NFL Week 16 Predictions: Best Picks Against the Spread

Payton Matthews | Updated Dec 16, 2019

eagles vs dolphins

Playoff berths can be clinched in several spots around the NFL in Week 16, which features three Saturday games and the final Monday night one of the 2019 campaign.

Here’s a quick look at all the Week 16 matchups with Sports Interaction’s Week 16 NFL odds. Games Sunday unless noted.

Houston Texans at Tampa Bay Buccaneers, Saturday

The Bucs are just playing out the string, with quarterback Jameis Winston having quite the season. He’s leading the NFL in interceptions easily, is first in passing yards and second in passing TDs. Doubtful any QB has led the league in all three categories in one season. Houston is still chasing a playoff berth, either a Wild-Card spot or the AFC South title. It would win the South on Saturday with a victory.

Point spread: Texans -2

Pick ATS: Houston

Buffalo Bills at New England Patriots, Saturday

The Patriots have won the AFC East every year since 2001, Tom Brady’s first season starting, but two. They will clinch another title with a victory. Buffalo has clinched at least a Wild-Card spot (as have the Patriots). Brady is 31-3 in his career against the Bills, although he struggled in 16-10 win in Week 4. Buffalo likely wins that game without four turnovers.

Point spread: Patriots -6

Pick ATS: New England

Los Angeles Rams at San Francisco 49ers, Saturday

The Rams technically are still alive for a Wild-Card spot but would need to win out and get plenty of unlikely help. The Niners had controlled their own destiny to be the NFC West champion and the conference’s top seed, but they lost all that with this past Sunday’s home upset loss to Atlanta. San Francisco’s defence utterly dominated the Rams in a 20-7 Week 6 win. L.A. didn’t convert a single third- or fourth-down conversion.

Point spread: 49ers -6.5

Pick ATS: San Francisco

Jacksonville Jaguars at Atlanta Falcons

Two teams playing out the string and likely two head coaches who will be fired very shortly after their Week 17 games in Jacksonville’s Doug Marrone and Atlanta’s Dan Quinn. Both clubs did pull off road upset victories in Week 15, though.

Point spread: Falcons -7

Pick ATS: Atlanta

Baltimore Ravens at Cleveland Browns

Baltimore on extra rest after routing the Jets on Thursday night in Week 15. The Ravens, on a franchise-record 10-game winning streak, can clinch the AFC’s top seed – and thus rest most key guys in Week 17 — with a victory. Cleveland’s slim post-season chances evaporated with a loss in Arizona on Sunday.  Baltimore lost 40-25 at home to the Browns in Week 4 in one of the more puzzling results of the year. The Ravens haven’t lost since.

Point spread: Ravens -10

Pick ATS: Cleveland

New Orleans Saints at Tennessee Titans

Short week for the Saints as they hosted Indianapolis on Monday night. New Orleans is still playing for a first-round playoff bye in the NFC. Drew Brees was likely to break Peyton Manning’s career TD pass record on Monday but if not then surely will here. The Titans were upset at home by Houston on Sunday to lose control of their playoff destiny.

Point spread: Saints -1 (may change depending on Monday)

Pick ATS: Tennessee

Carolina Panthers at Indianapolis Colts

Both eliminated from playoff contention with Carolina having fired Coach Ron Rivera a few weeks ago. The Panthers lost their sixth in a row Sunday, 30-24 at home to Seattle. Christian McCaffrey had two more TDs and leads the league with 18, while also becoming the first Carolina player to eclipse 2,000 yards from scrimmage in a season. Short week for the Colts after playing Monday in New Orleans.

Point spread: Colts -6.5 (may change depending on Monday)

Pick ATS: Indianapolis

Cincinnati Bengals at Miami Dolphins

Cincinnati could wrap up the No. 1 pick in the 2020 NFL Draft with a loss. The Bengals surely would take LSU quarterback Joe Burrow, the Heisman Trophy winner. Miami was the early-season favourite to finish with the NFL’s worst record but has played better since mid-season to “lose” out on that chance.

Point spread: Dolphins -1

Pick ATS: Miami

Pittsburgh Steelers at New York Jets

The Jets were routed in Baltimore last Thursday, while the Steelers were upset at home by the Bills on Sunday. Pittsburgh still controls its destiny for a Wild-Card spot, however. Big story here is former Steelers Pro Bowl running back Le’Veon Bell facing his former team the first time (assuming he plays). He sat out all of 2018 in a contract dispute with the team and then signed with the Jets in free agency.

Point spread: Steelers -3

Pick ATS: Pittsburgh

New York Giants at Washington Redskins

Only better 2020 draft status is at stake here for the potential loser. The Redskins fired their head coach weeks ago and the Giants are widely expected to do the same right after this disastrous season. New York beat Washington 24-3 in Week 4. Both teams turned it over four times, and the Redskins totaled 176 yards.

Point spread: Redskins -2.5

Pick ATS: Washington

Detroit Lions at Denver Broncos

Two teams playing out the string. Detroit has lost seven in a row, which probably will cost second-year coach Matt Patricia his job. Denver had a two-game winning streak end in a 23-3 loss in Kansas City. The Broncos’ offence struggled mightily in the snow.

Point spread: Broncos -6.5

Pick ATS: Denver

Oakland Raiders at Los Angeles Chargers

This is the last “home” game the Chargers will play in their 28,000-seat soccer stadium outside Los Angeles as they will be moving into a spectacular new building next season with the Rams. The Bolts’ season started going downhill in a 26-24 loss in Oakland when Philip Rivers was picked off three times, including the final play of the game.

Point spread: Chargers -5.5

Pick ATS: LA Chargers

Dallas Cowboys at Philadelphia Eagles

Arguably the most important game of Week 16 with the teams tied atop the NFC East. Dallas would clinch the division with a victory, but Philadelphia can’t do so with one. The Cowboys dominated the Eagles 37-10 in Week 7, outgaining Philadelphia 402-283 and forcing three Carson Wentz turnovers.

Point spread: Cowboys -2.5

Pick ATS: Philadelphia

Arizona Cardinals at Seattle Seahawks

Seattle tries to avoid looking ahead to a huge showdown with San Francisco on Week 17, while the Cardinals ended a six-game losing streak with an upset of Cleveland on Sunday. Arizona lost at home to Seattle 27-10 in Week 4. Russell Wilson threw for 240 yards and a score, while Jadeveon Clowney returned a Kyler Murray interception for a TD.

Point spread: Seahawks -9.5

Pick ATS: Seattle

Kansas City Chiefs at Chicago Bears

Sunday night game and the first meeting between quarterbacks taken No. 2 overall and No. 10 in the 2017 NFL Draft in Chicago’s Mitchell Trubisky and Kansas City’s Patrick Mahomes. The Bears, who have been eliminated from playoff contention, blew it by not taking Mahomes. It’s also the first time former Chiefs offensive coordinator Matt Nagy faces Kansas City in a regular-season game since taking over as Chicago’s head coach.

Point spread: Chiefs -5.5

Pick ATS: Kansas City

Green Bay Packers at Minnesota Vikings, Monday

Last Monday night game of the year and a huge one with the NFC North potentially at stake. The race is over if the Packers win because they beat the Vikings 21-16 in Week 2. Minnesota had 421 yards but was doomed by four turnovers.

Point spread: Vikings -4.5

Pick ATS: Minnesota