Manchester United vs. Tottenham Premier League Betting Odds, Picks: Red Devils favoured at Old Trafford

This weekend’s EPL matchups are packed with competitive showdowns you won’t want to miss.

Catch a long-standing rivalry between Manchester United and Tottenham Hotspur in matchweek six of the Premier League as Spurs head to Old Trafford.

Brace yourself for an epic contest, with kick-off on Saturday at 12:30 p.m. ET.

Manchester United vs. Tottenham EPL Odds and Betting Trends

After 207 games played between the two sides, United have the upper hand with 97 wins compared to the 58 of Tottenham. There have been 52 draws.

However, until United’s win in the most recent meeting in February, Spurs had put together an eight-game unbeaten streak against the red side of Manchester.

Tottenham have struggled at Old Trafford, though, with just one win picked up in their last five trips to the Theatre of Dreams.

For Saturday’s contest, the Red Devils are priced at -165 to get the win on the EPL odds, with Spurs available at +350 and the draw set at +320.

It is -158 for there to be under 3.5 goals, with the over set at +128.

Tottenham

Spurs secured their Premier League status on the final day of last season and they spent big this summer in a bid to enjoy a more produced 2026-27 campaign.

However, things are not going to plan for Tottenham and they find themselves bottom of the standings after the opening five games on two points.

Robert De Zerbi’s side are yet to win a league match, mixing two draws with three defeats, while their only victory this term came in the EFL Cup against Charlton.

Pressure is mounting on De Zerbi but a win at Old Trafford, which can be backed at +350, would help to ease the burden.

The good news for Tottenham is that James Maddison is expected to return for this contest after a spell on the sidelines. He is +330 to score any time, while teammate Savio is available at +490.

Manchester United

The Red Devils may look at this clash as a great opportunity to pick up the win, but they also haven’t been performing up to standards as they sit in 12th place with only one win from five attempts.

Michael Carrick’s men suffered a 1-0 loss to rivals City in the league before losing 3-2 against Brighton in the EFL Cup.

A 1-1 draw then came against Fulham prior to the international break and even that was fortunate, as United needed an 89th-minute equalizer from Matheus Cunha.

Bruno Fernandes has been at the forefront of the team’s midfield and offence, as the Portuguese star comes back from the break with three EPL goals. He is +145 to score any time.

Teammate Benjamin Sesko takes the highest likely goalscorer spot at +130, as he eyes his third goal of the campaign.

EPL Prediction: Who Will Win Manchester United vs. Tottenham?

The biggest consideration here is that Tottenham’s struggles persist from last season to the present.

United suffered several mishaps leading to two draws and two losses (one of them to City) this term, but the Red Devils have still scored six more goals than their opponents this season.

A huge factor to consider is Tottenham’s lacklustre offence, with De Zerbi’s side failing to score for their first four straight EPL games, only breaking through recently against Aston Villa before the break.

With United at home, showcasing a much higher-quality lineup than the Spurs with better goalscoring ability, it’s not a question of if the Red Devils will win, but by how much.

All things considered, go with the United -1.5 spread at +162 odds, as we’re likely to see a 2-0 scoreline at the very least.