Vikings vs. Cardinals Point Spread: NFL Week 2 Odds, Prediction

Andrew Rogers | Updated Sep 16, 2021

Kyler Murray was the complete package in a season-opening win over the Titans last week, throwing for 289 yards and four TDs, while adding a fifth score on the ground.

September 19, 2021, 4:05 PM ET
State Farm Stadium
Pointspread +4 -105
Moneyline +175
Over / Under o +51.5


Betting Action


Pointspread -4 -115
Moneyline -210
Over / Under u +51.5


Betting Action


The Minnesota Vikings’ defensive shortcomings were on full display in a surprising Week 1 loss to Cincinnati – and things are about to become a whole lot more difficult Sunday as they tangle with the Arizona Cardinals in Glendale. The Vikings have high hopes in an intriguing NFC North division – but dropping a 27-24 decision to the Bengals puts Minnesota behind the 8-ball early. The Cardinals, meanwhile, are soaring after trouncing Tennessee 38-13 to open the season.

Arizona is a 3.5-point favourite to win on the NFL odds, with a total of 50.5.

NFL Point Spread and Betting Analysis

Oddsmakers have been cautious not to overvalue these teams’ Week 1 performances, listing the host Cardinals as modest 3.5-point favourites (you can take the home team without the hook at -132). That line might also be due in part to the fact that the Cardinals have been a truly terrible cover option as a home favourite, going just 7-19 against the spread in the last 26 instances. The Vikings can match that level of ineptitude, entering Sunday on an eight-game cover-less streak.

Sunday’s total is among the highest of any Week 2 matchup at 50.5 – and the Over is still the overwhelming play, with more than 80 per cent of Sports Interaction bettors leaning in that direction. The Vikings have seen an average of 69.3 points scored in their previous three road games, while the Cardinals are on a red-hot 5-1 O/U run in their past six games at State Farm Stadium – a run that has seen them score 28 or more points in five of those six contests.

Minnesota Vikings

That star power on the offensive side of the football won’t matter if the Vikings can’t get some stops – and they were in short supply last week against a Bengals team that won just four games last season. The Bengals outgained Minnesota by a 149-67 margin on the ground in the game and were the far more disciplined team in the win, incurring just three penalties for 15 yards while forcing the visitors to commit 12 infractions for a whopping 116 yards.

Arizona Cardinals

Kyler Murray is ready to make his MVP futures bettors happy. He was the complete package in that season-opening win over the Titans, throwing for 289 yards and four TDs while adding a fifth score on the ground. You can still get Murray at a decent price in the current MVP market (+1000), but a strong showing against the Vikings might very well move him into the top three currently occupied by Patrick Mahomes (+410), Josh Allen (+800) and Tom Brady (+900).

NFL Prediction: Who Will Win Vikings vs. Cardinals?