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49ers vs. Cardinals Prediction, Odds & Stats November 21, 2022

Final Score
NFC West
Nov 21st, 8:15 PM EST
San Francisco
49ers
Arizona
Cardinals
38
10
San Francisco 49ers
Arizona Cardinals
47%
53%
Betting Action
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 13-4 0 17 14 7 +43
Arizona Cardinals 4-13 3 7 0 0 +9.5
Loading odds...

Latest Encounters

Date Result Competition Stats Recap
01/29/23
San Francisco 49ers SF ( 13-4 )
Philadelphia Eagles PHI ( 14-3 )
7   -   31
 NFC West
01/22/23
Dallas Cowboys DAL ( 12-5 )
San Francisco 49ers SF ( 13-4 )
12   -   19
 NFC East
01/14/23
Seattle Seahawks SEA ( 9-8 )
San Francisco 49ers SF ( 13-4 )
23   -   41
 NFC West

Betting Action

Spread Bets • 9.5
San Francisco 49ers SF
47%
Arizona Cardinals ARI
53%
Totals (O/U) • 43
Over 68%
Under 32%
Money Bets •
San Francisco 49ers SF
0%
Arizona Cardinals ARI
0%

Line History

Matchup Details

San Francisco 49ers SF
Arizona Cardinals ARI
Stat
5 Games Won 4
4 Games Lost 6
10-0 Last 10 1-9
0-0 W L Streak 0-0
4-5 Against The Spread 5-5
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
3-6 Total 5-5

Recent Meetings

date home-away ats o/u ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 281 95 186 488 36 452
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 260 106 154 355 73 282
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 314 67 247 387 159 228
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/29/2023 PHI 31 - SF 7 L +2 Under 45 164 81 83
01/22/2023 SF 19 - DAL 12 W -3.5 Under 45.5 282 76 206
01/14/2023 SF 41 - SEA 23 W -10 Over 41 332 104 228
01/08/2023 SF 38 - ARI 13 W -13.5 Over 39.5 255 61 194
01/01/2023 LV 34 - SF 37 L -5.5 Over 41 454 170 284
12/24/2022 SF 37 - WAS 20 W -6.5 Over 39.5 349 79 270
12/15/2022 SEA 13 - SF 21 W -3.5 Under 43.5 381 170 211
12/11/2022 SF 35 - TB 7 W -4.5 Over 37 322 69 253
12/04/2022 SF 33 - MIA 17 W -4.5 Over 46 308 33 275
11/27/2022 SF 13 - NO 0 W -9.5 Under 43.5 260 63 197
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/08/2023 SF 38 - ARI 13 L +13.5 Over 39.5 311 169 142
01/01/2023 ATL 20 - ARI 19 W +7 Under 40 298 132 166
12/25/2022 ARI 16 - TB 19 W +7.5 Under 40.5 325 121 204
12/18/2022 DEN 24 - ARI 15 L +2.5 Over 38 324 168 156
12/12/2022 ARI 13 - NE 27 L +1 Under 44 323 113 210
11/27/2022 ARI 24 - LAC 25 W +4.5 Over 47.5 366 181 185
11/21/2022 ARI 10 - SF 38 L +7.5 Over 43 314 67 247
11/13/2022 LAR 17 - ARI 27 W +3.5 Over 37.5 256 66 190
11/06/2022 ARI 21 - SEA 31 L -3 Over 49 262 122 140
10/30/2022 MIN 34 - ARI 26 L +4 Over 48 381 173 208

Odds Analysis

Team Rankings

San Francisco 49ers SF
Season stats rank
Total Yards 300.6 1
Passing Yards 222.88 20
Rushing Yards 77.71 2
Points Scored 16.29 1
Field Goal % 0.76 5
Arizona Cardinals ARI
Season stats rank
Total Yards 348.9 21
Passing Yards 230.29 24
Rushing Yards 118.59 14
Points Scored 26.41 31
Field Goal % 0.94 30
San Francisco 49ers SF
Season stats rank
Total Yards 365.6 5
Passing Yards 226.82 13
Rushing Yards 138.82 8
Points Scored 26.47 6
Field Goal % 0.84 18
Arizona Cardinals ARI
Season stats rank
Total Yards 323.5 22
Passing Yards 213.29 18
Rushing Yards 110.18 22
Points Scored 20 21
Field Goal % 0.88 10

Injuries

San Francisco 49ers SF
Arizona Cardinals ARI

San Francisco vs. Arizona Betting News

San Francisco 49ers SF

No posts found.
Arizona Cardinals ARI

No posts found.

San Francisco Vs Arizona Betting Trends

San Francisco 49ers SF

49ers are 1-4 ATS in their last 5 games after allowing less than 90 yards rushing in their previous game.

Under is 6-1 in 49ers last 7 games following a straight up win.

Under is 5-2 in 49ers last 7 games after accumulating more than 350 total yards in their previous game.

Under is 10-1 in 49ers last 11 games as a favorite.

Under is 10-2 in 49ers last 12 games on grass.

Arizona Cardinals ARI

Under is 9-1 in Cardinals last 10 Monday games.

Cardinals are 7-21-1 ATS in their last 29 games after allowing less than 90 yards rushing in their previous game.

Over is 5-2 in Cardinals last 7 games following a straight up win.

Cardinals are 1-5 ATS in their last 6 games following a ATS win.

Over is 5-2 in Cardinals last 7 games in Week 11.

NFC West Standings

Line Up - Last Game

San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
Arizona Cardinals
Pitchers
POS Player
Hitters
POS Player
  • SF
  • -9.5 +9.5
  • ARI
NFL Odds