49ers vs. Cardinals Prediction, Odds & Stats - November 16, 2025

Final Score
San Francisco
49ers
Arizona
Cardinals
41
22
San Francisco 49ers
Arizona Cardinals
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 11-4 13 12 10 6 +48.5
Arizona Cardinals 3-12 7 3 0 12 +3.5

Latest Encounters

Date Result Competition Stats Recap
12/22/25
San Francisco 49ers SF ( 11-4 )
Indianapolis Colts IND ( 8-7 )
48   -   27
NFC West
12/21/25
Atlanta Falcons ATL ( 6-9 )
Arizona Cardinals ARI ( 3-12 )
26   -   19
NFC South
12/14/25
Tennessee Titans TEN ( 3-12 )
San Francisco 49ers SF ( 11-4 )
24   -   37
AFC South
12/14/25
Arizona Cardinals ARI ( 3-12 )
Houston Texans HOU ( 10-5 )
20   -   40
NFC West
12/07/25
L.A. Rams Rams LAR ( 11-4 )
Arizona Cardinals ARI ( 3-12 )
45   -   17
NFC West
11/30/25
San Francisco 49ers SF ( 11-4 )
Cleveland Browns CLE ( 3-12 )
26   -   8
NFC West
11/30/25
Arizona Cardinals ARI ( 3-12 )
Tampa Bay Buccaneers TB ( 7-8 )
17   -   20
NFC West
11/24/25
Carolina Panthers CAR ( 8-7 )
San Francisco 49ers SF ( 11-4 )
9   -   20
NFC South
11/23/25
Jacksonville Jaguars JAC ( 11-4 )
Arizona Cardinals ARI ( 3-12 )
27   -   24
AFC South
11/09/25
L.A. Rams Rams LAR ( 11-4 )
San Francisco 49ers SF ( 11-4 )
42   -   26
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
San Francisco 49ers San Francisco 49ers
6 4 7-3 5W 5-5 0 0-0 0-0 6-4
Arizona Cardinals Arizona Cardinals
3 6 1-9 7L 6-3 0 0-0 0-0 5-4

Recent Meetings

date home-away ats o/u ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 488 36 452 281 95 186
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 260 106 154 355 73 282
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 440 145 295
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 306 136 170
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 252 91 161
11/24/2025 SF 20 - CAR 9 W -7 Under 49 230 69 161
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 281 95 186
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 401 126 275
11/02/2025 NYG 24 - SF 34 W -3 Over 47.5 380 159 221
10/26/2025 HOU 26 - SF 15 L +3 Under 41.5 223 48 175
10/19/2025 SF 20 - ATL 10 W -3 Under 46.5 292 62 230
10/12/2025 TB 30 - SF 19 L +2.5 Over 47 363 67 296
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/21/2025 ARI 19 - ATL 26 L +1.5 Under 48 320 132 188
12/14/2025 HOU 40 - ARI 20 L +7.5 Over 42 399 143 256
12/07/2025 ARI 17 - LAR 45 L +1.5 Over 49 314 51 263
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 279 95 184
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 326 55 271
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 488 36 452
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 372 198 174
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 333 123 210
10/19/2025 ARI 23 - GB 27 W +7 Over 44.5 330 94 236
10/12/2025 IND 31 - ARI 27 W +5.5 Over 46.5 355 150 205

Matchup Edge - Scoring Stats

avg rank edge in rank avg
26.13 8 Points Per Game 18 21.4
21.33 11 Points Allowed Per Game 28 27.6
5.4 8 1st Quarter Scoring Per Game 11 4.93
3.2 3 1st Quarter Scoring Allowed Per Game 24 6.07
7.6 8 2nd Quarter Scoring Per Game 15 6.47
7.4 18 2nd Quarter Scoring Allowed Per Game 22 8.07
5.73 8 3rd Quarter Scording Per Game 16 4.6
4.4 12 3rd Quarter Scoring Allowed Per Game 14 4.67
7.2 11 4th Quarter Scoring Per Game 23 5.4
6.33 13 4th Quarter Scoring Allowed Per Game 23 8.6
63.3 7 Red Zone Efficiency 19 55.4
353.67 9 Total Yards Per Game 16 332.53
10.32 17 Total Yards Per Play 28 8.6
3.6 27 Rushing Yards Per Play 16 4.33
34.27 9 Passing Attempts Per Game 1 38.67
10.54 15 Passing Yards Per Completion 26 9.21
2 4 Passing Tds Per Game 7 1.67
23.67 4 Completions Per Game 2 25.53
69.1 3 Completion % 13 66.0
99.26 8 Qb Rating 14 92.1
1.53 18 Defense Sacks Per Game 4 3.27
0.93 4 Defense Interceptions Per Game 7 0.67
1.27 11 Opponent Fumbles Per Game 10 1.2
0.4 6 Opponent Fumbles Lost Per Game 3 0.6
5 2 Penalties Per Game 13 6.87
37.67 3 Penalty Yards Per Game 15 49.73
20 12 Takeaway / Giveaway Differential 11 19
7.37 3 Yards Per Punt Return 20 3.56
27.93 4 Yards Per Kickoff Return 21 25.3

Odds Analysis

Team Rankings

offence
San Francisco 49ers SF
Season stats rank
Total Yards 353.7 9
Passing Yards 249.4 5
Rushing Yards 104.27 24
Points Scored 26.13 9
Field Goal % 0.91 6
Arizona Cardinals ARI
Season stats rank
Total Yards 332.5 16
Passing Yards 235.07 7
Rushing Yards 97.47 27
Points Scored 21.4 21
Field Goal % 0.74 30
defence
San Francisco 49ers SF
Season stats rank
Total Yards 353.7 9
Passing Yards 249.4 5
Rushing Yards 104.27 24
Points Scored 26.13 9
Field Goal % 0.91 6
Arizona Cardinals ARI
Season stats rank
Total Yards 332.5 16
Passing Yards 235.07 7
Rushing Yards 97.47 27
Points Scored 21.4 21
Field Goal % 0.74 30

Injuries

San Francisco 49ers SF
Arizona Cardinals ARI

NFC West Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player