NFL Week 10 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Nov 09, 2020

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There were reports last week that the NFL is considering expanding the already expanded playoff field from 14 to 16 teams if a certain some regular-season games are cancelled.

There were reports last week that the NFL is considering expanding the already expanded playoff field from 14 to 16 teams if a certain some regular-season games are cancelled. The way some teams are reporting COVID-19, that’s looking more and more likely but let’s hope not. Here’s a quick look at all the Week 10 matchups with Sports Interaction’s NFL odds. Games Sunday unless noted. Atlanta, Dallas, Kansas City and the NY Jets are on the bye.

Indianapolis Colts at Tennessee Titans, Thursday

One of the most important Thursday night games of the season as it turns out and arguably the marquee matchup of Week 10. The clubs will play again Week 12 at Indianapolis as they battle for the AFC South title – one of the two is going to win it. They split last year, each winning on the road. The road team is 4-1 against the spread in the past five meetings.

Point spread: Titans -2.5

Pick ATS: Tennessee

Houston Texans at Cleveland Browns

Cleveland is off its bye week. Houston improved to 2-2 under interim head coach Romeo Crennel with a 27-25 win at Jacksonville on Sunday – both of the Texans’ wins in 2020 are over the bad Jags. Receiver Will Fuller caught a touchdown pass for the sixth straight game. Running back David Johnson left in the first quarter and was placed in the concussion protocol, so it’s a race against time to be ready for this one.

Point spread: Browns -2.5

Pick ATS: Cleveland

Washington Football Team at Detroit Lions

Washington will turn to Alex Smith as its starting quarterback this week after Kyle Allen suffered a gruesome ankle injury in Sunday’s loss to the Giants. Detroit should have starting QB Matthew Stafford even though he left Sunday’s defeat to the Vikings to be checked for a concussion.

Point spread: Lions -4

Pick ATS: Detroit

Jacksonville Jaguars at Green Bay Packers

Looks to be easily the biggest mismatch of Week 10. Green Bay is in command of the NFC North and on extra rest after an easy victory in San Francisco last Sunday. Aaron Rodgers had four more TD passes. Jacksonville lost its seventh in a row Sunday, 27-25 at home to Houston, but sixth-round rookie QB Jake Luton looked pretty solid in his first NFL start.

Point spread: Packers -14

Pick ATS: Jacksonville (alternate spread of +14.5)

Philadelphia Eagles at New York Giants

Philadelphia comes off its bye and will get some injured players back, while New York beat Washington on Sunday – Giants QB Daniel Jones for some reason can always beat Washington but no other teams in the NFL. The Eagles got a very unlikely win at the Giants on Thursday night in Week 7, 22-21, as New York blew a 21-10 lead with less than five minutes to go. A dropped pass by Giants tight end Evan Engram contributed hugely to that loss.

Point spread: Eagles -3

Pick ATS: Philadelphia (alternate line of -2.5)

Tampa Bay Buccaneers at Carolina Panthers

The Bucs looked shockingly bad Sunday night in getting destroyed at home by New Orleans. Tampa Bay had five rushing attempts, the fewest in an NFL game ever. Tom Brady was picked off three times. Carolina played very well in Kansas City on Sunday in Christian McCaffrey’s return from injury but came up just short of the upset (early reports are McCaffrey may have suffered a new injury). Tampa Bay looks for the sweep as it beat Carolina 31-17 in Week 2. Leonard Fournette rushed for 103 yards and two scores.

Point spread: Bucs -6.5

Pick ATS: Tampa Bay

Denver Broncos at Las Vegas Raiders

The Broncos make their first-ever visit to Vegas in the first meeting of the year between AFC West rivals. Denver nearly pulled off another huge comeback win Sunday but fell by a touchdown in Atlanta. The Raiders won their second in a row, 31-26, at the Chargers thanks to a goal-line stop at the end.

Point spread: Raiders -4.5

Pick ATS: Las Vegas

Los Angeles Chargers at Miami Dolphins

Very intriguing matchup simply as it’s two good-rookie quarterbacks in the Bolts’ Justin Herbert (No. 6 overall pick) and the Dolphins’ Tua Tagovailoa (No. 5 overall). It’s very, very early, but so far it looks as if the Fins should have taken Herbert. Tua did look a lot better in Sunday’s upset of Arizona, though, than he did in his starting debut the week before. Herbert had another 300-yard, multiple-TD game, but the Chargers had yet another close loss Sunday vs. the Raiders.

Point spread: Dolphins -2.5

Pick ATS: Miami

Buffalo Bills at Arizona Cardinals

Buffalo played one of its best games of the season Sunday in doing Arizona a favour with a 44-34 win over NFC West-leading Seattle. Josh Allen, not Russell Wilson, was the best QB on the field with four total touchdowns. Arizona was upset at home by Miami and played without top running back Kenyan Drake. Good chance he’s back for this one.

Point spread: Cardinals -1.5

Pick ATS: Arizona

Seattle Seahawks at Los Angeles Rams

First meeting of the season between NFC West rivals. The Rams come off their bye week and probably have to win to have any shot at the division title. Seattle lost 44-34 in Buffalo as Russell Wilson turned the ball over four times, and that Seahawks defence continues to be a major issue.

Point spread: Rams -1

Pick ATS: Los Angeles

San Francisco 49ers at New Orleans Saints

The Niners are absolutely decimated by injuries and barely put up a fight last Thursday at home vs. Green Bay. The Saints could be due a minor letdown after utterly dominating the Bucs in Tampa on Sunday night, 38-3. The Saints are now the favourites to win the NFC. Maybe the most entertaining game of the 2019 regular season was the 49ers’ 48-46 win in New Orleans on a 30-yard field goal as time expired.

Point spread: Saints -6.5

Pick ATS: New Orleans

Cincinnati Bengals at Pittsburgh Steelers

Cincinnati comes off its bye week and stellar Bengals rookie QB Joe Burrow gets his first-ever look at the Steelers. They remained the NFL’s lone unbeaten but had to rally past a bad Dallas team Sunday to reach 8-0 for the first time in franchise history. For the second week in a row, Minkah Fitzpatrick knocked away a pass in the end zone to preserve the Steelers’ undefeated season.

Point spread: Steelers -8.5

Pick ATS: Cincinnati

Baltimore Ravens at New England Patriots

Sunday night game and a short week for the Pats after playing at the New York Jets on Monday to conclude Week 9. Baltimore won at a good Colts team Sunday, but the offence continued to struggle a bit. Top cornerback Marlon Humphrey (COVID) and running back Mark Ingram (injury) both missed it.

Point spread: Ravens -7 (may change after Monday)

Pick ATS: Baltimore (alternate line of -6.5)

Minnesota Vikings at Chicago Bears, Monday

First meeting of the season between NFC North rivals with Chicago sweeping in 2019 in low-scoring games (the Vikings rested starters in Week 17). These teams are going different directions now, though, with the Bears continuing to sputter on offence in a three-game skid – top RB David Montgomery might have a concussion — and the Vikings riding running back Dalvin Cook to back-to-back impressive wins.

Point spread: Vikings -2.5

Pick ATS: Minnesota