Panthers vs. Cardinals Point Spread: NFL Week 10 Odds, Prediction

Daniel Coyle | Updated Nov 11, 2021

The Arizona Cardinals will be aiming to cement their lead atop the NFC West divisional standings when they return home on Sunday to face the struggling Carolina Panthers in NFL Week 10 action.

November 14, 2021, 4:05 PM ET
State Farm Stadium
Pointspread +7 -113
Moneyline +266
Over / Under o +41.5


Betting Action


Pointspread -7 -107
Moneyline -337
Over / Under u +41.5


Betting Action


Arizona rebounded from their first loss of the season to claim a 31-17 win in San Francisco last weekend, and now sport a league-leading 8-1 straight up record. The Panthers arrive in the desert looking for answers after being handed a crushing 24-6 defeat by the visiting New England Patriots that marks their forth loss in five outings.

The Cardinals are 10.5-point favourites to win on the NFL odds, with a total of 44.0.

NFL Point Spread and Betting Analysis

With the backing of 61 per cent of Sports Interaction bettors, the Cardinals have made modest gains on the Week 10 odds, climbing to 10.5-point favourites after opening at -10. The total has dipped slightly to 44 since opening at 44.5. However, the OVER continues to attract 67 per cent of totals wagers.

Sunday afternoon’s matchup at State Farm Stadium marks the first meeting between these two teams this season, and their first clash in the desert since 2019. The Panthers have dominated head-to-head, tallying straight up and against the spread wins in each of their past five dates with Arizona, capped by a stunning 31-21 win as 3-point home underdogs in October of last year.

Carolina also upset the Cardinals in its last trip to Arizona, marching to a lopsided 38-20 victory as 2.5-point underdogs, and snapped a run of five straight outright and against the spread victories by home favourites. The Panthers’ recent victories have also extended a steady trend towards lopsided results, with each of the past 10 meetings between these two teams getting settled by at least seven points.

Carolina Panthers

The Panthers surrendered just 10 points per game during a season-opening 3-0 tear, but have now allowed an average of 25.5 points per game during a subsequent 1-5 run. The loss of quarterback Sam Darnold to injury has further complicated matters. Darnold was struggling before being sidelined by a shoulder injury, failing to find the end zone while averaging just 137.7 passing yards per game over his past three outings. Not surprisingly, that has been bad news for the Panthers overall attack, which has averaged just 7.3 points per game during that stretch. However, it does set the stage for second year passer PJ Walker to make his second career start. Walker has seen limited action this season, going 3-for-15 for 33 yards in a pair of limited appearances.

In a surprising move, Carolina made some mid-week noise by signing Cam Newton as quarterback insurance on Thursday.  Newton previously spent nine years as the Panthers starting QB until he was released in 2020.  The former No. 1 overall pick and 2015 NFL MVP spent last year in New England and was cut by the Patriots just before the start of the 2021 season.  Newton completed 65.8 per cent of his passes with New England last year, throwing for 2,657 yards, eight touchdowns and 10 interceptions.  He added another 592 yards on the ground and rushed for 12 touchdowns.

Arizona Cardinals

The Cardinals rebounded in impressive fashion after dropping a 24-21 decision to the Green Bay Packers in Week 8. Even with quarterback Kyler Murray and receivers DeAndre Hopkins and A.J. Green on the shelf due to injury, Arizona easily disposed of the overmatched San Francisco 49ers in a 31-17 win that was not as close as the score indicated. Green looks set to return. However, both Murray and Hopkins remain questionable after missing Wednesday’s practice. If Murray is unable to go, look for veteran Colt McCoy to make a second straight start. That could mean another busy day for rusher James Conner, who racked up 96 yards and a pair of scoring runs last weekend in San Francisco.

NFL Prediction: Who Will Win Panthers vs. Cardinals?