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49ers vs. Cardinals Prediction, Odds & Stats November 16, 2025

Final Score
NFC West
Nov 16th, 4:05 PM EST
San Francisco
49ers
Arizona
Cardinals
41
22
San Francisco 49ers
Arizona Cardinals
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 12-5 13 12 10 6 +48.5
Arizona Cardinals 3-14 7 3 0 12 +3.5
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Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
 NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
 NFC West
01/04/26
Arizona Cardinals ARI ( 3-14 )
L.A. Rams Rams LAR ( 12-5 )
20   -   37
 NFC West

Line History

Matchup Details

San Francisco 49ers SF
Arizona Cardinals ARI
Stat
6 Games Won 3
4 Games Lost 6
7-3 Last 10 1-9
0-0 W L Streak 0-0
5-5 Against The Spread 6-3
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
6-4 Total 5-4

Recent Meetings

date home-away ats o/u ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 488 36 452 281 95 186
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 260 106 154 355 73 282
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 236 108 128
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 361 75 286
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 361 180 181
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 440 110 330
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 440 145 295
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 306 136 170
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 LAR 37 - ARI 20 L +14 Over 49 395 143 252
12/28/2025 CIN 37 - ARI 14 L +6.5 Over 50.5 449 120 329
12/21/2025 ARI 19 - ATL 26 L +1.5 Under 48 320 132 188
12/14/2025 HOU 40 - ARI 20 L +7.5 Over 42 399 143 256
12/07/2025 ARI 17 - LAR 45 L +1.5 Over 49 314 51 263
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 279 95 184
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 326 55 271
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 488 36 452
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 372 198 174
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 333 123 210

Odds Analysis

Team Rankings

San Francisco 49ers SF
Season stats rank
Total Yards 340.2 20
Passing Yards 232.41 25
Rushing Yards 107.82 11
Points Scored 21.82 13
Field Goal % 0.67 1
Arizona Cardinals ARI
Season stats rank
Total Yards 357.7 28
Passing Yards 230.76 24
Rushing Yards 126.94 25
Points Scored 28.71 29
Field Goal % 0.9 24
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 9
Field Goal % 0.92 6
Arizona Cardinals ARI
Season stats rank
Total Yards 325.8 19
Passing Yards 232.65 7
Rushing Yards 93.12 31
Points Scored 20.88 23
Field Goal % 0.76 30

Injuries

San Francisco 49ers SF
Arizona Cardinals ARI

San Francisco vs. Arizona Betting News

San Francisco 49ers SF

No posts found.
Arizona Cardinals ARI

No posts found.

San Francisco Vs Arizona Betting Trends

San Francisco 49ers SF

Over is 5-2 in 49ers last 7 games after allowing more than 350 total yards in their previous game.

49ers are 1-4 ATS in their last 5 games as a road underdog of 3.5-10.0.

Over is 5-1 in 49ers last 6 vs. a team with a losing record.

Under is 16-7-1 in 49ers last 24 games after allowing more than 30 points in their previous game.

49ers are 1-6 ATS in their last 7 games as a road underdog.

Arizona Cardinals ARI

Over is 4-1 in Cardinals last 5 games as a home underdog of 3.5-10.0.

Cardinals are 7-3 ATS in their last 10 home games.

Over is 6-1 in Cardinals last 7 games after allowing more than 350 total yards in their previous game.

Over is 4-1 in Cardinals last 5 games as a home underdog of 10.5 or greater.

Over is 5-1 in Cardinals last 6 games as a favorite.

NFC West Standings

Line Up - Last Game

San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
Arizona Cardinals
Pitchers
POS Player
Hitters
POS Player
  • SF
  • -3.5 +3.5
  • ARI
NFL Odds