NFL Point Spreads Week 6: Best Picks Against the Spread

Payton Matthews | Updated Oct 07, 2019

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Here's a closer look at the betting odds and game predictions for all the Week 6 action, including your best picks against the spread.

Every team in the NFL has now played at least a quarter of its schedule – two hadn’t entering Week 5. Here’s a quick look at all the Week 6 matchups with Sports Interaction NFL odds. Games Sunday unless noted. Buffalo, Chicago, Indianapolis and Oakland are on the bye.

NFL Week 6 Betting Odds

New York Giants at New England Patriots, Thursday

Of course, Eli Manning and the Giants upset Tom Brady and the heavily-favoured Patriots in two Super Bowls. Manning, though, is no longer New York’s starting QB. Rookie Daniel Jones had been 2-0 as the starting QB but lost 28-10 to Minnesota on Sunday. New York star tailback Saquon Barkley sat again with a high ankle sprain but might return here.

Point spread: Patriots -17

Pick ATS: New York

Carolina Panthers at Tampa Bay Buccaneers

A 9:30 a.m. ET kickoff from London with Tampa designated the home team. This already concludes the season series between NFC South rivals. On a Thursday night in Week 2, Tampa Bay was a 20-14 upset winner in Charlotte thanks to a goal-line stand in the final minute-plus. That was the last game Panthers star QB Cam Newton played as he has been out with a foot injury and most likely won’t play this week. Carolina has yet to lose under backup Kyle Allen.

Point spread: Panthers -1

Pick ATS: Tampa Bay

Seattle Seahawks at Cleveland Browns

Big-time rest advantage here for Seattle as it knocked off the Rams 30-29 on Thursday behind a near-perfect night from Russell Wilson (17-for-23, 268 yards, four TDs). He is yet to throw an interception this year and off to a historically good start. Meanwhile, it’s a short week for Cleveland after visiting San Francisco on Monday.

Point spread: Browns -2 (may change depending on Monday)

Pick ATS: Cleveland

Houston Texans at Kansas City Chiefs

Matchup of the AFC’s, if not the NFL’s, two most exciting young quarterbacks in the Texans’ Deshaun Watson and Chiefs’ Patrick Mahomes. The latter was chosen No. 10 overall in the 2017 draft and Watson No. 12. Both the Texans and Chiefs traded up to get their guy. Mahomes is a bit banged up but will play.

Point spread: Chiefs -6.5

Pick ATS: Houston

Washington Redskins at Miami Dolphins

This might be the most interesting bad game in NFL history because both teams are so wretched it might be each’s only realistic chance to avoid 0-16. Miami comes off a bye week and still hasn’t scored a second-half point this year. Washington was crushed at home by New England on Sunday and, not surprisingly, fired Coach Jay Gruden on Monday. Bill Callahan takes over as interim coach.

Point spread: Redskins -3.5

Pick ATS: Miami

Philadelphia Eagles at Minnesota Vikings

Philly was an easy home winner over the Jets on Sunday, 31-6. The Eagles became the first team in NFL history to record 10 sacks and score two defensive touchdowns in a game. Minnesota has alternated wins and losses all season and comes off a 28-10 victory at the Giants behind a fourth 100-yard rushing game this year by Dalvin Cook.

Point spread: Vikings -3

Pick ATS: Minnesota

New Orleans Saints at Jacksonville Jaguars

The Saints still have yet to lose since future Hall of Fame quarterback Drew Brees was sidelined by injury. Teddy Bridgewater threw for 314 yards and four scores in Sunday’s victory over Tampa Bay. Michael Thomas caught two of those scores. Jacksonville had a two-game winning streak snapped in a 34-27 loss in Carolina. Another fine outing, though, for rookie QB Gardner Minshew as he threw for 374 yards and two scores. Pro Bowl cornerback Jalen Ramsey sat again with an injury.

Point spread: Pick’em

Pick ATS: New Orleans

Cincinnati Bengals at Baltimore Ravens

Winless Cincinnati was upset at home by previously winless Arizona on Sunday, 26-23. It’s the seventh time Cincinnati has opened 0-5 since 1990, the most in the league over that span. Might be time to get a look at rookie QB Ryan Finley. Baltimore was a 26-23 OT winner in Pittsburgh to snap a two-game slide. Justin Tucker hit a 46-yard field goal in OT. These teams split last year.

Point spread: Ravens -12

Pick ATS: Baltimore

San Francisco 49ers at Los Angeles Rams

Short week for the 49ers, who were the NFC’s only unbeaten team entering Monday’s game vs. Cleveland. The Rams lost their second straight last Thursday, 30-29 in Seattle. Greg Zuerlein, perhaps the NFL’s best kicker (he hit a winning 57-yarder in overtime to win last season’s NFC title game), pushed a 44-yard FG attempt just right with 11 seconds left.

Point spread: Rams -4

Pick ATS: Los Angeles

Atlanta Falcons at Arizona Cardinals

Now that one coach has been fired in the NFL, don’t be shocked if the next to go is Atlanta’s Dan Quinn – especially if the Falcons lose here to fall to 1-5. They allowed 53 points in Sunday’s loss in Houston. Rookie QB and first-year coach Kliff Kingsbury got their first NFL win Sunday as Arizona was a 26-23 upset winner in Cincinnati. Murray threw for 253 yards and rushed for 93 and a score. Zane Gonzalez hit the winning field goal as time expired.

Point spread: Falcons -1.5

Pick ATS: Arizona

Tennessee Titans at Denver Broncos

Tennessee was beaten 14-7 at home by Buffalo on Sunday. The Titans had just 252 yards even with the return of Pro Bowl left tackle Taylor Lewan from a four-game suspension. Cairo Santos missed three field goals and had a fourth blocked. Here’s guessing the Titans work out other kickers this week. Denver got coach Vic Fangio his first win in a 20-13 upset at the Chargers. Denver hadn’t forced a turnover all season but had three takeaways Sunday.

Point spread: Broncos -2.5

Pick ATS: Denver

Dallas Cowboys at New York Jets

Dallas was manhandled at home Sunday by Green Bay, 34-24. Dak Prescott threw for 463 yards but was picked off three times. Amari Cooper had 11 catches for 226 yards and a score. The Jets thought they might get starting QB Sam Darnold back from mono on Sunday, but he wasn’t able to go and they were pounded 31-6 in Philadelphia. Likely that Darnold plays this week.

Point spread: Cowboys -8.5

Pick ATS: New York

Pittsburgh Steelers at Los Angeles Chargers

The Sunday night game, and they played a barnburner last season in Pittsburgh with the Steelers blowing a 16-point lead and losing at home – the first time in team history it lost a home game when leading by at least 16 points. Already having lost starting QB Ben Roethlisberger to a season-ending injury, the Steelers lost No. 2 Mason Rudolph on a scary hit in Sunday’s home loss to Baltimore. If he can’t play here, it will be unknown rookie Devlin Hodges. The Chargers were upset at home by Denver, turning it over three times.

Point spread: Chargers -6

Pick ATS: Los Angeles

Detroit Lions at Green Bay Packers, Monday

Detroit is 2-1-1 yet is just a few points from being 4-0 … and also 0-4. Their games have been decided by a total of 10 points. The Packers won in Dallas on Sunday behind 107 yards rushing and four scores from Aaron Jones. Top receiver Davante Adams didn’t play due to injury. Detroit used to never win in Wisconsin but has each of the past two years and swept Green Bay in each season.

Point spread: Packers -4.5

Pick ATS: Green Bay