49ers vs. Saints Prediction, Odds & Stats - September 14, 2025

Final Score
San Francisco
49ers
New Orleans
Saints
26
21
San Francisco 49ers
New Orleans Saints
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 9-4 6 10 3 7 +40.5
New Orleans Saints 3-10 0 7 7 7 +3

Latest Encounters

Date Result Competition Stats Recap
12/07/25
New Orleans Saints NO ( 3-10 )
Tampa Bay Buccaneers TB ( 7-6 )
24   -   20
NFC South
11/30/25
San Francisco 49ers SF ( 9-4 )
Cleveland Browns CLE ( 3-10 )
26   -   8
NFC West
11/30/25
New Orleans Saints NO ( 3-10 )
Miami Dolphins MIA ( 6-7 )
17   -   21
NFC South
11/24/25
Carolina Panthers CAR ( 7-6 )
San Francisco 49ers SF ( 9-4 )
9   -   20
NFC South
11/23/25
Atlanta Falcons ATL ( 4-9 )
New Orleans Saints NO ( 3-10 )
24   -   10
NFC South
11/16/25
San Francisco 49ers SF ( 9-4 )
Arizona Cardinals ARI ( 3-10 )
41   -   22
NFC West
11/09/25
L.A. Rams Rams LAR ( 10-3 )
San Francisco 49ers SF ( 9-4 )
42   -   26
NFC West
11/09/25
New Orleans Saints NO ( 3-10 )
Carolina Panthers CAR ( 7-6 )
17   -   7
NFC South
11/02/25
New Orleans Saints NO ( 3-10 )
L.A. Rams Rams LAR ( 10-3 )
10   -   34
NFC South
11/02/25
San Francisco 49ers SF ( 9-4 )
N.Y. Giants Giants NYG ( 2-11 )
34   -   24
NFC West
10/26/25
Tampa Bay Buccaneers TB ( 7-6 )
New Orleans Saints NO ( 3-10 )
23   -   3
NFC South
10/26/25
San Francisco 49ers SF ( 9-4 )
Houston Texans HOU ( 8-5 )
15   -   26
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
San Francisco 49ers San Francisco 49ers
1 0 6-4 3W 1-0 0 0-0 0-0 0-1
New Orleans Saints New Orleans Saints
0 1 3-7 1W 0-1 0 0-0 0-0 0-1

Recent Meetings

date home-away ats o/u NO:Total Net Yards NO:Net Rushing Yards NO:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
09/14/2025 NO 21 - SF 26 SF -3 Over 44.5 307 121 186 344 77 267
08/18/2024 SF 16 - NO 10 SF -1.5 Under 38 271 134 137 315 93 222
11/27/2022 SF 13 - NO 0 SF -9.5 Under 43.5 260 63 197 317 96 221
11/15/2020 NO 27 - SF 13 NO -9.5 Under 50 281 49 232 237 114 123
12/08/2019 NO 46 - SF 48 SF +1 Over 45.5 516 162 354 465 116 349
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
11/02/2025 NYG 24 - SF 34 W -3 Over 47.5 380 159 221
10/26/2025 HOU 26 - SF 15 L +3 Under 41.5 223 48 175
10/19/2025 SF 20 - ATL 10 W -3 Under 46.5 292 62 230
10/12/2025 TB 30 - SF 19 L +2.5 Over 47 363 67 296
10/02/2025 LAR 23 - SF 26 W +8.5 Over 47.5 407 74 333
09/28/2025 SF 21 - JAC 26 L -4.5 Over 45.5 325 151 174
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/07/2025 TB 20 - NO 24 W +8.5 Over 41.5 301 179 122
11/30/2025 MIA 21 - NO 17 W +5.5 Under 42.5 298 164 134
11/23/2025 NO 10 - ATL 24 L +2.5 Under 40 293 79 214
11/09/2025 CAR 7 - NO 17 W +4.5 Under 38.5 175 73 102
11/02/2025 LAR 34 - NO 10 L +14 Under 44.5 438 171 267
10/26/2025 NO 3 - TB 23 L +5.5 Under 46.5 275 48 227
10/19/2025 CHI 26 - NO 14 L +3.5 Under 43.5 386 222 164
10/12/2025 NO 19 - NE 25 L +3.5 Under 45.5 296 73 223
10/05/2025 NO 26 - NYG 14 W +1.5 Under 41.5 332 88 244
09/28/2025 BUF 31 - NO 19 W +17.5 Over 48.5 356 165 191

Matchup Edge - Scoring Stats

San Francisco 49ers SF
New Orleans Saints NO
avg rank edge in rank avg
23.62 14 Points Per Game 28 15.85
20.69 8 Points Allowed Per Game 21 24.23
4.62 12 1st Quarter Scoring Per Game 23 2
2.92 2 1st Quarter Scoring Allowed Per Game 24 7.62
7.23 10 2nd Quarter Scoring Per Game 18 6.38
7.23 18 2nd Quarter Scoring Allowed Per Game 24 9.08
4.77 14 3rd Quarter Scording Per Game 21 3.15
4.85 14 3rd Quarter Scoring Allowed Per Game 7 3.77
6.77 13 4th Quarter Scoring Per Game 24 4.31
5.69 9 4th Quarter Scoring Allowed Per Game 2 3.77
62.5 7 Red Zone Efficiency 29 41.2
341.15 12 Total Yards Per Game 26 293.77
9.86 20 Total Yards Per Play 28 8.56
3.5 30 Rushing Yards Per Play 29 3.65
34.62 6 Passing Attempts Per Game 8 34.31
10.27 17 Passing Yards Per Completion 29 8.79
1.69 5 Passing Tds Per Game 14 1
23.62 2 Completions Per Game 6 22.69
68.2 5 Completion % 13 66.1
93.73 12 Qb Rating 28 82.96
1.54 19 Defense Sacks Per Game 8 2.69
1 3 Defense Interceptions Per Game 5 0.85
1.31 9 Opponent Fumbles Per Game 8 1.23
0.38 8 Opponent Fumbles Lost Per Game 3 0.69
5.15 2 Penalties Per Game 17 7.23
38.38 2 Penalty Yards Per Game 16 52.92
18 9 Takeaway / Giveaway Differential 11 20
6.68 6 Yards Per Punt Return 25 3.38
28.03 4 Yards Per Kickoff Return 17 25.5

Odds Analysis

Team Rankings

offence
San Francisco 49ers SF
Season stats rank
Total Yards 341.2 12
Passing Yards 242.62 6
Rushing Yards 98.54 25
Points Scored 23.62 16
Field Goal % 0.93 6
New Orleans Saints NO
Season stats rank
Total Yards 293.8 26
Passing Yards 199.38 21
Rushing Yards 94.38 28
Points Scored 15.85 30
Field Goal % 0.69 32
defence
San Francisco 49ers SF
Season stats rank
Total Yards 341.2 12
Passing Yards 242.62 6
Rushing Yards 98.54 25
Points Scored 23.62 16
Field Goal % 0.93 6
New Orleans Saints NO
Season stats rank
Total Yards 293.8 26
Passing Yards 199.38 21
Rushing Yards 94.38 28
Points Scored 15.85 30
Field Goal % 0.69 32

Injuries

San Francisco 49ers SF
New Orleans Saints NO

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player