NFL Week 6 Odds and Predictions: Best Picks Against the Spread
Here’s a look at all Week 6 games with NFL odds and played Sunday unless noted.
San Francisco 49ers at Seattle Seahawks, Thursday
Both teams had shocking home losses on Sunday, the 49ers blowing 13-pont halftime lead and falling to Arizona, and Seattle getting completely outplayed by the New York Giants. The Niners had to sign a new kicker this week in Matthew Wright as Jake Moody injured his ankle while attempting to make a tackle on a kick return Sunday. Star running back Christian McCaffrey will not make his season debut this week off injury. San Francisco has won five straight in the NFC West rivalry including playoffs. Both wins last year were by double digits.
Pick ATS: San Francisco (alternate line of -2.5)
Jacksonville Jaguars “at” Chicago Bears
Kickoff at 9:30 a.m. ET from Tottenham Hotspur Stadium in London and matchup of former No. 1 overall picks and quarterbacks in Jacksonville’s Trevor Lawrence and Chicago’s Caleb Williams. Both played well in home wins Sunday. Lawrence snapped a nine-start losing streak by throwing for a career-high 371 yards in a 37-34 win over the Colts. Williams threw for 304 yards and two scores in a blowout of Carolina, Chicago’s eighth straight home win. The Jags will stay in the UK after this game and face New England in Week 8.
Pick ATS: Chicago
Arizona Cardinals at Green Bay Packers
Arizona rallied from a 13-point halftime deficit on Sunday in San Francisco to stun the Niners 24-23 on a 35-yard field goal with 1:37 left. Kyler Murray threw for 195 yards and a TD and rushed for 83 yards and a score. Starting guard Will Hernandez suffered a season-ending injury. Green Bay was down starting wideouts Christian Watson (injury) and Romeo Doubs (one-game suspension) but won at the Rams 24-19 on Sunday. Green Bay defensive back Xavier McKinney became the first player since the 1970 merger with an interception in each of his first five games with a team.
Pick ATS: Green Bay
Indianapolis Colts at Tennessee Titans
The Titans are out of their bye and off their first win of the season, 31-12 in Miami, despite young starting QB Will Levis leaving early with a shoulder injury. Levis has struggled this year and Mason Rudolph played well in relief, but Coach Brian Callahan said Levis remains the starter if healthy. The Colts were down starting QB Anthony Richardson and No. 1 RB Jonathan Taylor and lost 37-34 in Jacksonville on Sunday. Both could return this week. Joe Flacco threw for 359 yards and three scores in place of Richardson, but Coach Shane Steichen says there is no QB controversy if Richardson is healthy. The Colts swept the 2023 series vs. the Titans but both were close.
Pick ATS: Tennessee
Houston Texans at New England Patriots
Could be a trap game for Houston off a 23-20 last-second home win over Buffalo on Sunday in a possible AFC playoff preview. The Texans are 4-1 this season despite a scoring margin of -12. That’s the second-worst scoring margin by a 4-1 team in NFL history behind the 1976 Raiders. Star Texans wideout Nico Collins left with a hamstring injury. New England lost its fourth in a row Sunday, 15-10 vs. Miami, and coach Jerod Mayo finally is hinting he might bench struggling veteran QB Jacoby Brissett for rookie Drake Maye. The Pats have lost seven straight at home.
Pick ATS: New England (alternate line of +7.5)
Tampa Bay Buccaneers at New Orleans Saints
The NFC South rivals split last year, each winning on the road by double digits. The Bucs left Tampa early this week for New Orleans ahead of Hurricane Milton. They played on Thursday in Week 5 and lost 36-30 in overtime in Atlanta. Mike Evans caught a TD pass for his 100th career NFL touchdown, the 26th player in NFL history to reach triple digits. It’s a short week for New Orleans after losing a third straight game Monday, 26-13 in Kansas City, with QB Derek Carr leaving with an oblique injury. His backup is 2023 fourth-round pick Jake Haener.
Pick ATS: Tampa Bay
Cleveland Browns at Philadelphia Eagles
Few teams needed a bye more than the Eagles as they played without their two superstar receivers in AJ Brown and DeVonta Smith and Pro Bowl right tackle Lane Johnson in their Week 4 blowout loss in Tampa. Good chance all three return for this one. Cleveland needs to move on from QB Deshaun Watson but simply can’t because of his monster contract. Watson was terrible again Sunday in a 34-13 loss in Washington. He has five straight games with at least 25 attempts and fewer than 200 passing yards, tied for the longest streak to start a season in the past 75 years by any NFL quarterback.
Pick ATS: Cleveland
Washington Commanders at Baltimore Ravens
This will be a fun matchup between electric dual-threat QBs in Commanders rookie Jayden Daniels and two-time league MVP Lamar Jackson of the Ravens. Washington tied its 2023 season win total on Sunday by improving to 4-1 with a blowout of Cleveland. Daniels joined Jackson (four times including this year) and Michael Vick (twice) as the only NFL QBs with at least 1,000 passing yards and 300 rushing yards through his team’s first five games of a season. Washington’s 13 rush TDs are tied for the most of any team through five games in the Super Bowl era. The Ravens looked dead Sunday in Cincinnati down 10 with about five minutes left but rallied for a 41-38 OT win. Jackson had his sixth career game with at least four passing TDs and 50 rushing yards, three more than any other player in league history.
Pick ATS: Baltimore
Los Angeles Chargers at Denver Broncos
The Bolts are 2-2 out of their bye week and look just like Coach Jim Harbaugh’s teams at Michigan: Rather conservative offensively with a run-heavy attack and a physical defence. QB Justin Herbert hasn’t been healthy for a few weeks so he needed the bye. A few other key players missed the Week 4 loss to Kansas City and should return. Denver won its third in a row Sunday, 34-18 over Las Vegas. Cornerback Patrick Surtain II had two picks, including returning one 100 yards for a TD. It was the Broncos’ most points scored since Week 14 in 2021. The Broncos swept the Chargers in 2023.
Pick ATS: Denver (alternate line of +3.5)
Pittsburgh Steelers at Las Vegas Raiders
Could Pittsburgh coach Mike Tomlin be ready to change quarterbacks? It depends on if Russell Wilson is cleared to make his debut, but the Steelers struggled again offensively on Sunday night in their second straight loss, 20-17 to Dallas. Justin Fields was pretty solid with two TD passes and no turnovers but also only 131 yards passing. The Raiders played without Pro Bowl receiver Davante Adams, who is likely to be traded this week after requesting one, and lost 34-18 in Denver. Starting QB Gardner Minshew was pulled for Aidan O’Connell and Coach Antonio Pierce hasn’t decided yet who starts this week. It’s probably O’Connell’s turn.
Pick ATS: Pittsburgh (alternate line of -2.5)
Detroit Lions at Dallas Cowboys
Detroit comes off its bye week after a historic showing from QB Jared Goff in the team’s 42-29 home win over Seattle in Week 4 as Goff was 18-for-18 for 292 yards and two scores, and he even caught a TD pass from receiver Amon-Ra St. Brown. Kurt Warner had the previous league mark for the passes without an incompletion, going 10-for-10 for Arizona against Houston in 2005. Yet Goff didn’t even get a game ball as Coach Dan Campbell said he blew it not realizing his QB had been perfect. Dallas was a 20-17 winner in Pittsburgh on Sunday night on a Dak Prescott 4-yard TD pass in the final minute. The Cowboys were without All-Pro pass-rusher Micah Parsons, who might be back this week.
Pick ATS: Dallas
Atlanta Falcons at Carolina Panthers
Atlanta pulled into a tie for first in the NFC South with a wild 36-30 OT home win over Tampa Bay on Thursday in Week 5 behind a franchise-record 509 yards passing from Kirk Cousins. He became the first player in NFL history with a 450-yard passing game with three different teams (also Washington and Minnesota). Carolina was blown out in Chicago on Sunday. The Panthers’ 165 points allowed are the most in franchise history through five games. Carolina only had two wins in 2023 but one was home to Atlanta.
Pick ATS: Atlanta
Cincinnati Bengals at New York Giants
Sunday night game. The teams have combined for only three wins and there was some discussion about flexing it out but no dice. Cincinnati could easily be 5-1 but lost another tough one Sunday, 41-38 in OT to Baltimore despite leading by 10 with about five minutes left in regulation. Kicker Evan McPherson, one of the NFL’s best, missed a potential winning 53-yard field goal in OT due to a bad hold. It was the most points scored for Cincinnati in a loss since 2007. The Giants have played better on the road this year and upset the Seahawks in Seattle on Sunday, 29-20, despite playing without No. 1 running back Devin Singletary and stellar rookie WR Malik Nabers. Both could return this week.
Pick ATS: Cincinnati (alternate line of -3)
Buffalo Bills at New York Jets, Monday
Buffalo was dominant offensively in its 3-0 start but has scuffled in losing two straight. QB Josh Allen managed just 131 yards passing on 9-for-30 in Sunday’s 23-20 loss in Houston on a long last-second field goal. Allen’s completion per centage of only 30 was the worst by any NFL quarterback with at least 30 attempts since 1992. Buffalo had eight punts, tied for its most in a game with Allen. The Jets lost 23-17 to Minnesota in London with Aaron Rodgers throwing three picks and suffering a minor injury, although he says he will be fine for this one. The tabloids were calling for the head of Coach Robert Saleh, and he was fired on Tuesday. Defensive coordinator Jeff Ulbrich will step in as interim head coach. The teams split last season, each winning at home.
Pick ATS: New York (alternate line of +3)