NFL Week 3 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Sep 21, 2020

chiefs vs ravens

It’s only Week 3 of this NFL season, but it’s fair to say the most anticipated regular-season game of the year has arrived: Kansas City at Baltimore between the two Super Bowl favourites.

Here’s a quick look at all the Week 3 matchups with Sports Interaction’s NFL odds. Games Sunday unless noted.

Miami Dolphins at Jacksonville Jaguars, Thursday

Miami is 0-2 following a close home loss to Buffalo on Sunday. The clock is ticking on how much longer veteran QB Ryan Fitzpatrick remains the team’s starter over No. 5 overall pick Tua Tagovailoa. The Jaguars have been much more competitive than expected, upsetting Indianapolis in Week 1 and pushing the Titans to the wire in a 33-30 loss on Sunday. It’s the first regular-season meeting between the state rivals since Week 16 of 2018 when the Jaguars were 17-7 upset winners in Miami.

Point spread: Jaguars -3

Pick ATS: Jacksonville (-2.5 alternate line)

Chicago Bears at Atlanta Falcons

How is this for a statistic? Entering Sunday, teams that scored at least 39 points in an NFL game and didn’t turn the ball over once were 440-0 all-time. Make that 440-1 after the Falcons somehow blew a 15-point lead with less than two minutes remaining at the Cowboys and lost 40-39 on Sunday. It’s a minor miracle Coach Dan Quinn, who is already on a major hot seat, wasn’t fired immediately. The Bears improved to 2-0 with a 17-13 win over the New York Giants on Sunday. Mitchell Trubisky had two TD passes.

Point spread: Falcons -3

Pick ATS: Atlanta (alternate line of -2.5)

Los Angeles Rams at Buffalo Bills

The Rams return to the East Coast for a second straight week after knocking off the Eagles 37-19 in Philadelphia on Sunday to improve to 2-0. Jared Goff threw three TD passes, all to tight end Tyler Higbee. The Bills look like the team to beat in the AFC East at 2-0 after winning 31-28 in Miami on Sunday. Josh Allen had a career-high 417 yards passing and Buffalo totaled 524 yards, its most since 2000.

Point spread: Bills -3

Pick ATS: Buffalo (-2.5 alternate line)

Washington Football Team at Cleveland Browns

The Browns looked like a completely different offensive team Thursday in Week 2 in beating the Bengals 35-30 than they did in getting destroyed Week 1 in Baltimore. Then again, the competition level was quite different vs. Cincinnati. Washington is 1-1 as well following a 30-15 loss at Arizona on Sunday. It wasn’t really that close.

Point spread: Browns -7

Pick ATS: Cleveland (alternate line of -6.5)

Tennessee Titans at Minnesota Vikings

The Vikings are one of the biggest surprises of the early season and not in a good way at 0-2. They were dominated Sunday in a 28-11 loss at Indianapolis. Kirk Cousins was terrible, completing just 11 of 26 for 113 yards and three picks. He had had a 0.0 passer rating late into the third quarter. The Titans could easily be 0-2 but are 2-0, winning those games by a combined five points. Stephen Gostkowski hit the winning 49-yard field goal Sunday against the Jaguars late in the fourth quarter.

Point spread: Titans -1.5

Pick ATS: Minnesota

Las Vegas Raiders at New England Patriots

This could be the definition of a trap game for the Raiders as they are on a short week and played their Las Vegas home debut Monday vs. New Orleans. New England lost a thriller in Seattle on Sunday night 35-30 as Cam Newton was stopped on a run just short of the goal line as time expired. The former league MVP was marvelous otherwise, throwing for 397 yards and a TD and rushing for two scores.

Point spread: Patriots -6.5 (may change after Monday’s game)

Pick ATS: New England

New York Giants quarterback Daniel Jones

San Francisco 49ers at New York Giants

The 49ers were gutted by injuries Sunday but still crushed the New York Jets.  Nick Bosa, the 2019 NFL Defensive Rookie of the Year, reportedly suffered a season-ending torn ACL. QB Jimmy Garoppolo also left injured but that’s not believed to be serious. The Giants fell to 0-2 with Sunday’s loss in Chicago and also lost star running back Saquon Barkley to a season-ending torn ACL.

Point spread: 49ers -4

Pick ATS: San Francisco

Cincinnati Bengals at Philadelphia Eagles

The Bengals are winless, but they have lost those two games by just eight points, and QB Joe Burrow already is showing he was a worthy No. 1 overall pick. In last Thursday’s 35-30 loss to Cleveland, his 37 completions were an NFL rookie record. Philly is a surprising 0-2 after being dominated at home Sunday by the Rams. QB Carson Wentz already has been picked off four times this year.

Point spread: Eagles -6.5

Pick ATS: Philadelphia

Houston Texans at Pittsburgh Steelers

Houston is 0-2 but also has played arguably the NFL’s two best teams in Kansas City and Baltimore. The trade of DeAndre Hopkins looks worse by the week. Pittsburgh has unusually scored 26 points in back-to-back games and won them both. Ben Roethlisberger looks back to full health with five TD passes on the season.

Point spread: Steelers -4.5

Pick ATS: Pittsburgh

New York Jets at Indianapolis Colts

The Jets are an utter mess and quite possibly the NFL’s worst team. They were stomped at home by the 49ers on Sunday even though San Francisco saw three of its best players leave due to injury. It’s only a matter of time before Coach Adam Gase is fired. The Colts won their home opener Sunday, 28-11 over Minnesota. Rookie Jonathan Taylor rushed for 101 yards and a TD, the first Colts rookie to top the 100-yard mark since 2012.

Point spread: Colts -9.5

Pick ATS: NY Jets (alternate line of +10)

Carolina Panthers at Los Angeles Chargers

Perhaps the most shocking development of Sunday was the Chargers turning to rookie No. 6 overall pick Justin Herbert at quarterback right before kickoff against the Chiefs because of a very strange chest injury to Tyrod Taylor. Herbert looked good in throwing for a TD and rushing for one but the Bolts blew a lead and lost in OT. Coach Anthony Lynn says Taylor is his starter if healthy. We’ll believe that when we see it. Carolina is 0-2 and rebuilding but has been competitive under first-year coach Matt Rhule. Star running back Christian McCaffrey is going to miss 4-6 weeks due to an ankle injury suffered Sunday.

Point spread: Chargers -6.5

Pick ATS: Los Angeles

Tampa Bay Buccaneers at Denver Broncos

Tom Brady got his first win with the Bucs on Sunday, 31-17 over Carolina. Brady wasn’t all that great, though. New addition Leonard Fournette rushed for 103 yards and two touchdowns – one late that gave Tampa a backdoor cover. This writer picked Denver to be the surprise champion of the AFC West. To be fair, that was before the Broncos started losing key players to injury. QB Drew Lock left Sunday’s 26-21 loss in Pittsburgh with a shoulder issue that will sideline him 2-6 weeks. Top wideout Courtland Sutton is done for the year. Yeah, forget that AFC West title.

Point spread: Bucs -6

Pick ATS: Tampa Bay

Detroit Lions at Arizona Cardinals

The Lions were crushed Sunday in Green Bay 42-21. Detroit allowed 31 straight points to turn a 14-3 lead into a 34-14 deficit. Arizona is 2-0 following a 30-15 win over Washington on Sunday. Kyler Murray threw for a TD and rushed for two. These teams opened the 2019 season against one another in the desert – Murray’s NFL debut for the Cards — and the Lions blew a 24-6 fourth-quarter lead and had to settle for a 27-27 tie.

Point spread: Cardinals -6.5

Pick ATS: Arizona

Dallas Cowboys at Seattle Seahawks

Dallas had one of the most unlikely comeback wins in franchise history Sunday, roaring back from down 29-10 at halftime and 39-24 with less than two minutes left to stun the Falcons 40-39. Dak Prescott had a monster game in throwing for 450 yards and a TD and rushing for three scores. Seattle won a thriller Sunday night over New England, stopping Pats QB Cam Newton short of the goal line on the final play. Russell Wilson was brilliant with five TD passes.

Point spread: Seahawks -3.5

Pick ATS: Seattle (alternate line of -2.5)

Green Bay Packers at New Orleans Saints

Sunday night game, so a bit less of a short week for the Saints after they visited the Raiders on Monday in Week 2 without injured All-Pro receiver Michael Thomas. Green Bay smashed the Lions behind 168 yards rushing and three total TDs from Aaron Jones. This could be the last-ever matchup between future Hall of Famer QBs Aaron Rodgers and Drew Brees with most expecting Brees to retire after this season. They could always meet in the playoffs, though.

Point spread: Saints -4 (may change after Monday’s game)

Pick ATS: Green Bay

Kansas City Chiefs at Baltimore Ravens, Monday

Huge, huge game as the winner has a crucial leg up for the top seed in the AFC playoffs. It also features the past two NFL MVP winners in Lamar Jackson and Patrick Mahomes – they were the two betting favourites entering this year. Baltimore lost one road game last season and it was Week 3 in Kansas City, 33-28. Mahomes threw for three TDs, while Jackson was held to just a rushing score.

Point spread: Ravens -3

Pick ATS: Baltimore (-2.5 alternate line)