NFL Week 7 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Oct 19, 2020

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When the NFL schedule was released in May, a few Week 7 matchups looked terrific on paper. Now, it’s a bit of a mediocre slate overall with a few expected good teams having disappointed.

Here’s a quick look at all the Week 7 matchups with Sports Interaction’s NFL odds. Games Sunday unless noted. Indianapolis, Miami, Minnesota and Baltimore are on the bye.

New York Giants at Philadelphia Eagles, Thursday

Quite the ugly primetime matchup between one-win NFC East clubs. The Eagles were supposed to be good but aren’t very – in part because they have been gutted by injuries, especially on the offensive line and at receiver. Top running back Miles Sanders and Pro Bowl tight end Zach Ertz both left Sunday’s loss to Baltimore injured. The Giants got their first win of the season and of the Joe Judge era Sunday but nearly let Washington rally at the end.  Philadelphia has won nine of the past 10 vs. New York.

Point spread: Eagles -6

Pick ATS: Philadelphia

Detroit Lions at Atlanta Falcons

Perhaps the Falcons should have fired Coach Dan Quinn earlier as they looked like a totally different team under interim coach Raheem Morris on Sunday in getting their first victory of the season, 40-23 at Minnesota. Matt Ryan threw for 371 yards and four scores, two to Julio Jones. There were reports that the Lions were prepared to fire coach Matt Patricia if they lost Sunday in Jacksonville, but Detroit dominated in a 34-16 win.

Point spread: Falcons -3

Pick ATS: Atlanta (alternate line of -2.5)

Cleveland Browns at Cincinnati Bengals

This wraps up the season series between former Heisman winners Baker Mayfield and Joe Burrow. Cleveland won 35-30 in Week 2 on a Thursday. Burrow had the better numbers, but the Browns absolutely dominated with their ground game. Mayfield was pulled from Sunday’s lopsided loss to Pittsburgh, but Coach Kevin Stefanski made it clear he’s still the team’s starting QB.

Point spread: Browns -3.5

Pick ATS: Cleveland

Pittsburgh Steelers at Tennessee Titans

This was to be played Week 4, but the Titans’ COVID-19 issues pushed it back. They are the only two unbeaten teams left in the AFC. The Titans rode NFL rushing leader Derrick Henry’s 212 yards rushing and two scores in rallying past Houston on Sunday. However, Pro Bowl offensive tackle Taylor Lewan reportedly tore his ACL. The Steelers won their 17th in a row at home vs. the Browns, 38-7. The defence was brilliant.

Point spread: Steelers -1.5

Pick ATS: Tennessee

Carolina Panthers at New Orleans Saints

The Saints come off their bye week and will have All-Pro receiver Michael Thomas back in the lineup from injury/suspension for the first time since Week 1. The Panthers had a three-game winning streak snapped in a home loss to Chicago with QB Teddy Bridgewater having his worst game of the season. New Orleans swept Carolina in 2019. Bridgewater was with the Saints last year.

Point spread: Saints -7.5

Pick ATS: New Orleans (alternate line of -7)

Buffalo Bills at New York Jets

Short week for Buffalo after hosting Kansas City on Monday. The Jets are simply sad at this point as they are the only winless team in the league following a 24-0 loss in Miami on Sunday. Starting QB Sam Darnold missed his second in a row with a shoulder injury but might play this week. Buffalo beat the visiting Jets 27-17 in Week 1 in a fairly ugly, sloppy game overall that featured two turnovers for each team and nearly 170 yards in penalties.

Point spread: Bills -11 (may change after Monday)

Pick ATS: New York

Dallas Cowboys at Washington Football Team

Short week for Dallas after hosting Arizona on Monday in the Cowboys’ first game since QB Dak Prescott went down with a season-ending injury. It’s Andy Dalton’s team now. Washington coach Ron Rivera has always been very aggressive and was Sunday when he tried for two points and the win in the final seconds vs. the Giants, but Washington couldn’t convert. Dallas had little trouble sweeping Washington in 2019.

Point spread: Cowboys -3 (may change after Monday)

Pick ATS: Dallas (alternate line of -2.5)

Green Bay Packers at Houston Texans

Green Bay had looked like perhaps the NFC’s best team through five weeks but was blown off the map Sunday in a 38-10 loss in Tampa. Aaron Rodgers played one of the worst games of his career in completing just 45.7 percent of his passes with no TDs and two picks – one returned for a score. The Texans had the unbeaten Titans on the ropes Sunday but ended up losing 42-36 in OT. Interim Houston head coach Romeo Crennel made a puzzling decision to try for a two-point conversion when up 36-29 with under two minutes left. It didn’t work.

Point spread: Packers -3

Pick ATS: Green Bay (alternate line of -2.5)

Seattle Seahawks at Arizona Cardinals

Seattle comes out of its bye looking like the NFC’s best team (maybe the NFL’s) and with Russell Wilson as the MVP favourite. It’s a short week for Arizona as it visited Dallas on Monday night. These NFC West rivals split last year. The game in the desert was won 27-10 by Seattle. It was basically over at halftime. The Cards are much better this year.

Point spread: Seahawks -3

Pick ATS: Seattle (-2.5 alternate line)

Kansas City Chiefs at Denver Broncos

Short week for Kansas City after visiting Buffalo on Monday without No. 2 wideout Sammy Watkins due to injury. He’s not likely for this one, either. The Broncos pulled the biggest upset of Sunday despite not scoring a touchdown, 18-12 at New England. Kansas City swept Denver last year by a combined score of 53-9 despite Patrick Mahomes missing a half of one game due to injury. The Chiefs are on an eight-game winning streak in the series.

Point spread: Chiefs -8.5

Pick ATS: Denver

San Francisco 49ers at New England Patriots

This matchup looked great back in May, but the Niners have underachieved and the Patriots lost Tom Brady (who grew up not far from San Francisco as a Niners fan). San Francisco did snap a two-game skid Sunday night with a 24-16 upset of the Rams but lost top tailback Raheem Mostert to injury. The Patriots had been 39-0 all-time under Bill Belichick when not allowing a TD in a game. Make that 39-1 after Sunday’s stunning 18-12 home loss to Denver.

Point spread: Patriots -5

Pick ATS: New England

Jacksonville Jaguars at Los Angeles Chargers

Jacksonville continued its regression since a Week 1 win by losing 34-16 at home to one-win Detroit on Sunday. Coach Doug Marrone might be gone by the time you read this. The Bolts come out of their bye week on a four-game losing streak but easily could have won them all behind rising star rookie QB Justin Herbert. These clubs met Week 15 last year in Florida and the Chargers rolled 45-10. That was their only victory in their final seven games.

Point spread: Chargers -8

Pick ATS: Los Angeles

Tampa Bay Bucs at Las Vegas Raiders

Sunday night game. The Raiders were a rumored suitor for Tom Brady this offseason to stir up some buzz in their first year in Vegas. Of course, Raiders coach Jon Gruden was once traded by the franchise to Tampa Bay and led the Bucs to their only Super Bowl title around two decades ago. Tampa Bay was an impressive 38-10 home winner over Green Bay on Sunday despite a fairly quiet game from Brady. Las Vegas is off its bye week and stunned the Chiefs in K.C. in Week 5.

Point spread: Bucs -3

Pick ATS: Las Vegas (alternate line of +3.5)

Chicago Bears at Los Angeles Rams, Monday

This could have playoff tiebreaker ramifications with Chicago top the NFC North at 5-1 and L.A. second in the NFC West at 4-2. Don’t expect many points here as both offences are rather conservative and both defences good. The Rams hosted the Bears in Week 11 last year and won 17-7 in a horribly ugly defensive game.

Point spread: Rams -7

Pick ATS: L.A. (alternate line of -6.5)