A tumultuous season for the San Francisco 49ers has taken another strange turn with the temporary move to Arizona.
It might show up as a home game on their schedule, but nothing about San Francisco’s Monday night matchup with the Buffalo Bills will provide the comforts of familiar surroundings. COVID-19 protocols have forced the 49ers out of their normal home at Levi’s Stadium and into State Farm Stadium in Glendale, home to the Arizona Cardinals. There also won’t be any fans in the stands, which should greatly benefit the visiting Bills in their quest to reach the AFC playoffs.
NFL Week 13 MNF Point Spread and Betting Analysis
The Bills come in favoured by just under a field goal, and Sports Interaction participants are siding with the AFC East leaders at an 84-percent clip. Buffalo has fared well in recent history against NFC foes, covering each of its previous five games vs. the other conference. The 49ers have covered just one of their previous five “home” games, but are an impressive 8-3 against the spread (ATS) in their last encounters with AFC opponents.
The total for this one is still up in the air, but we can study recent trends nonetheless – and they paint a picture that could be difficult for bettors to distinguish. On one hand, the Bills are 8-3 to the Over in their last 11 games and have a 4-1 O/U mark in their last five games away from Bills Stadium. San Francisco, however, has converted the Under in four of its past six games and has seen 43 or fewer total points scored four times over that span.
Buffalo Bills
Is it worth taking a shot on the Stefon Diggs touchdown prop this weekend? That’s one of the top questions prop bettors are facing heading into this encounter. Diggs ranks among the NFL leaders with 945 receiving yards on the season, but has found the end zone just four times – and only two of those touchdowns have come in his last eight games. Diggs sees too many targets to ignore, but keep your touchdown expectations reasonable.
San Francisco 49ers
A tumultuous season for the 49ers has taken another strange turn with the temporary move to Arizona, where the 49ers will be forced to play at least their next two home games. But maybe the move is a blessing for San Francisco, which has looked dismal at Levi’s Stadium so far this season. The 49ers come into Week 13 with a 1-4 SU and ATS record at home for the year, having failed to score more than 24 points in any home game in 2020.
NFL Prediction: Who Will Win Bills vs. 49ers?
Line History
Sports Interaction customers are placing their bets on:
time | fav | line | total |
---|---|---|---|
Opening 26 Nov 5:16am | BUF | -2.5 -115 | O +48.5 -110 |
Closing 7 Dec 11:51pm | BUF | -1.5 -101 | O +48 -115 |
- Regular Season
- Playoffs
Bills Team Leaders
Touchdowns |
8 |
Rushing |
687 |
Passing |
4544 |
Receiving |
127 |
Sacks |
5 |
Interceptions |
3 |
Touchdowns |
10 |
Rushing |
600 |
Passing |
2437 |
Receiving |
60 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
2 |
Rushing |
145 |
Passing |
817 |
Receiving |
20 |
Sacks |
3 |
Interceptions |
1 |
Touchdowns | |
Rushing | |
Passing | Did not qualify |
Receiving | |
Sacks | |
Interceptions |
- Regular Season
- Playoffs
49ers Team Leaders
Touchdowns |
8 |
Rushing |
687 |
Passing |
4544 |
Receiving |
127 |
Sacks |
5 |
Interceptions |
3 |
Touchdowns |
10 |
Rushing |
600 |
Passing |
2437 |
Receiving |
60 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
2 |
Rushing |
145 |
Passing |
817 |
Receiving |
20 |
Sacks |
3 |
Interceptions |
1 |
Touchdowns | |
Rushing | |
Passing | Did not qualify |
Receiving | |
Sacks | |
Interceptions |
Weather

condition | dome |
Injuries
Cole Beasley (WR)
Quinton Jefferson (DL)
Vernon Butler (DT)
Gabriel Davis (WR)
Cole Beasley (WR)
Darryl Johnson (DE)
Ed Oliver (DT)
Justin Zimmer (DT)
Zack Moss (RB)
Isaiah McKenzie (WR)
Kevin Givens (DL)
Dre Greenlaw (LB)
Emmanuel Moseley (CB)
Justin Skule (T)
Jordan Willis (DL)
Robbie Gould (K)
Mark Nzeocha (LB)
K'Waun Williams (CB)
Tarvarius Moore (DB)
Brandon Aiyuk (WR)
Injuries
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Cole Beasley (WR) | Prob Sun | Knee - 21 / 01 / 21 | 1-0 | 0-1 | + - |
Beasley is tending to a knee injury, but it is likely that he will suit up for the AFC Championship game versus the Chiefs. |
|||||
Quinton Jefferson (DL) | Prob Sun | Ankle - 20 / 01 / 21 | 1-0 | 0-1 | + - |
Jefferson has an injured ankle, but it is anticipated that he will line up against the Chiefs in the AFC Championship game. |
|||||
Vernon Butler (DT) | Ques Sun | Quadricep - 20 / 01 / 21 | 1-0 | 0-1 | + - |
Butler is bothered by a quad injury, and it has yet to be established if he will take part in the AFC Championship game versus the Chiefs. |
|||||
Gabriel Davis (WR) | Ques Sun | Ankle - 16 / 01 / 21 | 1-1 | 1-1 | + - |
Davis is nursing an ankle injury, and his status for the AFC Championship game versus the Chiefs is in question. |
|||||
Cole Beasley (WR) | Prob Sat | Knee - 12 / 01 / 21 | 1-1 | 1-1 | + - |
Beasley is nursing a knee injury, but it is anticipated that he will be available for the AFC divisional round versus the Ravens. |
|||||
Darryl Johnson (DE) | Prob Sun | Knee - 12 / 01 / 21 | 1-1 | 1-1 | + - |
Johnson is dealing with a knee injury, but it is anticipated that he will partake in the AFC Championship game against the Chiefs. |
|||||
Ed Oliver (DT) | Prob Sat | Ankle - 12 / 01 / 21 | 1-1 | 1-1 | + - |
Oliver is tending to an ankle injury, but it is anticipated that he will be active for the AFC divisional round versus the Ravens. |
|||||
Justin Zimmer (DT) | Prob Sat | Groin - 12 / 01 / 21 | 1-1 | 1-1 | + - |
Zimmer is bothered by a groin injury, but it is likely that he will line up against the Ravens in the AFC divisional round. |
|||||
Zack Moss (RB) | I-R | Ankle - 09 / 01 / 21 | 2-1 | 2-1 | + - |
Moss has been posted to the injured reserve list due to an ankle injury. |
|||||
Isaiah McKenzie (WR) | Prob Sat | Ankle - 05 / 01 / 21 | 2-1 | 2-1 | + - |
McKenzie is tending to an ankle injury, but it is expected that he will line up against the Colts in the AFC Wild Card game. |
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Kevin Givens (DL) | Out Sun | Undisclosed - 01 / 01 / 21 | 1-0 | 0-1 | + - |
Givens will be unavailable for Sunday's clash against the Seahawks for unlisted reasons. |
|||||
Dre Greenlaw (LB) | Out Sun | Calf - 01 / 01 / 21 | 1-0 | 0-1 | + - |
Greenlaw has a calf injury, and it will keep him on the sidelines versus the Seahawks on Sunday. |
|||||
Emmanuel Moseley (CB) | Ques Sun | Hamstring - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Moseley is battling a hamstring issue, and it is unknown if he will be good to go against the Seahawks on Sunday. |
|||||
Justin Skule (T) | Ques Sun | Knee - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Skule has a knee injury, and it remains to be seen if he will partake in Sunday's game against the Seahawks. |
|||||
Jordan Willis (DL) | out for season | Ankle - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Willis has been placed on the injured reserve list as he has an ankle injury, ending his season. |
|||||
Robbie Gould (K) | Out indefinitely | Illness - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Gould has landed on the Injured Reserve/COVID-19 list, and will be out for an unknown length of time. |
|||||
Mark Nzeocha (LB) | Ques Sun | Illness - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Nzeocha is ailing from an illness, and it is unknown if he will participate against the Seahawks on Sunday. |
|||||
K'Waun Williams (CB) | Out Sun | Shin - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Williams is managing a shin injury, and it will prevent him from playing against the Seahawks on Sunday. |
|||||
Tarvarius Moore (DB) | Ques Sun | Ankle - 28 / 12 / 20 | 1-0 | 0-1 | + - |
Moore is dealing with an ankle injury, leaving his status against the Seahawks on Sunday hazy. |
|||||
Brandon Aiyuk (WR) | Out Sun | Ankle - 28 / 12 / 20 | 1-0 | 0-1 | + - |
Aiyuk is battling an ankle injury, and he will not be available Sunday versus the Seahawks. |
-
BUFFALO BILLS
27 -
SAN FRANCISCO 49ERS
20
Score
Prediction
-
Line History
Sports Interaction customers are placing their bets on:
time fav line total Opening 26 Nov 5:16am BUF -2.5 -115 O +48.5 -110 Closing 7 Dec 11:51pm BUF -1.5 -101 O +48 -115 -
- Regular Season
- Playoffs
Bills Team Leaders
Touchdowns 8
Rushing 687
Passing 4544
Receiving 127
Sacks 5
Interceptions 3
Touchdowns 10
Rushing 600
Passing 2437
Receiving 60
Sacks 8.5
Interceptions 2
Touchdowns 2
Rushing 145
Passing 817
Receiving 20
Sacks 3
Interceptions 1
Touchdowns Rushing Passing Did not qualify Receiving Sacks Interceptions -
- Regular Season
- Playoffs
49ers Team Leaders
Touchdowns 8
Rushing 687
Passing 4544
Receiving 127
Sacks 5
Interceptions 3
Touchdowns 10
Rushing 600
Passing 2437
Receiving 60
Sacks 8.5
Interceptions 2
Touchdowns 2
Rushing 145
Passing 817
Receiving 20
Sacks 3
Interceptions 1
Touchdowns Rushing Passing Did not qualify Receiving Sacks Interceptions -
Weather
condition dome -
Injuries
Cole Beasley (WR)
Prob Sun Knee - 21 / 01 / 21Quinton Jefferson (DL)
Prob Sun Ankle - 20 / 01 / 21Vernon Butler (DT)
Ques Sun Quadricep - 20 / 01 / 21Gabriel Davis (WR)
Ques Sun Ankle - 16 / 01 / 21Cole Beasley (WR)
Prob Sat Knee - 12 / 01 / 21Darryl Johnson (DE)
Prob Sun Knee - 12 / 01 / 21Ed Oliver (DT)
Prob Sat Ankle - 12 / 01 / 21Justin Zimmer (DT)
Prob Sat Groin - 12 / 01 / 21Zack Moss (RB)
I-R Ankle - 09 / 01 / 21Isaiah McKenzie (WR)
Prob Sat Ankle - 05 / 01 / 21Kevin Givens (DL)
Out Sun Undisclosed - 01 / 01 / 21Dre Greenlaw (LB)
Out Sun Calf - 01 / 01 / 21Emmanuel Moseley (CB)
Ques Sun Hamstring - 31 / 12 / 20Justin Skule (T)
Ques Sun Knee - 31 / 12 / 20Jordan Willis (DL)
out for season Ankle - 31 / 12 / 20Robbie Gould (K)
Out indefinitely Illness - 30 / 12 / 20Mark Nzeocha (LB)
Ques Sun Illness - 30 / 12 / 20K'Waun Williams (CB)
Out Sun Shin - 30 / 12 / 20Tarvarius Moore (DB)
Ques Sun Ankle - 28 / 12 / 20Brandon Aiyuk (WR)
Out Sun Ankle - 28 / 12 / 20Injuries
player (position) status ats*current o/u* notes Cole Beasley (WR) Prob Sun Knee - 21 / 01 / 21 1-0 0-1 + - Beasley is tending to a knee injury, but it is likely that he will suit up for the AFC Championship game versus the Chiefs.
Quinton Jefferson (DL) Prob Sun Ankle - 20 / 01 / 21 1-0 0-1 + - Jefferson has an injured ankle, but it is anticipated that he will line up against the Chiefs in the AFC Championship game.
Vernon Butler (DT) Ques Sun Quadricep - 20 / 01 / 21 1-0 0-1 + - Butler is bothered by a quad injury, and it has yet to be established if he will take part in the AFC Championship game versus the Chiefs.
Gabriel Davis (WR) Ques Sun Ankle - 16 / 01 / 21 1-1 1-1 + - Davis is nursing an ankle injury, and his status for the AFC Championship game versus the Chiefs is in question.
Cole Beasley (WR) Prob Sat Knee - 12 / 01 / 21 1-1 1-1 + - Beasley is nursing a knee injury, but it is anticipated that he will be available for the AFC divisional round versus the Ravens.
Darryl Johnson (DE) Prob Sun Knee - 12 / 01 / 21 1-1 1-1 + - Johnson is dealing with a knee injury, but it is anticipated that he will partake in the AFC Championship game against the Chiefs.
Ed Oliver (DT) Prob Sat Ankle - 12 / 01 / 21 1-1 1-1 + - Oliver is tending to an ankle injury, but it is anticipated that he will be active for the AFC divisional round versus the Ravens.
Justin Zimmer (DT) Prob Sat Groin - 12 / 01 / 21 1-1 1-1 + - Zimmer is bothered by a groin injury, but it is likely that he will line up against the Ravens in the AFC divisional round.
Zack Moss (RB) I-R Ankle - 09 / 01 / 21 2-1 2-1 + - Moss has been posted to the injured reserve list due to an ankle injury.
Isaiah McKenzie (WR) Prob Sat Ankle - 05 / 01 / 21 2-1 2-1 + - McKenzie is tending to an ankle injury, but it is expected that he will line up against the Colts in the AFC Wild Card game.
player (position) status ats*current o/u* notes Kevin Givens (DL) Out Sun Undisclosed - 01 / 01 / 21 1-0 0-1 + - Givens will be unavailable for Sunday's clash against the Seahawks for unlisted reasons.
Dre Greenlaw (LB) Out Sun Calf - 01 / 01 / 21 1-0 0-1 + - Greenlaw has a calf injury, and it will keep him on the sidelines versus the Seahawks on Sunday.
Emmanuel Moseley (CB) Ques Sun Hamstring - 31 / 12 / 20 1-0 0-1 + - Moseley is battling a hamstring issue, and it is unknown if he will be good to go against the Seahawks on Sunday.
Justin Skule (T) Ques Sun Knee - 31 / 12 / 20 1-0 0-1 + - Skule has a knee injury, and it remains to be seen if he will partake in Sunday's game against the Seahawks.
Jordan Willis (DL) out for season Ankle - 31 / 12 / 20 1-0 0-1 + - Willis has been placed on the injured reserve list as he has an ankle injury, ending his season.
Robbie Gould (K) Out indefinitely Illness - 30 / 12 / 20 1-0 0-1 + - Gould has landed on the Injured Reserve/COVID-19 list, and will be out for an unknown length of time.
Mark Nzeocha (LB) Ques Sun Illness - 30 / 12 / 20 1-0 0-1 + - Nzeocha is ailing from an illness, and it is unknown if he will participate against the Seahawks on Sunday.
K'Waun Williams (CB) Out Sun Shin - 30 / 12 / 20 1-0 0-1 + - Williams is managing a shin injury, and it will prevent him from playing against the Seahawks on Sunday.
Tarvarius Moore (DB) Ques Sun Ankle - 28 / 12 / 20 1-0 0-1 + - Moore is dealing with an ankle injury, leaving his status against the Seahawks on Sunday hazy.
Brandon Aiyuk (WR) Out Sun Ankle - 28 / 12 / 20 1-0 0-1 + - Aiyuk is battling an ankle injury, and he will not be available Sunday versus the Seahawks.