NFL Week 13 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Dec 01, 2020


While there were no bye weeks in Week 12 around the NFL, the Tampa Bay Buccaneers and Carolina Panthers are off this week – that’s it for the byes in the regular season.

Here’s a quick look at all the Week 13 matchups with Sports Interaction’s Week 13 NFL odds. Games Sunday unless noted. There is no Thursday game this week.

Dallas Cowboys at Baltimore Ravens, Tuesday

We are listing this Tuesday game (Dec. 8) first because this was to be the Thursday matchup of Week 13, but Baltimore is dealing with a major COVID-19 outbreak (star QB Lamar Jackson among those who tested positive) and its Week 12 matchup vs. Pittsburgh was pushed to Wednesday (Dec. 2). This looked like one of the marquee matchups of the 2020 regular season when the schedule was released in May and a possible Super Bowl 55 preview, but both clubs have hugely disappointed and could miss the playoffs entirely.

Point spread: TBA (depends on Ravens this Wednesday, Jackson, etc.)


New Orleans Saints at Atlanta Falcons

The Saints go for the season sweep of the Falcons after winning 24-9 in Atlanta just two weeks ago as New Orleans backup QB Taysom Hill ran for two scores in his first NFL start. The Saints improved to 2-0 under Hill with Sunday’s easy win in Denver even though Hill has yet to throw a TD pass (has run for four scores in his two starts). Atlanta surprisingly routed the visiting Raiders 43-6 on Sunday in easily the team’s best defensive effort of the year.

Point spread: Saints -3

Pick ATS: Atlanta (alternate line of +3.5)

Detroit Lions at Chicago Bears

Chicago has dominated its division rival of late and won 27-23 in Motown in Week 1 thanks to a huge fourth-quarter comeback led by Mitchell Trubisky. It should be him starting again even though Trubisky was mostly brutal in Sunday’s 41-25 loss at Green Bay in his first start since Week 3. That Chicago offence is completely broken. Detroit was embarrassed at home last Thursday by Houston and then fired coach Matt Patricia and GM Bob Quinn. Offensive coordinator Darrell Bevell will finish the year as interim head coach.

Point spread: Bears -3

Pick ATS: Chicago (alternate line of -2.5)

Cleveland Browns at Tennessee Titans

Potential AFC playoff preview. The Titans took over sole possession of first in the AFC South with a very impressive 45-26 win in Indianapolis on Sunday. Derrick Henry had his third straight 100-yard game with 178 and three TDs on 27 carries. Cleveland won its third in a row but didn’t look great doing it, 27-25 in Jacksonville. Two of the team’s best defensive players, Myles Garrett and Denzel Ward, missed it. Sounds like Garrett, one of the league’s top pass rushers, will return this week but not Ward.

Point spread: Titans -5.5

Pick ATS: Tennessee

Cincinnati Bengals at Miami Dolphins

Sadly, NFL fans will not get Joe Burrow vs. Tua Tagovailoa here as Burrow, the No. 1 overall pick in this year’s draft, suffered a season-ending injury in Week 11. Former practice squad player Brandon Allen started Sunday’s Bengals loss to the Giants in place of Burrow and was terrible. Tua missed Week 12 with a thumb injury and probably will not be ready for this one. Ryan Fitzpatrick led an easy win over the Jets on Sunday.

Point spread: Dolphins -11.5

Pick ATS: Cincinnati

Jacksonville Jaguars at Minnesota Vikings

Jacksonville set a franchise single-season record by losing its 10th straight game Sunday and then fired general manager David Caldwell but not Coach Doug Marrone. That makes zero sense, but Marrone’s a goner after the year regardless. Minnesota kept its Wild-Card hopes alive with a 28-27 comeback win over Carolina. Star wideout Adam Thielen, who had been leading the league in TD catches, missed it on the COVID-19 list.

Point spread: Vikings -9.5

Pick ATS: Jacksonville

Las Vegas Raiders at New York Jets

The playoff-hopeful Raiders laid a major egg Sunday in a 43-6 loss in Atlanta. Derek Carr is having a nice year but was not good. Top running back Josh Jacobs left with an injury and probably misses this one. The Jets remain the NFL’s lone winless team following a 20-3 home loss to Miami. It’s still a miracle Coach Adam Gase is employed. He won’t be too much longer.

Point spread: Raiders -7.5

Pick ATS: New York

Indianapolis Colts at Houston Texans

First meeting of the season between AFC South rivals and they play again in two weeks. The Colts were missing a handful of starters on the COVID-19 list and were blasted at home by the Tennessee Titans on Sunday. Houston is playing much better of late thanks to QB Deshaun Watson, who torched the Detroit Lions last Thursday.

Point spread: Colts -2.5

Pick ATS: Houston (alternate line of +3)

Los Angeles Rams at Arizona Cardinals

It’s the first meeting of the year between NFC West rivals and they play again Week 17. The Rams were upset 23-20 at home by San Francisco on Sunday. Los Angeles turned the ball over four times – QB Jared Goff was responsible for three of them. Arizona was upset Sunday at New England. Kyler Murray is dealing with a bit of a shoulder issue and didn’t look close to 100 percent.

Point spread: Rams -3

Pick ATS: Arizona (alternate line of +3.5)

New York Giants at Seattle Seahawks

The Seahawks are on a short week after visiting Philadelphia on Monday in Week 12. The Giants were 19-17 winners at Cincinnati on Sunday but saw quarterback Daniel Jones leave with a hamstring injury. He’s likely to miss at least one game. Veteran journeyman Colt McCoy is the backup.

Point spread: TBA (Seattle game Monday/Jones status)


Philadelphia Eagles at Green Bay Packers

The Eagles are on a short week as they hosted Seattle on Monday to close Week 12. If QB Carson Wentz struggled in that one, there have been rumours he could be benched for rookie Jalen Hurts. Green Bay moved another step toward the NFC North title with an easy 41-25 win over Chicago on Sunday. Aaron Rodgers threw for four scores. Safety Darnell Savage became the first Packers player with two interceptions in a game in nearly four years

Point spread: Packers -7

Pick ATS: Green Bay (alternate line of -6.5)

New England Patriots at Los Angeles Chargers

New England kept its playoff hopes alive Sunday with a 20-17 win over Arizona on Nick Folk’s 50-yard field goal as time expired. The Pats won despite just 179 yards of offence. No team in the NFL manages to find more creative ways to lose games than the Chargers it seems and that was the case Sunday in a 27-17 defeat in Buffalo. Some very questionable clock management decisions by Bolts coach Anthony Lynn.

Point spread: Pick’em

Pick ATS: Los Angeles

Denver Broncos at Kansas City Chiefs

The Sunday night game. Kansas City looks for the season sweep as it won easily 43-16 in Denver in Week 7. The Broncos turned it over four times but otherwise were better statistically. Kansas City won in Tampa on Sunday in a potential Super Bowl preview behind 462 yards passing and three scores from MVP favourite Patrick Mahomes. Denver was down all three of its quarterbacks Sunday due to COVID-19 protocols and had to start practice squad receiver Kendall Hinton at the position. He completed one pass for 13 yards with two picks in a 31-3 loss to New Orleans.

Point spread: Chiefs -14

Pick ATS: Kansas City (alternate line of -13.5)

Washington Football Team at Pittsburgh Steelers, Monday

This was moved from Sunday to Monday because the Steelers had to finish Week 12 on Wednesday due to Baltimore’s COVID-19 issues. Got all that? Washington won its second in a row last Thursday, 41-16 in Dallas. Running back Antonio Gibson continued his stellar rookie campaign with 115 yards rushing and three touchdowns. He might still have a shot to catch Justin Herbert for Offensive Rookie of the Year.

Point spread: TBA (after Tuesday’s Pittsburgh game)


Buffalo Bills “at” San Francisco 49ers, Monday

This game will not be played in the Bay Area but in Arizona because of new COVID-19 regulations in California – the Niners’ Week 14 home game also will be in Phoenix. San Francisco can’t even practice in its facility so presumably will fly out early this week. It will thus be Buffalo’s second game in the desert this season. The Bills lost to the Cardinals in Week 10 on a Hail Mary.

Point spread: Bills -2.5

Pick ATS: Buffalo