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Colts vs. Chargers Prediction, Odds & Stats October 19, 2025

Final Score
AFC South
Oct 19th, 4:05 PM EDT
Indianapolis
Colts
L.A. Chargers
Chargers
38
24
Indianapolis Colts
Los Angeles Chargers
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 8-9 6 17 15 0 +40.5
Los Angeles Chargers 11-6 3 0 14 7 -2.5

Latest Encounters

Date Result Competition Stats Recap
01/11/26
L.A. Chargers Chargers LAC ( 11-6 )
New England Patriots NE ( 14-3 )
3   -   16
 AFC West
01/04/26
L.A. Chargers Chargers LAC ( 11-6 )
Denver Broncos DEN ( 14-3 )
3   -   19
 AFC West
01/04/26
Indianapolis Colts IND ( 8-9 )
Houston Texans HOU ( 12-5 )
30   -   38
 AFC South
12/28/25
Jacksonville Jaguars JAC ( 13-4 )
Indianapolis Colts IND ( 8-9 )
23   -   17
 AFC South
12/27/25
Houston Texans HOU ( 12-5 )
L.A. Chargers Chargers LAC ( 11-6 )
20   -   16
 AFC South
12/22/25
San Francisco 49ers SF ( 12-5 )
Indianapolis Colts IND ( 8-9 )
48   -   27
 NFC West
12/21/25
L.A. Chargers Chargers LAC ( 11-6 )
Dallas Cowboys DAL ( 7-9 )
34   -   17
 AFC West
12/14/25
Indianapolis Colts IND ( 8-9 )
Seattle Seahawks SEA ( 14-3 )
16   -   18
 AFC South
12/14/25
L.A. Chargers Chargers LAC ( 11-6 )
Kansas City Chiefs KC ( 6-11 )
16   -   13
 AFC West
12/08/25
Philadelphia Eagles PHI ( 11-6 )
L.A. Chargers Chargers LAC ( 11-6 )
19   -   22
 NFC East
12/07/25
Indianapolis Colts IND ( 8-9 )
Jacksonville Jaguars JAC ( 13-4 )
19   -   36
 AFC South
11/30/25
Houston Texans HOU ( 12-5 )
Indianapolis Colts IND ( 8-9 )
20   -   16
 AFC South

Line History

Matchup Details

Indianapolis Colts IND
L.A. Chargers Chargers LAC
Stat
5 Games Won 4
1 Games Lost 2
2-8 Last 10 7-3
0-0 W L Streak 0-0
4-2 Against The Spread 3-3
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
3-3 Total 2-4

Recent Meetings

date home-away ats o/u LAC:Total Net Yards LAC:Net Rushing Yards LAC:Passing Yards IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards
10/19/2025 LAC 24 - IND 38 IND +1.5 Over 48.5 445 54 391 401 120 281
12/26/2022 IND 3 - LAC 20 LAC -3.5 Under 47.5 314 101 213 173 69 104
09/08/2019 LAC 30 - IND 24 LAC -6 Over 47.5 376 203 173 435 125 310
09/25/2016 IND 26 - LAC 22 IND -1.5 Under 51.5 352 37 315 410 93 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 HOU 38 - IND 30 W +9.5 Over 37.5 354 76 278
12/28/2025 IND 17 - JAC 23 L +7 Under 48.5 370 121 249
12/22/2025 IND 27 - SF 48 L +5.5 Over 46.5 440 145 295
12/14/2025 SEA 18 - IND 16 W +10 Under 41.5 215 97 118
12/07/2025 JAC 36 - IND 19 L -1.5 Over 45.5 285 89 196
11/30/2025 IND 16 - HOU 20 L -3.5 Under 44.5 364 108 256
11/23/2025 KC 23 - IND 20 L +3.5 Under 49.5 255 74 181
11/09/2025 IND 31 - ATL 25 W -7 Over 48.5 290 140 150
11/02/2025 PIT 27 - IND 20 L -2.5 Under 51.5 368 55 313
10/26/2025 IND 38 - TEN 14 W -3.5 Over 48 341 113 228
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/11/2026 NE 16 - LAC 3 L +3.5 Under 45.5 381 146 235
01/04/2026 DEN 19 - LAC 3 L +7 Under 37.5 240 116 124
12/27/2025 LAC 16 - HOU 20 L -1.5 Under 41 275 74 201
12/21/2025 DAL 17 - LAC 34 W +1.5 Over 50.5 340 91 249
12/14/2025 KC 13 - LAC 16 W +5.5 Under 41.5 239 49 190
12/08/2025 LAC 22 - PHI 19 W +2.5 Over 40.5 275 169 106
11/30/2025 LAC 31 - LV 14 W -10 Over 41.5 341 192 149
11/16/2025 JAC 35 - LAC 6 L -3 Under 43.5 345 192 153
11/09/2025 LAC 25 - PIT 10 W -2.5 Under 45.5 314 115 199
11/02/2025 TEN 20 - LAC 27 L -10.5 Over 44 206 88 118

Matchup Edge - Scoring Stats

Indianapolis Colts IND
L.A. Chargers Chargers LAC
avg rank edge in rank avg
2.1 1 Qb Rating 1 2.1

Odds Analysis

Team Rankings

Indianapolis Colts IND
Season stats rank
Total Yards 349.8 24
Passing Yards 247.94 31
Rushing Yards 101.88 7
Points Scored 24.24 21
Field Goal % 0.86 16
L.A. Chargers Chargers LAC
Season stats rank
Total Yards 285.2 5
Passing Yards 179.88 5
Rushing Yards 105.35 8
Points Scored 20 9
Field Goal % 0.89 23
Indianapolis Colts IND
Season stats rank
Total Yards 345.9 9
Passing Yards 227.82 9
Rushing Yards 118.06 17
Points Scored 27.41 8
Field Goal % 0.94 2
L.A. Chargers Chargers LAC
Season stats rank
Total Yards 333.8 12
Passing Yards 212.24 18
Rushing Yards 121.59 12
Points Scored 21.65 20
Field Goal % 0.93 4

Injuries

Indianapolis Colts IND
L.A. Chargers Chargers LAC

Indianapolis vs. L.A. Chargers Betting News

Indianapolis Colts IND

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L.A. Chargers Chargers LAC

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Indianapolis Vs L.A. Chargers Betting Trends

Indianapolis Colts IND

Colts are 1-4 ATS in their last 5 games after scoring more than 30 points in their previous game.

Colts are 3-7 ATS in their last 10 games as a favorite of 3.5-10.0.

Over is 8-3 in Colts last 11 games overall.

Colts are 5-2 ATS in their last 7 games as a road favorite of 3.5-10.0.

Colts are 1-4 ATS in their last 5 road games vs. a team with a winning home record.

L.A. Chargers Chargers LAC

Chargers are 15-5-1 ATS in their last 21 games as a favorite of 3.5-10.0.

Chargers are 5-2 ATS in their last 7 games following a ATS loss.

Under is 4-1 in Chargers last 5 games overall.

Chargers are 2-5 ATS in their last 7 games as a home underdog.

Chargers are 8-3 ATS in their last 11 games following a straight up win.

Line Up - Last Game

Indianapolis Colts
Pitchers
POS Player
Hitters
POS Player
Los Angeles Chargers
Pitchers
POS Player
Hitters
POS Player
  • IND
  • +2.5 -2.5
  • LAC
NFL Odds