Titans vs. Patriots Point Spread: NFL Week 12 Odds, Prediction

Daniel Coyle | Updated Nov 25, 2021

The Patriots will be looking to extend the NFL’s longest current win streak to six games on Sunday, when they entertain the injury-plagued Titans in NFL Week 12 action.

November 28, 2021, 1:00 PM ET
Gillette Stadium
Pointspread +7 +100
Moneyline +270
Over / Under o +43.5


Betting Action


Pointspread -7 -120
Moneyline -328
Over / Under u +43.5


Betting Action


The Patriots claimed sole possession of first place in the AFC East standings for the first time since 2019 with a 25-0 rout of the Atlanta Falcons last weekend. Conversely, the Titans are coming off an historic 22-13 loss to the visiting Houston Texans that snapped s six-game win streak.

The Titans have steadily gained ground since opening as 5.5-point road favourites, vaulting to their current position at -7 while attracting 54% of bets. The total has dipped slightly to 44 since opening at 44.5, defying a trend that has seen the OVER attract a sizeable 85% of wagers in totals betting.

NFL Point Spread and Betting Analysis

Sunday afternoon’s matchup at Gillette Stadium marks the first meeting between these AFC rivals since Week 17 of last season. The Titans marched to a 20-13 victory as 4.5-point road underdogs in that contest, and have now limited the Patriots to just 23 total points in back-to-back straight up and against the spread wins. Tennessee’s recent success flips the script on what was a lengthy stretch of futility against the Patriots. The Titans posted outright losses in seven previous dates with New England, falling to defeat by an average margin of 20.4 points during that stretch, which also featured a steady 5-2 run for the OVER.

Tennessee Titans

The Titans have plenty of work to do to overcome their second overall loss of the season, and second defeat in their past five while favoured by at least seven points. Tennessee seemed to be looking past the woeful Texans in last weekend’s shocking defeat. Quarterback Ryan Tannehill earned himself goat horns while tossing four picks, enabling the Texans to seize and early lead they would not relinquish despite compiling just 190 total yards of offence. While Tannehill is a good bet to overcome last week’s debacle, it remains to be seen who he will throw to.

Derrick Henry and Julio Jones top a growing list of injuries in Tennessee. And no fewer than 10 players were unable to participate in Wednesday practice. That includes receivers AJ Brown and Jeremy McNichols, as well as linebackers David Long Jr., Harold Landry III, and Rashaan Evans.

New England Patriots

The Patriots continued their surprising resurgence with yet another outstanding performance in last weekend’s win over the Falcons. With their first shutout win of the season, the Patriots have now limited opponents to just 13 total points over their past three contests, and to an average of just eight points per game during their current 5-0 run. Overall, the Pats have denied opponents scoring runs in five of their past seven contests, and to fewer than 80 rushing yards on four occasions over that stretch.

A fearsome pass defence has also allowed just one total scoring toss over the past three games while racking up eight total picks and 10 total sacks. More of the same should be expected this time around as the Patriots hand Tennessee a second straight upset defeat.

NFL Prediction: Who Will Win Titans vs. Patriots?