It might show up as a home game on their schedule, but nothing about San Francisco’s Monday night matchup with the Buffalo Bills will provide the comforts of familiar surroundings. COVID-19 protocols have forced the 49ers out of their normal home at Levi’s Stadium and into State Farm Stadium in Glendale, home to the Arizona Cardinals. There also won’t be any fans in the stands, which should greatly benefit the visiting Bills in their quest to reach the AFC playoffs.

NFL Week 13 MNF Point Spread and Betting Analysis

The Bills come in favoured by just under a field goal, and Sports Interaction participants are siding with the AFC East leaders at an 84-percent clip. Buffalo has fared well in recent history against NFC foes, covering each of its previous five games vs. the other conference. The 49ers have covered just one of their previous five “home” games, but are an impressive 8-3 against the spread (ATS) in their last encounters with AFC opponents.

The total for this one is still up in the air, but we can study recent trends nonetheless – and they paint a picture that could be difficult for bettors to distinguish. On one hand, the Bills are 8-3 to the Over in their last 11 games and have a 4-1 O/U mark in their last five games away from Bills Stadium. San Francisco, however, has converted the Under in four of its past six games and has seen 43 or fewer total points scored four times over that span.

Buffalo Bills

Is it worth taking a shot on the Stefon Diggs touchdown prop this weekend? That’s one of the top questions prop bettors are facing heading into this encounter. Diggs ranks among the NFL leaders with 945 receiving yards on the season, but has found the end zone just four times – and only two of those touchdowns have come in his last eight games. Diggs sees too many targets to ignore, but keep your touchdown expectations reasonable.

San Francisco 49ers

A tumultuous season for the 49ers has taken another strange turn with the temporary move to Arizona, where the 49ers will be forced to play at least their next two home games. But maybe the move is a blessing for San Francisco, which has looked dismal at Levi’s Stadium so far this season. The 49ers come into Week 13 with a 1-4 SU and ATS record at home for the year, having failed to score more than 24 points in any home game in 2020.

NFL Prediction: Who Will Win Bills vs. 49ers?

• Regular Season
• Playoffs

Bills Team Leaders

BUF

Touchdowns	Stefon Diggs 8
Rushing	Devin Singletary 687
Passing	Josh Allen 4544
Receiving	Stefon Diggs 127
Sacks	A.J. Klein 5
Interceptions	Tre'Davious White 3

SF

Touchdowns	Jeff Wilson Jr. 10
Rushing	Jeff Wilson Jr. 600
Passing	Nick Mullens 2437
Receiving	Brandon Aiyuk 60
Sacks	Kerry Hyder Jr. 8.5
Interceptions	Jason Verrett 2

BUF

Touchdowns	Dawson Knox 2
Rushing	Josh Allen 145
Passing	Josh Allen 817
Receiving	Stefon Diggs 20
Sacks	Jerry Hughes 3
Interceptions	Taron Johnson 1

SF

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

• Regular Season
• Playoffs

49ers Team Leaders

BUF

Touchdowns	Stefon Diggs 8
Rushing	Devin Singletary 687
Passing	Josh Allen 4544
Receiving	Stefon Diggs 127
Sacks	A.J. Klein 5
Interceptions	Tre'Davious White 3

SF

Touchdowns	Jeff Wilson Jr. 10
Rushing	Jeff Wilson Jr. 600
Passing	Nick Mullens 2437
Receiving	Brandon Aiyuk 60
Sacks	Kerry Hyder Jr. 8.5
Interceptions	Jason Verrett 2

BUF

Touchdowns	Dawson Knox 2
Rushing	Josh Allen 145
Passing	Josh Allen 817
Receiving	Stefon Diggs 20
Sacks	Jerry Hughes 3
Interceptions	Taron Johnson 1

SF

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

Weather

condition

dome

Injuries

Buffalo

Cole Beasley (WR)

Prob Sun Knee - 21 / 01 / 21

Quinton Jefferson (DL)

Prob Sun Ankle - 20 / 01 / 21

Vernon Butler (DT)

Ques Sun Quadricep - 20 / 01 / 21

Gabriel Davis (WR)

Ques Sun Ankle - 16 / 01 / 21

Cole Beasley (WR)

Prob Sat Knee - 12 / 01 / 21

Darryl Johnson (DE)

Prob Sun Knee - 12 / 01 / 21

Ed Oliver (DT)

Prob Sat Ankle - 12 / 01 / 21

Justin Zimmer (DT)

Prob Sat Groin - 12 / 01 / 21

Zack Moss (RB)

I-R Ankle - 09 / 01 / 21

Isaiah McKenzie (WR)

Prob Sat Ankle - 05 / 01 / 21

San Francisco

Kevin Givens (DL)

Out Sun Undisclosed - 01 / 01 / 21

Dre Greenlaw (LB)

Out Sun Calf - 01 / 01 / 21

Emmanuel Moseley (CB)

Ques Sun Hamstring - 31 / 12 / 20

Justin Skule (T)

Ques Sun Knee - 31 / 12 / 20

Jordan Willis (DL)

out for season Ankle - 31 / 12 / 20

Robbie Gould (K)

Out indefinitely Illness - 30 / 12 / 20

Mark Nzeocha (LB)

Ques Sun Illness - 30 / 12 / 20

K'Waun Williams (CB)

Out Sun Shin - 30 / 12 / 20

Tarvarius Moore (DB)

Ques Sun Ankle - 28 / 12 / 20

Brandon Aiyuk (WR)

Out Sun Ankle - 28 / 12 / 20

Injuries

Buffalo

player (position)	status		ats*current	o/u*	notes
Cole Beasley (WR)	Prob Sun	Knee - 21 / 01 / 21	1-0	0-1	+ -
Beasley is tending to a knee injury, but it is likely that he will suit up for the AFC Championship game versus the Chiefs.
Quinton Jefferson (DL)	Prob Sun	Ankle - 20 / 01 / 21	1-0	0-1	+ -
Jefferson has an injured ankle, but it is anticipated that he will line up against the Chiefs in the AFC Championship game.
Vernon Butler (DT)	Ques Sun	Quadricep - 20 / 01 / 21	1-0	0-1	+ -
Butler is bothered by a quad injury, and it has yet to be established if he will take part in the AFC Championship game versus the Chiefs.
Gabriel Davis (WR)	Ques Sun	Ankle - 16 / 01 / 21	1-1	1-1	+ -
Davis is nursing an ankle injury, and his status for the AFC Championship game versus the Chiefs is in question.
Cole Beasley (WR)	Prob Sat	Knee - 12 / 01 / 21	1-1	1-1	+ -
Beasley is nursing a knee injury, but it is anticipated that he will be available for the AFC divisional round versus the Ravens.
Darryl Johnson (DE)	Prob Sun	Knee - 12 / 01 / 21	1-1	1-1	+ -
Johnson is dealing with a knee injury, but it is anticipated that he will partake in the AFC Championship game against the Chiefs.
Ed Oliver (DT)	Prob Sat	Ankle - 12 / 01 / 21	1-1	1-1	+ -
Oliver is tending to an ankle injury, but it is anticipated that he will be active for the AFC divisional round versus the Ravens.
Justin Zimmer (DT)	Prob Sat	Groin - 12 / 01 / 21	1-1	1-1	+ -
Zimmer is bothered by a groin injury, but it is likely that he will line up against the Ravens in the AFC divisional round.
Zack Moss (RB)	I-R	Ankle - 09 / 01 / 21	2-1	2-1	+ -
Moss has been posted to the injured reserve list due to an ankle injury.
Isaiah McKenzie (WR)	Prob Sat	Ankle - 05 / 01 / 21	2-1	2-1	+ -
McKenzie is tending to an ankle injury, but it is expected that he will line up against the Colts in the AFC Wild Card game.

San Francisco

player (position)	status		ats*current	o/u*	notes
Kevin Givens (DL)	Out Sun	Undisclosed - 01 / 01 / 21	1-0	0-1	+ -
Givens will be unavailable for Sunday's clash against the Seahawks for unlisted reasons.
Dre Greenlaw (LB)	Out Sun	Calf - 01 / 01 / 21	1-0	0-1	+ -
Greenlaw has a calf injury, and it will keep him on the sidelines versus the Seahawks on Sunday.
Emmanuel Moseley (CB)	Ques Sun	Hamstring - 31 / 12 / 20	1-0	0-1	+ -
Moseley is battling a hamstring issue, and it is unknown if he will be good to go against the Seahawks on Sunday.
Justin Skule (T)	Ques Sun	Knee - 31 / 12 / 20	1-0	0-1	+ -
Skule has a knee injury, and it remains to be seen if he will partake in Sunday's game against the Seahawks.
Jordan Willis (DL)	out for season	Ankle - 31 / 12 / 20	1-0	0-1	+ -
Willis has been placed on the injured reserve list as he has an ankle injury, ending his season.
Robbie Gould (K)	Out indefinitely	Illness - 30 / 12 / 20	1-0	0-1	+ -
Gould has landed on the Injured Reserve/COVID-19 list, and will be out for an unknown length of time.
Mark Nzeocha (LB)	Ques Sun	Illness - 30 / 12 / 20	1-0	0-1	+ -
Nzeocha is ailing from an illness, and it is unknown if he will participate against the Seahawks on Sunday.
K'Waun Williams (CB)	Out Sun	Shin - 30 / 12 / 20	1-0	0-1	+ -
Williams is managing a shin injury, and it will prevent him from playing against the Seahawks on Sunday.
Tarvarius Moore (DB)	Ques Sun	Ankle - 28 / 12 / 20	1-0	0-1	+ -
Moore is dealing with an ankle injury, leaving his status against the Seahawks on Sunday hazy.
Brandon Aiyuk (WR)	Out Sun	Ankle - 28 / 12 / 20	1-0	0-1	+ -
Aiyuk is battling an ankle injury, and he will not be available Sunday versus the Seahawks.