49ers vs. Cardinals Prediction, Odds & Stats - November 16, 2025

Final Score
San Francisco
49ers
Arizona
Cardinals
41
22
San Francisco 49ers
Arizona Cardinals
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 9-4 13 12 10 6 +48.5
Arizona Cardinals 3-9 7 3 0 12 +3.5

Latest Encounters

Date Result Competition Stats Recap
11/30/25
San Francisco 49ers SF ( 9-4 )
Cleveland Browns CLE ( 3-9 )
26   -   8
NFC West
11/30/25
Arizona Cardinals ARI ( 3-9 )
Tampa Bay Buccaneers TB ( 7-5 )
17   -   20
NFC West
11/24/25
Carolina Panthers CAR ( 7-6 )
San Francisco 49ers SF ( 9-4 )
9   -   20
NFC South
11/23/25
Jacksonville Jaguars JAC ( 8-4 )
Arizona Cardinals ARI ( 3-9 )
27   -   24
AFC South
11/09/25
L.A. Rams Rams LAR ( 9-3 )
San Francisco 49ers SF ( 9-4 )
42   -   26
NFC West
11/09/25
Arizona Cardinals ARI ( 3-9 )
Seattle Seahawks SEA ( 9-3 )
22   -   44
NFC West
11/03/25
Arizona Cardinals ARI ( 3-9 )
Dallas Cowboys DAL ( 6-5 )
27   -   17
NFC West
11/02/25
San Francisco 49ers SF ( 9-4 )
N.Y. Giants Giants NYG ( 2-11 )
34   -   24
NFC West
10/26/25
San Francisco 49ers SF ( 9-4 )
Houston Texans HOU ( 7-5 )
15   -   26
NFC West
10/19/25
Green Bay Packers GB ( 8-3 )
Arizona Cardinals ARI ( 3-9 )
27   -   23
NFC North

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
San Francisco 49ers San Francisco 49ers
6 4 6-4 3W 5-5 0 0-0 0-0 6-4
Arizona Cardinals Arizona Cardinals
3 6 1-9 4L 6-3 0 0-0 0-0 5-4

Recent Meetings

date home-away ats o/u ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 488 36 452 281 95 186
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 260 106 154 355 73 282
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
11/02/2025 NYG 24 - SF 34 W -3 Over 47.5 380 159 221
10/26/2025 HOU 26 - SF 15 L +3 Under 41.5 223 48 175
10/19/2025 SF 20 - ATL 10 W -3 Under 46.5 292 62 230
10/12/2025 TB 30 - SF 19 L +2.5 Over 47 363 67 296
10/02/2025 LAR 23 - SF 26 W +8.5 Over 47.5 407 74 333
09/28/2025 SF 21 - JAC 26 L -4.5 Over 45.5 325 151 174
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 279 95 184
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 326 55 271
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 488 36 452
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 372 198 174
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 333 123 210
10/19/2025 ARI 23 - GB 27 W +7 Over 44.5 330 94 236
10/12/2025 IND 31 - ARI 27 W +5.5 Over 46.5 355 150 205
10/05/2025 ARI 21 - TEN 22 W -8.5 Over 41.5 360 168 192
09/25/2025 ARI 20 - SEA 23 L -2.5 Under 43.5 253 89 164
09/21/2025 SF 16 - ARI 15 L +3.5 Under 44.5 355 73 282

Matchup Edge - Scoring Stats

avg rank edge in rank avg
23.62 13 Points Per Game 19 22.08
20.69 8 Points Allowed Per Game 23 25.25
4.62 12 1st Quarter Scoring Per Game 11 4.75
2.92 2 1st Quarter Scoring Allowed Per Game 19 5.08
7.23 12 2nd Quarter Scoring Per Game 16 6.75
7.23 15 2nd Quarter Scoring Allowed Per Game 17 7.33
4.77 14 3rd Quarter Scording Per Game 10 5.17
4.85 15 3rd Quarter Scoring Allowed Per Game 8 3.83
6.77 13 4th Quarter Scoring Per Game 20 5.42
5.69 9 4th Quarter Scoring Allowed Per Game 23 8.75
62.5 9 Red Zone Efficiency 16 57.4
341.15 11 Total Yards Per Game 16 337.25
9.86 20 Total Yards Per Play 26 8.7
3.5 28 Rushing Yards Per Play 16 4.31
34.62 8 Passing Attempts Per Game 1 38.75
10.27 17 Passing Yards Per Completion 27 9.02
1.69 7 Passing Tds Per Game 9 1.58
23.62 4 Completions Per Game 1 26.25
68.2 5 Completion % 7 67.7
93.73 15 Qb Rating 13 94.09
1.54 20 Defense Sacks Per Game 4 3.5
1 3 Defense Interceptions Per Game 10 0.58
1.31 14 Opponent Fumbles Per Game 15 1.33
0.38 10 Opponent Fumbles Lost Per Game 4 0.67
5.15 2 Penalties Per Game 20 7.42
38.38 2 Penalty Yards Per Game 16 54.67
18 12 Takeaway / Giveaway Differential 9 15
6.68 5 Yards Per Punt Return 15 4.3
28.03 5 Yards Per Kickoff Return 21 25.22

Odds Analysis

Team Rankings

offence
San Francisco 49ers SF
Season stats rank
Total Yards 341.2 11
Passing Yards 242.62 5
Rushing Yards 98.54 26
Points Scored 23.62 14
Field Goal % 0.93 3
Arizona Cardinals ARI
Season stats rank
Total Yards 337.3 16
Passing Yards 236.67 8
Rushing Yards 100.58 24
Points Scored 22.08 20
Field Goal % 0.78 26
defence
San Francisco 49ers SF
Season stats rank
Total Yards 341.2 11
Passing Yards 242.62 5
Rushing Yards 98.54 26
Points Scored 23.62 14
Field Goal % 0.93 3
Arizona Cardinals ARI
Season stats rank
Total Yards 337.3 16
Passing Yards 236.67 8
Rushing Yards 100.58 24
Points Scored 22.08 20
Field Goal % 0.78 26

Injuries

San Francisco 49ers SF
Arizona Cardinals ARI

NFC West Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player