.m. ET, and feel free to get the rundown of the greatest picks for this week’s clash by reviewing my matchup picks below.
Liverpool is a -160 favourite to win on the EPL odds, while United is a +375 underdog. A regulation draw is listed at +340.
Liverpool vs. Manchester United EPL Odds and Betting Trends
Liverpool is weakened, Manchester United is desperate and both teams are hungry for a crucial three points out of this one. The last five meetings between the two sides saw Liverpool win two Premier League matches and draw two, with United knocking out the Reds in the FA Cup quarter-finals in the 2023-2024 season with a 4-3 extra-time win. The most recent matchup on Matchday 20 of the 2024-2025 season ended in a 2-2 draw at Anfield.
Out of the last four home games where Liverpool faced the Red Devils, they’ve scored 11 goals, yet their last two home games ended in 0-0 and 2-2 draws. With the last five matchups between the two seeing a total of 18 goals, an under 3.5 today is listed at -135. Liverpool are your majority favourites at -160 with Anfield at their back, although these teams are no strangers to drawing in these big-time matchups, with a tie for today’s match set at +340. United has a lot of ground to cover this morning, coming into the match-up at +375 to win on away soil.
Liverpool
Now’s the time for Liverpool to prove their toughness and overcome adversity after suffering three losses in a row, two in the EPL to Chelsea and Crystal Palace, and one to Galatasaray in the Champions League. The Reds will most certainly seek another first-place finish by the end of this season, meaning a win over Manchester United is necessary.
Liverpool takes the top five anytime goalscorer odds for today’s match with Alexandar Isak (+110), Hugo Ekitike (+115), Mohammad Salah (+130), Cody Gakpo (+225) and Federico Chiesa (+255), all set to score before any United player. Ekitikie will want to end his goal-scoring drought after netting three this season already, with Gakpo and Salah close behind with two each.
Manchester United
Tenth-place Manchester United will take any points they can get to avoid another sub-14th-place finish by the end of the season. While they lost 3-1 to Brentford on Sep. 27, their most recent match ended in 2-0 victory over Sunderland, and they showcase a promising 2-1 result over Chelsea in Matchweek 5, one of the two teams that beat Liverpool this season.
Benjamin Sesko and Bruno Fernandes are the only stand-out goal scorers this season for the Red Devils, each with two goals. Sesko comes into this one at +280 to score anytime, with Fernandes marked at +425 – so United will need to pray for another stroke of luck to pull ahead in this one.
EPL Prediction: Who Will Win Liverpool vs. Manchester United?
While draws are prominent in these matchups, Liverpool has much to play for. They are on an uncharacteristic three-game losing streak, have some of the best talent and passion out of all of Europe and play at home today for the potential 12th man. United aren’t having a showstopping season regardless of how poor Liverpool performs, and with those key factors in mind, I’m thinking Liverpool will take a 3-0 win today with Salah and Gakpo finding the back of the net in this one.